cytoplasmic dyneins and axonemal dyneins , which are also called ciliary or flagellar dyneins. (wikipedia.org)
Axonemal dynein causes sliding of microtubules in the axonemes of cilia and flagella and is found only in cells that have those structures. (wikipedia.org)
The inner dynein arm regulates axonemal bending motion in eukaryotes. (rupress.org)
In addition, proteolysis increases the specific ATPase activity of dynein and removes a portion of it from the axonemal structure. (rupress.org)
Cryo-electron tomography revealed that the densities of two inner dynein arms were missing from at least two doublet microtubules in the axonemal structure. (elsevierpure.com)
They are divided into two subgroups of axonemal and cytoplasmic dyneins. (utsouthwestern.edu)
Microtubules8
Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells . (wikipedia.org)
Cytoplasmic dynein positions the spindle at the site of cytokinesis by anchoring to the cell cortex and pulling on astral microtubules emanating from centrosome . (wikipedia.org)
Dynein pulls the microtubules and chromosomes to one end of the cell. (wikipedia.org)
When the end of the microtubules become close to the cell membrane, they release a chemical signal that punts the dynein to the other side of the cell. (wikipedia.org)
Coordinated beating and bend propagation of cilia and flagella are generated by active sliding of peripheral doublet microtubules driven by ensembles of various types of dyneins. (rupress.org)
It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly. (embl.de)
Microtubules serve as a rail on which motor proteins, such as kinesin and dynein superfamily proteins, convey their cargoes. (embl.de)
The motor protein belongs to the ATPase family of proteins associated with diverse cellular activities and plays a critical role in transporting cargoes to the minus end of the microtubules. (mun.ca)
Cilia4
Dynein transports various cellular cargos , provides forces and displacements important in mitosis , and drives the beat of eukaryotic cilia and flagella . (wikipedia.org)
Daw1 is a cytoplasmic protein thought to be required for cilia beating by controlling import of dynein arms into cilia. (uoregon.edu)
It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. (utsouthwestern.edu)
An ATPase called dynein transfers the energy generated during ATP hydrolysis into the mechanical labour required to beat cilia and flagella. (risingacademy.org)
Inner dynein arms1
We used cryo-electron tomography to reconstruct the three-dimensional structure of inner dynein arms from Chlamydomonas reinhardtii . (rupress.org)
Motility3
The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. (utsouthwestern.edu)
Their motility depends on the assembly of outer dynein arms: ATPases which power ciliary beating. (uoregon.edu)
He was an assistant and associate professor at the University of Medicine and Dentistry of New Jersey from 1978-1993, conducting basic research on the role of the dynein ATPase in flagellar motility in sea urchin spermatozoa and teaching pharmacology to medical students. (communityscience.org)
Ciliary2
Defects in dynein arm function occur in Primary Ciliary Dyskinesia, a disorder affecting 1:15,000-30,000 human births. (uoregon.edu)
This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. (utsouthwestern.edu)
Protein9
While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)
We recently described the structure of M. musculus RNF213 (PDB: 6TAX) and characterized its enzymatic activity, revealing it as a large monomeric protein with a functional dynein-like AAA (ATPases Associated with diverse cellular Activities) core that exists alongside a novel E3 ligase module ( 16 ). (biorxiv.org)
One protein (flagellin), which bears no resemblance to tubulin or dynein, makes up the bacterial flagellum, a specialised component of the extracellular cell wall. (risingacademy.org)
Dynein is a ~1.2 MDa cytoskeletal motor protein that carries organelles via retrograde transport in eukaryotic cells. (mun.ca)
Utilizing the refined structure of the motor domain obtained through protein conformational search in this study exhibits that Arg1852 of the yeast cytoplasmic dynein could involve in the "glutamate switch" mechanism in cytoplasmic dynein 1 in lieu of the conserved Asn in AAA+ protein family. (mun.ca)
Among these are energy-consuming enzymes such as GTPases, protein kinases, ATP-dependent RNA helicases, and AAA-type (ATPases associated with various cellular activities) ATPases, which suggests that the energy derived from nucleotide hydrolysis confers directionality to ribosome assembly. (silverchair.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Dynein Heavy Chain Domain Containing Protein 1 (DNHD1) in samples from Tissue homogenates and other biological fluids. (youngresearch.eu)
Description: A sandwich ELISA kit for detection of Dynein Heavy Chain Domain Containing Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (youngresearch.eu)
Kinesin3
Dynein and kinesin can both be exploited by viruses to mediate the viral replication process. (wikipedia.org)
Kinesin and dynein superfamily proteins and the mechanism of organelle transport. (embl.de)
This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins. (embl.de)
Tubulin1
Dynein ATPase (EC 3.6.4.2, dynein adenosine 5'-triphosphatase) is an enzyme with systematic name ATP phosphohydrolase (tubulin-translocating). (wikipedia.org)
Microtubule motor1
Here we showthat Lis1 is enriched in neurons relative to levels in other cell types,and that Lis1 interacts with the microtubule motor cytoplasmic dynein.Production of more Lis1 in non-neuronal cells increases retrogrademovement of cytoplasmic dynein and leads to peripheral accumulation ofmicrotubules. (embl.de)
Cellular1
Here, we show that an energy-consuming enzyme, the AAA-type (ATPases associated with various cellular activities) ATPase Rix7, restructures a novel pre-60S particle at the transition from the nucleolus to nucleoplasm. (silverchair.com)
Axonal transport1
[2] [3] Dynein carries organelles, vesicles and possibly microtubule fragments along the axons of neurons toward the cell body in a process called retrograde axonal transport . (wikipedia.org)
Polypeptide2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse ATPase, H+/K+ Exchanging Alpha Polypeptide (ATP4a) in Tissue homogenates and other biological fluids. (tuberculosisdrugresearch.org)
Description: A sandwich ELISA kit for detection of ATPase, H+/K+ Exchanging Alpha Polypeptide from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosisdrugresearch.org)
Hydrolysis1
The motor domain of dynein possesses a hexameric head, where ATP hydrolysis occurs. (mun.ca)
Nexin1
Note that you can see the dynein arms and the nexin links. (cytochemistry.net)
Axonemes1
Supernatant dynein had a greater specific ATPase activity than dynein extracted from axonemes. (rupress.org)
Chlamydomonas1
In the Chlamydomonas reinhardtii flagellar axoneme, at least 11 dynein heavy chains (three outer arm and eight inner arm) exist, and each could play crucial and distinct roles in proper flagellar functions ( Kagami and Kamiya, 1992 ). (rupress.org)
Mechanism1
Our findings provide an example for a non-conventional translocation mechanism and can explain how Kar3 substitutes for key functions of Dynein in the yeast nucleus. (elifesciences.org)
Molecular1
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. (utsouthwestern.edu)
Proteolysis was accompanied by an increase in the ATPase activity of the digest: by centrifuging down the insoluble digestion products it was shown that digestion resulted in the appearance of ATPase activity in the soluble phase with a concomitant decrease in ATPase activity in the pellet fraction. (rupress.org)
Undergoes a functional cycle linked to its ATPase activity. (qedbio.com)
Activation of Escherichia coli F1-ATPase by lauryldimethylamine oxide and ethylene glycol: relationship of ATPase activity to the interaction of the .epsilon. (mcmaster.ca)
Both subunits contain ATPase activity. (umassmed.edu)
Enzyme1
Our findings show that RNF213 represents an undescribed type of a transthiolation E3 enzyme and is regulated by adenine nucleotide concentration via its ATPase core, possibly allowing it to react to changing metabolic conditions in the cell. (biorxiv.org)
Outer arm1
To interact with the B-microtubule through stalks, the inner-arm dyneins must have either different handedness or, more probably, the opposite orientation of the AAA rings compared with the outer-arm dyneins. (rupress.org)
Doublets1
The dynein arms press on the neighbouring outer doublets, causing a sliding movement to happen between adjacent outer doublets, using ATP generated by mitochondria near the base of the cilium or flagellum as fuel. (risingacademy.org)
Dimer1
The dynein f dimer is located close to the surface of the A-microtubule, whereas the other six heavy chain rings are roughly colinear at a larger distance to form three dyads. (rupress.org)
Structural2
Structural characterization has revealed the presence of a dynein- like ATPase module and an unprecedented but poorly understood E3 module. (biorxiv.org)
This study exploits in silico methods to look at the analogues' effects on the functionally essential subsites of the motor domain of dynein 1, since no similar experimental structural data are available. (mun.ca)
Linker2
Shown is the order of regions of interest for human cytoplasmic dynein 2 motor domains as they occur from the linker to C-terminal. (wikipedia.org)
Does dynein generate force by the linker swing? (nii.ac.jp)
Function1
Lis1 deficiency produces the opposite phenotype.Our results indicate that abundance of Lis1 in neurons may stimulatespecific dynein functions that function in neuronal migration and axongrowth. (embl.de)
Chains2
In each of the six heavy chains (dynein a, b, c, d, e, and g), the N-terminal tail extends from the distal side of the ring. (rupress.org)
Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. (utsouthwestern.edu)
Organelle transport1
Cytoplasmic dynein, found in all animal cells and possibly plant cells as well, performs functions necessary for cell survival such as organelle transport and centrosome assembly. (wikipedia.org)
Complex1
Cytoplasmic dynein helps to position the Golgi complex and other organelles in the cell. (wikipedia.org)
In the cell, RNF213 was shown to be involved in fatty acid metabolism ( 11 ), and to associate with intracellular lipid droplets in a manner dependent on its E3 ligase and ATPase activities ( 12 ). (biorxiv.org)