The association between aPL antibodies and particular human leukocyte antigen (HLA) alleles and HLA-linked epitopes has been reported in studies of patients with lupus erythematous (eg, HLA-DR7, HLA-DR4). (medscape.com)
During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
Alleles2
The HLA-DR3 phenotypes seem to predispose to the formation of aCL antibodies and antinuclear antibodies (ANAs), but this has not been confirmed in patients, and particular HLA alleles associated with recurrent miscarriage have not been reported. (medscape.com)
In the case of systemic lupus erythematosus (SLE) and related illnesses, many of the HLA class II alleles are associated with the presence of specific autoantibodies or clinical phenotypes. (musculoskeletalkey.com)
Epitopes1
Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
Antibodies2
The underlying mechanism is believed to involve the production of antibodies against a person's own tissues. (wikipedia.org)
Women with the clinical features of APS should be tested for 3 antiphospholipid antibodies that have proven association with the diagnosis of APS: lupus anticoagulant (LAC), anticardiolipin (aCL) antibody, and anti-beta-2glycoprotein I antibody. (medscape.com)
Molecules6
The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)
Proteins1
The similarity between antigens of Streptococcus pyogenes and multiple cardiac proteins can cause a life-threatening type II hypersensitivity reaction. (wikipedia.org)
Recognize1
Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)
Structural1
Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
Cells3
During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells which differentiate into helper T2 cells. (wikipedia.org)
During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. (frontiersin.org)
The innate immune system comprises physical, chemical, and biological barriers (e.g., the skin , gastric acid , commensal organisms ) and both cellular (e.g., granulocytes , natural killer cells , mast cells ) and humoral ( complement system ) defense mechanisms . (amboss.com)
Presence1
CONCLUSION: In this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen. (bvsalud.org)
Patients3
OBJECTIVE: To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status. (bvsalud.org)
In AS patients, the absence of HLA-B27 seems to be related to an increase in the probability of starting the disease with cervical pain and peripheral manifestations. (bvsalud.org)
In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. (bvsalud.org)
Cell1
The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)
Provide2
The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)
They also provide weak evidence that the association between maternal height and gestational age is causal. (immport.org)
Disease1
Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
Primary1
APS is classified as primary or secondary, depending on its association with other autoimmune disorders. (medscape.com)
Evidence1
To date, there is no evidence showing any causative association between vaccines and CD development. (mdpi.com)
Phenotypes3
HLA D locus-related (DR) antigens and Gm phenotypes were determined in 30 patients with epidemic polyarthritis following Ross River virus (RRV) infection and contrasted with those in comparison series of 119 (DR) and 1220 (Gm) normal subjects. (nih.gov)
The HLA-DR3 phenotypes seem to predispose to the formation of aCL antibodies and antinuclear antibodies (ANAs), but this has not been confirmed in patients, and particular HLA alleles associated with recurrent miscarriage have not been reported. (medscape.com)
The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. (wjgnet.com)
Haplotype2
The cause of the clinically apparent hepatotoxicity from abacavir is hypersensitivity in some cases and is typically associated with the HLA-B*57:01 haplotype. (nih.gov)
Human leukocyte antigen (HLA) haplotype DQ2 or DQ8 identified by molecular genetic testing of HLA-DQA1 and HLA-DQB1 . (nih.gov)
Genetic4
These correlations point to possible mechanisms by which genetic traits might influence the occurrence or consequence of RRV infection. (nih.gov)
Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. (wjgnet.com)
The spondyloarthritides are a group of overlapping disorders that share certain clinical features and genetic associations. (clinicalgate.com)
The similarities in clinical manifestations and genetic predisposition suggest that these disorders share pathogenic mechanisms. (clinicalgate.com)
Barriers2
The innate immune system comprises physical, chemical, and biological barriers (e.g., the skin , gastric acid , commensal organisms ) and both cellular (e.g., granulocytes , natural killer cells , mast cells ) and humoral ( complement system ) defense mechanisms . (amboss.com)
6. Promiscuity of the AlloHLA-A2 restricted T cell repertoire hampers the generation of minor Histocompatibility antigen-specific cytotoxic T cells across HLA barriers. (nih.gov)
17. Possible involvement of allogeneic antigens recognised by donor-derived CD4 cytotoxic T cells in selective GVL effects after stem cell transplantation of patients with haematological malignancy. (nih.gov)
CHARACTERIZATION1
13. High-throughput characterization of 10 new minor histocompatibility antigens by whole genome association scanning. (nih.gov)
Susceptibility2
The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)
Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 allelic variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. (nih.gov)
Binding repertoire1
Abacavir binds to the antigen-binding cleft of the HLA-B*57:01 molecule and alters its peptide binding repertoire. (nih.gov)
Potent1
Memory response becomes more potent and faster after subsequent exposures to an antigen . (amboss.com)
Human1
12. Isolation of human CD4/CD8 double-positive, graft-versus-host disease-protective, minor histocompatibility antigen-specific regulatory T cells and of a novel HLA-DR7-restricted HY-specific CD4 clone. (nih.gov)
Degree2
Although it is commonly accepted that necrobiosis lipoidica (NL) is associated with diabetes mellitus (DM), there is some controversy regarding the degree of this association. (thedoctorsdoctor.com)
8. Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation. (nih.gov)
Specific2
The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)
Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)
Memory T cel1
16. Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin, Fas ligand, and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways. (nih.gov)
Normal1
Before starting abacavir, she had tested negative for the HLA B*57:01 allele and had normal serum aminotransferase levels. (nih.gov)
Class1
14. HLA class I epitope discovery in type 1 diabetes. (nih.gov)
Major histoco1
Strong association with major histocompatibility complex (MHC) and several non-MHC genes, such as interferon-induced helicase 1 and c-type lectin domain family 16, have been found for both autoimmune disorders and IgA deficiency. (medscape.com)
Host2
9. Repertoire analysis of CD8+ T cell responses to minor histocompatibility antigens involved in graft-versus-host disease. (nih.gov)
During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells which differentiate into helper T2 cells. (wikipedia.org)
Unknown1
There are few cases of nonhypersensitivity abacavir induced hepatitis (Case 1) in which the mechanism is unknown. (nih.gov)