• Using an in vitro cell-free assay, we demonstrate that KAE609 directly inhibits ScPma1p ATPase activity. (jcvi.org)
  • Fluoride also inhibits Na+-K+ ATPase, and increases intracellular Na+, so could increase Cai via Na+-Ca2+ exchange. (fluoridealert.org)
  • In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. (hmdb.ca)
  • It inhibits the Na+-K+ ATPase pump. (medscape.com)
  • Digoxin inhibits sodium-potassium-activated ATPase, thereby decreasing sodium efflux and the trans-membrane potential. (medscape.com)
  • it has been hypothesized that dietary calcium may increase prostate cancer risk by reducing circulating levels of 1,25-dihydroxyvitamin D (1,25[OH] 2 D) (10), which promotes the differentiation and inhibits the proliferation of prostate cells (11). (cdc.gov)
  • There are at least thirteen subunits identified to form a functional V-ATPase complex, which consists of two domains. (wikipedia.org)
  • The Vo domain contains six different subunits, a, d, c, c', c", and e, with the stoichiometry of the c ring still a matter of debate with a decamer being postulated for the tobacco hornworm (Manduca sexta) V-ATPase. (wikipedia.org)
  • The mammalian Vo domain contains tissue-specific isoforms for subunits a and d, while yeast V-ATPase contains two organelle-specific subunit isoforms of a, Vph1p, and Stv1p. (wikipedia.org)
  • These structures have revealed that the V-ATPase has a 3-stator network, linked by a collar of density formed by the C, H, and a subunits, which, while dividing the V1 and Vo domains, make no interactions with the central rotor axle formed by the F, D, and d subunits. (wikipedia.org)
  • Na + /K + ATPase (NKA) comprises several subunits to provide isozyme heterogeneity in a tissue-specific manner. (ku.dk)
  • To address this, the KSU scientists turned to RNAi, focusing on V-ATPase - a class of evolutionarily conserved enzymes with a variety of cellular functions including nutrient uptake and ion balance in the gut system, with various subunits previously identified as essential. (genomeweb.com)
  • To determine if RNAi could be used to knock down this target in P. maidis , the KSU group first tried feeding third-stage nymphs dsRNA against the V-ATPase subunits V-ATPase B or V-ATPase D and negative control dsRNA. (genomeweb.com)
  • Str at 1, 10, and 25 micromol/L in NC and Str at 0.1, 1, 10, and 25 micromol/L) in FC elevated the calcium transient amplitude and increased the positive inotropic effects in a concentration-dependent manner, respectively. (unboundmedicine.com)
  • In FC, both the mitogen-activated protein kinase (MAPK) and reactive oxygen species (ROS) signal transduction pathway of Na+/K+-ATPase were involved in the increase of the calcium transient induced by Str, but only activation of the MAPK pathway increased the calcium transient in NC. (unboundmedicine.com)
  • For example, the proton gradient across the yeast vacuolar membrane generated by V-ATPases drives calcium uptake into the vacuole through an H+ /Ca2+ antiporter system. (wikipedia.org)
  • Using transgenic A. thaliana expressing APOAEQUORIN , we showed transient increase of cytoplasmic calcium level [Ca 2+ ] cyt in response to diethyl ether application. (frontiersin.org)
  • ATPase was strongly activated by magnesium and calcium. (cdc.gov)
  • When added together, potassium did not increase the enzyme activity beyond that shown by calcium alone. (cdc.gov)
  • The maximum calcium or magnesium enhancement of ATPase activity occurred at pH 8.0. (cdc.gov)
  • Acute fluoride intoxication increases intracellular calcium (Cai), manifested by increased twitch tension in cardiac muscle, and by potassium efflux (mediated by Ca2+-dependent K+ channels) in fluoridated erythrocytes. (fluoridealert.org)
  • Digoxin increases the force of contraction of the heart muscle by inhibiting the activity of an enzyme (ATPase) that controls movement of sodium, calcium, and potassium into the heart muscle. (hdkino.org)
  • Inhibiting ATPase increases calcium in the heart muscle, which increases the force of heart contractions. (hdkino.org)
  • Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise -induced hearing loss in mice. (cdc.gov)
  • Sodium preferentially exchanges with calcium, increasing the intracellular calcium and resulting in an increase in contractility. (medscape.com)
  • Blockade of efflux of sodium increases calcium in myocytes resulting in increased activation of contractile proteins in the cardiac muscle. (medscape.com)
  • Vacuolar-type ATPase (V-ATPase) is a highly conserved evolutionarily ancient enzyme with remarkably diverse functions in eukaryotic organisms. (wikipedia.org)
  • We have shown that this process is triggered by recruitment of ATG16L1 by the vacuolar-type H-translocating ATPase (V-ATPase) proton pump, suggesting a role for pH sensing in recruitment of Atg8-family proteins to single membranes. (babraham.ac.uk)
  • Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation. (babraham.ac.uk)
  • Top-ranked genes cluster into distinct pathways, including the vacuolar ATPase proton pump, Retromer, and Commander complexes. (cdc.gov)
  • V-ATPase however, is a proton pump that uses the energy from ATP hydrolysis to produce a proton gradient. (wikipedia.org)
  • The aim of this study was to test for the molecular and functional expression of the non-gastric H + /K + ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 cells, to unravel its potential role as putative apoptosis-counteracting ion transporter as well as to test for the effect of the H + /K + ATPase inhibitor SCH28080 in apoptosis. (karger.com)
  • Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. (jcvi.org)
  • Mavacamten is a cardiac myocin-ATPase inhibitor targeted at treating hypertrophic cardiomyopathy (HCM). (oslo-universitetssykehus.no)
  • Background - Increasing sarcoplasmic/endoplasmic reticulum (SR) Ca2+-ATPase (SERCA) uptake activity is a promising therapeutic approach for heart failure. (gla.ac.uk)
  • Mathematical simulations demonstrate that the functional increase in SR Ca2+-ATPase uptake activity at MOI 50 (and increased cytosolic Ca2+ buffering) is sufficient to curtail the Ca2+ transient amplitude and explain the reduced contraction. (gla.ac.uk)
  • The experimental results showed that DOX/CS-NPs had a DOX-loading capacity of 71.76 ± 0.87 %, and that coating of DOX/CS-NPs with 4T1CM significantly increased the NP uptake and cytotoxic effect in breast cancer cells. (bvsalud.org)
  • Our results suggest that specific self-recognition to source cells resulting in homotypic targeting increased the uptake and the cytotoxic capacity of 4T1@DOX/CS-NPs by breast cancer cells in vitro and in vivo. (bvsalud.org)
  • Molecular characterization and transcriptional regulation of the Na +/K+ ATPase α subunit isoforms during development and salinity challenge in a teleost fish, the Senegalese sole (Solea senegalensis). (ualg.pt)
  • Lung liquid clearance and Na, K-ATPase activity and protein abundance were increased in HV T adβ 1 ,-infected lungs as compared with sham and adnull-infected HVT lungs. (northwestern.edu)
  • Increases in the platelet membrane cholesterol phospholipid (C/P) ratio, phosphotidylethanolamine, phosphotidylserine with decreased phosphotidylcholine, Na(+)/k(+)-ATPase activity, fluidity and no significant change in phosphotidylinositol and sphingomylein, as well as increases in plasma total cholesterol, LDL-cholesterol, protein carbonyls with decreased HDL-cholesterol and sulfhydryl groups were observed in cigarette smokers. (nih.gov)
  • These data indicate that this eukaryotic cell-free expression system has a high success rate and that the addition of specific reagents can increase the yield of soluble protein. (iucr.org)
  • An increased level of apolipoprotein A-I (apoA-I), which is the main protein of HDL, has also been found to increase breast cancer risk. (news-medical.net)
  • The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and cell cycle regulation. (portlandpress.com)
  • Valosin-containing protein (VCP, also p97, or Cdc48p in yeast) is an evolutionarily conserved, homo-hexameric, ubiquitin-selective, AAA-ATPase that functions in numerous ubiquitin-dependent protein quality control pathways. (portlandpress.com)
  • The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment. (babraham.ac.uk)
  • Alternatively, 5,6-epoxycholesterol can be converted into dendrogenin A by the enzyme DNA-dependent ATPase (DDA) synthase. (news-medical.net)
  • Hypercapnia Induces Inositol-Requiring Enzyme 1alpha-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase beta-Subunit. (nih.gov)
  • lansoprazole will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. (medscape.com)
  • The plasma lipid profile, platelet carbonyls, sulfhydryl groups, Na(+)/k(+)-ATPase activity, fluidity using a fluorescent probe 1,6-diphenyl-1,3,5-hexatriene (DPH), total cholesterol and phospholipids as well individual phospholipids were determined. (nih.gov)
  • Our data support a model in which KAE609 exerts its antimalarial activity by directly interfering with P-type ATPase activity. (jcvi.org)
  • Plays a key role in increased proteasome activity in bryonic st cells (ESCs): its high expression in ESCs promotes enhanced assbly of the 26S proteasome, followed by higher proteasome activity. (joplink.net)
  • The effects of ions and antischistosomal drugs on adenosine- triphosphatase (ATPase) activity in Schistosoma-mansoni were investigated. (cdc.gov)
  • Ouabain produced a maximum inhibition of 17 percent of schistosomal ATPase under optimal ionic conditions for sodium, potassium and magnesium induced ATPase activity. (cdc.gov)
  • A four- to five-fold rise in the Na+,K(+)-ATPase activity is also developmentally induced. (jci.org)
  • Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. (jci.org)
  • An increased expression of LDL receptor has also been found in breast cancer cells enriched with cholesteryl esters, which could be due to higher activity of acyl-coenzyme A: cholesterol acyltransferase. (news-medical.net)
  • This review summarizes recent research on VCP that has uncovered surprising new ways that this ATPase is regulated, new aspects of recognition of substrates and novel pathways and substrates that utilize its activity. (portlandpress.com)
  • It also increases glucose oxidation and magnesium-activated sodium-potassium ATPase activity. (weeksmd.com)
  • Mouse Na+/K+-ATPase beta1-subunit has a K+-dependent cell adhesion activity for beta-GlcNAc-terminating glycans. (nih.gov)
  • Our main goal was to find out whether quercetin, resveratrol, or caffeic acid, in the nano- and low micromolar concentration ranges, can improve the ATPase activity in human erythrocyte membranes with excess cholesterol. (bvsalud.org)
  • They are also useful for periodic home inotropic therapy in end-stage disease, in which cardiac transplant is not feasible, to improve the quality of life. (medscape.com)
  • V-ATPases in the osteoclast plasma membrane pump protons onto the bone surface, which is necessary for bone resorption. (wikipedia.org)
  • In the intercalated cells of the kidney, V-ATPases pump protons into the urine, allowing for bicarbonate reabsorption into the blood. (wikipedia.org)
  • The Na+,K(+)-ATPase ion pump plays a critical role in fluid and electrolyte physiology of the small intestine. (jci.org)
  • Through this three-year NIH Research Enhancement Award (R15), Sodhi aims to reveal more about the activation of sodium pump, or Na/K-ATPase, signaling specifically in fat cells known as adipocytes. (marshall.edu)
  • Electroporation-mediated in vivo gene delivery of the Na+/K+-ATPase pump reduced lung injury in a mouse model of lung contusion. (nih.gov)
  • Digoxin is also used for increasing myocardial contractility in pediatric patients with heart failure . (hdkino.org)
  • Digoxin is also used to increase myocardial contractility in pediatric patients with heart failure. (hdkino.org)
  • Digoxin improves myocardial contractility, reduces heart rate, and lowers sympathetic stimulation in chronic heart failure. (medscape.com)
  • Increased oxygen bioavailability improved the metabolism of the seeds, which extruded 5-fold more protons from the embryos. (researchgate.net)
  • [ 8 ] Because of its narrow therapeutic index, toxicity may result even with mildly increased digoxin level. (medscape.com)
  • Mechanical ventilation with high tidal volumes (HV T ) downregulates alveolar Na,K-ATPase function and impairs lung liquid clearance. (northwestern.edu)
  • We conclude that the effects of fluoride on adenylate cyclase are not important in intact tissue, and that inhibition of Na+-K+ ATPase and subsequent Na2+-Ca2+ exchange may be the mechanism of increased Cai in acute fluoride toxicity. (fluoridealert.org)
  • The Archaea-type ATPase (A-ATPase) is a related group of ATPases found in archaea that often work as an ATP synthase. (wikipedia.org)
  • To determine whether different Na+/K+-ATPase signal transduction pathways have positive inotropic effects on normal ventricular myocytes (NC) and failing ventricular myocytes (FC), and are involved in an increase of [Ca2+]i induced by strophanthidin (Str). (unboundmedicine.com)
  • The present study suggests that Na+/K+-ATPase signaling pathways involved in the inotropic effects of Str in NC and FC are consistent, and Na+/K+-ATPase signaling pathways involved in the increase of [Ca2+]i by Str in NC and FC are different. (unboundmedicine.com)
  • Special cellular machinery should be activated to fight against increased reactive oxygen species (ROS) level to protect from oxidative injury. (springer.com)
  • In recent studies, Sodhi and colleagues have demonstrated that Na/K-ATPase signaling can amplify oxidative stress under diseased conditions. (marshall.edu)
  • We tested whether increased SERCA1a expression levels enhance myocyte contractility in a gene-dose - dependent manner. (gla.ac.uk)
  • Conclusions - Moderate SERCA1a gene transfer and expression improve contractility and Ca2+ cycling. (gla.ac.uk)
  • The ATP12A gene codes for a non-gastric H + /K + ATPase, which is expressed in a wide variety of tissues. (karger.com)
  • These results suggest that Na,K-ATPase subunit gene over-expression in the alveolar epithelium increases Na,K-ATPase function and lung liquid clearance in a model of HV T . We provide here the first evidence that using a genetic approach improves active Na + transport and thus liquid clearance in the setting of mild ventilation-induced lung injury. (northwestern.edu)
  • These results suggest that Na,K-ATPase subunit gene over-expression in the alveolar epithelium increases Na,K-ATPase function and lung liquid clearance in a model of HVT. (northwestern.edu)
  • We show here that S. cerevisiae also acquires mutations in a gene encoding a P-type ATPase (ScPMA1) after exposure to spiroindolones and that these mutations are sufficient for resistance. (jcvi.org)
  • In synaptic transmission in neuronal cells, V-ATPase acidifies synaptic vesicles. (wikipedia.org)
  • In addition, cell membrane permeability for ions also increased under anesthesia. (frontiersin.org)
  • Renal losses of hydrogen ions occur whenever the distal delivery of sodium increases in the presence of excess aldosterone, which stimulates the electrogenic epithelial sodium channel (ENaC) in the collecting duct. (medscape.com)
  • Plasma membrane V-ATPases are involved in processes such as pH homeostasis, coupled transport, and tumor metastasis. (wikipedia.org)
  • Likewise, in vivo models of breast cancer have demonstrated that a high-cholesterol diet increases tumor growth by 20%, as well as the likelihood of metastasis. (news-medical.net)
  • We hypothesized that overexpression of Na,K-ATPase in the alveolar epithelium could counterbalance these changes and increase clearance in a rat model of mild ventilation-induced lung injury. (northwestern.edu)
  • We provide here the first evidence that using a genetic approach improves active Na+ transport and thus liquid clearance in the setting of mild ventilation-induced lung injury. (northwestern.edu)
  • The percentage of inhaled benzene that was absorbed and retained during a 6-hour exposure period decreased from 33 to 15% in rats and from 50 to 10% in mice when the exposure concentration was increased from about 10 to 1,000 ppm (Sabourin et al. (cdc.gov)
  • Similarly, high-fat diets have been found to increase serum cholesterol and leptin levels, as well as facilitate breast cancer development, particularly in postmenopausal mice and obese mice. (news-medical.net)
  • Likewise, 27-hydroxycholesterol, an endogenous oxysterol, increases estrogen receptor- and liver X receptor-dependent tumor growth in mice. (news-medical.net)
  • The administration of the peptide, NaKtide, in mice can antagonize this signaling, thereby improving the diseased condition. (marshall.edu)
  • KAE609 also increases cytoplasmic hydrogen ion concentrations in yeast cells. (jcvi.org)
  • For many years, mercury was used in a wide variety of human activities, and now, exposure to this metal from both natural and artificial sources is significantly increasing. (hindawi.com)
  • Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. (medscape.com)
  • Genetically predicted BMI was strongly associated with both, susceptibility (OR=1.31 per 1 SD increase) and hospitalization (OR=1.62 per 1 SD increase) even after adjustment for genetically predicted visceral obesity traits. (cdc.gov)
  • lansoprazole decreases levels of rilpivirine by increasing gastric pH. (medscape.com)
  • Acalabrutinib solubility decreases with increasing gastric pH. (medscape.com)
  • The resultant increase in vagal tone decreases conduction through the atrioventricular node (AVN). (medscape.com)
  • Thus, HIIT downregulates FXYD5 and increases the distribution of glycosylated NKAβ1 in type IIa muscle fibres, which is likely independent of a change in the number of NKA complexes. (ku.dk)
  • The expression of this isotype, considered at the level of mRNA, is under developmental control, with the adult intestine exhibiting approximately a threefold increase in alpha 1 message over the neonate. (jci.org)
  • An increase in the abundance of alpha 1 isotype parallels the changes in its mRNA expression. (jci.org)
  • In breast cancer cells, 27-hydroxycholesterol has been found to increase matrix metalloproteinase 9 (MMP9) expression, activate signal transducer and activator of transcription 3 (STAT3), increase migration, invasion and epithelial-to-mesenchymal transition, as well as activate oncoprotein Myc by increasing its stability. (news-medical.net)
  • Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation. (uib.no)
  • Progesterone regulation of Na/K-ATPase β1 subunit expression in the mouse uterus during the peri-implantation period. (nih.gov)
  • Na/K-ATPase beta1 subunit expression is required for blastocyst formation and normal assembly of trophectoderm tight junction-associated proteins. (nih.gov)
  • Embryotrophic factor-3 from human oviductal cells enhances proliferation, suppresses apoptosis and stimulates the expression of the beta1 subunit of sodium-potassium ATPase in mouse embryos. (nih.gov)
  • V-ATPases are also found in the plasma membranes of a wide variety of cells such as intercalated cells of the kidney, osteoclasts (bone resorbing cells), macrophages, neutrophils, sperm, midgut cells of insects, and certain tumor cells. (wikipedia.org)
  • Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
  • In the present work, five genes encoding different Na(+),K(+) ATPase (NKA) α-isoforms in the teleost Solea senegalensis are described for the first time. (ualg.pt)
  • Expressions of most genes involved in KS synthesis increased from E9 to E16, and then decreased from E16 to E20. (unboundmedicine.com)
  • and sodium-potassium ATPase transporter (ATP1A1), sodium-bicarbonate transporter (NBC), and carbonic anhydrase II (CA2) increased 5- to 10-fold. (unboundmedicine.com)
  • [ 5 , 6 ] The resting transmembrane potential and action potential of electrically excitable cells is also affected by sodium potassium ATPase. (medscape.com)
  • V-ATPases acidify a wide array of intracellular organelles and pumps protons across the plasma membranes of numerous cell types. (wikipedia.org)
  • V-ATPases couple the energy of ATP hydrolysis to proton transport across intracellular and plasma membranes of eukaryotic cells. (wikipedia.org)
  • V-ATPases are found within the membranes of many organelles, such as endosomes, lysosomes, and secretory vesicles, where they play a variety of roles crucial for the function of these organelles. (wikipedia.org)
  • ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. (nih.gov)
  • Newer approaches are looking instead for ways of altering the pharmacokinetics of established drugs, particularly with respect to improving the ability of these to penetrate cell membranes at the end-organ/tissue level. (weeksmd.com)
  • Quantification of mRNA abundance after a salinity challenge showed that atp1a1a transcript levels increased significantly in the gill of soles transferred to high salinity water (60 ppt). (ualg.pt)
  • The nymphs fed V-ATPase D dsRNA showed a "significant reduction" in target transcript abundance after six days of feeding, which corresponded to an increase in mortality. (genomeweb.com)
  • Increased plasma LDL-cholesterol, VLDL-cholesterol and total cholesterol might have resulted in the increased C/P ratio and decreased platelet membrane fluidity of cigarette smokers. (nih.gov)
  • Menopausal women who consume diets that are high in cholesterol are at an increased risk of breast cancer risk. (news-medical.net)
  • Although reduced HDL-cholesterol levels have been found to increase breast cancer risk, increased levels of total cholesterol and low-density lipoprotein (LDL)-cholesterol are associated with a reduced risk of breast cancer. (news-medical.net)
  • In women with triple-negative breast cancer, high triglyceride level and low HDL-cholesterol level increase the risk of mortality. (news-medical.net)
  • Cholesterol has been shown to increase cancer cell proliferation by stimulating AKT phosphorylation. (news-medical.net)
  • It is known that the activities of Na+/K+- and Ca2+-ATPases in the plasma membrane with an excess of cholesterol are compromised. (bvsalud.org)
  • The yeast V-ATPase is the best characterized. (wikipedia.org)
  • The complex structure of the V-ATPase has been revealed through the structure of the M. Sexta and Yeast complexes that were solved by single-particle cryo-EM and negative staining, respectively. (wikipedia.org)
  • V-ATPases in the acrosomal membrane of sperm acidify the acrosome. (wikipedia.org)
  • RESULTS AND CONCLUSION: Plasma TC increased by 4.33% while RBC membrane TC decreased by 20.32% in copper-toxic group compared to control. (bvsalud.org)
  • Number of cis- and saturated fatty acids increased in copper-treated plasma and RBC membrane compared to control. (bvsalud.org)
  • Sodium fluoride produces a K+ efflux by increasing intracellular Ca2+ through Na+-Ca2+ exchange. (fluoridealert.org)
  • Caffeine-induced Ca2+ transients indicated significantly increased SR Ca2+ content in Ad-SERCA1a- infected cells, by 72% at MOI 10 and by 87% at MOI 50. (gla.ac.uk)
  • In estrogen receptor-positive and triple-negative breast cancer cells, oncosterone increases cellular proliferation and promotes cancer progression. (news-medical.net)
  • Accumulation of cholesteryl esters in breast cancer cells has been found to increase cancer aggressiveness. (news-medical.net)
  • Interestingly, by optimizing the ratio of RBCMs:4T1CMs, it was possible to increase the homotypic targeting properties towards breast cancer cells. (bvsalud.org)
  • The compound increases insulin release selectively at high glucose concentrations and is therefore of interest in type 2 diabetes. (researchgate.net)
  • Further increases in solubility were obtained by the addition of the NVoy polymer reagent to the reaction mixture. (iucr.org)
  • The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase, PfATP4. (jcvi.org)
  • Normally, arterial PaCO 2 increases by 0.5-0.7 mm Hg for every 1 mEq/L increase in plasma bicarbonate concentration, a compensatory response that is very quick. (medscape.com)
  • For example, if the increase in PaCO 2 is more than 0.7 times the increase in bicarbonate, then metabolic alkalosis coexists with primary respiratory acidosis. (medscape.com)
  • Day 1 13C con- centrations of cerebrum and cerebellum were also significantly increased but the increase was inconsistent, significant only on one additional day of the postexposure period, possibly reflecting translocation across the blood-brain barrier in certain brain regions. (cdc.gov)
  • ACTH increased the levels of cortisol in plasma and urine, and of irEDLS in plasma. (lu.se)
  • By integrating these findings, we propose an updated and unifying mechanism for noncanonical autophagy, centered on ATG16L1 and V-ATPase. (babraham.ac.uk)
  • Upon V0-V1 binding, V-ATPase recruits ATG16L1, via K490, during LC3-associated phagocytosis (LAP), STING- and drug-induced CASM, indicating a common mechanism. (babraham.ac.uk)
  • Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. (hmdb.ca)
  • There is a clear unmet need to develop novel mechanistically based therapeutic options with improved efficacy and favourable safety profiles. (nature.com)
  • tested 24-h seed pre-treatments with H2O2 with 50 mM being optimal with improved seed germination, seedling vigour and growth in corn, squash (Cucurbita pepo L.) and tomato (Solanum lycopersicum L.). Increased germination and seedling growth of peas (Pisum sativum L. 'Alaska') was shown by Barba-Espin et al. (researchgate.net)
  • The plants pre-treated with diethyl ether, and thus with induced HSPs, had increased tolerance of photosystem II to subsequent heat stress through the process known as cross-tolerance or priming. (frontiersin.org)
  • However, decreased renal clearance, rather than increased production or release, may be the main cause of increased plasma levels of irEDLS in uremia. (lu.se)
  • Increased oxygen bioavailability may be used to improve production of the tested crops. (researchgate.net)
  • H2O2 increases germination rates by breaking down the seed coat, thus allowing the seed to take in oxygen more quickly. (researchgate.net)
  • Fluoride, like isoproterenol, stimulates adenylate cyclase, and could increase Cai via the effects of cAMP on Ca2+ channels. (fluoridealert.org)
  • The researchers were also able to successfully feed dsRNA against another V-ATPase to brown planthoppers, triggering reductions in target transcripts but with no apparent effect on mortality. (genomeweb.com)
  • RNAi-based methods of controlling various aphid species have been attempted, and in 2009 a group from the University of Manitoba reported that feeding dsRNA targeting V-ATPase to pea aphids led to significant mortality. (genomeweb.com)
  • However, studies have shown increased mortality related to arrhythmogenic potential. (medscape.com)
  • In contrast, atp1a3a transcripts increased at low salinity (5 ppt). (ualg.pt)
  • In situ hybridization (ISH) analysis revealed that the number of ionocytes expressing atp1a1a transcripts in the primary gill filaments was higher at 35 and 60 ppt than at 5 ppt and remained undetectable or at very low levels in the lamellae at 5 and 35 ppt but increased at 60 ppt. (ualg.pt)
  • ARNIs may reduce hospitalizations for heart failure but do not improve other outcomes. (msdmanuals.com)