AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bronchial HyperreactivityBronchial Provocation TestsMethacholine ChlorideAsthmaBronchoconstrictor AgentsRespiratory HypersensitivityHypersensitivity, ImmediateForced Expiratory VolumeBronchiAllergensImmunoglobulin ESkin TestsBronchoconstrictionRespiratory Function TestsHistamineHypersensitivityRespiratory SoundsAdministration, InhalationRhinitis, Allergic, SeasonalAirway ResistanceOvalbuminBronchitisEosinophilsVital CapacityMethacholine CompoundsPeak Expiratory Flow RateSpirometryBronchoalveolar Lavage FluidLungAnhydridesSkiingAirway ObstructionAnti-Asthmatic AgentsBronchodilator AgentsPulmonary EosinophiliaEosinophiliaBeclomethasoneCoughEosinophil Granule ProteinsAsthma, Exercise-InducedRhinitisMitesRespiratory SystemHockeyEmergency RespondersRhinitis, Allergic, PerennialAntigens, DermatophagoidesRespiratory Tract DiseasesSaline Solution, HypertonicBudesonideInflammationPrevalenceBreath TestsGinkgolidesDustPollenLeukocyte CountMice, Inbred BALB CAndrostadienesAdrenal Cortex HormonesMuscle, SmoothOccupational DiseasesGuinea PigsDouble-Blind MethodOccupational ExposureDisease Models, AnimalSputumAnti-Inflammatory AgentsInterleukin-13AlbuterolCross-Sectional StudiesPlatelet Activating FactorNebulizers and VaporizersNitric OxideInterleukin-5TracheaTh2 CellsRisk FactorsDose-Response Relationship, DrugCytokinesOzoneStatistics, NonparametricGoblet CellsQuestionnairesPyroglyphidaeAirway RemodelingBronchoalveolar LavageMucusSmokingCase-Control StudiesSensitivity and SpecificityCohort StudiesAnalysis of VarianceOxidants, PhotochemicalIntradermal TestsDermatitis, AtopicRadioallergosorbent TestPatch TestsAerosolsOdds Ratio
Airway hyperresponsivenessResponsivenessPathogenesis of bronchialMethacholineAtopicAsthma and atopySymptomsInflammationAllergensExposureReactivityBronchiolitisChronicGenesSeverityObstructionAcuteMucosaAllergenAsthmaticRhinitisInflammatoryLung function in childhoodAdulthoodSensitisationChildhoodFunctionClinicalSerumAllergyCases
Airway hyperresponsiveness6
  • However, only 9mo, HDM-exposed mice demonstrated significant airway hyperresponsiveness compared to age-matched controls. (cdc.gov)
  • The chronic inflammation of asthma is associated with airway hyperresponsiveness that leads to recurrent symptoms, yet lung function may nevertheless remain normal. (cmaj.ca)
  • Identification of airway hyperresponsiveness thus has clinical value, particularly in the diagnosis of asthma in people with normal spirometry results or with symptoms uncharacteristic of asthma. (cmaj.ca)
  • Airway hyperresponsiveness is usually measured using direct stimuli, such as methacholine or histamine, that act by stimulating specific receptors on the bronchial smooth muscle to cause contraction and narrowing of the airways. (cmaj.ca)
  • It is characterized by airway hyperresponsiveness and recurrent episodes of acute symptoms such as wheezing, coughing, chest tightness, and shortness of breath (SOB) which affects approximately 262 million people and causes 455,000 annual deaths worldwide (World Health Organization [WHO], 2023). (nursingce.com)
  • Chronic asthma symptoms are related to a combination of inflammation and airway hyperresponsiveness. (nursingce.com)
Responsiveness6
  • Associations with lung function, bronchial hyper-responsiveness (BHR), allergic sensitisation, asthma and rhinitis were analysed. (bmj.com)
  • We assessed sensitisationto eight allergens and bronchial hyper-responsiveness (BHR) to methacholine asa dichotomous variable and as a log slope. (herts.ac.uk)
  • Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families. (parisdescartes.fr)
  • We prospectively examined atopic findings, therapeutic effects of inhaled procaterol, azelastin, and/or glucocorticoids, improvement of FEV 1 i by bronchodilator therapy and bronchial responsiveness to methacholine in 20 patients. (go.jp)
  • Bronchial responsiveness to methacholine was normal in Group 1 while that in Group 2 was hyperreactive. (go.jp)
  • Determinants of allergen-induced asthma: dose of allergen, circulating IgE antibody concentration, and bronchial responsiveness to inhaled histamine. (mcmaster.ca)
Pathogenesis of bronchial2
  • Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. (wikipedia.org)
  • The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma. (edu.pk)
Methacholine1
  • At this age 1373 children (94%) completed standardized questionnaires, 1,043 (72%) skin-prick testing, 953 (65%) serum inhalant immunoglobulin E antibody screening and 784 (54%) methacholine bronchial challenges. (soton.ac.uk)
Atopic3
  • The prevalence of respiratory symptoms, atopic sensitization and bronchial hyperresponsiveness was compared in a random sample of adults, 20-44 yrs of age, in two cities in West and East Germany, Hamburg and Erfurt, respectively. (ersjournals.com)
  • According to the American Academy of Allergy, Asthma & Immunology, atopy refers to the genetic tendency to develop allergic diseases such as allergic rhinitis, asthma and atopic dermatitis (eczema). (theglobalfool.com)
  • Not all children with atopy will have atopic disease or develop symptoms after exposure to an allergen. (theglobalfool.com)
Asthma and atopy2
  • Therefore, these data may support the hypothesis that childhood factors and exposure to indoor allergens and irritants may have been more relevant for the development of asthma and atopy than the potential long-term exposure to high concentrations of sulphur dioxide and particulate matter. (ersjournals.com)
  • The studies found that children who lived on farms had a lower prevalence of asthma and atopy and were exposed to a greater variety of environmental microorganisms than children in the reference group. (medscape.com)
Symptoms3
  • Results: Regardless of the asthma assessment used, there was no association between asthma symptoms, diagnosis of asthma, atopy, BHR as log slope, binary or categorical and height, leg length or the ratio of sitting height to leg length. (herts.ac.uk)
  • Information on possible confounders in terms of smoking, birth weight, number of siblings and socio-economic factors such as household possessions, car ownership and education was available.Results: Regardless of the asthma assessment used, there was no associationbetween asthma symptoms, diagnosis of asthma, atopy, BHR as log slope, binary or categorical and height, leg length or the ratio of sitting height to leg length. (herts.ac.uk)
  • Sensitizer-induced OA was diagnosed by serial measurement of peak expiratory flow (PEF) at and away from work or by combination of serial PEF measurement at and away from work and non-specific bronchial provocation at and away from work in subjects with diagnosed asthma and work-relatedness of the symptoms. (peertechzpublications.com)
Inflammation3
  • Females dominated the severe asthma group (female/male ratio 4.4:1 versus 1.6:1 in the controlled asthmatics), and compared with controlled asthmatics, they had a predominantly neutrophilic inflammation (sputum neutrophils, 36 versus 28%) and evidence of ongoing mediator release but less atopy. (ersjournals.com)
  • Background: The fraction of exhaled nitric oxide (FeNO) has been suggested as a non-invasive marker of eosinophilic inflammation in asthma, but lately rather as a biomarker of atopy than of asthma itself. (uib.no)
  • Asthma is a clinical syndrome characterized by episodic reversible airway obstruction, increased bronchial reactivity, and airway inflammation. (medscape.com)
Allergens3
  • 1 The onset of asthma is often preceded by allergic disease (eczema or hay fever) and a positive result of skin tests with allergens (atopy). (bmj.com)
  • Some researchers attribute the development of asthma to a combination of atopy (a genetic tendency towards an IgE-mediated overreaction to external triggers), a familial tendency, and exposure to particular childhood upper respiratory infection(s), allergens, or triggers. (nursingce.com)
  • Atopy is typically associated with heightened immune responses, more specifically with excessive IgE production in response to common allergens, especially inhaled allergens and food allergens. (theglobalfool.com)
Exposure2
  • If most studies quantitative estimates of its contribution have available, it should be possible to determine exposure levels been evaluated only for atopy, a host factor (4). (cdc.gov)
  • The aim of the study was to investigate the impact of atopy, pollen exposure, and pharmacolo. (biomedcentral.com)
Reactivity1
Bronchiolitis2
  • We aimed to assess if FeNO was different in children with former hospitalization for bronchiolitis and a control group, and to explore whether the role of FeNO as a marker of asthma, atopy or bronchial hyperresponsiveness (BHR) differed between these two groups of children. (uib.no)
  • The associations for atopy and BHR were similar in the post-bronchiolitis and in the control group. (uib.no)
Chronic1
  • 1 ). Bronchial asthma is a chronic in- Islamic Republic of Iran Pouramjad et oids (moderate dose of fluticasone). (who.int)
Genes1
  • [ 4 ] These genes are thought to be involved in atopy, bronchial hyperresponsiveness, elevated IgE levels, and other asthma-related traits, although the effect of each gene on asthma susceptibility seems to be small. (medscape.com)
Severity1
  • Asthma is an inflammatory disorder of the airways associated with airflow obstruction and bronchial hyperresponsiveness that varies in severity across the spectrum of the disease. (ersjournals.com)
Obstruction1
  • The obstruction of airways in acute fatal asthma is due to contraction of bronchial smooth muscle, thickening of airway wall and intraluminal mucus and debris. (edu.pk)
Acute1
  • Kokuludag A, Sin A, Terzioglu E, Saydam G, Sebik F. Elevation of serum eosinophil cationic protein, soluble tumor necrosis factor receptors and soluble intercellular adhesion molecule-1 levels in acute bronchial asthma. (edu.pk)
Mucosa1
  • Asthma is an inflammatory condition of the bronchial mucosa affecting 10% of children and 5% of adults in Western countries. (encyclopedia.pub)
Allergen2
  • Interleukin-3 in bronchial biopsies from nonasthmatics and patients with mild and allergen-induced asthma. (mcmaster.ca)
  • Nevertheless, the role of allergy in severe asthma has been historically questioned [ 10 ] , probably due to the difficulty of conducting bronchial allergen challenges (BAC) in moderate-to-severe asthmatics. (encyclopedia.pub)
Asthmatic1
  • This study was conducted to confirm the existence of non-asthmatic cough associated with atopy. (go.jp)
Rhinitis2
  • CONCLUSION: Rhinitis is common at the age of 10 y, with strong associations with atopy, wheezing, asthma and bronchial hyperresponsiveness. (soton.ac.uk)
  • The diagnosis of allergic rhinitis is based on the history, and tests are used only to confirm atopy. (medscape.com)
Inflammatory2
  • In contrast, atopy may be less important in patients with adult asthma and other factors such as intolerance to aspirin and related nonsteroidal anti-inflammatory drugs (NSAIDs) as well as occupational exposures have been suggested to play an important role in adults with more severe asthma 1 , 8 . (ersjournals.com)
  • 3,4 Studies have shown that 5-7 the involvement of a variety of inflammatory factors and cytokines in the occurrence and development of bronchial asthma, the release of various types of inflammatory factors, and the infiltration of different airway inflammatory cells are the common pathological characteristics of the disease. (elsevier.es)
Lung function in childhood1
  • In conclusion, bronchial hyperresponsiveness and a low level of lung function in childhood are independent risk factors for a low level of FEV 1 in early adulthood. (atsjournals.org)
Adulthood1
  • Objectives To investigate the influence of childhood living environment and biodiversity indicators on atopy, asthma and lung function in adulthood. (bmj.com)
Sensitisation1
  • Atopy has long been recognised as the risk factor that has the greatest influence on the emergence of persistent asthma inchildhood, especially sensitisation to aeroallergens in the home 7 . (ersjournals.com)
Childhood2
  • Atopy in childhood. (mcmaster.ca)
  • How much atopy is attributable to common childhood environmental exposures? (mcmaster.ca)
Function3
  • Two longitudinal studies, one of middle-aged and older men with no history of asthma, the other of subjects aged 65 yr or older, found that bronchial hyperresponsiveness (BHR) and atopy were both independent predictors of decline of lung function ( 15 , 16 ). (atsjournals.org)
  • A novel role for ciliary function in atopy: ADGRV1 and DNAH5 interactions. (parisdescartes.fr)
  • Rigid diagnostic criteria, using a combination of tests of lung function, BHR and atopy status, high resolution computed tomography (HRCT) chest scan and the newly developed biological techniques for the assessment of biomarker profiles, can facilitate the correct diagnosis and the distinction between the severe asthma phenotypes. (pneumon.org)
Clinical1
  • A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom Journal of Allergy and Clinical Immunology. (nottingham.ac.uk)
Serum1
  • Venge P. Serum measurement of eosinophil cationic protein (ECP) in bronchial asthma. (edu.pk)
Allergy2
  • Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research Journal of Allergy. (nottingham.ac.uk)
  • These facts demonstrate that atopy and allergy represent two different phenomena and collectively challenge the atopy-based classification of T2 asthma ( Table 1 ). (encyclopedia.pub)
Cases1