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  • foot ulcer
  • The SJHC harmonized foot ulcer assessment tool was developed to aid in the early detection of diabetic foot problems and to ensure prompt referral to the right foot care provider for appropriate treatment, thereby improving outcomes of the diabetic foot. (clinicaltrials.gov)
  • lower extremity
  • The evidence is adequate to conclude that HBO therapy is clinically effective and, thus, reasonable and necessary in the treatment of certain patients with limb-threatening diabetic wounds of the lower extremity. (cms.gov)
  • We encourage interested parties to undertake well-designed clinical trials to assess the clinical effectiveness of HBO therapy in other subgroups of diabetic lower extremity ulcers. (cms.gov)
  • Age and hyperglycemia are the most important risk factors for development and progression of subclinical lower extremity arterial disease in type 2 diabetic subjects. (diva-portal.org)
  • Clinical
  • Prevention or restoration of these changes via blockade of aldosterone action in the vascular wall with MR antagonists (i.e., spironolactone, eplerenone) may therefore account for the clinical benefit of these compounds in obese and diabetic patients with cardiovascular disease. (biomedsearch.com)
  • Basal ganglia stroke secondary to mineralizing angiopathy of lenticulostriate arteries is a well-recognized clinical entity following minor head trauma in children. (qxmd.com)
  • Our previous reports identify several significant associations between the genotypes of cytokine genes and T2DM and/or the clinical lipid parameters, which strongly suggest the participation of immune-regulatory molecules in lipid metabolism. (medsci.org)
  • Diabetic lung involvement is best characterized as a loss of physiological reserves ( 10 ) since in most reports the measured indexes fall well within 80% of the reference value, i.e., within the normal range of clinical testing that ordinarily would not prompt further diagnostic evaluation. (diabetesjournals.org)
  • Achilles Pain, Stiffness, and Muscle Power Deficits: Achilles Tendinitis--Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability, and Health from the Orthopaedic Section of the American Physical Therapy Association. (chiromatrixbase.com)
  • T2DM
  • Intriguingly, CTLA-4 -318 genotype was associated with circulatory triglycerides in T2DM subjects ( P= 0.019) although no significant association between CTLA-4 -318 ( P =0.119) and +49 ( P= 0.2) genotypes with T2DM was identified. (medsci.org)
  • In Taiwan, more than 98% of diabetic patients are characterized as T2DM [ 3 ], affecting more than 1 million individuals. (medsci.org)
  • To study the association of novel risk of cardiovascular factors, fibrinogen and C-reactive protein (CRP) and albuminuria as markers of CVD risk in newly diagnosed patients with T2DM. (rcsi.ie)
  • CAPN10 gene study suggests associations between genetic variability in this gene and T2DM in the Irish population and further exploration of this and other genes may lead to earlier identification of subjects for interventions to reduce the risk of development of the disease. (rcsi.ie)
  • The frequency of the GGT1 G allele was 20.8% in the T2DM subjects, and no associations were found between the GGT1 genotype and risk of T2DM. (biomedcentral.com)
  • anti-diabetic
  • The objectives of this investigation were: 1) to evaluate the distribution of APOE polymorphisms in a large diabetic case-control sample from South Asia, 2) to examine the impact of APOE polymorphisms on quantitative risk factors of T2D and CAD, and 3) to explore the contribution of APOE genotypes in the response to anti-diabetic therapy. (nih.gov)
  • Humans
  • In a report in The American Journal of Pathology investigators describe the generation of a successful novel transgenic rat model that accumulates amyloid specifically in brain blood vessels and strongly mimics many of the associated detrimental changes that are observed in humans - a condition known as cerebral amyloid angiopathy, which is also commonly observed in Alzheimer disease. (news-medical.net)
  • arteries
  • The measurement of ankle-to- brachial blood pressure index (ABI) to screen for asymptomatic LEAD in diabetic subjects is unreliable since a large proportion of patients have stiff ankle arteries (mediasclerosis) and thus may display a too high ABI. (diva-portal.org)
  • type
  • 11 The International Obesity Task Force (IOTF) reports that 1.7 billion of the worlds population is already at a heightened risk of weight-related, non-communicable diseases such as type 2 DM and its complications like CVD and diabetic kidney diseases. (mrimsjournal.com)
  • Thiazolidinediones (TZDs) are insulin sensitizers that decrease plasma glucose in type 2 diabetic patients. (clinicaltrials.gov)
  • We studied type 1-, type 2 diabetic and non-diabetic subjects without a previous history of LEAD and a composite variable of ankle - plus toe blood pressures and indices was compared to ABI alone in detecting LEAD. (diva-portal.org)
  • This is a Phase 2b, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of one or two applications of topically applied GAM501 (Ad5PDGF-B/Bovine Type I Collagen Gel) in subjects ≥ 18 years old with non-healing diabetic foot ulcers. (clinicaltrials.gov)
  • severe
  • One patient with severe angiopathy and proved osteomyelitis had a negative bone scintigraphy but a positive scintigraphy with labeled antibodies against granulocytes. (diabetesjournals.org)