• Atrial Flutter due to Amiodarone-Induced Thyrotoxicosis Months after D" by Ellen Horstmann et. (unmc.edu)
  • Value of entrainment mapping in determining the isthmus-dependent nature of atrial flutter in the presence of amiodarone. (univ-brest.fr)
  • In patients with isthmus-dependent atrial flutter, entrainment mapping from the isthmus during tachycardia results in postpacing intervals (PPI) close to the tachycardia cycle length (TCL). (univ-brest.fr)
  • The aim of our study was to assess the value of entrainment mapping in the presence of amiodarone in patients undergoing radiofrequency ablation (RFA) of isthmus-dependent atrial flutter. (univ-brest.fr)
  • METHODS AND RESULTS: The study consisted of 83 patients with isthmus-dependent atrial flutter: 52 were taking amiodarone at the time of RFA (group 1) and 31 were in a drug-free state (group 2). (univ-brest.fr)
  • In this setting, long return cycles exceeding the TCL by >20 msec do not exclude isthmus-dependent atrial flutter. (univ-brest.fr)
  • Atrial flutter is the second most common tachyarrhythmia, after atrial fibrillation . (medscape.com)
  • This block may also be variable and cause atrial flutter to appear as an irregular rhythm. (medscape.com)
  • Twelve-lead ECG showing atrial flutter with variable block. (medscape.com)
  • Atrial flutter can arise from conditions that lead to atrial dilatation. (medscape.com)
  • Metabolic conditions such as hyperthyroidism and alcoholism can also cause atrial flutter. (medscape.com)
  • Rarely, atrial fibrillation or atrial flutter may be due to pericardial disease or effusion or caused by carbon monoxide intoxication. (medscape.com)
  • Twelve-lead ECG of type I atrial flutter. (medscape.com)
  • See Atrial Flutter and Pediatric Atrial Flutter for complete information on these topics. (medscape.com)
  • Atrial flutter in an unstable patient should be treated immediately with synchronized cardioversion. (medscape.com)
  • For patient education information, see the Heart Health Center , as well as Atrial Flutter , Arrhythmias (Heart Rhythm Disorders) , Stroke , Supraventricular Tachycardia (SVT, PSVT) , and Palpitations . (medscape.com)
  • At the time of this update, there is no consensus on the optimal management of atrial flutter in the emergency department, due to a lack of robust evidence, as well as a wide variation in typical management. (medscape.com)
  • Look for underlying causes for atrial flutter. (medscape.com)
  • Secondary endpoints included freedom from any AF and freedom from symptomatic AF at 24 months, cumulative and per visit burden of symptomatic AF, time to first recurrence of AF after the blanking period, and atrial flutter longer than 1 minute. (acc.org)
  • Atrial flutter was detected in 31 patients in RFA group and in 40 patients in AAD group (p = 0.25). (acc.org)
  • Clinical reports have shown that dofetilide is effective in the treatment of supraventricular tachyarrhythmias, such as atrial fibrillation and atrial flutter. (bmj.com)
  • CARDIAC  Cardiac arrhythmia-  PSVT  ATRIL FLUTTER  ATRIAL FIBRILLATION  AND VENTRICULAR TACHY-CARDIA can be treated by giving anti-arrhythmic drugs to mother orally or by trans-placental route. (slideshare.net)
  • Coarse AF can be difficult to distinguish from atrial flutter. (challengercme.com)
  • Calcium channel blockers are especially effective in atrial tachycardia with triggered activity as the underlying mechanism. (medscape.com)
  • Beta-blockers can reduce the frequency and severity of atrial tachycardia episodes by controlling ventricular response. (medscape.com)
  • Many class III antidysrhythmic agents have been shown to be effective in maintaining sinus rhythm after conversion from atrial tachycardia. (medscape.com)
  • Focal atrial tachycardia is usually episodic or paroxysmal. (medscape.com)
  • Typically, atrial tachycardia manifests as a sudden onset of palpitations. (medscape.com)
  • Atrial tachycardia due to enhanced automaticity may be nonsustained but repetitive or it may be continuous or sustained, as in reentrant forms of atrial tachycardia. (medscape.com)
  • Atrial tachycardia may gradually speed up soon after its onset ("warm-up" phenomenon) and gradually slows down before termination ("cool-off" phenomenon). (medscape.com)
  • In a patient with supraventricular tachycardia (SVT), the presence of warm-up phenomenon on an electrocardiogram (eg, on Holter monitoring) suggests that the SVT is atrial tachycardia. (medscape.com)
  • Reentrant atrial tachycardia is not uncommon in patients with a history of a surgically repaired atrial septal defect. (medscape.com)
  • In patients with multifocal atrial tachycardia (MAT), the history may disclose an underlying illness that is causing the tachycardia. (medscape.com)
  • Weber R, Letsas KP, Arentz T, Kalusche D. Adenosine sensitive focal atrial tachycardia originating from the non-coronary aortic cusp. (medscape.com)
  • This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia. (wikipedia.org)
  • Amiodarone may be used in the treatment of ventricular tachycardia in certain instances. (wikipedia.org)
  • Individuals with hemodynamically unstable ventricular tachycardia should not initially receive amiodarone. (wikipedia.org)
  • Amiodarone can be used in individuals with hemodynamically stable ventricular tachycardia. (wikipedia.org)
  • Amiodarone and Ocular Toxicity An arrhythmia is a problem associated with the electrical activity of the heart resulting in a heartrate that can be too fast (tachycardia) or too slow (bradycardia). (bartleby.com)
  • Amiodarone HCl injection is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. (druglib.com)
  • Typical ECG findings with SVT include narrow-complex tachycardia, electrical alternans, evidence of atrial activation (P', F, or f waves), and response to treatments that slow down AV conduction. (vin.com)
  • Tachycardia termination occurred in 11 (38%) in the amiodarone group and 22 (67%) in the procainamide group. (medscape.com)
  • Individuals who have undergone open heart surgery are at an increased risk of developing atrial fibrillation (or AF) in the first few days post-procedure. (wikipedia.org)
  • Ablation therapy may be superior to antiarrhythmics in selected patients, including those with paroxysmal atrial fibrillation who are symptomatic but without structural heart disease, patients who are intolerant of antiarrhythmics, and patients with inadequate pharmacologic rhythm control. (aafp.org)
  • This article is based on Radiofrequency Ablation as Initial Therapy in Paroxysmal Atrial Fibrillation. (acc.org)
  • Numerous studies have documented the marginal efficacy of antiarrhythmic drugs (AAD) for maintaining sinus rhythm in patients with paroxysmal atrial fibrillation (AF). (acc.org)
  • paroxysmal atrial fibrillation - this comes and goes, usually stopping within 48 hours without any treatment. (azurewebsites.net)
  • As amiodarone can have serious side effects, it is mainly recommended only for significant ventricular arrhythmias. (wikipedia.org)
  • Amiodarone has been used both in the treatment of acute life-threatening arrhythmias as well as the long term suppression of arrhythmias. (wikipedia.org)
  • Amiodarone injection should be used for acute treatment until the patient's ventricular arrhythmias are stabilized. (druglib.com)
  • Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhythmias and atrial fibrillation. (uwi.edu)
  • In the light of the Cardiac Arrhythmia Suppression Trial (CAST) which suggested that class I antiarrhythmics may be linked to an increase in mortality, attention has been turned towards the use of class III drugs for the management of both atrial and ventricular arrhythmias. (annals.edu.sg)
  • The newest antiarrhythmic medication, dronedarone (Multaq) , is similar to amiodarone but doesn't have the iodine that makes amiodarone toxic. (stopafib.org)
  • and amiodarone or dronedarone for those with coronary heart disease, heart failure with preserved ejection fraction, or severe valvular disease. (stopafib.org)
  • Effects of dronedarone started rapidly after amiodarone discontinuation. (druglib.com)
  • HYPOTHESIS: A rapid switch from amiodarone to dronedarone is feasible. (druglib.com)
  • Atrial ventricular nodal ablation is recommended for patients refractory to medical therapy, usually older patients needing a pacemaker. (aafp.org)
  • Vernakalant suppressed sinus automaticity, ventricular contractility and intra-atrial/atrioventricular nodal/intraventricular conductions, and decreased cardiac output. (bvsalud.org)
  • However, in rapid atrial tachycardias with variable atrioventricular (AV) conduction and in MAT, the pulse may be irregular. (medscape.com)
  • 240 bpm in cats) and require atrial or atrioventricular junctional tissue for its initiation and maintenance. (vin.com)
  • citation needed] So-called 'acute onset atrial fibrillation', defined by the North American Society of Pacing and Electrophysiology (NASPE) in 2003, responds well to short duration treatment with amiodarone. (wikipedia.org)
  • CONCLUSIONS: Vernakalant demonstrated efficacy superior to amiodarone for acute conversion of recent-onset AF. (druglib.com)
  • citation needed] The benefit of amiodarone in the treatment of atrial fibrillation in the critical care population has yet to be determined but it may prove to be the agent of choice where the patient is hemodynamically unstable and unsuitable for DC cardioversion. (wikipedia.org)
  • Atrial fibrillation may be managed by administering drugs to slow heart rate or by restoring normal rhythm (cardioversion). (akcchf.org)
  • However, owners often decline cardioversion because of possible relapse of AF despite routine use of the antiarrhythmic agent, amiodarone. (akcchf.org)
  • This project is a randomized, placebo controlled clinical trial to determine whether ranolazine, given with amiodarone, prolongs normal rhythm after cardioversion compared to amiodarone alone and whether ranolazine also improves heart function. (akcchf.org)
  • Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device: results from the AATAC multicenter randomized trial. (acc.org)
  • Amiodarone hydrochloride injection is a class III antiarrhythmic drug. (druglib.com)
  • Micro-reentry and enhanced automaticity in one or more atrial circuits are the most common triggers for atrial fibrillation. (aafp.org)
  • Because the AV node cannot conduct at the same rate as the atrial activity, some form of conduction block is often seen, typically 2:1 (most common), 3:1, or 4:1. (medscape.com)
  • Pre-excited Atrial Fibrillation (antegrade conduction via accessory pathway, e.g. (fpnotebook.com)
  • Left atrial appendage obliteration is an option for reducing stroke risk. (aafp.org)
  • The mean CHADS2 score was 0.6 and the mean left atrial size was 40mm. (acc.org)
  • In the ARCH trial, intravenous amiodarone (2 g administered over 2 d) has been shown to reduce the incidence of atrial fibrillation after open heart surgery when compared to placebo. (wikipedia.org)
  • During or after treatment with intravenous amiodarone injection patients may be transferred to oral amiodarone therapy (see DOSAGE AND ADMINISTRATION ). (druglib.com)
  • Pharmacokinetics of intravenous amiodarone and its electrocardiographic effects on healthy Japanese subjects. (druglib.com)
  • Intravenous amiodarone was introduced to mainstream acute care providers in the resuscitation guidelines released in 2000. (medscape.com)
  • Dofetilide increased the atrial and ventricular effective refractory periods, as well as the antegrade and retrograde effective refractory period of the accessory pathway. (bmj.com)
  • 9 , 10 Studies have shown that dofetilide prolongs both atrial and ventricular monophasic action potential durations and increases atrial and ventricular effective and functional refractory periods. (bmj.com)
  • Moreover, vernakalant prolonged atrial/ventricular effective refractory period by 53/55 ms, respectively, whereas it delayed ventricular repolarization in a reverse frequency-dependent manner. (bvsalud.org)
  • She will determine whether ranolazine given with amiodarone prolongs normal rhythm compared to amiodarone alone and whether ranolazine also improves heart function. (akcchf.org)
  • Initial diagnosis was amiodarone pulmonary toxicity, but because of a rapidly favourable evolution, this diagnosis was questioned. (ersjournals.com)
  • A diagnosis of amiodarone pulmonary toxicity (APT) was made and the patient was treated with steroids. (ersjournals.com)
  • Pretreatment with amiodarone before intensive care administration, paroxysmal versus persistent AT, catecholamine infusion, and fluid and magnesium loading were among the covariates assessed in the model. (sorbonne-universite.fr)
  • Patients randomised to amiodarone will receive a loading dose (usually 300 mg over 1 hour) followed by a continuous infusion of (usually) between 300-1200 mg (usually 900 mg) per day with the treating clinician choosing the route of administration and duration. (who.int)
  • Atrial Fibrillation (AFib) is the most common type of heart arrythmia and occurs when the two atria of the heart beat in an irregular way thus inhibiting the flow of blood to the ventricles. (physiciansofficeresource.com)
  • Atrial fibrillation is a supraventricular arrhythmia characterized by uncoordinated electrical activation of the atria and an irregular, often rapid, ventricular response causing hemodynamic compromise. (aafp.org)
  • Late in 2010, the FDA approved a new anticoagulant drug called dabigatran (brand name Pradaxa) for the prevention of stroke in patients with an irregular heart beat called atrial fibrillation (AF). (clotcare.com)
  • Atrial fibrillation (AF) is a condition that causes an irregular heart rate. (azurewebsites.net)
  • Some people with atrial fibrillation have no symptoms and are completely unaware that their heart rate is irregular. (azurewebsites.net)
  • The most obvious symptom of atrial fibrillation (AF) is palpitations caused by a fast and irregular heartbeat. (azurewebsites.net)
  • [ 6 ] With respect to irregular WCT, amiodarone is contraindicated when there is concern for atrial fibrillation with pre-excitation. (medscape.com)
  • Amiodarone is the most effective antiarrhythmic for attaining and maintaining normal sinus rhythm. (stopafib.org)
  • Nowadays, flecainide is recommended as one of the first line therapies for pharmacological conversion as well as maintenance of sinus rhythm in patients with atrial fibrillation and/or supraventricular tachycardias. (wjgnet.com)
  • We discuss a case who had amiodarone-induced incessant Torsades de Pointes (TdP), that could only be suppressed by lidocaine. (uwi.edu)
  • A total of 1348 time-heart rate observations with 361 amiodarone dose administrations were analyzed during a period of up to 6 days after hospital treatment initiation using a nonlinear mixed-effect model. (sorbonne-universite.fr)
  • In case of paroxysmal AT in a patient not pretreated with amiodarone, a 300 mg intravenous loading dose combined with an 800 mg oral dose on the first day, followed by 800 mg/day orally for 4 days was effective in achieving a heart rate between 80 and 115 bpm within the first day, and to maintain it during the next 4 days. (sorbonne-universite.fr)
  • The aim of this phase I, dose-escalating study was to evaluate the pharmacokinetics, electrocardiographic effect and safety of amiodarone after a single intravenous administration in Japanese subjects. (druglib.com)
  • In most atrial tachycardias, the rate is regular. (medscape.com)
  • Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. (wikipedia.org)
  • Amiodarone injection also can be used to treat patients with VT/VF for whom oral amiodarone is indicated, but who are unable to take oral medication. (druglib.com)
  • Atrial fibrillation is a supraventricular arrhythmia that adversely affects cardiac function and increases the risk of stroke. (aafp.org)
  • Both vernakalant and amiodarone were safe and well tolerated in this study. (druglib.com)
  • We simultaneously assessed electropharmacological effects of anti-atrial fibrillatory drug vernakalant and its potential risk toward torsade de pointes. (bvsalud.org)
  • The magnitude of vernakalant to alter those variables was the greater among those drugs except that the atrial selectivity was the lesser of those. (bvsalud.org)
  • Thus, vernakalant is expected to be efficacious against atrial fibrillation, but caution should be excised on its use for patients having labile ventricular function and repolarization. (bvsalud.org)
  • Efficacy and Safety of Celivarone, With Amiodarone as Calibrator, in Patients With an Implantable Cardioverter-Defibrillator for Prevention of Implantable Cardioverter-Defibrillator Interventions or Death: The ALPHEE Study. (druglib.com)
  • Dr. Bright will evaluate dogs with naturally occurring atrial fibrillation and heart failure for their responsiveness to two drugs -- amidodarone, an antiarrhythmic agent, and ranolazine, a drug used in humans with coronary heart disease. (akcchf.org)
  • Results will validate combined ranolazine/amiodarone administration as an improved new treatment for atrial fibrillation in dogs with heart failure, extending their quality of life. (akcchf.org)
  • Combined administration of ranolazine and amiodarone provides greater suppression of AF in humans and research dogs than either drug alone. (akcchf.org)
  • Eleven dogs received conventional antiarrhythmic treatment (amiodarone plus placebo) and 11 received ranolazine (in addition to amiodarone). (akcchf.org)
  • Unfortunately, statistical analyses showed no beneficial effect of ranolazine compared to conventional treatment with amiodarone. (akcchf.org)
  • The 2011 Focused Update on the Management of Patients with Atrial Fibrillation-by the American College of Cardiology Foundation (ACCF), the AHA, and the Heart Rhythm Society (HRS)-addressed the issue of strict versus lenient rate control in patients with AF. (ahrq.gov)
  • Multaq was challenged to demonstrate product differentiation, particularly after receiving a non-approvable letter from FDA in 2006 and showing lower efficacy versus the generic standard of care (amiodarone) in 2008. (pharmexec.com)
  • We therefore performed pharmacodynamic modeling of heart rate reduction induced by amiodarone in these patients. (sorbonne-universite.fr)
  • Amiodarone was first made in 1961 and came into medical use in 1962 for chest pain believed to be related to the heart. (wikipedia.org)
  • A beta blocker or nondihydropyridine calcium channel blocker should be used to control heart rate in atrial fibrillation. (aafp.org)
  • Postoperative atrial fibrillation (POAF) is a common complication after heart surgery. (druglib.com)
  • Prevention of atrial fibrillation: report from a National Heart, Lung, and Blood Institute workshop. (nature.com)
  • Atrial fibrillation is a common heart rhythm abnormality (arrhythmia) in dogs. (akcchf.org)
  • Atrial fibrillation (AF) is a common heart rhythm abnormality (arrhythmia) that affects all breeds of dogs and frequently coexists with heart failure (HF) resulting in worsening of HF and high mortality. (akcchf.org)
  • Atrial fibrosis is one of the most fundamental mechanisms involved in the physiopathology of cardiovascular disease, which includes atrial fibrillation (AF) [ 1 , 2 ] and heart failure (HF) [ 3 ] . (medsci.org)
  • Try this case and test your knowledge of atrial fibrillation with heart failure. (challengercme.com)
  • Discuss treatment for paroxysmal (intermittent) symptomatic atrial fibrillation in a patient with heart failure. (challengercme.com)
  • The key point of this question is to know that most commonly used antiarrhythmic drugs for atrial fibrillation are contraindicated in patients with heart failure (the above patient). (challengercme.com)
  • This patient has heart failure and intermittent coarse atrial fibrillation (AF) with a rapid ventricular response of 145. (challengercme.com)
  • In its 2020 advanced cardiac life support guidelines, the American Heart Association and others continued to recommend amiodarone (class IIa recommendation since 2011 guidelines) as a rate-controlling agent in patients whose condition is intolerant of or unresponsive to standard rate-controlling agents (eg, patients with congestive HF who are unable to tolerate metoprolol or diltiazem). (challengercme.com)
  • Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery disease (CAD), valvular heart disease, diabetes mellitus, and hypertension. (medscape.com)
  • but it is possible for the heart rate to be within accepted limits or slower and still be in atrial fibrillation. (azurewebsites.net)
  • Atrial fibrillation occurs when abnormal electrical impulses suddenly start firing in the atria (upper chambers of the heart). (azurewebsites.net)
  • Atrial fibrillation is the most common heart rhythm disturbance and affects up to 800,000 people in the UK. (azurewebsites.net)
  • This study demonstrated that procainamide was more effective and safer than amiodarone for patients with WCT, including those with structural heart disease. (medscape.com)
  • Dabigatran, compared with warfarin, in adults with atrial fibrillation is associated with a lower risk of intracranial hemorrhage and similar risk of ischemic stroke and extracranial hemorrhage. (the-hospitalist.org)
  • 1 , 2 As the atria fibrillate, blood pools in the atria, and a clot may form in the atrial appendage, increasing the risk of embolic stroke. (aafp.org)
  • Atrial fibrillation is associated with a fivefold increased risk of stroke, 3 - 5 and it is the most common arrhythmia. (aafp.org)
  • To investigate whether the administration of renin-angiotensin system (RAS) inhibitors and statins could alleviate atrial fibrosis via platelet-derived growth factor (PDGF)/Rac1 /nuclear factor-kappa B (NF-κB) axis. (medsci.org)
  • Contribution to the Literature: The AATAC trial showed that catheter ablation led to a higher procedural success rate (freedom from atrial fibrillation) than amiodarone therapy. (acc.org)
  • Catheter ablation was associated with an improvement in freedom from atrial fibrillation. (acc.org)
  • in addition to new findings from a study published by the New England Journal of Medicine titled, " Progression of Atrial Fibrillation after Cryoablation or Drug Therapy " that focuses on the benefits of treating AFib patients with a cardiac catheter ablation rather than with drug therapy. (physiciansofficeresource.com)
  • Ablation therapy is used to destroy abnormal foci responsible for atrial fibrillation. (aafp.org)
  • While amiodarone is not approved for AF by the FDA, it is a commonly prescribed off-label treatment due to the lack of equally effective treatment alternatives. (wikipedia.org)
  • Clinical question: Are amiodarone and lidocaine associated with different outcomes for the treatment of in-hospital cardiac arrests? (the-hospitalist.org)
  • The study authors calculated that for every 1,000 person-years of amiodarone treatment, there were an additional 17 bleeding-related hospitalizations, including two major hemorrhagic events, as well as nine deaths with recent evidence of bleeding. (acpinternist.org)
  • Atrial fibrillation is generally not life threatening, many people live normal healthy lives with this condition, but it can be uncomfortable and often needs treatment. (azurewebsites.net)
  • [ 7 ] For treatment and conversion of stable narrow complex atrial fibrillation as well, procainamide has received strong support and is commonly used in Canada. (medscape.com)