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Adenosine TriphosphateAdenosine TriphosphatasesKineticsEndopeptidasesNeprilysinSerine EndopeptidasesThiorphanPHEX Phosphate Regulating Neutral EndopeptidaseProtease InhibitorsCysteine EndopeptidasesMolecular Sequence DataMetalloendopeptidasesAmino Acid SequenceSubstrate SpecificityHydrolysisGlycopeptidesNeurotensinLysostaphinSerine Proteinase InhibitorsAspartic Acid EndopeptidasesDipeptidesBase SequenceHydrogen-Ion ConcentrationBinding SitesAtrial Natriuretic FactorOligopeptidesCells, CulturedThiazepinesCell LineCalciumChromatography, High Pressure LiquidPeptide FragmentsRecombinant ProteinsPeptidesCathepsin BMutationProtein BindingElectrophoresis, Polyacrylamide GelBradykininSignal TransductionSubstance PCloning, MolecularSequence Homology, Amino AcidCarboxypeptidasesCell MembraneEnzyme ActivationAdenosine DiphosphateKidneyExopeptidasesEscherichia coliEnkephalin, LeucineATP Synthetase ComplexesRabbitsAminopeptidasesBotulinum Toxins, Type AIndansDose-Response Relationship, DrugHypophosphatemiaTime FactorsFlavobacteriumRNA, MessengerMolecular WeightPeptide HydrolasesBacterial ProteinsThermolysinPeptidoglycanEnzyme InhibitorsPropionatesProtein Processing, Post-TranslationalCattleATP-Dependent EndopeptidasesPhosphorylationMembrane ProteinsMice, Inbred C57BLRats, Sprague-DawleyCarboxypeptidases AProtein PrecursorsMice, KnockoutTransfectionSwineAmino AcidsSequence AlignmentChromatography, GelAngiotensin-Converting Enzyme InhibitorsFamilial Hypophosphatemic RicketsModels, MolecularPeptidyl-Dipeptidase AStructure-Activity RelationshipCatalysisProtein ConformationSubtilisinsModels, BiologicalIsoflurophateRats, WistarMagnesiumTranscription, GeneticLeucyl AminopeptidaseKininsReceptors, Purinergic P2Mitochondrial Proton-Translocating ATPases
ProteasePeptidase activityUbiquitinZincProteasomeActivityPeptidesHydrolysisEncodesPhosphorylationGeneEndoproteaseProtein kinasePhosphateATPaseFamilyProteasesCysteine EndopeptidasesProlyl endopeptidaseMitochondrialAdenosine triphosphatePutativeIntracellularProtein degradationTransporterProteinsEndoproteaseInhibitorComplexPeptideClpPGeneActivatorBacterialHelicasesInterproscanBINDING
Protease4
  • In molecular biology, the ATP-dependent Clp protease adaptor protein ClpS is a bacterial protein. (wikipedia.org)
  • In the bacterial cytosol, ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. (wikipedia.org)
  • Endopeptidase Clp Clp protease family Varshavsky A (August 2011). (wikipedia.org)
  • A heat-shock gene which encodes the ATP-dependent protease La. (enzyme-database.org)
Peptidase activity1
  • FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase acti. (riken.jp)
Ubiquitin2
  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). (cathdb.info)
  • Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (antibodies-online.com)
Zinc2
  • It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves syntaxin. (illnesshacker.com)
  • Botulinum Toxin Type B inhibits acetylcholine release at the neuromuscular junction via a three-stage process: 1) Heavy Chain mediated neuro specific binding of the toxin, 2) internalization of the toxin by receptor-mediated endocytosis, and 3) ATP and pH-dependent translocation of the Light Chain to the neuronal cytosol where it acts as a zinc-dependent endoprotease cleaving polypeptides essential for neurotransmitter release. (illnesshacker.com)
Proteasome1
  • The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. (novusbio.com)
Activity1
  • Here, we demonstrate that RNF213 E3 activity is dependent on ATP binding, rather than ATP hydrolysis, and is particularly responsive to the ATP/ADP/AMP ratio. (biorxiv.org)
Peptides1
  • The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. (nih.gov)
Hydrolysis1
Encodes1
  • previously strains which BRL-15572 contain a mutation in the operon, an operon that encodes an ATP- binding cassette (ABC) transportation program (16), are impaired within their ability to trigger endocarditis within a rat model (8). (careersfromscience.org)
Phosphorylation2
  • An in vitro binding kinetic analysis revealed that these phosphorylation-dependent events were attributable to a decrease in the affinity of phosphorylated Homer3 for its ligand. (jneurosci.org)
  • In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
Gene1
Endoprotease1
  • Desautels, M. and Goldberg, A.L. Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria. (enzyme-database.org)
Protein kinase1
  • We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)
Phosphate2
ATPase1
  • In the cell, RNF213 was shown to be involved in fatty acid metabolism ( 11 ), and to associate with intracellular lipid droplets in a manner dependent on its E3 ligase and ATPase activities ( 12 ). (biorxiv.org)
Family1
  • 42329 iron %28metal%29 dependent repressor%2C DtxR family CP001857 CDS Arcpr_0049 complement(42326. (go.jp)
Proteases2
  • ClpP: a distinctive family of cylindrical energy-dependent serine proteases. (medlineplus.gov)
  • In addition, there are a number of housekeeping proteases generally involved in regular protein turnover, such as HtrA, Lon, and LexA, and the ATP-dependent Clp and Hsl proteases. (ens-lyon.fr)
Cysteine Endopeptidases2
Prolyl endopeptidase2
  • Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. (medchemexpress.com)
  • During the first years of the 1990s I made an attempt with Johan Rosén to look for additional modifications of phosphopeptides, which led to the rediscovery of prolyl endopeptidase and the discovery of its preference for a phosphorylated substrate. (uu.se)
Mitochondrial1
  • Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease. (medlineplus.gov)
Adenosine triphosphate1
  • Cytoplasmic proteins targeted for turnover are covalently linked to the small protein ubiquitin , which then interacts with a large protein complex, the proteasome , to degrade the protein in an adenosine triphosphate (ATP)-dependent process. (basicmedicalkey.com)
Putative2
  • 11353) putative ABC transport system ATP-binding protein BBZA01000001 CDS ARMA_0011 complement(11350. (go.jp)
  • There are another 4 putative intracellular zinc-dependent metallopeptidases, generally membrane-bound, present in all strains (OG_1535, OG_554, OG_1722, OG_1779). (ens-lyon.fr)
Intracellular2
  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). (cathdb.info)
  • An intracellular protease/endopeptidase of the subtilase family (OG_3734) is found in 4 strains, i.e. (ens-lyon.fr)
Protein degradation2
  • In the bacterial cytosol, ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. (wikipedia.org)
  • ClpXP, an ATP-powered unfolding and protein-degradation machine. (medlineplus.gov)
Transporter1
  • protein_coding" "AHY40135","CJ8421_04560","Campylobacter jejuni","amino acid ABC transporter ATP-binding protein [Ensembl]. (ntu.edu.sg)
Proteins2
  • substrate proteins to degradation might be influenced by purified endopeptidases (chymotrypsin and trypsin). (123dok.net)
  • In the early 1970s Lorentz Engström, together with most of his research group, switched to the study of proteins phosphorylated by cyclic AMP-dependent protein kinase (PKA). (uu.se)
Endoprotease1
  • 1. Desautels, M. and Goldberg, A.L. Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria. (qmul.ac.uk)
Inhibitor2
  • AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC 50 of 0.8 nM. (medchemexpress.com)
  • TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC 50 of 1 nM for mTOR kinase. (medchemexpress.com)
Complex1
  • It uses aerobic degradation of complex porteinaceous substrates for energy and grows optimally at 90 degrees C. The ligopeptide transport systems, such as the dependent ATP-binding cassette (ABC) transporters, help these nutrients to sustain growth [3]. (kenyon.edu)
Peptide1
  • This peptidase hydrolyses oligopeptides beyond the N-terminal peptide bond which indicates that ApAAP exhibits endopeptidase activity. (kenyon.edu)
ClpP1
  • The ATP-dependent Clp protease (ClpP) plays an essential role not only in the control of protein quality but also in the regulation of bacterial pathogen virulence, making it an attractive target for antibacterial treatment. (uni-luebeck.de)
Gene1
  • A heat-shock gene which encodes the ATP-dependent protease La. (qmul.ac.uk)
Activator1
  • MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR . (medchemexpress.com)
Bacterial2
  • In molecular biology, the ATP-dependent Clp protease adaptor protein ClpS is a bacterial protein. (wikipedia.org)
  • The studies on the histidine phosphorylation of the bacterial phosphoenolpyruvate‑dependent phosphotransferase system and two‑component systems had become extensive at that time, while the progress of the studies on phosphohistidine in mammalian cells had been slower. (uu.se)
Helicases1
Interproscan1
  • Binding-protein-dependent transport system inner membrane component [Interproscan]. (ntu.edu.sg)
BINDING2
  • using our ATP-ABP, we characterized a wide range of ATPases and other active nucleotide- and nucleic acid-binding enzymes involved in multiple facets of cellular metabolism throughout development. (nih.gov)
  • 14787 ABC-2 type transport system ATP-binding protein BBZA01000002 CDS ARMA_0027 14784. (go.jp)