SubunitProteinChromatinEukaryotic DNA replicaInitiationDamaged replication forksHelicase during DNA replForksComplexesMitochondrialCerevisiaeChromosome replicationViralVirus replicationBacterialPhysiological processesActivatorEukaryotesProgressionProteins involvedGenomicMechanismsMitosisActivityYeastSequencesInhibitorInteractsSubunitsNucleosomeRepairBindsDrug targetsInhibitionHelicasesPriAHost proteinsTranscription factorMechanismTargetsBiochemicalForkCyclesHumansInsightsVirusesFamilyImportantCell
Subunit11
- Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene. (wikipedia.org)
- The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. (wikipedia.org)
- Biallelic intronic repeat expansions (a series of repeating nucleotide sequences) in the replication factor C subunit 1 (RFC1) gene causes cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS). (wikipedia.org)
- Regulation of RelA (p65) function by the large subunit of replication factor C". Molecular and Cellular Biology. (wikipedia.org)
- Among proteins associating with nonstructural protein 2, we focused on the ß subunit of the F1Fo-ATPase, which received a high probability score in our mass spectrometry analysis. (bvsalud.org)
- The siRNA-mediated down-regulation of the ß subunit of the F1Fo-ATPase reduced influenza virion formation and virus growth in cell culture. (bvsalud.org)
- Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
- The foundation recognition complicated (ORC), a six-subunit initiator proteins (2), exists in both pre- and post-RCs (10), and among its functions is definitely to mark the positioning of replication roots in the genome. (pkc-inhibitor.com)
- Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. (thermofisher.com)
- Eukaryotic TFIIH basal transcription factor complex helicase XPB subunit. (embl.de)
- 39504) translation initiation factor 2%2C alpha subunit CP001857 CDS Arcpr_0045 complement(39546. (go.jp)
Protein14
- The ORC-Cdc6 complex (product 1) assembles in step 1 around origin DNA and with the help of another replication initiator protein, Cdt1, it recruits the Mcm2-7 hexamer to the origin in step 2. (nature.com)
- After identifying over 1,000 host factors that coimmunoprecipitate with specific viral proteins, we generated a network of virus-host protein interactions based on the stage of the viral life cycle affected upon host factor downregulation. (bvsalud.org)
- Accordingly, we sought host factors that interact with the influenza viral nonstructural protein 2 by using coimmunoprecipitation followed by mass spectrometry. (bvsalud.org)
- Catalyzed by primosome proteins such as PriA, PriB, PriC, DnaT, and DnaG, DNA replication restart pathways facilitate origin-independent reloading of the replicative helicase onto a repaired DNA replication fork in a process that involves coordinated protein and nucleic acid binding within a nucleoprotein complex called the DNA replication restart primosome [ 2 ]. (biomedcentral.com)
- Overview on protein export and host cell remodeling beyond asexual replication, in Plasmodium gametocytes and liver stages. (mpg.de)
- Cdc6p is definitely a member from the huge AAA+ superfamily of ATPases, which include Orc1p, Orc4p, Orc5p, MCM, protein and replication aspect C (42). (pkc-inhibitor.com)
- To separate the role of Ded1p in viral protein translation from its putative replication function, we utilized a cell-free TBSV replication assay and recombinant Ded1p. (prolekarniky.cz)
- PriA protein is one of seven proteins that make up the restart primosome, an apparatus that promotes assembly of replisomes at recombination intermediates and stalled replication forks. (embl.de)
- The HIV-1 Rev protein is a key regulatory factor that is essential for both early and late phases of viral replication cycles, and therefore represents an important viral target for drug development. (nih.gov)
- The Hsp90 inhibitors we used (17-(allylamino)-17-demethoxygeldanamycin (17-AAG) and AUY922) have a high affinity for the unique ATP-binding pocket created by Hsp90 dimerization, and these competitive inhibitors specifically block the ATPase activity of the mature Hsp90 protein complex (24). (icem2012.org)
- 1251 orc1%2Fcdc6 family replication initiation protein CP001857 CDS Arcpr_0002 1251. (go.jp)
- 40535) Transcription factor TFIIB cyclin-related protein CP001857 CDS Arcpr_0047 complement(40887. (go.jp)
- In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
- Some studies indicate that the antibacterial mechanism of the silver nanoparticles (AgNPs) relays on their ability to penetrate the bacterial cell wall, causing direct and indirect lipidic peroxidation, which damages the cell membrane, disrupts the DNA replication, and repairs and inhibits the respiratory protein 4,5 . (bvsalud.org)
Chromatin11
- Chromatin organization is dynamically altered for diverse DNA metabolic transactions such as replication, transcription, and repair. (molcells.org)
- Chromatin dynamics is regulated by many factors, including histone tail modifiers, remodeling complexes, and histone chaperones ( Peterson and Almouzni, 2013 ). (molcells.org)
- The book highlights new insights into the replication process, from the assembly of pre-replication complexes, through polymerisation mechanisms, to considering replication in the context of chromatin and chromosomes. (rsc.org)
- Chromatin assembly factor 1. (lookformedical.com)
- This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
- In this closed state, chromatin structure becomes an obstacle for eukaryotic transcription by impeding the interaction of RNA polymerase machinery and most transcription factors (TFs). (cytoskeleton.com)
- This subset of transcription factors, known as pioneer transcription factors (PTFs), possess the ability to engage closed chromatin that is not accessible by other types of transcription factors, establish gene expression, and elicit cell reprogramming. (cytoskeleton.com)
- PTFs also enable other transcription factors, histone modifiers, and nucleosome remodeling complexes to alter the chromatin state and promote gene expression of silenced genes. (cytoskeleton.com)
- The transcription factors Oct4, Sox2, and Klf4 were found to trigger endogenous expression of pluripotent genes [2] and were identified as PTFs due to their ability to access closed chromatin [3] . (cytoskeleton.com)
- The INO80 complex is a large ATPase chromatin remodeller which contains 15 accessory subunits in S.cerevisiae. (figshare.com)
- We discuss what factors determine the sub pathway choice including etiology of the DSB, chromatin structure at the break site, processing of the DSBs and the mechanisms regulating the sub-pathway choice. (springeropen.com)
Eukaryotic DNA replica1
- Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. (wikipedia.org)
Initiation9
- SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation. (ifom.eu)
- Evidence extracted from research with fungus and indicate the fact that initiation of DNA replication is a multistep procedure. (pkc-inhibitor.com)
- Initiation of DNA replication is certainly triggered with the actions of at least two pieces of proteins kinase Rabbit Polyclonal to CEBPG actions, cyclin-dependent kinases (CDKs) and Dbf4p-Cdc7p. (pkc-inhibitor.com)
- Cdc18+ may be the homologue of and performs equivalent features in regulating initiation of DNA replication and perhaps entrance into mitosis (28, 40, 43). (pkc-inhibitor.com)
- Translation initiation factor 1A / IF-1 [Interproscan]. (ntu.edu.sg)
- Translation initiation factor SUI1 [Interproscan]. (ntu.edu.sg)
- The data obtained with wt and ATPase deficient Ded1p mutants support the model that Ded1p unwinds local structures at the 3′-end of the TBSV (−)RNA, rendering the RNA compatible for initiation of (+)-strand synthesis. (prolekarniky.cz)
- The prototype of DEAD-box proteins is the translation initiation factor eIF4A. (embl.de)
- 54053) translation initiation factor eIF-1A CP001857 CDS Arcpr_0064 complement(54088. (go.jp)
Damaged replication forks2
Helicase during DNA repl2
- In summary, our work provides fundamental insights into DDK structure, control and selective activation of the MCM2-7 helicase during DNA replication. (imperial.ac.uk)
- Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication. (ifom.eu)
Forks4
- Consequently, DNA replication forks that stall or collapse due to encounters of the replisome with DNA damage must be reactivated to allow complete replication of the genome and ensure survival of the cell. (biomedcentral.com)
- PriA is thought to recognize and bind to repaired DNA replication forks and D-loop recombination intermediates, facilitate assembly of the primosome complex by recruiting other primosome proteins, and catalyze duplex DNA unwinding using energy furnished by hydrolysis of ATP [ 4 , 5 ]. (biomedcentral.com)
- The controlled assembly of replication forks is critical for genome stability. (imperial.ac.uk)
- Cells have evolved with conserved recombination mediated genome editing pathways as a mean for repairing DSBs and restarting replication forks, thus allowing genome duplication to continue [ 8 ]. (springeropen.com)
Complexes2
- All such systems are multisubunit complexes with at least 3 dissimilar subunits embedded as a complex in the membrane (F 0 , a:b:c = 1:2:~12) and (usually) at least 5 dissimilar subunits attached to F 0 (F 1 , α:β:γ:δ:ε = 3:3:1:1:1 for F-type ATPases). (tcdb.org)
- Pursuing parting of sister chromatids at mitosis and through the following G1 stage, prereplication complexes (pre-RCs) are produced at roots of DNA replication. (pkc-inhibitor.com)
Mitochondrial3
- The F 1 portion of the bovine mitochondrial F-type ATPase has been solved to 2.8 Å resolution. (tcdb.org)
- It also covers mitochondrial DNA replication, and includes archaeal paradigms, which are proving increasingly relevant to the study of replication in higher eukaryotes. (rsc.org)
- We further found that efficient influenza virion formation requires the ATPase activity of F1Fo-ATPase and that plasma membrane-associated, but not mitochondrial, F1Fo-ATPase is important for influenza virion formation and budding. (bvsalud.org)
Cerevisiae3
- The S. cerevisiae ORC binds to specific DNA sequences throughout the cell cycle but becomes active only when it binds to the replication initiator Cdc6. (nature.com)
- In the budding yeast Saccharomyces cerevisiae , there are over 400 origins of DNA replication located on 16 chromosomes and they can function as autonomously replicating sequences (ARSs) when inserted into a plasmid 19 . (nature.com)
- The single genomic RNA codes for two replication proteins, p33 and p92 pol , which are sufficient to support TBSV replicon (rep)RNA replication in yeast ( Saccharomyces cerevisiae ) model host [13] , [14] . (prolekarniky.cz)
Chromosome replication2
- Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites. (ifom.eu)
- DSBs not only ensue from normal cellular metabolism, in the form of reactive oxygen species that can oxidize DNA bases [ 1 , 2 ], but can also be generated during physiological processes like chromosome replication, meiotic recombination and DNA replication transcription collision [ 3 - 7 ]. (springeropen.com)
Viral11
- Host factors required for viral replication are ideal drug targets because they are less likely than viral proteins to mutate under drug-mediated selective pressure. (bvsalud.org)
- We conducted a systematic analysis to identify and validate host factors that associate with influenza virus proteins and affect viral replication. (bvsalud.org)
- We propose a therapeutic regimen to supplement the current supportive therapy aiming to reduce viral load, the most important factor in the determination of mortality. (biomedcentral.com)
- Promising new inhibitors that target the viral helicase-primase complex have been reported to block replication of herpes simplex and varicella-zoster viruses, but they have no activity against human cytomegalovirus (HCMV), another herpesvirus. (frontiersin.org)
- The HCMV helicase-primase complex (pUL105-pUL102-pUL70) is essential for viral DNA replication and could thus be a relevant antiviral target. (frontiersin.org)
- Mutational analysis of several of these amino acids both in pUL105 and pUL70, proved that they are crucial for viral replication. (frontiersin.org)
- Altogether, the two host factors enhance TBSV replication synergistically by interacting with the viral (−)RNA and the replication proteins. (prolekarniky.cz)
- After translation of their mRNA-sense genomic RNA(s), the viral RNA and the viral replication proteins are recruited to the site of viral replication in membranous compartments. (prolekarniky.cz)
- This is then followed by (+)-strand synthesis in an asymmetric manner, producing excess amounts of (+)-strand progeny, which is released from replication for other viral processes. (prolekarniky.cz)
- The co-opted host proteins likely affect several steps in viral RNA replication, including the assembly of the replicase complex and/or viral RNA synthesis. (prolekarniky.cz)
- The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
Virus replication4
- Although genome-wide screens have identified host proteins involved in influenza virus replication, limited mechanistic understanding of how these factors affect influenza has hindered potential drug development. (bvsalud.org)
- The identification of host factors involved in virus replication is important to understand virus life cycles better. (bvsalud.org)
- Hence, our data identify plasma membrane-associated F1Fo-ATPase as a critical host factor for efficient influenza virus replication. (bvsalud.org)
- However, the functions of host factors in (+)RNA virus replication are known only for a small number of host factors [1] - [9] . (prolekarniky.cz)
Bacterial4
- Bacterial F-type ATPases pump 3-4 H + and/or Na + (depending on the system) out of the cell per ATP hydrolyzed. (tcdb.org)
- Bacterial DNA replication restart pathways facilitate reinitiation of DNA replication following disruptive encounters of a replisome with DNA damage, thereby allowing complete and faithful duplication of the genome. (biomedcentral.com)
- DNA replication restart pathways provide bacterial cells with a mechanism to reactivate replisomes that are disrupted in this manner [ 2 ]. (biomedcentral.com)
- The hexameric, ring-shaped bacterial termination factor Rho performs many functions: inducing termination at the end of genes, silencing transcriptional noise, reducing translational stress, and preventing replication-transcription collisions. (rsc.org)
Physiological processes1
- Like all viruses, the EBOV largely relies on host cell factors and physiological processes for its entry, replication, and egress. (biomedcentral.com)
Activator1
- E2Fs, a set of genes that encode a family of transcription factors (TFs) in most higher eukaryotes, are generally divided into the following three subfamilies: transcriptional activator E2Fs (E2F1-E2F3), repressor E2Fs (E2F4-E2F5), and inhibitor E2Fs (E2F6-E2F8) [14,15]. (fortunepublish.com)
Eukaryotes3
- V-type ATPases are found in vacuoles of eukaryotes and in bacteria. (tcdb.org)
- E2F is a group of genes that encodes a family of transcription factors in higher eukaryotes. (fortunepublish.com)
- The two most commonly used pathways to repair DSBs in higher eukaryotes include non-homologous end joining (NHEJ) and homologous recombination (HR). NHEJ is considered to be error-prone, intrinsically mutagenic quick fix remedy to seal together the broken DNA ends and restart replication. (springeropen.com)
Progression2
- During PDA progression, pancreatic acinar cells lose activity of the ClassI/II bHLH factors that regulate quiescence. (oncotarget.com)
- In addition to repair, DNA damage tolerance mechanisms ensure replication progression upon encountering unrepaired lesions. (brad.ac.uk)
Proteins involved2
- Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. (rsc.org)
- In Neisseria gonorrhoeae , the primosome proteins that catalyze DNA replication restart differ from the well-studied primosome proteins of E. coli with respect to the number of proteins involved and the affinities of their physical interactions: the PriA:PriB interaction is weak in E. coli , but strong in N. gonorrhoeae , and the PriB:DNA interaction is strong in E. coli , but weak in N. gonorrhoeae . (biomedcentral.com)
Genomic2
- G-quadruplex (G4) DNA, an alternate structure formed by Hoogsteen hydrogen bonds between guanines in G-rich sequences, threatens genomic stability by perturbing normal DNA transactions including replication, repair, and transcription. (nih.gov)
- This role of Rad5 is further highlighted after replication stress induced by hydroxyurea or by increasing rNMP genomic burden using a mutant DNA polymerase (Pol ε - Pol2-M644G). (brad.ac.uk)
Mechanisms2
- Below we discuss mechanisms in the form of pioneer transcription factors, histone modifications, and recently identified actin-dependent mechanisms that regulate chromosome accessibility and gene regulation during cellular reprogramming. (cytoskeleton.com)
- Dr. Eren received her Ph.D. from Worcester Polytechnic Institute (WPI), where she studied metal transport mechanisms across membranes by P-type ATPases. (nih.gov)
Mitosis2
- Besides its function in DNA replication, it could also be engaged inside a mitotic checkpoint control, because Cdc6-deprived candida cells that usually do not replicate DNA still go through a reductional mitosis (4, 47, 63). (pkc-inhibitor.com)
- Gross overexpression of Cdc18+ leads to repeated rounds of DNA replication in the lack of mitosis (23, 43). (pkc-inhibitor.com)
Activity7
- Conversely, ageing may be associated with loss of replication activity and restoring it to cells may moderate some of the diseases associated with old age. (rsc.org)
- We previously found that promoting transcriptional activity of the Class I bHLH factor E47 in highly aggressive PDA cells induced stable growth arrest in vitro and in vivo . (oncotarget.com)
- Thus, the weak interaction between N. gonorrhoeae PriB and DNA might be compensated for by the strong interaction between PriB and PriA, which could result in allosteric activation of PriA's ATPase activity. (biomedcentral.com)
- Such domains are commonly associated with DNA binding activity and transcription factors. (figshare.com)
- Our novel findings provide evidence that inhibition of Hsp90 activity prevents HIV gene expression in replication-competent cellular reservoirs that would typically cause rebound in plasma viremia after antiretroviral therapy cessation. (icem2012.org)
- The chaperone function of cellular Hsp90 is not restricted to activating HIV transcription, because we previously exhibited that replication-incompetent HIV with mutant capsids could be rescued by increased Hsp90 activity (21, 28). (icem2012.org)
- Among the origins of achlorhydria that are related to medical care, medications like proton pump inhibitors that block H+/K+ -ATPase activity can induce achlorhydria. (medscape.com)
Yeast1
- In this paper, we show that an essential translation factor, Ded1p DEAD-box RNA helicase of yeast, directly affects replication of Tomato bushy stunt virus (TBSV). (prolekarniky.cz)
Sequences1
- The molecular system that restricts firing of roots of replication to one time per cell routine invokes the purchased binding to and/or discharge of different replication proteins from particular DNA sequences (replicators) situated in the vicinity from the real roots of DNA replication. (pkc-inhibitor.com)
Inhibitor1
- Replication-competent virus was detected in spleen cells from these nonviremic Hsp90 inhibitor-treated mice, indicating the presence of a tissue reservoir of persistent contamination. (icem2012.org)
Interacts1
- The AAA+ ATPases have two AAA+ domains and a conserved bromodomain that most likely interacts with histones. (molcells.org)
Subunits1
- This transformation occurs through an intricate pathway of multiple intermediates, involving Rho contacts with RNA polymerase subunits and the general transcription factors N-utilizing substance A (NusA) and N-utilizing substance G (NusG), indicating the presence of numerous regulatory routes and checkpoints. (rsc.org)
Nucleosome1
- Conserved bromodomain-containing AAA+ ATPases play important roles in nucleosome organization as histone chaperones. (molcells.org)
Repair3
- In addition, Other study have found that DNA replication, recombination and repair are one of the reasons for the resistance of radiotherapy and chemotherapy in LACC [15]. (researchsquare.com)
- SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability. (ifom.eu)
- An ATP-dependent 3'-5' DNA helicase which is a component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. (embl.de)
Binds1
- The Origin Recognition Complex (ORC) binds to sites in chromosomes to specify the location of origins of DNA replication. (nature.com)
Drug targets2
- Exciting potential drug targets in DNA replication are discussed, particularly in the context of treating malaria and cancer. (rsc.org)
- Using compounds that inhibit these host factors, we validated several proteins, notably Golgi-specific brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF1) and JAK1, as potential antiviral drug targets. (bvsalud.org)
Inhibition4
- However, expression of a double point mutation, ies6(K114E/Y125A), in combination with rad50 deletion, caused a sensitivity to replication inhibition, but not chromosome segregation inhibition, indicating a potential separation of function in this utant due to the loss due of only one of the biological functions of Ies6. (figshare.com)
- HIV host factor by pharmacologic inhibition and by siRNA-mediated silencing of cellular Hsp90 in primary human cells (20). (icem2012.org)
- In this study, we provide novel evidence that 39.5 C accelerates transcription from the HIV promoter through specific inducible host transcription factors and that inhibition of Hsp90 greatly reduces gene expression. (icem2012.org)
- HIV transcription in the spleen reservoir was reduced by Hsp90 inhibition, but replication-competent virus was readily isolated when the spleen cells were activated by heat shock and by treatment with suberoylanilide hydroxamic acid (SAHA). (icem2012.org)
Helicases2
- FANCJ efficiently unwound in a kinetic and ATPase-dependent manner entropically favored unimolecular G4 DNA, whereas other Fe-S helicases tested did not. (nih.gov)
- Thus, two small RNA viruses, which do not code for their own helicases, seems to recruit a host RNA helicase to aid their replication in infected cells. (prolekarniky.cz)
PriA1
- DNA replication restart initiated by PriA helicase is a highly coordinated process and probably represents the major pathway of DNA replication restart in E. coli . (biomedcentral.com)
Host proteins2
- For efficient replication, (+)RNA viruses recruit numerous host proteins [1] - [5] . (prolekarniky.cz)
- Among the identified host proteins are RNA-binding proteins, such as translation factors, ribosomal proteins and RNA-modifying enzymes [1] . (prolekarniky.cz)
Transcription factor1
- These findings suggest a similar role for the human Rad5 homologues helicase-like transcription factor (HLTF) and SNF2 Histone Linker PHD RING Helicase (SHPRH) in rNMP tolerance, which may impact the response of cancer cells to replication stress-inducing therapeutics. (brad.ac.uk)
Mechanism2
- The results illuminate the molecular mechanism of a critical biochemical step in the licensing of eukaryotic replication origins. (nature.com)
- Act (FQPA) of 1996 requires that factors to be considered in establishing, modifying, or revoking tolerances for pesticide chemical residues shall include the available information concerning the cumulative effects of substances that have a common mechanism of toxicity, and combined exposure levels to the substance and other related substances. (cdc.gov)
Targets1
- Replication is, therefore, fundamental to a huge range of molecular biological and biochemical applications, and provides many potential targets for drug design. (rsc.org)
Biochemical2
- Interesting in its own right as a fascinating feat of biochemical regulation and coordination, DNA replication is at the heart of modern advances in molecular biology. (rsc.org)
- Biochemical research with provided extra support for the thought of Cdc6p (XCdc6p) as an important factor for building pre-RCs. (pkc-inhibitor.com)
Fork1
- PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. (lookformedical.com)
Cycles1
- All eukaryotic plus-stranded (+)RNA viruses have similar replication cycles in infected cells. (prolekarniky.cz)
Humans1
- Mutations in Cu-ATPases, a subfamily of ATPases, are associated with Menkes and Wilson's diseases in humans. (nih.gov)
Insights2
Viruses1
- Replication of plus-strand RNA viruses depends on recruited host factors that aid several critical steps during replication. (prolekarniky.cz)
Family1
- Predicated on series commonalities between Cdc6p, replication aspect C, and various other AAA+ family and on the characterization of the dominant-negative mutant, it's been suggested that fungus Cdc6p might work as an ATP-dependent MCM proteins loader (45, 63). (pkc-inhibitor.com)
Important1
- Copper-transporting ATPase is important for malaria parasite fertility. (mpg.de)
Cell1
- Candida displays a hereditary interaction using the ORC and it is a critical element for creating the competence of replication roots one time per cell routine (12, 33, 47, 48). (pkc-inhibitor.com)