Asthmatics are sensitive to aspirin. Medical search. Frequent questions

In addition to aspirin, patients also react to other NSAIDs such as ibuprofen, and to any medication that inhibits the cyclooxygenase-1 (COX-1) enzyme, although paracetamol (acetaminophen) in low doses is generally considered safe. (wikipedia.org)
In addition to aspirin and NSAIDs, consumption of even small amounts of alcohol also produces uncomfortable respiratory reactions in many patients. (wikipedia.org)
Salsalate tablets, USP should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. (nih.gov)
Up to 20% of the asthmatic population is sensitive to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) and present with a triad of rhinitis, sinusitis, and asthma when exposed to the offending drugs. (medscape.com)
The attacks may be precipitated following the ingestion of small amounts of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). (medscape.com)
Since this type of reaction to aspirin and other NSAIDs have occurred in aspirin-sensitive patients, Vioxx should not be given to aspirin-sensitive patients. (personalhealthzone.com)
Acetaminophen is the medicine most often used for fever and pain relief for people who cannot take aspirin and NSAIDs. (symptoma.com)
Aspirin, ibuprofen, naproxen and other NSAIDS help stop pain and fever because they block an enzyme called cyclooxygenase that is critical in creating other chemicals that cause inflammation. (symptoma.com)
bronchospasm (in asthmatic patients sensitive to aspirin or other NSAIDs). (azurewebsites.net)
Aspirin belongs to a group of medicines known as non-steroidal anti-inflammatory drugs (NSAIDS). (imedi.co.uk)
Some NSAIDs and aspirins will do this for you. (asthmaattacksymptom.com)
Those with known sensitivities to NSAIDs and aspirin should avoid these drugs as resulting asthma attacks can be severe and fatal. (jaxallergy.com)
Aspirin/NSAIDs inhibit cyclooxygenase (COX) and reduce prostaglandin synthesis, thereby reducing fever and relieving pain and inflammation. (farinelliandthekingbroadway.com)
The classic non-aspirin NSAIDs block both COX-1 and COX-2 isozymes to varying degrees, by binding an arginine molecule at position 120 halfway up their channel, thereby inhibiting access of arachidonic acid to the catalytic site and thus ultimately inhibiting the synthesis of prostaglandins, PGI2, and thromboxanes [22. (farinelliandthekingbroadway.com)
Aspirin inhibits COX irreversibly, while other NSAIDs inhibit COX in a reversible, concentration-dependent manner. (farinelliandthekingbroadway.com)
In contrast, atopy may be less important in patients with adult asthma and other factors such as intolerance to aspirin and related nonsteroidal anti-inflammatory drugs (NSAIDs) as well as occupational exposures have been suggested to play an important role in adults with more severe asthma 1 , 8 . (ersjournals.com)
If you are sensitive to certain medicines, such as aspirin, NSAIDs (nonsteroidal anti-inflammatory drugs) or beta blockers they may trigger asthma. (practo.com)
These include aspirin, non-steroid anti-inflammatory drugs (NSAIDs) such as diclofenac, ibuprofen and naproxen as well as beta-blockers. (aha.ch)

Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (NERD/N-ERD) or historically aspirin-induced asthma and Samter's Triad, refers to the triad of asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). (wikipedia.org)

Paradoxically, daily aspirin therapy after an initial desensitization can also help manage symptoms. (wikipedia.org)
Besides causing symptoms of asthma, aspirin can cause nasal congestion and abdominal pains in susceptible individuals. (symptoma.com)
Common symptoms that characterize aspirin-intolerant asthma are nasal polyps (often the first sign of the problem) accompanied by nasal sinusitis (inflammation in the nasal cavities). (knowledgeofhealth.com)
Over-the-counter pain relievers such as naproxen, aspirin and ibuprofen can also trigger serious asthma symptoms in some asthmatic patients. (jaxallergy.com)
Within 20 minutes to 3 hours of ingestion of a NSAID, aspirin-sensitive asthmatics can develop: respiratory symptoms such as acute bronchospasm, rhinorrhoea, conjunctival irritation and/or cutaneous flushing of the head and neck, and even circulatory collapse and respiratory arrest. (farinelliandthekingbroadway.com)
It has long been known that 5-10% of asthmatics are exquisitely sensi-tive to aspirin, so that ingestion of even a very small dose causes profound bronchoconstriction and symptoms of systemic release of histamine, such as flushing and abdominal cramping. (brainkart.com)
Studies have estimated that approximately 15-20% of people tend to have asthma symptoms after taking aspirin. (epainassist.com)

The disorder typically progresses to asthma, then nasal polyposis, with aspirin sensitivity coming last. (wikipedia.org)
The association of aspirin sensitivity, asthma, and nasal polyposis was first described by Widal et al [ 1 ] in 1922. (medscape.com)
Most often, this sensitivity to aspirin develops in adulthood. (symptoma.com)
It is important that people with aspirin sensitivity read labels of all over-the-counter drugs used to treat pain, colds and flu, and fever . (symptoma.com)
Patients with known aspirin sensitivity should continue to avoid aspirin or non-steroidal anti-inflammatory agents while taking montelukast sodium ( 5.3 ). (nih.gov)
At first glance it appears that vitamin C is problematic, because it further inhibits COX-2, but by a different mechanism - by reduction of oxygen free radicals and increased sensitivity of COX-2 to be inhibited by aspirin, thus allowing a lower dose of aspirin to be used. (knowledgeofhealth.com)
The prevalence of sulfite sensitivity in the general population is unknown, but it appears to be more common in asthmatics, particularly those who have nasal polyps and are sensitive to acetylsalicylic acid (aspirin), which may precipitate asthma attacks. (fidufoods.com)

So, if you need to control pain or fever for someone who has an Aspirin and Asthma problem, see the individual pages on Tylenol Side Effects and Ibuprofen Side Effects to get more details. (symptoma.com)
Aspirin-induced asthma is a severe inflammatory disease, which affects patients after ingestion of aspirin or other non-steroidal anti-inflammatory drugs (ibuprofen). (knowledgeofhealth.com)
Some people with asthma are sensitive to aspirin, ibuprofen, diclofenac and other drugs in the NSAID family. (bsaci.org)
Do not use in case you are allergic to any ingredients, pain relievers which includes aspirin, ibuprofen or other anti-inflammatories. (imtiaztrader.com)

Another common symptom asthmatics may experience is a potentially life-threatening closure of their bronchial airways due to a sudden allergic-like reaction called anaphylaxis (ana-fill-ax-iss). (knowledgeofhealth.com)
Anaphylaxis, whether among asthmatics or non-asthmatics, is characterized by hives, (itchy red welts on the surface of the skin, aka urticaria), rapid swelling of the skin (angioedema), and more acutely, a sudden, severe allergic reaction accompanied by a sharp drop in blood pressure and breathing difficulties that are also characteristic of aspirin-induced asthma. (knowledgeofhealth.com)
Do not use if sensitive or allergic to aspirin. (dockpharmacy.com)
Because this reaction to aspirin is not associated with any evidence of allergic sensitization to aspirin or its metabolites and because it is produced by any of the nonsteroidal anti-inflammatory agents, it is thought to result from inhibition of prostaglandin synthetase (cyclooxygenase), shifting arachidonic acid metabolism from the prostaglandin to the leukotriene pathway. (brainkart.com)
In those asthmatic patients in whom Airlast ( ANTI-INFLAMMATORY_ANTI-BRONCHOCONSTRICTIVE) is indicated in asthma, Airlast ( ANTI-INFLAMMATORY_ANTI-BRONCHOCONSTRICTIVE) can also provide symptomatic relief of seasonal allergic rhinitis. (pillintrip.com)
Conversely, many asthmatics also suffer from allergic rhinitis. (aha.ch)

This condition is known as 'NSAID or aspirin associated respiratory disease. (jaxallergy.com)
What is the role of aspirin in the pathogenesis of NSAID-induced gastric damage? (farinelliandthekingbroadway.com)

The active substances are: aspirin (acetylsalicylic acid), paracetamol, caffeine, sodium hydrogen carbonate and citric acid. (imedi.co.uk)

If an aspirin-sensitive asthmatic takes aspirin it can cause severe narrowing of the airway (bronchospasm), and even death. (personalhealthzone.com)

If patients are atopic, chronic rhinitis and asthma occur earlier in life, unlike aspirin intolerance and nasal polyps [3]. (symptoma.com)

Aspirin-induced asthma (AIA) refers to the development of bronchoconstriction in asthmatic individuals following the ingestion of aspirin. (medscape.com)

AERD affects an estimated 0.3-0.9% of the general population in the US, including around 7% of all asthmatics, about 14% of adults with severe asthma, and ~5-10% of patients with adult onset asthma. (wikipedia.org)
Modern medicine says it has no clue why aspirin can provoke a sudden and severe invasion of white blood cells (eosinophils) that block the upper and lower airways. (knowledgeofhealth.com)
More severe asthmatics requiring regular steroid tablets should talk to their doctor about also receiving the pneumoccocal vaccination. (bsaci.org)
Despite being treated with higher doses of inhaled corticosteroids (median dose 1773 µg) and for a third of the severe asthmatics also being treated with regular, oral-steroid therapy (median daily dose 19 mg), the subjects with severe asthma met the inclusion criteria. (ersjournals.com)
Females dominated the severe asthma group (female/male ratio 4.4:1 versus 1.6:1 in the controlled asthmatics), and compared with controlled asthmatics, they had a predominantly neutrophilic inflammation (sputum neutrophils, 36 versus 28%) and evidence of ongoing mediator release but less atopy. (ersjournals.com)
These more severe asthmatics, which account for ∼10% of the asthmatic population, have a disproportionate impact on healthcare utilisation, accounting for up to at least half of the direct and indirect costs for asthma 2 . (ersjournals.com)
These severe asthmatics also have greater absenteeism from work on account of their disease. (ersjournals.com)

Aspirin desensitization has a role in the management of AIA, especially in patients who need prophylaxis from thromboembolic diseases, myocardial infarction, and stroke. (medscape.com)
Apart from its analgesic and antipyretic properties, aspirin also possesses antiplatelet activity and is, therefore, used in the prophylaxis of thromboembolism, the prevention of transient ischemic attacks, and the reduction of the risk of morbidity and mortality in patients with unstable angina and myocardial infarction. (medscape.com)
The prevalence of AIA in the community is not certain, but patients with AIA constitute about 10 to 20% of the asthmatic population, [ 2 , 3 ] and AIA is more common in women. (medscape.com)
Aspirin-induced asthma is a specific syndrome affecting asthmatic patients, consisting of chronic rhinosinusitis , nasal polyps , and asthma attacks caused by aspirin and other non-steroidal anti-inflammatory cyclooxygenase enzyme inhibiting drugs. (symptoma.com)
Even mild, intermittent asthma patients may have acute episodes induced by aspirin consumption and up to one-quarter of patients that need to be admitted to the hospital due to a crisis have ingested non-steroidal anti-inflammatories during the last 3 hours [5]. (symptoma.com)
Higher concentrations of leukotriene B4 in EBC of asthmatic patients in comparison with healthy control subjects increase asthma severity in adults. (cmdm.tw)
LTB4 concentrations in EBC were also increased in COPD patients and asthmatic patients compared to healthy controls. (cmdm.tw)
A significant increase in patients with aspirin-Induced asthma in 5-HETE, 12-HETE, and 15-HETE levels of EBC was associated by an increase in level of LTC4, LTD4, and LTE4, but not in LTB4. (cmdm.tw)
Non-asthmatic patients with nasal polyps have been found to have lower blood concentrations of antioxidants including vitamin C. (knowledgeofhealth.com)
Symptomatic GI disturbances occur in 2-10% of healthy individuals receiving normal doses of aspirin-containing products for analgesia or fever and 30-90% of patients with preexisting peptic ulcer gastritis or duodenitis. (wellrx.com)
Rare cases of esophagitis have been reported in patients receiving aspirin-containing capsules or tablets. (wellrx.com)
Aspirin-sensitive patients often tolerate acetaminophen and other prescribed pain relievers. (jaxallergy.com)
Endoscopically identifiable gastric mucosal lesions occur in most patients who receive a single dose of aspirin. (themeditary.com)
Anorectal ulceration and rectal stenosis have been reported in patients who abuse aspirin-containing rectal suppositories. (themeditary.com)
Although therapy, used according to management guidelines, controls the disease in the majority of patients, it is recognised that a subgroup of asthmatics show reduced responsiveness to the standard therapy and experience greater morbidity and a lower quality of life than those asthmatics whose disease is adequately controlled by therapy 1 . (ersjournals.com)
87.1% of asthmatic patients report benefits of antifungal therapy. (disturbmenot.co)

Aspirin also has anti-inflammatory properties, whilst caffeine acts as mild stimulant. (imedi.co.uk)
The major biological mechanism behind aspirin-induced asthma is an imbalance of anti-inflammatory molecules - namely the inhibition of cycyloxygenase-2 (COX-2), which then triggers inflammation in airways and results in spasm in the bronchus (a passageway into the lungs). (knowledgeofhealth.com)
Hypersensitivity to aspirin or other non-steroidal anti-inflammatory drugs (including when taken by mouth) especially where associated with a history of asthma. (dockpharmacy.com)
2. Dexamethasone sodium sulfate (Decadron®) 7.5 mg or betamethasone 6.0 mg intravenously q4h until contrast study must be done in patent with known allergy to methylpred-nisolone, aspirin, or non-steroidal anti-inflammatory drugs, especially if asthmatic. (radiologyer.com)

Common medications used for controlling high blood pressure often times contain beta blockers, which asthmatics may be more sensitive to. (asthmaattacksymptom.com)
Non-selective beta-blockers ( propranolol ) are often avoided in asthmatics due to the potential to provoke bronchoconstriction and jeopardize asthma control. (jaxallergy.com)
Cardio-selective beta-blockers are thought to be a safer choice for asthmatics given their limited action in the lungs. (jaxallergy.com)

However, high doses of allergy relief medications can cause harmful side effects for those you are sensitive to them or when they are combined with certain medications. (jaxallergy.com)

GC-MS can be used to accurately quantify and measured EBC of leukotrienes in asthmatic adults and children. (cmdm.tw)
Trials with leukotriene inhibitors have demonstrated an important role for leukotrienes in aspirin-induced asthma. (brainkart.com)

Acupressure is particularly helpful in cases of acute asthmatic attack. (awakeningspirit.com)

caffeine contains aspirin. (wellrx.com)
This document contains side effect information about aspirin / caffeine. (themeditary.com)

LT-modifying drugs are effective in blocking the bronchoconstriction provoked by aspirin and are used in the treatment of this condition. (medscape.com)

Some studies suggest a possible association between the development of Reye's Syndrome and the use of medicines containing salicylate or aspirin. (nih.gov)
Aspirin is not only one of the best-documented medicines in the world, but also one of the most frequently used drugs of all times. (medscape.com)
Aspirin can affect the way in which some medicines work. (imedi.co.uk)
Consult your doctor before use if you are pregnant, breastfeeding, asthmatic or on any other medicines. (dockpharmacy.com)
seek advice from your physician before use in case you are pregnant, breastfeeding, asthmatic or on any prescribed medicines. (imtiaztrader.com)

It is interesting to learn that aspirin-induced asthma was first described in 1922 , about the time aspirin was aggressively marketed by Bayer around the world. (knowledgeofhealth.com)

These allergens then enter the house and if an asthmatic patient is around, it triggers an asthma attack. (epainassist.com)

Support for this idea was provided by the demonstration that leukotriene pathway inhibitors impressively reduce the response to aspirin challenge and improve overall control of asthma on a day-to-day basis. (brainkart.com)

pH, LTB4 and 8-isoprostane in EBC are sensitive markers of airway inflammation in children with AD. (cmdm.tw)

By inhibiting the COX pathway, aspirin diverts arachidonic acid metabolites to the LO pathway. (medscape.com)

It is usually caused by sudden and extreme emotional reactions such as laughing, crying, anger, stress, or due to contact with certain chemicals like cigarette smoke, aspirin, cleaning agents. (practo.com)

People with asthma also have over-sensitive airways, so their airways react to triggers that do not affect other people. (bsaci.org)
Everyone's asthma is different and triggers for asthma vary between asthmatics. (bsaci.org)

In sufferers, the mucous membrane lining the airways is chronically inflamed, making the lower airways - more accurately, the bronchi - more sensitive to various irritants. (aha.ch)

Acetaminophen and aspirin are analgesics. (wellrx.com)

In the United States, the annual consumption of aspirin is approximately 80 billion tablets, while in the United Kingdom it is approximately 100 tons. (medscape.com)

These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)

Among non-asthmatic children, a shortage of vitamin C was found to be associated with nasal sinus inflammation , which is a characteristic of aspirin-induced asthma. (knowledgeofhealth.com)

Asthmatics or anyone sensitive to asprin should consult their doctor. (lifepharmacy.co.uk)

LTB4 concentrations were also increased in asthmatic children compared to healthy subjects, with differences detected for 2 degrees of asthma severity. (cmdm.tw)

Avoid all food colorings, if sensitive to aspirin, particularly tartrazine which gives the yellow color to margarine. (awakeningspirit.com)

Both acetaminophen and aspirin have been associated with renal adverse effects. (wellrx.com)
The mechanism of an aspirin-induced decrease in renal function may be related to inhibition of renal prostaglandin synthesis with consequent decreases in renal blood flow. (themeditary.com)

Aspirin-induced hepatotoxicity, presenting as hepatitis, is a dose-related reaction and is usually reversible after discontinuation of aspirin therapy. (wellrx.com)

Both acetaminophen and aspirin can be hepatotoxic. (wellrx.com)

In some instances, aspirin-induced asthma may provoke a violent spasm in the bronchus with loss of consciousness and respiratory arrest . (knowledgeofhealth.com)

This syndrome is referred to as aspirin-induced asthma (AIA). (medscape.com)
There is a possible association between aspirin and Reyes syndrome when given to children. (imedi.co.uk)

2- Asthmatic episodes wit trouble breathing. (webeyeclinic.com)

A study conducted on around 50,000 newborn children found out children whose mother took aspirin while pregnant had increased chances of getting asthma than the others. (epainassist.com)

Aspirin and paracetamol are both used for the treatment of pain and reduction of fever. (imedi.co.uk)

Asthmatics may experience greater breathing difficulties and shortness of breath at such times. (aha.ch)

High-resolution computed tomography (CT) scanning is more sensitive than chest radiography for defining the radiographic abnormalities. (medscape.com)
Asthmatics who quit smoking have 80% lower odds of having tightness in the chest . (knowledgeofhealth.com)

Anatomy6

Organisms1

Diseases12

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes10

Health Care3

NSAIDs18

Nonsteroidal anti-1

Symptoms7

Sensitivity7

Ibuprofen4

Allergic6

NSAID2

Acetylsalicylic acid1

Bronchospasm1

Intolerance1

Ingestion1

Severe7

Patients16

Anti-inflammatory4

Beta blockers3

Doses1

Leukotrienes2

Acute1

Caffeine2

Bronchoconstriction1

Medicines5

19221

Allergens1

Control of asthma1

Airway1

Metabolites1

Reactions1

Triggers2

Airways1

Analgesics1

Consumption1

Inflammatory1

Inflammation1

Consult1

Severity1

Avoid1

Renal2

Dose1

Acetaminophen1

Provoke1

Syndrome2

Episodes1

Pregnant1

Fever1

Breathing difficulties1

Chest2