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  • aortic
  • In this type of VSD, the aortic valve cusp prolapses into the defect. (renalandurologynews.com)
  • We present a case of a 71-year-old Caucasian male with a ventriculo-atrial defect due to infective endocarditis, originating from his aortic root near a bioprosthetic aortic valve, implanted 4 years earlier. (biomedcentral.com)
  • We report a ventriculo-atrial defect due to a paravalvular aortic prosthetic defect, secondary to inflammation, a novel third type of a Gerbode defect. (biomedcentral.com)
  • In this paper we present a case of a third type Gerbode defect, a peri-prosthetic defect with a left-to right shunt due to prosthesis dehiscence, creating a direct shunt from the left ventricle and aortic annulus into the right atrium. (biomedcentral.com)
  • 1 Excluding bicuspid aortic valves, the majority of untreated patients born with congenital heart disease die in infancy or childhood, and only 15-25% survive into adulthood. (asahq.org)
  • cardiovascular
  • Under normal conditions, the cardiovascular system (heart, blood vessels) contains two separate circulatory systems - venous (right) and arterial (left). (nationwidechildrens.org)
  • This results in volume overload of one or more cardiovascular chambers or structures depending on the location of the defect. (asahq.org)
  • The Ts65Dn DS mouse model is trisomic for the distal part of mouse chromosome 16 and displays similar features with post-natal lethality and cardiovascular defects. (prolekare.cz)
  • Mutations
  • Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. (mybiosource.com)
  • As a result, two novel heterozygous PITX2c mutations, p.H98Q and p.M119T, were identified in 2 unrelated patients with atrial septal defects, respectively. (medsci.org)
  • These findings firstly link PITX2c loss-of-function mutations to atrial septal defects in humans, which provide novel insight into the molecular mechanism responsible for CHD, suggesting potential implications for the early prophylaxis and allele-specific treatment of CHD. (medsci.org)
  • Most of the known causes of congenital heart disease are sporadic genetic changes, either focal mutations or deletion or addition of segments of DNA. (wikipedia.org)
  • The coinheritance of NKX2.5 mutations with various congenital heart defects suggests that this transcription factor contributes to diverse cardiac developmental pathways. (xenbase.org)
  • valve
  • The P-wave contour during IART often differs from the familiar sawtooth appearance of flutter because the reentrant path does not necessarily propagate around the tricuspid valve ring but instead may rotate around patches, atriotomy incisions, and other atypical conduction obstacles. (ahajournals.org)
  • Echocardiography revealed mild to moderate right atrial enlargement and thickening of the right atrioventricular (AV) valve. (thefreedictionary.com)
  • Panel A: Mid-esophageal RV inflow/outflow view shows a paravalvular abcess near the atrial septum and involvment of the tricuspid valve insertion (arrow). (biomedcentral.com)
  • Most of the time, there is one "common" valve separating the hearts upper and lower chambers (1) instead of two separate valves. (mottchildren.org)
  • The workload is further increased by leakage of the heart valve. (mottchildren.org)
  • A d-loop ventricle is one in which the internal pattern of the right ventricle conforms to a right-hand pattern, in which an extended thumb indicates the attachment to the tricuspid valve and in which the fingers indicate the right ventricular outflow tract when the palm is placed on the septal surface. (medscape.com)
  • 25 Atrioventricular septal defect with common valve orifice but without atrial component. (norma-capitel.com)
  • 31 Valve prosthesis in a trioventricular septal defects. (norma-capitel.com)
  • phenotypes
  • 3 , 4 Mouse models with haploinsufficiency in either factor replicate the human phenotypes: NKX2.5 haploinsufficiency results in defective central and peripheral conduction systems along with absence of the AVN subdomain. (ahajournals.org)