CalciumAdenosine TriphosphateAdenosine TriphosphatasesKineticsProteolysisMolecular Sequence DataHydrolysisPeptide HydrolasesAmino Acid SequenceEndopeptidasesCalpainProtein BindingTrypsinCell LineBinding SitesPeptide FragmentsCells, CulturedProteasome Endopeptidase ComplexMutationElectrophoresis, Polyacrylamide GelSignal TransductionCysteine EndopeptidasesPhosphorylationUbiquitinsRecombinant ProteinsMolecular WeightEnzyme ActivationBase SequenceEscherichia coliAdenosine DiphosphateSubstrate SpecificityProtein ConformationChymotrypsinProtein Processing, Post-TranslationalMembrane ProteinsHydrogen-Ion ConcentrationTime FactorsSerine EndopeptidasesProtease InhibitorsModels, BiologicalMultienzyme ComplexesCell MembraneATP Synthetase ComplexesCarrier ProteinsCattleBacterial ProteinsRabbitsDNA-Binding ProteinsProteinsUbiquitinRNA, MessengerThermolysinProtein Structure, TertiaryRecombinant Fusion ProteinsSaccharomyces cerevisiaeMagnesiumDose-Response Relationship, DrugTransfectionBlotting, WesternModels, MolecularTranscription FactorsEnzyme InhibitorsTranscription, GeneticSequence Homology, Amino AcidMice, Inbred C57BLApoptosisPeptidesMice, KnockoutMacromolecular SubstancesHeLa CellsUbiquitin-Protein LigasesCysteine Proteinase InhibitorsTemperatureSaccharomyces cerevisiae ProteinsMutagenesis, Site-DirectedEndopeptidase ClpMitochondriaBiological TransportCell Cycle ProteinsGene Expression RegulationLeupeptinsAmino AcidsReceptors, Purinergic P2Mitochondrial Proton-Translocating ATPasesCloning, MolecularImmunoblottingLigasesCell Line, TumorCytosolLysosomesEndopeptidase KProtein TransportATP-Dependent ProteasesMetalloendopeptidasesNuclear ProteinsLiverRats, Sprague-DawleyStructure-Activity RelationshipProtein KinasesCatalysis