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  • NSAID
  • Regular aspirin use was associated with lower cancer incidence and cancer mortality, but non-aspirin non-steroidal anti-inflammatory drug (NSAID) use was not, according to one of the largest studies ever conducted to look at the impact of these agents on overall cancer risk. (webwire.com)
  • Among 22,507 cancer-free postmenopausal women who participated in the Iowa Women s Health Study and provided information on aspirin and NSAID use, those who said they regularly used aspirin had a 16 percent reduced risk of developing cancer more than a decade later, as well as a 13 percent reduced risk of dying from cancer over this same time period, compared to women who did not use aspirin. (webwire.com)
  • While the researchers note that one of the weaknesses of this study was that the women were given only a single survey of aspirin and non-aspirin NSAID use, it also had many strengths including the prospective cohort study design, relatively long follow-up (up to 12 years) on a large number of participants, during which time many developed (3,487) and died (1,193) from cancer. (webwire.com)
  • The various non-allergic NSAID hypersensitivity syndromes affect 0.5-1.9% of the general population, with AERD affecting about 7% of all asthmatics and about 14% of patients with severe asthma. (wikipedia.org)
  • 4 The attack can begin within minutes or up to two hours after taking aspirin or another NSAID . (asthma.net)
  • Aspirin-induced asthma NSAID hypersensitivity reactions "salicylism" at Dorland's Medical Dictionary Pfaar O, Klimek L (Dec 2006). (wikipedia.org)
  • acetylsalicylic acid
  • The new drug, formally acetylsalicylic acid, was named aspirin by Hoffmann's employer Bayer AG after the old botanical name for meadowsweet, Spiraea ulmaria. (wikipedia.org)
  • In addition to serving as an important active metabolite of aspirin (acetylsalicylic acid), which acts in part as a prodrug to salicylic acid, it is probably best known for its use as a key ingredient in topical anti-acne products. (wikipedia.org)
  • Salicylic acid was one of the original starting materials for making acetylsalicylic acid (aspirin) in 1897. (wikipedia.org)
  • It is poorly soluble in water (2 g/L at 20 °C). Aspirin (acetylsalicylic acid or ASA) can be prepared by the esterification of the phenolic hydroxyl group of salicylic acid with the acetyl group from acetic anhydride or acetyl chloride. (wikipedia.org)
  • Acidification of the product with sulfuric acid gives salicylic acid: It can also be prepared by the hydrolysis of aspirin (acetylsalicylic acid) or methyl salicylate (oil of wintergreen) with a strong acid or base. (wikipedia.org)
  • AERD
  • Moreover, patients with clinical characteristics suggestive of AERD who received add-on reslizumab showed clinically improvements in asthma-related quality of life vs. placebo. (empr.com)
  • patients
  • One in five patients with asthma are at risk of suffering a severe reaction to aspirin - much higher than previously thought, research revealed today. (gazettelive.co.uk)
  • suggests that breast cancer patients who have asthma could reduce their risk of cancer spread by using readily available inhaler medications. (webwire.com)
  • 6 Inhibition of PGE 2 synthesis seems to be particularly important in AIA for several reasons: PGE 2 can relax bronchial muscle, inhibit the formation or release of various bronchoconstrictor agents such as leukotrienes and histamine (levels of which are raised in patients with AIA), and PGE 2 administered as an aerosol inhibits aspirin induced bronchoconstriction. (bmj.com)
  • patients with acute asthma, acute exacerbation of chronic obstructive bronchitis and acute CSU student Sascha Franzel died from acute asthmatic attack. (typepad.com)
  • The underlying cause of the disorder is not fully understood, but there have been several important findings: Abnormally low levels of prostaglandin E2 (PGE2), which is protective for the lungs, has been found in patients with aspirin-induced asthma and may worsen their lung inflammation. (wikipedia.org)
  • The attachment of platelets to certain leukocytes in the blood of patients with aspirin-sensitive asthma has also been shown to contribute to the overproduction of leukotrienes. (wikipedia.org)
  • The study authors studied clinical asthma exacerbations (CAE) among patients with previously inadequately inhaled corticosteroid-controlled asthma and a history of ASA, after treatment with reslizumab. (empr.com)
  • Reslizumab-treated patients in all 3 subgroups showed significant improvements in asthma control vs. placebo-treated patients by the end of the 52-week study period. (empr.com)
  • Samter and Beers (2) found no examples of familial aspirin disease in their groups of more than 1000 patients. (annals.org)
  • For a portion of patients Prinzmetal's angina may be a manifestation of vasospastic disorder and is associated with migraine, Raynaud's phenomenon or aspirin-induced asthma. (wikipedia.org)
  • Chronic
  • However, it does provide provocative evidence that regular aspirin use may play a role in preventing the most common chronic diseases in western countries, namely cancer and heart disease. (webwire.com)
  • By Erin Udell Industries & Occupations Hazards & Exposures Prevention of Occupational Asthma: Introduction Asthma is a chronic inflammatory disorder of the airways in which many cells & cellular elements play a role (mast cells, Asthma is a common condition that affects the airways. (typepad.com)
  • disease such as smoker's lungs, asthma, a chronic heart, liver heard, like creaking and bubbling sounds when breathing. (typepad.com)
  • Asthma is a long-lasting (chronic) lung disease. (foresthillspediatrics.com)
  • Asthma is a disease of chronic inflammation, and it is known that transgenic mice born without TBX21 spontaneously develop abnormal lung function consistent with asthma. (wikipedia.org)
  • inflammation
  • An intriguing study, conducted in mice and supported by an ongoing examination of breast cancer patient records, suggests a link between the pulmonary inflammation seen in asthma and increased risk of lung metastasis. (webwire.com)
  • reactions
  • I had what they called mini-anaphylactic reactions nearly every day and was put on prednisone, asthma medication and an antihistamine on a daily schedule to control reactions. (fedup.com.au)
  • prevalence
  • Considering the relatively high prevalence of asthma occurring in families, familial aspirin-induced asthma appears to be rare, there being only one other case report in the literature (1). (annals.org)
  • adults with asthma
  • But a study by researchers in the UK and Australia calculated that 21pc of adults with asthma and 5pc of children were sensitive to the drug, also found in cold remedies, and many may be unaware they are at risk. (gazettelive.co.uk)
  • doses
  • During provocative challenge, the person is given incrementally higher doses of salicylates, usually aspirin, under medical supervision, until either symptoms appear or the likelihood of symptoms appearing is ruled out. (wikipedia.org)
  • found
  • One large study found that women who regularly use aspirin developed fewer cancers than women who did not, while another, conducted in mice and now being confirmed in an analysis of breast cancer patient records, discovered a link between asthma and an increased risk of cancer metastasis to the lungs. (webwire.com)
  • The researchers also looked at whether smoking status had any impact on the potential preventive effects of aspirin and found that while these agents were associated with lower cancer incidence and mortality among former and never smokers, the same apparent benefits were not seen among active smokers. (webwire.com)
  • The authors were also able to adjust the results for a large number of lifestyle factors, and found little evidence that these other factors could explain the aspirin and cancer associations observed in this study. (webwire.com)