Mouse Monoclonal AntibodyDetects endogenous levelsMonoclonal AntibodiesProteinEnzymePeptideRabbitTherapeuticLevelsSpecificallyActiveACLYPolyclonalAcetyl-CoA and oxaloacetateCleavageSynthaseMonoclonal antibodyInhibitorOxaloacetateReactsHistone acetylationBindsTherapeuticEnzymesELISAMutantProliferationFattySynthesisHumanDetectionHypoxiaMitochondrialCholesterolProductCellFormRoleExpression
Mouse Monoclonal Antibody1
- ATP-citrate lyase Mouse Monoclonal Antibody detects endogenous levels of ATP-citrate lyase protein. (ebiocell.com)
Detects endogenous levels1
- AKT1 Antibody detects endogenous levels of total AKT1. (affbiotech.com)
Monoclonal Antibodies3
- Security and Tolerability of three CGRP Monoclonal Antibodies in Apply: A Retrospective Cohort Examine Goal: We sought to evaluate the protection and tolerability of three calcitonin gene-related peptide (CGRP) monoclonal antibodies in sufferers with power migraine who have failed a number of lessons of migraine preventive therapies. (tuberculosistest.net)
- Complete Evaluation of the Antigenic Influence of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised Towards Lineage A Main Capsid Proteins of Vaccine-Associated Genotypes Human papillomavirus (HPV) is the causative agent of cervical and different epithelial cancers. (tuberculosistest.net)
- Backside-up pattern preparation for the LC-MS/MS quantification of anti-cancer monoclonal antibodies in bio matrices Therapeutic monoclonal antibodies (mAbs) are quickly taking on the remedy of many malignancies, and an astonishing variety of mAbs is in improvement. (tuberculosistest.net)
Protein6
- Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. (affbiotech.com)
- Evolocumab and alirocumab are antibodies targeting the PCSK9 protein, causing it to lose its function. (lipidtools.com)
- AGR2 is also a pro-oncogenic protein that stimulates EGFR ligand amphiregulin , regulate p53 signaling, and interact with the AAA+ protein Reptin. (medchemexpress.com)
- An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. (lookformedical.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human GA Binding Protein Transcription Factor Alpha (GABPa) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (therabio.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human GA Binding Protein Transcription Factor Alpha (GABPa) in samples from serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (therabio.org)
Enzyme10
- Bempedoic acid inhibits an enzyme called ATP-citrate lyase. (lipidtools.com)
- The RET Assay Kit comes in a convenient 96-well format, with enough purified recombinant RET enzyme, RET substrate peptide (IRF-1Rtide), ATP and kinase assay buffer for 100 enzyme reactions. (morulaivf.com)
- The BTK Assay Kit comes in a convenient 96-well format, with enough purified recombinant BTK enzyme, PolyGluTyr peptide, ATP, and kinase assay buffer for 100 enzyme reactions. (morulaivf.com)
- They are inactive forms of the enzyme argininosuccinate lyase. (lookformedical.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Farnesyl Diphosphate Synthase (FDPS) in Tissue homogenates, cell lysates and other biological fluids. (isogem.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Farnesyl Diphosphate Synthase (FDPS) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (isogem.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) in samples from Serum, plasma, tissue homogenates and other biological fluids. (isogem.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) in tissue homogenates, cell lysates and other biological fluids. (isogem.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Angiomotin (AMOT) in Tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Nuclear Factor I/X (NFIX) in Tissue homogenates and other biological fluids. (operatiebrp.nl)
Peptide1
- These peptide usually contains the epitope recognized by the antibody. (affbiotech.com)
Rabbit2
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. (cusabio.com)
- That's why we've invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality. (stratech.co.uk)
Therapeutic1
- Together these data show that metabolic reprogramming, which includes FAO and glutamine metabolism, controls the activation of pro-inflammatory and anti-tumorigenic polarization, and highlight a therapeutic potential of metabolic preconditioning of tumor-associated macrophages before agonistic anti-CD40 treatments. (acir.org)
Levels1
- FPR2 agonist 3 (compound CMC23) can limit the lactate dehydrogenase release in LPS ( HY-D1056 ) -stimulated cultures and decrease the levels of pro-inflammatory IL-1β and IL-6 . (medchemexpress.cn)
Specifically1
- Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. (affbiotech.com)
Active1
- Bempedoic acid is a pro-drug that is converted into its active form in liver cells but not in muscle cells. (lipidtools.com)
ACLY7
- Bempedoic acid has emerged as a potent inhibitor of ATP-citrate lyase (ACLY), a target for the reduction of LDL cholesterol (LDL-C). We review the impact of bempedoic acid treatment on lipoprotein metabolism and atherosclerosis in preclinical models and patients with hypercholesterolemia. (nih.gov)
- The liver-specific activation of bempedoic acid inhibits ACLY, a key enzyme linking glucose catabolism to lipogenesis by catalyzing the formation of acetyl-CoA from mitochondrial-derived citrate for de novo synthesis of fatty acids and cholesterol. (nih.gov)
- ATP citrate lyase (ACLY) is an enzyme that in animals represents an important step in fatty acid biosynthesis. (siderac.com)
- ATP citrate lyase/ACLY cDNA clones are full length sequence confirmed and expression validated. (siderac.com)
- The gene encoding ATP-citrate lyase, designated ACLY, was mapped to human chromosome 17q12-q21 by PCR on a panel of human/rodent somatic cell hybrids and localized to 17q21.1 by PCR on a panel of radiation hybrids. (siderac.com)
- ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA. (siderac.com)
- In addition, PD-1 inactivation enforces ATP citrate lyase (ACLY) activity, which generates extramitochondrial acetyl-CoA for histone acetylation to enable hyperactivity of activating protein 1 (AP-1) transcription factors. (bvsalud.org)
Polyclonal3
- The following product was used in this experiment: ATP Citrate Lyase Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-78712, RRID AB_2745828. (thermofisher.com)
- Samples were loaded onto a 5% SDS-PAGE gel and probed with an ATP citrate lyase polyclonal antibody (Product # PA5-29495) at a dilution of 1:1000. (siderac.com)
- Invitrogen Anti-ATP Citrate Lyase Polyclonal, Catalog # PA5-29497. (siderac.com)
Acetyl-CoA and oxaloacetate4
- It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. (thermofisher.com)
- J. Bgee i: ENSMUSG00000020917, Expressed in inguinal mammary gland and 345 other tissues: The 4 substrates of this enzyme are ADP, phosphate, acetyl-CoA, and oxaloacetate, whereas its 3 products are ATP, citrate, and CoA. (siderac.com)
- citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. (siderac.com)
- The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitochondria by the SLC25A1 carrier in Acetyl Coenzyme A (acetyl-CoA) and oxaloacetate. (siderac.com)
Cleavage1
- An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. (lookformedical.com)
Synthase1
- In enzymology, an ATP citrate synthase (EC 2.3.3.8) is an enzyme that catalyzes the chemical reaction. (siderac.com)
Monoclonal antibody2
- Tuning Monoclonal Antibody Galactosylation utilizing Raman Spectroscopy-Managed Lactic Acid Feeding A key side of large-scale manufacturing of biotherapeutics is a well-designed and consistently-executed upstream cell tradition course of. (tuberculosistest.net)
- Monoclonal antibody (mAb) crystalline suspension formulation is a promising alter native for high concentration subcutaneous drug delivery. (tuberculosistest.net)
Inhibitor2
- A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, showing that ATP citrate lyase inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. (siderac.com)
- Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP) , a cytoplasmic serine endoprotease ( IC 50 = 12 nM). (medchemexpress.cn)
Oxaloacetate1
- ADP + phosphate + acetyl-CoA + oxaloacetate ⇌ ATP + citrate + CoA. (siderac.com)
Reacts1
- This antibody reacts with Human, Mouse, Rat … TATA Acetyl-CoA is a vital building block for the endogenous biosynthesis of fatty acids and cholesterol and is involved in isoprenoid-based protein modifications. (siderac.com)
Histone acetylation2
- This renders ACL a key regulator of histone acetylation levels and gene … To provide a novel ATP:citrate lyase gene. (siderac.com)
- However, cellular citrate remains critically low in mutant Th17 cells, which interferes with oxidative phosphorylation (OXPHOS), lipid synthesis, and histone acetylation, crucial for transcription of Th17 signature genes. (bvsalud.org)
Binds1
- This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Therapeutic2
- Backside-up pattern preparation for the LC-MS/MS quantification of anti-cancer monoclonal antibodies in bio matrices Therapeutic monoclonal antibodies (mAbs) are quickly taking on the remedy of many malignancies, and an astonishing variety of mAbs is in improvement. (tuberculosistest.net)
- Developing biological formulations to maintain the chemical and structural integrity of therapeutic antibodies remains a significant challenge. (tuberculosistest.net)
Enzymes1
- In contrast, VLCFAs provoked pro-inflammatory responses through scavenger receptor CD36-mediated uptake, cumulating in JNK signalling and expression of matrix-degrading enzymes and chemokine release. (biomed.news)
ELISA2
- Description: A sandwich quantitative ELISA assay kit for detection of Human ATP Binding Cassette Transporter C9 (ABCC9) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
- Description: A sandwich ELISA kit for detection of ATP Binding Cassette Transporter C9 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
Mutant1
- This is in contrast to Sordaria macrospora, in which fruiting body formation is initiated but maturation is defective in an ATP-citrate lyase mutant. (siderac.com)
Proliferation2
- Here, we show that PDH is essential for the generation of a glucose-derived citrate pool needed for Th17 cell proliferation, survival, and effector function. (bvsalud.org)
- The rapid ATP production of glycolysis is thought to benefit the enhanced proliferation of cancer cells. (biomedcentral.com)
Fatty1
- By converting citrate to acetyl-CoA, the enzyme links carbohydrate metabolism, which yields citrate as an intermediate, with fatty acid biosynthesis, which consumes acetyl-CoA. (siderac.com)
Synthesis1
- ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. (thermofisher.com)
Human4
- E. coli-derived human ATP citrate lyase recombinant protein (Position: M1-I180). (thermofisher.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human ATP Binding Cassette Transporter C9 (ABCC9) in Tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Neuroplastin (NPTN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (wildpalm.net)
- Complete Evaluation of the Antigenic Influence of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised Towards Lineage A Main Capsid Proteins of Vaccine-Associated Genotypes Human papillomavirus (HPV) is the causative agent of cervical and different epithelial cancers. (tuberculosistest.net)
Detection1
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cell Division Cycle Protein 25 (CDC25) in Tissue homogenates, cell lysates and other biological fluids. (isogem.org)
Hypoxia1
- The hypoxia-inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response increasing the pro-survival and pro-invasive phenotype of cancer cells, and determine a broad metabolic rewiring. (mdpi.com)
Mitochondrial1
- Dysfunctional autoimmune Tregs display pro-inflammatory features and altered mitochondrial metabolism, but contributing factors remain elusive. (bvsalud.org)
Cholesterol1
- We have shown that cholesterol accumulation due to myeloid cell deficiency of the cholesterol transporters ATP Binding Cassette A1 and G1 (ABCA1/G1) promotes NLRP3 inflammasome activation in macrophages and neutrophils and induces prominent NETosis in atherosclerotic plaques. (biomed.news)
Product1
- If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)
Cell2
- Western blot analysis of ATP citrate lyase using A) 30 µg PC-12 whole cell lysate and B) 30 µg Rat2 whole cell lysate. (siderac.com)
- Increasing cellular citrate in PDH-deficient Th17 cells restores their metabolism and function, identifying a metabolic feedback loop within the central carbon metabolism that may offer possibilities for therapeutically targeting Th17 cell-driven autoimmunity. (bvsalud.org)
Form3
- We demonstrate that both Acl1 and Acl2 subunits are required to form a functional ATP-citrate lyase in A. niger. (siderac.com)
- In its severest form, X-ALD causes cerebral myelin destruction with infiltration of pro-inflammatory skewed monocytes/macrophages. (biomed.news)
- Olmesartan Medoxomil is a pro-drug containing an ester moiety that, after oral administration, is rapidly cleaved to release the active form Olmesartan (RNH-6270). (xcessbio.com)
Role1
- Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease [1] [2] . (medchemexpress.cn)
Expression1
- ABCD1 deficiency impaired VLCFA homeostasis and prolonged pro-inflammatory gene expression upon LPS treatment. (biomed.news)