Asymmetric stem cell division asymmetric cell division. Medical search. Frequent questions

Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)
Eosinophils are derived from hematopoietic stem cells initially committed to the myeloid line and then to the basophil-eosinophil granulocyte lineage. (medscape.com)

During human forebrain development, neural progenitor cells (NPCs) in the ventricular zone (VZ) undergo asymmetric cell divisions to produce a self-renewed progenitor cell, maintaining the potential to go through additional rounds of cell divisions, and differentiating daughter cells, populating the developing cortex. (elifesciences.org)
Previous work in the embryonic rodent brain suggested that the preferential inheritance of the pre-existing (older) centrosome to the self-renewed progenitor cell is required to maintain stem cell properties, ensuring proper neurogenesis. (elifesciences.org)
During human brain development, neural progenitor cells (NPCs) undergo two modes of cell division. (elifesciences.org)
1.0875 and 1.0770 g/mL per murine and human stem/progenitor cells, respectively). (bioinf.org)
Clare's lab recently identified a population of progenitor/stem cells in mice that, on transplantation, is sufficient to generate a fully functional thymus. (eurostemcell.org)
Figure 3) or PSA-NCAM are markers frequently used for intermediate progenitor cells and early immature neurons (PMID: 29625071). (sanbio.nl)
However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)
These approaches result in the loss of all histological information pertaining to the in vivo locale of MaSC and progenitor cells. (frontiersin.org)
Instead, we used laser microdissection to excise putative progenitor cells and control cells from their in situ locations in cryosections and characterized the molecular properties of these cells. (frontiersin.org)
MaSC/progenitor cells were identified based on their ability to retain bromodeoxyuridine for an extended period. (frontiersin.org)
whereas LREC in suprabasal epithelial layers are enriched for more committed progenitor cells, expressing some genes that are associated with stem cell attributes along with those indicative of cell differentiation. (frontiersin.org)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

Including discussions of the molecular basis of polarization mechanisms, asymmetric division of stem cells during development, the generation of left-right asymmetry of the body axis in mammals, and theoretical approaches to symmetry breaking, the volume is a vital reference for molecular, cell, and developmental biologists, as well as physical scientists interested in how and why symmetry breaking occurs in living systems. (cshlpress.com)
The cosegregation of 'immortal' template DNA strands and their link with the asymmetry apparatus has important implications for stem cell biology and cancer. (nih.gov)
1] ^ Ralph A. Neumüller,Juergen A. Knoblich Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer Genes Dev. (stemcellthailand.org)

In cell biology, single-cell variability occurs when individual cells in an otherwise similar population differ in shape, size, position in the cell cycle, or molecular-level characteristics. (wikipedia.org)
Single-cell analysis allows scientists to study the properties of a single cell of interest with high accuracy, revealing individual differences among populations and offering new insights in molecular biology. (wikipedia.org)
Thus, accurate measurement of gene expression in individual cells allows researchers to better understand these critical aspects of cellular biology. (wikipedia.org)
Nichole Broderick from UConn's Department of Molecular and Cell Biology has received almost $2M over five years from the National Institutes of General Medical Sciences to improve our understanding about the microbiome. (uconn.edu)
This latest project from professor of cell biology, Dr. Mayu Inaba, builds on her previous discovery of microscopic protrusions found only on stem cells. (uconn.edu)
The unique educational content found on this site was developed collaboratively with award-winning high school educators, international stem cell organizations, and professional medical animators-creating dynamic and engaging educational resources that teach pertinent cellular biology topics through the lens of stem cells and cellular reprogramming. (ca.gov)
It contains stem cell biology, ethics, and policy information and teaching resources. (ca.gov)
Insights into the biology of stem cells will be gained by confirmation and characterization of candidate MaSC markers identified in this study. (frontiersin.org)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
Dedicated to the advancement of research in all branches of cell biology. (bscb.org)
I then moved to the Beatson Institute in Glasgow to pursue my Doctoral degree in Cancer Cell Biology and have just recently graduated. (bscb.org)
Although my degree was in Biochemistry, I guess I was quite influenced by the many cell biologists who taught me and so it was a rather natural transition for me to go into cell biology for my graduate work. (bscb.org)
Similarly, single cell methods are vital in stem cell research and cancer biology, where isolated populations of primary cells are heterogeneous due to limitations in purification protocols, and it is often a minority cell population that is the most relevant. (justia.com)

Thus, the data described here use a novel genetic approach to birthdate centrosomes in human cells and identify asymmetric inheritance of centrosomes as a mechanism to maintain self-renewal properties and to ensure proper neurogenesis in human NPCs. (elifesciences.org)
TBC1D15-NuMA1 association impaired asymmetric division machinery by hijacking NuMA from LGN binding, thereby favoring TIC self-renewal. (nature.com)
Furthermore, we demonstrate that the asymmetric cell-fate determinant Numb segregates selectively to one daughter cell during mitosis and before differentiation, suggesting that Numb is associated with self-renewal. (nih.gov)
Finally, we show that template DNA cosegregates with Numb in label-retaining cells that express the self-renewal marker Pax7. (nih.gov)
Each GSC undergoes an asymmetric self-renewal division that gives rise to both a GSC,which remains associated with the CpCs, and a more posterior located cystoblast (CB). (biologists.com)
A stem cell is an undifferentiated cell that can undergo an asymmetric self-renewal division to produce one descendant like itself and one descendant whose progeny ultimately differentiate into a defined cell type( Fuchs and Segre, 2000 ). (biologists.com)
Neural stem cells (NSCs) are undifferentiated neural cells with the capacity for long-term self-renewal and for differentiation into all types of neuronal and glial cells. (sanbio.nl)
To qualify as stem cells, self-renewal has to be shown as well [ 10 ]. (hindawi.com)
Overview on self-renewal or differentiation of stem cells in their respective stem cell niche. (hindawi.com)
The term stem cell is also used in reference to any adult cells that are capable of assisting in the restoration of adult tissue via self-renewal. (citizendium.org)
Enriched expression of genes in LRECb was associated with stem cell attributes and identified WNT, TGF-β, and MAPK pathways of self renewal and proliferation. (frontiersin.org)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

The available experimental data support the hypothesis that the cap cells(CpCs) at the anterior tip of the germarium form an environmental niche for germline stem cells (GSCs) of the Drosophila ovary. (biologists.com)
This study shows that, similarly to H3 , histone H4 is inherited asymmetrically in Drosophila melanogaster male germline stem cells undergoing asymmetric division. (sdbonline.org)

Many stem cells undergo asymmetric division to produce a self-renewing stem cell and a differentiating daughter cell. (sdbonline.org)
This is one of the processes in regenerative medicine that allows stem cells to undergo to maintain their number and form a "stem cell reserve. (stemcellthailand.org)

Soon after Barack Obama is sworn in as President next week, he is expected to reverse the ban on federal funding for embryonic stem cell research. (ca.gov)
However, supporters of embryonic stem cell research frequently contend that even the comparison to abortion is inappropriate, since while a several month old fetus might have sufficient neurological development to be conscious in some meaningful sense, a human embryo in the blastocyst stage has so little development that one can safely conclude that it cannot exist as a conscious being. (citizendium.org)

Understanding this, and investigating the role of asymmetric mitotic nuclear envelope remodelling on cell fate, is what I aim to study in the future. (bscb.org)

Here, we reconstructed Par-dependent polarity using non-polarized Drosophila S2 cells expressing all three components endogenously in the cytoplasm. (elifesciences.org)
We used Drosophila Schneider cells (S2 cells) of mesodermal origin, as host cells for cell-autonomous reconstruction of cell polarity ( Schneider, 1972 ). (elifesciences.org)

Using a novel, recombination-induced tag exchange-based genetic tool to birthdate and track the segregation of centrosomes over multiple cell divisions in human embryonic stem cell-derived regionalised forebrain organoids, we show the preferential inheritance of the older mother centrosome towards self-renewed NPCs. (elifesciences.org)
Asymmetric divisions result in two daughter cells with different fates and cellular behaviour: one daughter remains in the VZ and retains the ability to self-renew, comparable to the mother cell. (elifesciences.org)
The stem cell population is maintained by asymmetric divisions in which one daughter cell commits to specific fate and the other maintains parental pluripotency. (nature.com)
Retention of labeled DNA strands may be attributed to the ability of stem cells to retain the parental DNA strand during asymmetric cell division ( Cairns, 1975 ) or to quiescence of the stem cell population such that the DNA label is not diluted by frequent cell divisions ( Klein and Simons, 2011 ). (frontiersin.org)

We're a partnership of more than 400 stem cell and regenerative medicine labs across Europe, connected via research centres, consortia, networks and hubs. (eurostemcell.org)
Paolo De Coppi is a Consultant Paediatric Surgeon at Great Ormond Street Hospital (GOSH), and Reader and Head of Stem Cells and Regenerative Medicine at the UCL Institute of Child Health in London. (eurostemcell.org)
Students begin by studying planaria as a model organism using a lab protocol incorporated in the CIRM-developed Unit 2: Adult Stem Cells, Homeostasis, and Regenerative Medicine. (ca.gov)

In contrast to the above model, we find that an enhancer trap inserted near the Dpp target gene, Daughters against Dpp ( Dad ), is expressed in additional somatic cells within the germarium,suggesting that Dpp protein may be distributed throughout the anterior germarium. (biologists.com)
Two or three GSCs lie at the anterior tip of the germarium in contact with somatic CpCs and in close apposition to somatic terminal filament (TF) cells. (biologists.com)
NPCs can additionally be obtained by direct reprogramming of somatic cells from different cell lineage (PMID: 22445518). (sanbio.nl)
The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
Totipotent cells have the capacity to differentiate to all cell types, including somatic cells, germ cells, and certain cells that exist outside the embryo and are important to fetal development that are termed extraembryonic cells. (citizendium.org)
The most infamous study of embryonic stem cells asserted that cloned human embryos had been created via somatic cell nuclear transfer, and stem cells had been generated from these embryos. (citizendium.org)
The process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state. (bvsalud.org)

If asymmetric segregation of centrosomes occurs in NPCs of the developing human brain, which depends on unique molecular regulators and species-specific cellular composition, remains unknown. (elifesciences.org)
Polarization is a fundamental cellular property that plays a vital role in various biological processes in multi-cellular as well as single-cell organisms. (elifesciences.org)
More specifically, the Moore Lab is interested in understanding how NSCs utilize asymmetric cell division to maintain a pristine proteome and preserve cellular function. (wisc.edu)
In 1974, I published a paper in Nature on the ageing growth and death of cells in which I put forward a new hypothesis that accounts for many of the facts of cellular senescence and regeneration in plants and in animals. (sheldrake.org)
If so, our understanding of cellular senescence, rejuvenation and potential immortality could be brought together in a new synthesis, which I call the cellular rejuvenation hypothesis: damaged cell constituents build up in all cells, but cells can be rejuvenated either by growth and cell division or, in 'immortal' cell lines, by excreting damaged cell constituents. (sheldrake.org)
The ageing and death of cells in higher plants and higher animals are discussed in relation to cellular rejuvenation by growth and division. (sheldrake.org)
This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
Obligatory asymmetric replication is a fundamental aspect of DNA replication in cells with linear chromosomes and has several biological implications, from the molecular machinery needed to accomplish replication to broader considerations about genome stability and cellular aging . (stemcellthailand.org)

Symmetric division of NSCs maintains the population of undifferentiated NSCs, while asymmetric division gives rise to neural progenitors. (sanbio.nl)
To qualify as a stem cell, these cells must be able to self-renew, most likely by symmetric cell division to produce two daughter cells with the same stem cell qualities. (hindawi.com)
Undergoing symmetric or asymmetric cell division, the stem cell turns into two daughter cells. (tigerfitness.com)
Through symmetric cell division, both of the daughter cells are also stem cells. (tigerfitness.com)
France), I worked on the molecular mechanisms underlying the cortical remodelling and successive shape modifications that accompany symmetric cell division (S.Carreno and F.Payre Labs). (bscb.org)

Thus, this reconstruction system provides an experimental paradigm to study features of the assembly process and structure of Par-dependent cell-autonomous polarity. (elifesciences.org)
I then joined the C.Cabernard Lab (Switzerland) for my first postdoc, to explore how asymmetric spindle and cortical polarity are coupled to regulate asymmetric stem cell division and cell fate acquisition, in vivo. (bscb.org)

It is worth noting that the proliferation and differentiation of stem cells cannot be separated from the surrounding microenvironment, and immune system related cells are an important part of the microenvironment of the OGSCs nest [ 14 ]. (biomedcentral.com)

Tumor-initiating stem-like cells (TICs) are defective in maintaining asymmetric cell division and responsible for tumor recurrence. (nature.com)
Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)

Strikingly, some of these cells display selective template-DNA strand segregation during mitosis in the muscle fibre in vivo, as well as in culture independent of their niche, indicating that genomic DNA strands are nonequivalent. (nih.gov)
Indeed, although nuclei are the defining feature of eukaryotic cells, we still do not know why cells have developed so many strategies to divide their nucleus, from closed to open mitosis. (bscb.org)

He has been leader of a research group at the Max-Delbrück-Center for Molecular Medicine in Berlin until 2011 focusing his research on signal transduction mechanisms in human and murine embryonic stem cells. (eurostemcell.org)
The Moore Lab is interested in understanding the mechanisms that neural stem cells (NSCs) utilize to stay active during aging. (wisc.edu)
However, Dad-lacZ expression within the germline is present only in GSCs and to a lower level in CBs, suggesting there are mechanisms that actively restrict Dpp signaling in germ cells. (biologists.com)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
Over the past 2 decades, substantial progress has been made in understanding the mechanisms of eosinophil production, eosinophil programmed cell death (apoptosis), and how eosinophil immunology contributes to both host defenses against infections and to tissue damage within the host in cases of allergic and autoimmune diseases. (medscape.com)

By contrast, mammalian embryonic stem cells and many cancerous and 'immortalized' cell lines divide symmetrically, and yet replicate indefinitely. (sheldrake.org)
We speculate that the new nonapoptotic function of C. elegans CED-3 caspase in asymmetric neuroblast division is relevant to the function(s) of mammalian caspases in stem cells. (ucl.ac.uk)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

Aberration of asymmetric segregation of centrosomes by genetic manipulation of the centrosomal, microtubule-associated protein Ninein alters fate decisions of NPCs and their maintenance in the VZ of human cortical organoids. (elifesciences.org)
Its asymmetric distribution goes through three steps: emergence of cortical dots, development of island-like structures with dynamic amorphous shapes, repeating fusion and fission, and polarized clustering of the islands. (elifesciences.org)

Here, we report that Caenorhabditis elegans CED-3 caspase regulates asymmetric cell division. (ucl.ac.uk)

A subset of NSCs is present in the developed nervous system and acts as a reservoir of cells for cell replacement and nervous tissue regeneration (PMID: 20110496). (sanbio.nl)
The use of the pluripotent and/or self-renewing qualities of stem cells is believed to have therapeutic benefits for the regeneration of tissue in humans. (citizendium.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
and stem cell regeneration. (lu.se)

Many of the 131 cells that are "programmed" to die during C. elegans development are the smaller daughter of a neuroblast that divides asymmetrically by size and fate. (ucl.ac.uk)
We have previously shown that CED-3 caspase is activated in such neuroblasts, and that before neuroblast division, a gradient of CED-3 caspase activity is formed in a ced-1 MEGF10 (multiple EGF-like domains 10)-dependent manner. (ucl.ac.uk)

Neurogenesis is thought to be sustained throughout life through the constant regulation of neural stem cell (NSC) quiescence exit, a time in which a NSC enters the cell cycle to generate more neural stem cells and/or other neural cell types. (wisc.edu)

and from 2002 on pluripotency in embryonic stem cells in the lab of Ali H. Brivanlou. (eurostemcell.org)
A process where fully differentiated or specialized cells revert to pluripotency or a less differentiated cell type. (bvsalud.org)

Fürthauer M. Fürthauer M. Semin Cell Dev Biol. (nih.gov)
J Cell Biol. (bscb.org)

Previous molecular characterizations of mammary stem cells (MaSC) have utilized fluorescence-activated cell sorting or in vitro cultivation of cells from enzymatically dissociated tissue to enrich for MaSC. (frontiersin.org)

Furthermore, the use of diphtheria toxin -- which is far more toxic to human cells than mouse cells -- to destroy the human neurons in the mice reversed the observed improvements in motor function. (citizendium.org)
This result suggests that the observed increase in motor function was indeed produced by neurons derived from the human embryonic stem cells. (citizendium.org)
Neural stem cells are self-renewing multipotent cells that generate the neurons and glia of the nervous system of all animals during embryonic development. (tigerfitness.com)
This is the area where neural stem cells produce new neurons. (tigerfitness.com)

Such tissue renewal may be accomplished via the use of adult stem cells, or embryonic stem cells, which may be derived from a human embryo in the blastocyst stage. (citizendium.org)
Adult stem cells hold great promise in mitigating much of the ethical debate over embryonic stem cell use. (citizendium.org)
Some neural stem cells live in the adult vertebrate brain and continue to produce throughout life. (tigerfitness.com)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)

Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. (springer.com)
Cancer stem cells (CSCs) represent a small subset of the tumor population and reside at the apex of the hierarchy [ 9 ]. (springer.com)
Apart from CSCs, there are a myriad of factors and interactions between various cell types and the tumor microenvironment (TME) that ultimately affect CCA progression. (springer.com)
A vestibular schwannoma (acoustic neuroma) is a Schwann cell-derived tumor of the 8th cranial nerve. (msdmanuals.com)
As the tumor continues to enlarge, the cerebellum, brain stem, and nearby cranial nerves (5th and 9th to 12th) can also become compressed. (msdmanuals.com)

Cell-fate-determinant molecule NUMB-interacting protein (TBC1D15) is overexpressed and contributes to p53 degradation in TICs. (nature.com)
Based on these findings, we propose that CED-3 caspase plays a critical role in the asymmetric division by size and fate of neuroblasts, and that this contributes to the reproducibility and robustness with which the smaller daughter cell is produced and adopts the apoptotic fate. (ucl.ac.uk)

Investigation of variability within a population of cells contributes to understanding of developmental and pathological processes, A sample of cells may appear similar, but the cells can vary in their individual characteristics, such as shape and size, mRNA expression levels, genome, or individual counts of metabolites. (wikipedia.org)
The findings will be of interest to developmental neurobiologists, but also more broadly to cell and developmental biologists. (elifesciences.org)
Asymmetric cell division, creating sibling cells with distinct developmental potentials, can be manifested. (washington.edu)

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) are being investigated as a new source of cardiac cells for drug safety assessment. (bioinf.org)
Immunofluorescent staining of PAX6 ( 12323-1-AP , 1:250 dilution) with 4% PFA fixed control human-induced pluripotent stem cell (hiPSC)-derived NPCs. (sanbio.nl)
NPCs can be differentiated from embryonic stem cells (ESCs) but also from induced pluripotent stem cells (iPSCs) (PMID: 11731782). (sanbio.nl)
The term stem cell is generally used to describe cells that are totipotent , pluripotent , or multipotent . (citizendium.org)
Pluripotent cells may differentiate to cells of most types, and multipotent cells are capable only of differentiating to certain types within a group of cells that perform similar functions. (citizendium.org)

Using pulse-chase labelling with BrdU to mark the putative stem cell niche, we identify a subpopulation of label-retaining satellite cells during growth and after injury. (nih.gov)

What are neural stem cells (NSCs), neural progenitors, and neural precursors (NPCs)? (sanbio.nl)

Obligatory asymmetric replication is also known as asymmetric cell division is the process by which a stem cell undergoes differentiation or division. (stemcellthailand.org)

Therefore, we hypothesized that CRC cancer stem cell markers (CRCSC) will identify a group of patients at high risk for progression. (jcancer.org)
Alternatively, NPCs can be isolated from fresh nervous tissues using cell sorting with NPC markers (PMID: 11121071). (sanbio.nl)
Following verification of a stem-like signature (upregulated expression of stemness markers, resistance to chemotherapy, increased spheroid formation, and tumorigenesis capabilities despite inoculation of a small number of cells), we analyzed the interaction of these cells with macrophages via direct and indirect coculture assays. (springer.com)
Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
Our results support the use of DNA label retention to identify MaSC and also provide a molecular profile and novel candidate markers for these cells. (frontiersin.org)

Moreover, in multicellular organisms, symmetry breaking allows the generation of cells with different fates and underpins the complex arrangement of tissues and organs achieved during embryogenesis. (cshlpress.com)
Ident- cult to deduce interaction rules from observations of the ified transcription factors for specific cell fates are, for entire system. (lu.se)

UConn researchers have patented a new co-polymer that can carry drugs and bio-responsively release them in cancer cells to target the disease with less toxicity to healthy tissue. (uconn.edu)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)

The fundamental work that shows the preferential inheritance of the older centrosomes by the self-renewing daughter cells in human is supported by strong evidence. (elifesciences.org)

The ovarian microenvironment affects the proliferation and differentiation of OGSCs, and immune cells and related cytokines are important components of the microenvironment. (biomedcentral.com)

Cells with identical genomes may vary in the expression of their genes due to differences in their specialized function in the body, their timepoint in the cell cycle, their environment, and also noise and stochastic factors. (wikipedia.org)

We isolated four categories of cells from mammary epithelium of female calves: bromodeoxyuridine label retaining epithelial cells (LREC) from basal (LRECb) and embedded layers (LRECe), and epithelial control cells from basal and embedded layers. (frontiersin.org)
This dictates cycles of mammary growth, differentiation, lactation, and regression, during which mammary stem cells (MaSC) provide for the lineages of luminal and basal (myoepithelial) epithelial cells in the ducts and alveoli. (frontiersin.org)
During rapid mammary growth in the mouse, label retaining epithelial cells (LREC) appear to retain label by asymmetric distribution of DNA strands, as evidenced by a rapid proliferation index of the LREC ( Smith, 2005 ). (frontiersin.org)

These findings describe a mechanism for the maintenance of proteostasis in neural stem cells with implications for other stem cell niches throughout the body in a variety of contexts. (wisc.edu)
They learn about a variety of techniques for obtaining stem cells and the scientific and ethical implications of those techniques. (ca.gov)
This obligatory asymmetric replication has implications for the DNA replication process, including coordination of replication machinery, the need for multiple enzymes like ligases and primases, and potential sources of replication errors. (stemcellthailand.org)

It also occurs in the formation of egg cells in plants and animals. (sheldrake.org)
The subtype of leukemia is determined by the hematopoietic lineage of neoplastic cells and the stage at which maturational arrest occurs. (medscape.com)

It was found that ovoid cells in the epithelial layer of the ovary simultaneously expressed the germ cell specific marker MVH and the proliferation of cell marker BrdU using double-immunofluorescence staining. (biomedcentral.com)

Population-level views of cells can offer a distorted view of the data by averaging out the properties of distinct subsets of cells. (wikipedia.org)
NPCs are distinct from differentiated cells of the nervous system at the molecular level. (sanbio.nl)
Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)

The plane of GSC division is perpendicular to the anteroposterior axis of the germarium such that the daughter cell that stays in contact with the CpCs remains a GSC,while the more posterior daughter cell becomes a cystoblast (CB). (biologists.com)
Thus one daughter cell will pay the price of mortality while the other is rejuvenated. (sheldrake.org)

A) Representative division of a vimentin-mNeon neural stem cell during quiescence exit in vitro. (wisc.edu)
Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)

defining the role of oriented cell division in development and disease. (unm.edu)
The thymus plays a central role in the development of the body's immune system as it is the main site in which T cells are generated. (eurostemcell.org)
T cells are a type of white blood cell that play an important role in immunity. (eurostemcell.org)
Current knowledge about the most aggressive forms of BC points to the role of specific cells with stem properties located within BC, the so-called "BC stem cells" (BCSCs). (wjgnet.com)
These results suggest a role for DNA replication in patterning epigenetic information in asymmetrically dividing cells in multicellular organisms. (sdbonline.org)
Hat1 is implicated in chromatin assembly and DNA repair but its role in cell functions is not clearly elucidated. (sdbonline.org)
ConnectEd California created a module exploring the government's role in medical decisions that affect people's lives, focusing on stem cell research ( Subunit 1 ) and other areas in which federal or state governments have influenced biomedical research and healthcare practices. (ca.gov)

In mammals, caspases affect various aspects of stem cell lineages. (ucl.ac.uk)

This discovery invalidated the "fixation theory of primordial follicle pool" and suggested for the first time the hypothesis that germ stem cells also exist in the ovary. (biomedcentral.com)

Development of new or improved laboratory/experimental techniques, instruments, or supporting software that measure the location and dynamics of molecules in situ, and organelles, cells, or tissues on the nanometer and micrometer length scales. (nih.gov)

In recent years, the discovery of ovarian germ stem cells (OGSCs) has provided a new research direction for the treatment of female infertility. (biomedcentral.com)

Within a single human, individual cells typically have identical genomes, though there are interesting exceptions, such as B-cells, which have variation in their DNA enabling them to generate different antibodies to bind to the variety of pathogens that can attack the body. (wikipedia.org)
Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)
that is, they have the ability to generate other stem cells and perpetuate themselves. (bvsalud.org)
This image illustrates the diversity of cells that work together to generate a functional brain. (bscb.org)

Stem cell niche. (bvsalud.org)

Niikura [ 5 ] and others observed germ cells expressing Stra8 (stimulated by retinoic acid gene 8) in the ovarian surface epithelium, indicating that there may be germ cells with meiotic function in the ovary. (biomedcentral.com)

Vimentin enhances neural stem cell (NSC) proliferation with aging through assisting in aggresome-mediated protein turnover. (wisc.edu)
Vimentin-mediated proteasome localization to the aggresome in neural stem cells enhances quiescence exit. (wisc.edu)

Considerable effort over the last decade has been directed towards developing integrated and scalable single cell genetic analysis on chip (7, 8). (justia.com)

Properly controlled, adequately sized studies have yet to demonstrate that human embryonic stem cells have medical value in humans. (citizendium.org)

EuroStemCell has key partnerships with European Union-funded stem cell research consortia who provide significant contribution to the project financially and scientifically. (eurostemcell.org)
He co-ordinates the EU Horizon2020 funded stem cell research consortium - INTENS which aims to aims to make a functional reconstructed bowel for people with Short Bowel Syndrome. (eurostemcell.org)
California's landmark stem cell research program made headlines nationally, but what is the latest story behind the science? (ca.gov)
NWABR (https://www.nwabr.org/stem-cell-curriculum-request) curriculum and resources explore the scientific and ethical issues involved in stem cell research. (ca.gov)
While exploring the ethics of stem cell research, students develop an awareness of the many shades of gray among the viewpoints of stakeholders in the debate. (ca.gov)
They become familiar with current U.S. stem cell research policies and regulations, issues regarding private and public funding, and how stem cells may be used to treat diseases and advance scientific knowledge. (ca.gov)
Recent research with animal cells, yeasts and bacteria show that damaged cell constituents do in fact build up, but can be diluted by growth and cell division, especially by asymmetric cell division. (sheldrake.org)
Human embryos fertilized in the ordinary manner and harvested in the blastocyst stage have been used as an extensive source of stem cells for research purposes, and have been shown to possess therapeutic value in laboratory animals. (citizendium.org)
Some new research was released showing that using our legs - particularly weight-bearing exercise - sends signals to the brain that are vital to producing healthy neural cells. (tigerfitness.com)
High-throughput single cell measurement technologies are therefore of interest and have broad applications in clinical and research settings. (justia.com)
Accordingly, a goal of microfluidics research has been the development of integrated technology for scalable analysis of transcription in single cells. (justia.com)

We now show that CED-3 caspase is necessary for the ability of neuroblasts to divide asymmetrically by size. (ucl.ac.uk)

We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)

Anatomy12

Organisms3

Diseases1

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes11

Information Science1

Hematopoietic Stem2

Progenitor14

Asymmetry3

Biology14

Self-renewal12

Germline stem cells2

Undergo2

Embryonic Stem Cel2

Mitotic1

Drosophila2

Divisions4

Regenerative Medicine3

Somatic7

Cellular8

Symmetric5

Polarity2

Differentiation of stem cells1

Responsible for tumor2

Mitosis2

Mechanisms5

Mammalian3

Cortical2

Regulates1

Regeneration4

Neuroblast2

Neurogenesis1

Pluripotency2

Biol2

Fluorescence-activated cell1

Neurons4

Adult4

Tumor5

Fate2

Developmental3

Pluripotent5

Putative1

NSCs1

Undergoes1

Markers5

Fates2

Tissue2

Inheritance1

Microenvironment1

Stochastic1

Epithelial cells3

Implications3

Occurs2

Germ cell1

Distinct3

Daughter cell2

Vitro4

Role7

Lineages1

Hypothesis1

Tissues1

Ovarian germ1

Generate4

Niche1

Ovary1

Enhances2

Genetic1

Demonstrate1

Research11

Caspase1

Therapies1