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  • neurons
  • Cell replacement therapy depends on the efficient production (proliferation) of stem cells maturating into neurons, and later into cortical motor neurons or spinal cord motor neurons. (wingsforlife.com)
  • However, the yield of neurons derived from both embryonic and neural stem cells in vitro is generally low, even with the most successful protocol to generate the spinal cord motor neurons. (wingsforlife.com)
  • This project aims at understanding how neurons are "born" under normal conditions during development (asymmetric division) and to apply this knowledge to improve culture conditions subsequently. (wingsforlife.com)
  • During cortical development in mammals, the expansion of the cortical wall relies on the generation of large numbers of neurons by neural stem/progenitor cells (NSPCs) situated in the inner wall of the neural tube termed the ventricular zone (VZ). (wiley.com)
  • RGs produce self-renewing apical progenitors (APs), together with terminally differentiated neurons (blue), intermediate progenitors (IPs, green), or outer radial glial cells (oRGs, yellow). (wiley.com)
  • From guiding branching neurons in the developing brain to maintaining a healthy heartbeat, there seems to be no job that the immune cells can't tackle. (the-scientist.com)
  • asymmetry
  • https://doi.org/10.1083/jcb.201807102 ) use magnetic tweezers to induce asymmetric division in sea urchin zygotes, demonstrating that asymmetry could arise from a time-dependent weakening of centering forces. (rupress.org)
  • Cell biologists have lately come to appreciate that asymmetry of department is a vital regulatory phenomenon within the destiny of a cellphone. (agnichakra.com)
  • segregation
  • 08903, USA co-segregation of template DNA strands and the stem-cell pathways associated with it in e-mail: pinesr@cinj.rutgers.edu normal and CSCs. (scribd.com)
  • Caenorhabditis
  • 1 ) injected magnetic beads into single-cell Caenorhabditis elegans embryos and measured the effective stiffness and damping of the spindle centering machinery. (rupress.org)
  • germline stem cells
  • This quantity covers the present wisdom base at the position of signaling and environmental pathways that regulate the conventional improvement of germline stem cells, meiotic development of oocytes, occasions of oocyte maturation and fertilization, and the delivery of an embryo. (skindeeptattoos.net)
  • tissue homeostasis
  • The continual maintenance of a reservoir of tissue-specific stem A debated question in CSC biology is whether neoplastic trans- cells affords an organism with the ability to generate all the differ- formation emerges from normal stem/progenitor cells or from entiated cells needed for tissue homeostasis and repair through- more differentiated cells that commandeer stem cell properties out its lifespan. (scribd.com)
  • Stem cells have elaborate cellular mechanisms to ensure the asymmetric outcome of the division, producing one stem cell and one differentiating cell, which is the key to tissue homeostasis. (nih.gov)
  • diversity
  • Often the model plant Arabidopsis thaliana is used to illustrate the implementation of asymmetric cell division to create pattern and diversity. (uu.nl)
  • These results suggest that motile cells lacking constitutive attachment can receive provisional polarity cues from the microenvironment to generate daughter cell diversity and self-renewal. (sciencemag.org)
  • dynamics
  • Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales. (biologists.org)
  • Cytoskeletal
  • These aims will be addressed by time-lapse imaging of fluorescent protein fusions within meiotic embryos that have been depleted of key cytoskeletal regulators and cell-cycle regulators by RNA interference and by protein biochemistry. (grantome.com)
  • multicellular
  • Cell division is a highly orchestrated process, critical to the growth and development of multicellular organisms. (rupress.org)
  • Multicellular organisms develop their large variety of cell types from just one single cell, the zygote. (uu.nl)