• Also summarized here are the publications describing the clinical experience with the cryoballoon catheter ablation in both paroxysmal and persistent atrial fibrillation, its safety and efficacy, and discussions on the technical aspect of the cryoballoon ablation procedure. (hindawi.com)
  • Over time, the repetitive stretching of the left atrium may result in a persistent left atrial enlargement. (wikipedia.org)
  • In atrial fibrillation, the upper chambers of the heart (the atria) beat irregularly (quiver) instead of beating effectively to move blood into the ventricles. (stvincent.org)
  • Atrial fibrillation occurs when the smaller upper chambers of the heart, called atria, get irregular electrical signals that disrupt the coordinated pumping of blood through the heart to the rest of the body. (redorbit.com)
  • Renal dysfunction is an independent risk factor for stroke, especially in the setting of atrial fibrillation (AF), and adding it as a scoring element to current risk stratification models, such as CHADS2 , seems to improve stroke risk prediction. (medpagetoday.com)
  • disorder of cardiac rhythm characterized by rapid, irregular atrial impulses and ineffective atrial contractions. (fpnotebook.com)
  • Familial atrial fibrillation appears to be inherited in an autosomal dominant pattern, which means the defective gene is located on an autosome, and only one copy of the defective gene - inherited from one parent - is sufficient to cause the disorder. (wikipedia.org)
  • The first is what we have learned about the electrophysiological mechanisms responsible for the onset of atrial fibrillation, and the second is what we know about its maintenance. (ahajournals.org)
  • Atrial fibrillation may be a primary electrical abnormality of the heart, be associated with underlying heart problems including problems with heart valves, coronary arteries, heart muscle, congestive heart failure or be related to problems with the thyroid gland or other disorders of metabolism. (hrsonline.org)
  • To complement the CHADS2 score, the ESC guidelines on atrial fibrillation management recommend using the new CHA2DS2-VASc score (Congestive heart failure, Hypertension, Age ≥75 years (doubled), Diabetes mellitus, Stroke (doubled), Vascular disease, Age 65-74 years, Sex category], which is more inclusive of 'stroke risk modifier' risk factors. (wikipedia.org)
  • The intention was to eliminate AF by using incisional scars to block abnormal electrical circuits (atrial macroreentry) that initiate and perpetuate the abnormal electrical waves of AF. (wikipedia.org)
  • The mutations known to be possibly involved in atrial fibrillation concern KCNQ1 with gain of function in IKs, KCNE2, KCNA5 and SCN5A for which there is a missence mutation leading to the occurrence of Early After Depolarisations. (escardio.org)
  • It is associated with multiple genes: Mutations in the KCNQ1 gene cause familial atrial fibrillation. (wikipedia.org)
  • A small percentage of all cases of familial atrial fibrillation are associated with changes in the KCNE2, KCNJ2, and KCNQ1 genes. (wikipedia.org)