Associated with zika virus infections. Medical search. Frequent questions

The study, which drew on data from two cohorts of Nicaraguan children who lived through a Zika epidemic in 2016 and a dengue epidemic in 2019, is the first to investigate the impacts of Zika immunity on dengue disease in humans. (sciencedaily.com)
When chikungunya, another mosquito-borne virus, and Zika appeared in Nicaragua in 2014 and 2016, respectively, the cohort was expanded to capture cases of these emerging pathogens. (sciencedaily.com)
The two arrived at the very beginning of what would become a massive epidemic of dengue virus Type 2, one of the more severe of the four flavors, or serotypes, of dengue, and the first major outbreak of dengue since the Zika epidemic in 2016. (sciencedaily.com)
Davidson A, Slavinski S, Komoto K, Rakeman J, Weiss D. Suspected female-to-male sexual transmission of Zika virus - new York City, 2016. (springer.com)
Male-to-male sexual transmission of Zika virus--Texas, January 2016. (springer.com)
11 April 2016, Cairo - The WHO country office, Egypt and Department of Public Health and Community Medicine, Faculty of Medicine, Cairo University, conducted a symposium on enhancing preparedness and response capacities to Zika virus infection from 30 to 31 March 2016. (who.int)
However, to date (7 February 2016), no countries of the Region have reported either local transmission or importation of the Zika virus but countries need to be vigilant in order to prevent its spread if it were to reach the Region. (who.int)
Emerging and reemerging diseases were highlighted in a talk on infections in the pediatric population given by Sheila Fallon Friedlander, M.D., during the MauiDerm 2016 meeting. (dermatologytimes.com)
Zika virus (ZIKV) is an arbovirus belonging to the flaviviridae family with a risk assessment that has been increasing in recent years and was labeled a global health emergency by the World Health Organization in 2016. (uky.edu)
During 2014-2016, the pandemics of chikungunya and Zika virus transiently inserted those diseases into the top 5. (health.mil)
In 2016, in response to the WHO declaration, the Thai government called on hospitals in the country to collect urine, blood and plasma samples from people with symptoms that may be associated with Zika, in other words, people with fever or rash symptoms. (medindia.net)
Veljkovic, V & Paessler, S 2016, ' Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection ', F1000Research , vol. 5, 190. (utmb.edu)
The fourth meeting of the Emergency Committee (EC) on Zika and microcephaly convened by the Director-General under the International Health Regulations (2005) regarding microcephaly, other neurological disorders and Zika virus was on 1 September 2016. (who.int)

The Brazil Ministry of Health developed a case definition for Zika virus-related microcephaly (head circumference ≥2 standard deviations [SD] below the mean for sex and gestational age at birth). (cdc.gov)
A task force and registry were established to investigate Zika virus-related cases of microcephaly and to describe the clinical characteristics of cases. (cdc.gov)
The increased occurrence of microcephaly associated with cerebral damage characteristically seen in congenital infections in Zika virus-affected areas is suggestive of a possible relationship. (cdc.gov)
By September, reports of an increase in the number of infants born with microcephaly in Zika virus-affected areas began to emerge, and Zika virus RNA was identified in the amniotic fluid of two women whose fetuses had been found to have microcephaly by prenatal ultrasound. (cdc.gov)
The Brazil Ministry of Health (MoH) established a task force to investigate the possible association of microcephaly with Zika virus infection during pregnancy and a registry for incident microcephaly cases (head circumference ≥2 standard deviations [SD] below the mean for sex and gestational age at birth) and pregnancy outcomes among women suspected to have had Zika virus infection during pregnancy. (cdc.gov)
Further studies are needed to confirm the association of microcephaly with Zika virus infection during pregnancy and to understand any other adverse pregnancy outcomes associated with Zika virus infection. (cdc.gov)
Previous research had found zika infection in the first or second trimester to be most critical for the occurrence of microcephaly owing to issues relating to the neural development of the fetus. (news-medical.net)
Microcephaly - a smaller than normal head - is the most well-known and visible consequence of Zika virus exposure. (sfn.org)
Recent research, however, has found brain and behavior abnormalities in Zika-exposed infants without microcephaly. (sfn.org)
Zika virus outbreaks were first found to be associated with birth defects including microcephaly, in which the baby is born with an abnormally small head and brain, in 2015 in Brazil, where dengue virus, a virus closely related to Zika virus, is endemic. (infectioncontroltoday.com)
Our research may explain the high rate of microcephaly and birth defects observed in the recent Zika virus outbreak in South America. (infectioncontroltoday.com)
Zika virus infection is a zoonosis which is associated with congenital birth defects, with microcephaly the most widely known. (radiopaedia.org)
The concern with Zika virus, which is a flavivirus related to dengue and transmitted by the same Aedes mosquito, relates to the potential association between maternal infection and infants born with microcephaly. (dermatologytimes.com)
Dr. Friedlander noted that accompanying the recent outbreak of Zika virus infections in Brazil there has been a tremendous uptick in the number of newborns with microcephaly - from 147 in 2014 to 2,782 in 2015, according to information from the Centers for Disease Control. (dermatologytimes.com)
The information is worrisome considering the consequences of microcephaly, which can range from mild developmental delay to severe motor and intellectual deficits, and the growing number of cases of Zika virus infection in countries outside Brazil, including the United States. (dermatologytimes.com)
Although a causal association between maternal Zika virus infection and congenital microcephaly is still under investigation, most everyone is convinced that it is real. (dermatologytimes.com)
As for microcephaly, a neurological condition in which the baby's head is smaller than what is expected for its age and gender, one out of 25 children born of mothers infected by the zika virus during pregnancy presented this dysfunction at birth or during follow-up. (fiocruz.br)
The risk of children of mothers infected by the zika virus during pregnancy developing microcephaly was 2.6% at birth or when first evaluated, increasing to 4% in the first preschool years. (fiocruz.br)
In 2015, maternal ZIKV infection during pregnancy was associated with fetal loss, spontaneous abortions and neurological disorders, such as microcephaly in neonates, but most of the newborns (~ 90%) showed no manifestations at birth. (mouseclinic.de)
Zika virus infection in a pregnant woman can cause microcephaly (a serious birth defect) and eye and other abnormalities in the baby. (msdmanuals.com)
BACKGROUND Zika virus (ZIKV) has been linked to neonatal microcephaly. (fiocruz.br)
The first outbreak of the Zika virus occurred in Brazil in 2015, becoming a serious public health problem due to the increase in the number of cases of microcephaly in infected pregnant women. (bvsalud.org)
ZIKV infection often causes no or only mild symptoms, but it can also trigger severe consequences, including microcephaly in infants and Guillain-Barré syndrome, uveitis, and neurologic manifestations in adults. (encyclopedia.pub)
ZIKV infection in pregnant women has received considerable attention due to the vertical transmission of ZIKV from the maternal placenta to fetuses, resulting in high rates of microcephaly [ 10 ] [ 11 ] . (encyclopedia.pub)
Zika infections in developing babies have been linked to microcephaly, a condition in which a baby is born with an unusually small brain. (oviahealth.com)
The most worrisome and well-publicized effect of Zika virus infection is that of microcephaly . (familydoctor.co.nz)
This link was first noticed in September 2015 in Brazil where the recognition of the Zika virus outbreak coincided with an increase in the incidence of microcephaly (5). (familydoctor.co.nz)
Since then a causal relationship between prenatal Zika virus infection and microcephaly has been demonstrated (5). (familydoctor.co.nz)
Not all women with prenatal Zika virus infection will give birth to babies with microcephaly. (familydoctor.co.nz)
It isn't currently clear why some mothers infected with the Zika virus will give birth to a baby with microcephaly whilst others do not. (familydoctor.co.nz)
It should be noted that there are a multitude of causes of microcephaly other than pre-natal Zika virus infection. (familydoctor.co.nz)
On the basis of the known link between Zika virus infection and microcephaly there is little doubt that women who are currently pregnant, or who are trying to get pregnant, have the greatest potential burden of disease. (familydoctor.co.nz)
The 2015 Brazilian Zika virus (ZIKV) outbreak has been associated with an estimated 20-fold increase in cases of microcephaly in newborns ( Center for Disease Control, 2017 ). (eneuro.org)
In particular, the infection route and cellular mechanisms contributing to ZIKV-induced microcephaly are still unclear. (eneuro.org)
The infection can have devastating consequences for pregnant women and their children, many of whom are born with a type of brain malformation known as microcephaly. (charite.de)
We already know that Zika virus infection during pregnancy can damage the fetus, leading to microcephaly and other potentially serious symptoms," explains the study's lead investigator, Prof. Dr. Felix Drexler of Charité's Institute of Virology. (charite.de)
Until now, however, we failed to understand why there is an increased incidence of Zika-associated microcephaly in certain areas such as the Northeast of Brazil," says Prof. Drexler. (charite.de)
They also conducted tests on 29 mothers who had developed Zika virus infection during pregnancy and whose babies were later born with microcephaly. (charite.de)
The recent Zika virus infection (Zika) epidemic in Brazil has been associated with neurological anomalies, including an increase in the number of cases of microcephaly and, more recently, Guillain-Barré syndrome (GBS) [1, 2]. (paho.org)
The Zika virus (ZIKV) is one of the most infamous mosquito-borne flavivirus on recent memory due to its potential association with high mortality rates in fetuses, microcephaly and neurological impairments in neonates, and autoimmune disorders. (asme.org)
While a case report provided evidence of microcephaly in association with ZIKV infection, the case report also showed that a 25-year-old European woman who lived in Brazil was infected with the virus. (atmph.org)
A case report published in January 2017 showed evidence of microcephaly in a woman with ZIKV infection. (atmph.org)
Scientists provide a potential biological link between Zika virus infection and microcephaly. (the-scientist.com)
The study, albeit preliminary, offers the first suggestion of how Zika infection of pregnant women might lead to microcephaly in their babies. (the-scientist.com)
On hearing about the Zika-microcephaly crisis in Brazil, Ming realized she had a unique opportunity to examine whether human neural progenitor cells might be susceptible to infection. (the-scientist.com)

ZIKV infection was suspected and DOI:http://dx.doi.org/10.3201/eid2008.130095 several diagnostic tests were ordered. (cdc.gov)
Zika virus (ZIKV) is mainly transmitted through Aedes mosquito bites, but sexual and post-transfusion transmissions have been reported. (springer.com)
During acute infection, ZIKV is detectable in most organs and body fluids including human semen. (springer.com)
So far, the consensus is that ZIKV infection in the testes or epididymis might affect sperm development and, consequently, male fertility. (springer.com)
This manuscript provides an updated overview of the cellular and molecular mechanisms of ZIKV infection and reviews data on ZIKV persistence in semen and associated risks to the male reproductive system described in human and animal models studies. (springer.com)
In the light of the identified gaps in our accumulated knowledge on the subject, we highlight the importance for couples seeking ART to follow the constantly revised guidelines and the need of specific ZIKV diagnosis tools for semen screening to contain ZIKV virus spread and make ART safer. (springer.com)
By analyzing blood serum samples from eight of these patients, researchers from the Carlos Chagas Institute at the Oswaldo Cruz Foundation in the city of Curitiba, state of Paraná, and from the Institute of Tropical Medicine at the Federal University of Rio Grande do Norte were able to determine the culprit: the ZIKV virus, responsible for zika fever ( Memórias do Instituto Oswaldo Cruz , June 2015). (fapesp.br)
Zika virus (ZIKV) infection in pregnancy is associated with congenital neurological abnormalities. (physiciansweekly.com)
Our understanding of the full clinical spectrum of ZIKV infection is incomplete. (physiciansweekly.com)
Using data from this prospective cohort study consisting of 650 women attending a high-risk pregnancy clinic during the Zika virus outbreak in Brazil, we investigated the extent to which specific symptoms can be utilized to differentiate ZIKV-infected pregnant women from those with other pregnancy-related problems. (physiciansweekly.com)
Scientists from the Heinrich-Pette-Institute Hamburg and the University of Veterinary Medicine Hannover in collaboration with the German Mouse Clinic and several other institutes showed in this study that maternal Zika virus (ZIKV) infection during early development also affects the supposedly healthy offspring at later age. (mouseclinic.de)
One year after the outbreak of the ZIKV, the WHO called for the long-term consequences of a ZIKV infection to be investigated. (mouseclinic.de)
The data support the hypothesis that maternal ZIKV infection during early embryogenesis impairs the fetal development in the uterus. (mouseclinic.de)
The authors observed that the dose of ZIKV infection applied to pregnant mice plays an important role. (mouseclinic.de)
High doses led to increased miscarriages, but with a low ZIKV infection dose, the offspring were phenotypically inconspicuous. (mouseclinic.de)
Outcomes of Zika virus (ZIKV) infection in pregnant women vary from the birth of asymptomatic offspring to abnormal development and severe brain lesions in fetuses and infants. (uea.ac.uk)
To partially reproduce in utero infection in humans, we directly inoculated selected porcine conceptuses with ZIKV. (uea.ac.uk)
Our data suggest that porcine model of persistent in utero ZIKV infection has a strong potential for translational research and can be used to test therapeutic interventions in vivo. (uea.ac.uk)
Anti-ZIKV activity of TAM was assessed by compound screens using an infectious virus and mechanistic details were gleaned from time of addition and virucidal studies. (uky.edu)
Virus titers show diminished replication of ZIKV over 7 days compared to controls. (uky.edu)
To characterize the spectrum of ZIKV disease in pregnancy, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in fetuses. (fiocruz.br)
The timing of acute ZIKV infection ranged from 5 to 38 weeks of gestation. (fiocruz.br)
28% had fever (short-term and low-grade).Women who were positive for ZIKV were more likely than those who were negative for the virus to have maculopapular rash (44% vs. 12%, P=0.02), conjunctival involvement (58% vs. 13%, P=0.002), and lymphadenopathy (40% vs. 7%, P=0.02). (fiocruz.br)
CONCLUSIONS Despite mild clinical symptoms, ZIKV infection during pregnancy appears to be associated with grave outcomes, including fetal death, placental insufficiency, fetal growth restriction, and CNS injury. (fiocruz.br)
Zika virus ( ZIKV ) is part of this genus. (bvsalud.org)
It was initially reported in Brazil in December 2014 as an unknown acute generalized exanthematous disease and was subsequently identified as ZIKV infection . (bvsalud.org)
We used molecular and microbiological assessments to report the initial case of vertically transmitted ZIKV infection with congenital syndrome associated with a neurological syndrome , where a mutation in the CDK5RAP2 gene was also identified. (bvsalud.org)
Zika virus (ZIKV) is an arthropod-borne virus that belongs to the Flavivirus genus and is principally transmitted by Aedes aegypti mosquitoes. (encyclopedia.pub)
ZIKV was first isolated in 1947 from a rhesus monkey from the Zika forest of Uganda [ 2 ] . (encyclopedia.pub)
The primary target tissues of ZIKV infection have been recognized as the maternal placenta and fetal brain. (encyclopedia.pub)
Accordingly, many researchers have focused primarily on understanding the mechanisms of ZIKV infection in the placenta and fetus when seeking to develop vaccines and therapeutics. (encyclopedia.pub)
Mouse models have shown slight differences in viral susceptibility to and clinical manifestations of ZIKV infection in the maternal placenta and fetus depending on the genetic background and/or route of administration. (encyclopedia.pub)
We demonstrated in vitro that chloroquine reduces the number of ZIKV-infected cells, virus production and cell death promoted by ZIKV infection without cytotoxic effects. (ufg.br)
Prenatal exposure to Zika virus (ZIKV) can result in microencephaly and congenital Zika syndrome, although some brain cells and structures are spared by the virus for unknown reasons. (eneuro.org)
Here, a novel murine model of fetal ZIKV infection incorporating intraventricular infection and cell type-specific in utero electroporation (IUE) was used to identify the time course of ZIKV infection and to determine the identity of cells that are initially infected or spared during neocortical neurogenesis. (eneuro.org)
In vivo time course studies revealed the presence of ZIKV in apical radial glial cells (aRGCs) at early time points following virus exposure, while basal intermediate progenitor cells (bIPCs) became maximally (ZIKV + ) after 3 d of virus exposure. (eneuro.org)
ZIKV-infected fetal brains exhibited microencephaly as early as 1 d following infection, regardless of developmental age. (eneuro.org)
While 60% of aRGC basal fibers were perturbed during infection, 40% retained normal morphology, indicating that aRGCs are not uniformly vulnerable to ZIKV infection. (eneuro.org)
The results indicate that one class of aRGCs preferentially express the putative ZIKV entry receptor AXL and that these cells are more vulnerable to ZIKV infection than other aRGC subtypes with low AXL expression. (eneuro.org)
Together, these data uncover crucial temporal and cellular details of ZIKV fetal brain infection for prevention strategies and for management of congenital Zika syndrome. (eneuro.org)
The transcriptional signatures of neural precursor cells (NPCs) were used for the first time to test Zika virus (ZIKV) susceptibility in a direct fetal brain infection model. (eneuro.org)
The in silico analysis shows that the envelope glycoproteins E of Zika viruses (ZIKV) isolated in Asia, Africa and South and Central America encode highly conserved information determining their interacting profile and immunological properties. (utmb.edu)
This similarity suggests possible repurposing of the seasonal influenza vaccine containing pdmH1N1 component for prevention of the ZIKV infection. (utmb.edu)
The increase in ZIKV infection cases has prompted a significant increase in the incidence of the disease. (atmph.org)
There are no specific symptoms associated with ZIKV infection. (atmph.org)

Like the dengue and chikungunya viruses, the zika virus is also transmitted by the mosquito Aedes aegypti . (fapesp.br)
Other viral infections being seen more commonly in infants are Chikungunya and syphilis. (dermatologytimes.com)
In her presentation, Dr. Friedlander said dermatologists should be aware of recent increases in cases of Zika virus infection, Chikungunya virus infection, and syphilis in newborns. (dermatologytimes.com)
Cases of Chikungunya virus infection have also been noted in the United States. (dermatologytimes.com)
Also transmitted through the bite of the Aedes mosquito, Chikungunya virus infection is sometimes referred to as "dengue light" because its symptoms tend to be milder than those of dengue virus infection. (dermatologytimes.com)
However, in newborn infants, Chikungunya virus infection has been associated with severe disease and fatalities. (dermatologytimes.com)
Recently as well, a report from Colombia has linked an epidemic of Chikungunya virus infection with cases of congenital infection and a high stillbirth rate, Dr. Friedlander said. (dermatologytimes.com)
Cutaneous findings of Chikungunya virus infection in neonates include a maculopapular and sometimes blistering rash, black streaks in the nails, and persistent hyperpigmentation after recovery from the acute disease. (dermatologytimes.com)
Zika virus belongs to the same family of viruses as dengue and chikungunya and is predominantly transmitted by the same mosquito, the Aedes aegypti but may also be transmitted via blood transfusion, from mother to unborn baby and also through sexual intercourse. (sundominica.com)
Since May of 2015, authorities have been issuing warnings about Zika transmission in Brazil, describing its epidemic potential as being similar to that of dengue fever and chikungunya [1, 2]. (paho.org)

In addition to removing potential breeding areas for mosquitoes, pregnant women in Zika-affected areas should wear protective clothing, apply a U.S. Environmental Protection Agency (EPA)-approved insect repellent, and sleep in a screened room or under a mosquito net. (cdc.gov)
Pregnant women in Zika virus-affected areas should protect themselves from mosquito bites by using air conditioning, screens, or nets when indoors, wearing long sleeves and pants, using permethrin-treated clothing and gear, and using insect repellents when outdoors. (cdc.gov)
Women who have been infected or suspect an infection should wait at least 8 weeks before trying to get pregnant. (denverhealth.org)
In cases of zika infection in obese pregnant women, she explained, transcription of genes and production of proteins involved in the immune response are both diminished. (news-medical.net)
The group analyzed 30 placenta samples from obese and non-obese pregnant women infected by zika supplied by Oswaldo Cruz Foundation (FIOCRUZ), a research institution subordinated to the Brazilian Ministry of Health, and 39 from healthy women supplied by Patrícia Rondó, a researcher at USP's School of Public Health who is conducting a population study of pregnant women in Araraquara, São Paulo state. (news-medical.net)
The analysis showed that zika can alter the placenta morphologically in obese pregnant women and aggravate insufficiency of the placental type I interferon pathway. (news-medical.net)
In obese pregnant women who contracted zika, we observed a decrease in transcriptional expression of RIG-I and IFIH1 [ the precursor gene for the protein MDA-5 ]. (news-medical.net)
Pregnant women should avoid traveling to countries with active transmission of Zika, including Florida's Miami-Dade County. (sdaho.org)
State Epidemiologist Dr. Lon Kightlinger says travelers to Zika-affected areas, particularly pregnant women, should follow strict mosquito control precautions. (sdaho.org)
Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms? (physiciansweekly.com)
The result of infection can be devastating for pregnant women. (dermatologytimes.com)
It brings together individual data of children born from 1,548 pregnant women residing in different regions of the country, who had a confirmed diagnosis of infection by the zika virus during pregnancy, which allowed for a more accurate estimate of the risks. (fiocruz.br)
Researcher Flor Ernestina Martinez-Espinosa, of Fiocruz Amazônia, is a senior co-author of the study (together with Patrícia Brasil, of INI/Fiocruz), and coordinated one of the cohorts of pregnant women exposed to the zika virus. (fiocruz.br)
The Zika virus is spread by mosquitoes, but it can also be spread through sexual intercourse, through blood transfusions, and from a pregnant woman to her baby before or during birth. (msdmanuals.com)
perspectives of abortion for the pregnant woman with Zika virus regarding the medical, emotional and social consequences. (bvsalud.org)
However, it's not the effects in adults that are generally of concern for most people, but rather the effects that the Zika virus could have on developing babies of infected, pregnant mothers. (oviahealth.com)
Many national health departments have published advisories for women who are pregnant or trying to conceive about the travel risks to certain parts of the world where Zika can be found in mosquitoes. (oviahealth.com)
The United States' CDC recommends that pregnant women avoid travel to all places where Zika infections are common. (oviahealth.com)
If you are pregnant or trying to conceive, it's probably best to avoid travel to places where the virus is spreading. (oviahealth.com)
The threat of Zika can be scary for women who are pregnant or trying to conceive, and especially for those who live in places where Zika is spreading. (oviahealth.com)
As Zika virus infection of pregnant women may result in congenital defects in the newborn, the vaccine will attempt to protect against congenital Zika syndrome during the current or any future outbreak. (wikipedia.org)
Vaccines made from live, weakened viruses are common and effective, but can't be given to pregnant women. (wustl.edu)
Pregnancy suppresses a woman's immune system, so a weak virus that safely immunizes most people could make pregnant women ill. (wustl.edu)
In the case of Zika - where viral infection of pregnant women can cause devastating birth defects or miscarriage - a live-virus vaccine would be unusable, but a protein-based vaccine could be a lifesaver. (wustl.edu)
Diamond said that studies to determine whether vaccinating pregnant women against Zika could protect their fetuses likely would need to be done in primates. (wustl.edu)
Added Fremont, "This is particularly important for pregnant women who want to know whether they were infected with Zika earlier in their pregnancy. (wustl.edu)
It is important to understand the mechanisms of Zika virus transmission and the effects of this condition on pregnant women. (atmph.org)
The National Institutes of Health launched a study to determine the possible risks Zika infection may pose to HIV-positive pregnant women. (beckershospitalreview.com)
1. Study participants will include pregnant women infected with HIV only, Zika virus only and concurrent infections with HIV and Zika. (beckershospitalreview.com)

Risk factors such as the timing of the infection during pregnancy and whether it was a primary infection, reinfection or chronic infection, as well as membrane rupture and birth type, can influence the incidence of fetal transmission, she added. (news-medical.net)
Obesity in general (not in the context of pregnancy) has been found to correlate with impaired responses to infections and vaccines, and it is a risk factor for many diseases. (news-medical.net)
This study is the first to report a possible mechanism for the enhancement of Zika virus progression during pregnancy in an animal model. (infectioncontroltoday.com)
Results of the study, 'Dengue virus immunity increases Zika virus-induced damage during pregnancy,' were published in the February issue of Immunity, a journal published by Cell Press. (infectioncontroltoday.com)
The research team led by Jean Lim, PhD, associate professor of microbiology and co-director of microbiology multidisciplinary training in the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, transferred dengue virus-specific antibodies into mice prior to infection with Zika virus during pregnancy. (infectioncontroltoday.com)
Our data demonstrate that antibodies generated from a previous dengue virus infection can enhance the severity of Zika virus infection during pregnancy,' said Dr. Lim. (infectioncontroltoday.com)
A national collaboration between researchers from Fiocruz and from 25 other Brazilian institutions grouped in the Brazilian Consortium of Cohorts related to the zika virus (ZBC Consortium), with support of the London School of Hygiene & Tropical Medicine (LSHTM), assessed the impact of infection by the zika virus during pregnancy on the health of the babies. (fiocruz.br)
Published in The Lancet Regional Health - Americas last Monday (November 28), the study showed that approximately one-third of the children born of mothers infected during pregnancy presented, in their first years of life, abnormalities consistent with congenital zika syndrome (CZS). (fiocruz.br)
This work provides a fundamental contribution to the understanding of the consequences for the health of infection by the zika virus during pregnancy. (fiocruz.br)
To describe the legal abortion at Zika virus infection during pregnancy regarding medical, emotional and social consequences. (bvsalud.org)
Authorizing the termination of pregnancy after diagnosis of the virus Zika guarantees women the free exercise of their reproductive rights, which is not confused with state imposition of abortion or eugenic practice. (bvsalud.org)
CDC has updated its interim guidance for U.S. healthcare providers caring for infants born to mothers with possible Zika virus infection during pregnancy. (cdc.gov)
Depending on where you live, it might be standard protocol for your doctor to test you for Zika during pregnancy, or before you try to conceive. (oviahealth.com)
If you've been diagnosed with Zika during pregnancy, it's best to speak to your doctor right away. (oviahealth.com)
There is substantial evidence existing indicating that the Zika virus is transmitted from mother to fetus during pregnancy. (familydoctor.co.nz)
The international team of researchers set out to look for cofactors which might be responsible for determining whether a Zika virus infection during pregnancy will have devastating consequences. (charite.de)
Despite having recently developed a mouse model of Zika infection during pregnancy, the researchers have not yet tested whether vaccinating mothers with a portion of the Zika envelope protein could protect a fetus from infection. (wustl.edu)
One method to prevent a pregnancy from being infected with Zika virus is to avoid mosquito breeding areas. (atmph.org)
To prevent a pregnancy from being affected by Zika, women should avoid travel to countries or regions that are at risk for the disease. (atmph.org)

An outbreak of Zika virus infection, a flavivirus transmitted by Aedes mosquitoes, was first recognized in northeastern Brazil in early 2015. (cdc.gov)
In early 2015, an outbreak of Zika virus, a flavivirus transmitted by Aedes mosquitoes, was identified in northeast Brazil, an area where dengue virus was also circulating. (cdc.gov)
The dengue virus is similar to the Zika virus - they belong to the same viral family, called the Flaviviridae, and both are transmitted by the Aedes mosquito. (imperial.ac.uk)
Zika virus in Gabon (Central Africa) - 2007: a new threat from Aedes albopictus? (springer.com)
Zika virus is transmitted to people through the bite of an infected mosquito from the Aedes genus, mainly Aedes aegypti in tropical regions. (who.int)
Zika is a single RNA stranded flavivirus usually transmitted by a mosquito vector , for example, Aedes aegypti . (radiopaedia.org)
If they live in an area with Aedes mosquitoes, the mosquitoes may bite them, then spread the virus to other people living in the area, resulting in local transmission of the Zika virus. (msdmanuals.com)
4) Aedes aegypti fed at the times of virus isolation failed to transmit the infection to infant white mice. (paho.org)
An intense and sustained campaign aimed at reducing the breeding Aedes aegypti mosquito is required to minimize the spread Zika virus infection in Dominica. (sundominica.com)
Aedes aegypti mosquitos transmit the Zika virus to humans. (hopkinsmedicine.org)
The Aedes mosquito - potentially together with flaviviruses like dengue and Zika - is found in most tropical and subtropical countries, and South-East Asia is no exception. (medindia.net)

Many viruses can be passed from mosquitoes. (denverhealth.org)
County officials say there are no reports of the virus being locally transmitted by mosquitoes . (theverge.com)
Zika is a tropical mosquito-borne infection, and the virus is not known to be carried by the mosquitoes found in South Dakota. (sdaho.org)
The best ways to prevent Zika virus infection are to avoid being bitten by mosquitoes and to avoid unprotected sex with a partner who has or may have the infection. (msdmanuals.com)
When mosquitoes bite an infected person, they ingest blood containing the virus. (msdmanuals.com)
The virus replicates in the mosquitoes and, after a few days, when the mosquitoes bite another person, they can transmit the virus to that person. (msdmanuals.com)
This means that most infections are transmitted through mosquito bites in tropical and subtropical climates, by one of two types of mosquitoes that can carry the virus. (oviahealth.com)
Because it can be transmitted sexually, a person could theoretically be at risk for infection even if they've never been to an area where Zika-carrying mosquitoes live. (oviahealth.com)
Zika virus is transmitted to humans by infected mosquitoes which causes mild fever with maculopapular rash. (medindia.net)
Infected mosquitoes carry Zika virus. (atmph.org)
It is unclear whether this lab virus still behaves in the same way as do Zika viruses currently circulating in Brazilian mosquitoes and infected humans," he said. (the-scientist.com)

This immune interaction, called antibody-dependent enhancement, could complicate the search for a safe and effective vaccine that protects against Zika without also increasing the risk of dengue. (sciencedaily.com)
This interaction, known as antibody-dependent enhancement, could make it harder for researchers to design a safe and effective vaccine that protects against Zika without also increasing the risk of dengue. (sciencedaily.com)
That finding raises the questions: Could a vaccine only targeted at Zika actually put people at increased risk of more severe dengue disease? (sciencedaily.com)
And how can you design a Zika vaccine that only induces good antibodies that protect you against Zika, but doesn't induce these other, potentially enhancing antibodies that are harmful against disease? (sciencedaily.com)
There is no vaccine for the Zika virus. (denverhealth.org)
A second study by the same team, published in Nature , suggests an antibody that works against the dengue virus may also neutralise Zika - providing a potential target for a vaccine. (imperial.ac.uk)
A Zika virus vaccine is designed to prevent the symptoms and complications of Zika virus infection in humans. (wikipedia.org)
The goal of a Zika virus vaccine is to produce specific antibodies against the Zika virus to prevent infection and severe disease. (wikipedia.org)
The challenges in developing a safe and effective vaccine include limiting side effects such as Guillain-Barré syndrome, a potential consequence of Zika virus infection. (wikipedia.org)
Additionally, as dengue virus is closely related to Zika virus, the vaccine needs to minimize the possibility of antibody-dependent enhancement of dengue virus infection. (wikipedia.org)
The vaccine consists of a DNA plasmid encoding the E and PrM proteins which make up the outer protein coat of the Zika virus virion. (wikipedia.org)
Based on a previous platform used to develop a West Nile virus vaccine, the DNA vaccine is designed to assemble protein particles that mimic Zika virus and trigger the body's immune response. (wikipedia.org)
This vaccine is based on the same technology used to develop a vaccine against Japanese Encephalitis Virus. (wikipedia.org)
As the ZPIV vaccine contains inactivated Zika particles, the virus cannot replicate and cause disease in humans. (wikipedia.org)
A live attenuated vaccine, in which the virus is genetically altered as to not cause disease in humans, is undergoing phase 1 clinical trials. (wikipedia.org)
A chimeric Binjari-Zika vaccine is highly effective for immunization in mice. (wikipedia.org)
Scientists at Washington University School of Medicine in St. Louis have identified antibodies capable of protecting against Zika virus infection, a significant step toward developing a vaccine, better diagnostic tests and possibly new antibody-based therapies. (wustl.edu)
In a study published July 27 in Cell, the researchers identified the precise spot on the virus that the antibodies recognized, information that could be used to develop a vaccine against Zika. (wustl.edu)
A vaccine designed to elicit similar antibodies might be able to protect people from Zika strains worldwide. (wustl.edu)
We think that this piece of the viral envelope protein alone would be able to elicit a protective immune response to Zika," Fremont said, referring to the possibility of making a vaccine from an engineered viral protein rather than the whole virus. (wustl.edu)
However, the previous paper lacked the detailed description of how the antibodies interact with the virus, information that could aid in designing a Zika vaccine. (wustl.edu)

Researchers at the University of São Paulo (USP) in Brazil have shown for the first time that gestational obesity associated with infection by zika virus influences the placenta's antiviral response, weakening the organ's capacity to attack the pathogen and protect the fetus. (news-medical.net)
Zika virus replication in the mosquito Culex quinquefasciatus in Brazil. (springer.com)
Guillain-Barre syndrome after Zika virus infection in Brazil. (springer.com)
According to the researchers, identifying the zika virus as being responsible for an epidemic of the disease in northeastern Brazil makes this the first report of autochthonous transmission (within the same state or city) of zika fever in Brazil. (fapesp.br)
Researchers believe that this will make it easier for the virus to disperse into other regions of Brazil. (fapesp.br)
The results were found after the combined analysis of data from 13 studies that investigate pediatric results in pregnancies affected by the zika virus during the 2015-2017 epidemic in Brazil. (fiocruz.br)
This view very quickly shifted in 2015 as the Zika virus hit Brazil and the Americas. (familydoctor.co.nz)
In order to study interactions between dengue and Zika viruses, the researchers first compared the genomes of all known dengue viruses currently found in Brazil. (charite.de)
They did so to establish whether, over the past few decades, the Northeast of Brazil had been exposed to different dengue viruses than those found in other regions, and whether people in the Northeast had developed different immunity as a result. (charite.de)
Cross-Protection of Dengue Virus Infection against Congenital Zika Syndrome, Northeastern Brazil. (charite.de)

Getting sick with the mosquito-borne Zika virus makes people more vulnerable to developing dengue disease later on, and to suffering from more severe symptoms when they do get sick from dengue, finds a new study published online today (Thursday, Aug. 27) in the journal Science . (sciencedaily.com)
The virus spreads in the body and leads to symptoms. (denverhealth.org)
A blood test will be done to find out which virus is causing symptoms. (denverhealth.org)
The Zika virus may exist in the body or in sperm for a period of time even after symptoms have passed. (denverhealth.org)
The Zika virus can cause fevers, rashes, joint pain, and conjunctivitis, but it only elicits symptoms in about 20 percent of those infected. (theverge.com)
The virus was identified in a woman who traveled to a country where Zika virus is currently transmitted and later developed symptoms. (sdaho.org)
Demographic and clinical data including physical symptoms during follow-up were recorded and analyzed with respect to Zika virus exposure status. (physiciansweekly.com)
Zika virus infection is a mosquito-borne viral infection that typically causes no symptoms but can cause fever, rash, joint pain, or infection of the membrane that covers the white of the eye (conjunctivitis, or pinkeye). (msdmanuals.com)
Symptoms of Zika virus infection, if they occur, are usually mild. (msdmanuals.com)
Doctors suspect Zika based on a person's symptoms and recent travel history and confirm the diagnosis based on results of blood or urine tests. (msdmanuals.com)
Zika infections don't always show symptoms, so some people who are infected with Zika might not have any idea if they aren't tested. (oviahealth.com)
These symptoms are thought to occur within roughly 1 week of contracting the virus (2). (familydoctor.co.nz)
She presented in our emergency department with symptoms suggestive of Zika including difficulty walking, non-purulent conjunctivitis, rash, myalgia, and arthralgia for 12 days. (paho.org)
For the new study, Pardo's team designed strategies with colleagues in Colombia to evaluate patients with suspected neurological problems associated with Zika and provided tools for viral tests of blood, cerebrospinal fluid and urine samples from 68 people with symptoms of Guillain-Barré. (hopkinsmedicine.org)
Almost all patients displayed two or more clinical symptoms of Zika infection, which include fever, headache, rash and conjunctivitis. (hopkinsmedicine.org)
The researchers say that almost one-half of the study participants complained of neurologic symptoms within four days of the onset of Zika symptoms - an unusually fast response, they say, than is found in people who develop Guillain-Barré symptoms after other viral infections, such as influenza and herpesviruses. (hopkinsmedicine.org)
It is a disease that is difficult to study, since most people infected by Zika do not fall ill or suffer only minor symptoms," explains Henrik Salje, a statistician and epidemiologist in the Mathematical Modeling of Infectious Diseases Unit at the Institut Pasteur. (medindia.net)

Congenital Zika vial infection has been shown to cause various brain abnormalities affecting both grey and white matter and ventricular size 4,5 . (radiopaedia.org)
Outline outpatient management of infants with laboratory evidence of congenital Zika virus infection with and without abnormalities consistent with congenital Zika syndrome. (cdc.gov)

Inoculation resulted in rapid trans-fetal infections, persistent infection in conceptuses, molecular pathology in fetal brains, fetal antibody and type I interferon responses. (uea.ac.uk)
Initially, the researchers assumed that it was the human antibodies produced in response to prior dengue virus infection which might contribute to the fetal damage caused during subsequent infection with the Zika virus. (charite.de)
The two main problems with this virus are that, occasionally, it can lead to neurological complications, such as Guillain-Barr syndrome, or severe fetal brain developmental defects. (medindia.net)

There are four more confirmed case of Zika Virus infection in Dominica at this time, the Ministry of Health and Environment has announced. (sundominica.com)

The greatest risk of Zika virus infection is likely during the first trimester though it is thought damage can be caused as late as early in the third trimester (2). (familydoctor.co.nz)
Summarizing the findings of the study, Prof. Drexler says: "The results show that preexisting immunity against dengue virus significantly reduces the risk of Zika virus infection resulting in serious consequences for the unborn child. (charite.de)

Dominica reports four new cases of Zika virus infection. (sundominica.com)

A Possible Association Between Zika Virus Infection and CDK5RAP2 Mutation. (bvsalud.org)
Though studies have shown a strong association between Zika virus infection and Guillain-Barré syndrome (4) as of yet a causative link has not yet been fully established (3). (familydoctor.co.nz)

[ 13 ] In fact, the relationship between Zika virus infection and cancer is very interesting. (oaepublish.com)

When Zika first emerged in Latin America in late 2015, many speculated whether the flavivirus, a close cousin to the dengue viruses, might interact with the dengue viruses in a similar way. (sciencedaily.com)
To expedite this process, an on-market drug, tamoxifen (TAM), was selected as a promising candidate for repurposing due to its wide range of biological activities and because it has already been shown to possess activity against hepatitis C virus, a flavivirus in a separate genus. (uky.edu)
it belongs to genus Flavivirus in the Flaviviridae family and is closely related to the dengue, yellow fever, Japanese encephalitis, and West Nile viruses [ 1 ] . (encyclopedia.pub)
The Zika virus is a Flavivirus that is predominately a mosquito borne virus. (familydoctor.co.nz)

A new study finds that people who have antibodies to the mosquito-borne Zika virus are more vulnerable to developing dengue disease. (sciencedaily.com)
Its findings confirm earlier suspicions that some antibodies to the Zika virus, which usually serve to protect the body from infection, may actually interact with dengue viruses in ways that can make dengue infection worse. (sciencedaily.com)
Since 2004, Harris and her colleagues in Nicaragua have monitored a cohort of approximately 3,800 children living in Managua, the country's capital, tracking any signs of dengue disease and collecting annual blood samples to test for the virus and its antibodies. (sciencedaily.com)
But the inverse question, whether Zika antibodies protect against future dengue disease, or potentially enhance it, remained a mystery. (sciencedaily.com)
In the new Nature Immunology paper, supported by the Wellcome Trust and the Medical Research Council , the researchers used antibodies that recognise the dengue virus collected from individuals who had been infected with dengue. (imperial.ac.uk)
Their results suggest dengue antibodies can recognise and bind to Zika, due to the similarities between the viruses. (imperial.ac.uk)
Crucially, they also suggest that pre-existing dengue antibodies can amplify a Zika infection through a phenomenon called antibody-dependent enhancement (ADE). (imperial.ac.uk)
When dengue first infects the body, the immune system makes antibodies against the virus. (imperial.ac.uk)
Antibodies are large proteins that latch onto invading bacteria or viruses, neutralising them and enabling the immune system to destroy the pathogens. (imperial.ac.uk)
If someone is infected a second time by a different strain, the antibodies from the first attack can only partially bind to the virus, and are unable to prevent infection. (imperial.ac.uk)
The existing dengue antibodies latch onto Zika, due to similarity between the viruses. (imperial.ac.uk)
However the antibodies are unable to latch onto Zika securely, and so the antibody simply facilitates entry of Zika into the human immune cells, where it replicates. (imperial.ac.uk)
Previous work from the team has shown the immune system generates different types of antibodies to dengue that bind to various areas of the virus. (imperial.ac.uk)
In the current study, the team found a group of antibodies that bind to a certain site on the dengue virus - called EDE1 antibodies - were able to prevent the Zika virus from entering the immune cell. (imperial.ac.uk)
In a second study, published in Nature and co-authored by Professor Felix Rey from the Institut Pasteur and Professor Screaton from Imperial, the team confirmed that EDE1 antibodies bind efficiently to the Zika virus and potently neutralise infection. (imperial.ac.uk)
Zika-infected human placental tissues also showed increased replication in the presence of dengue antibodies. (infectioncontroltoday.com)
It had been known for some time that, under certain conditions, these antibodies are capable of enhancing the effects of subsequent dengue infections with a different dengue virus serotype. (charite.de)
These tests were conducted to determine whether these women had antibodies against the four types of dengue virus found in the area. (charite.de)
Scientists at Washington University School of Medicine in St. Louis have identified antibodies capable of protecting against Zika virus infection, and located the precise spot on the Zika virus that the antibodies recognize. (wustl.edu)
The work, in mice, helps clarify recent research that also identified protective Zika antibodies but lacked important details on how the antibodies interact with the virus. (wustl.edu)
The antibodies bound exclusively to Zika and not to related viruses, which means they are specific enough to be used in diagnostic tests. (wustl.edu)
Importantly, some of our antibodies are able to neutralize African, Asian and American strains of Zika virus to about the same degree," said Daved Fremont, a professor of pathology and immunology and a co-senior author on the paper. (wustl.edu)
Fremont, co-senior author Michael Diamond, MD, PhD, and colleagues identified six antibodies that bound strongly to Zika virus and used a technique called X-ray crystallography to zero in on the binding site. (wustl.edu)
They locked the virus and the antibodies into place together - or crystallized them - and visualized the adjacent structures by bouncing X-rays off them. (wustl.edu)
The two most protective antibodies bound to the same region of the viral envelope protein that covers the surface of the virus. (wustl.edu)
The antibodies described in this study, which reliably distinguished Zika from closely related viruses, also could be incorporated into a diagnostic test. (wustl.edu)
A complementary test would measure the amount of Zika-specific antibodies in people's blood, which could identify people infected months or years prior. (wustl.edu)
Another 18 had no evidence of Zika virus in urine but showed the immunologic footprints of Zika infection through the presence of virus-specific antibodies in their blood or spinal fluid. (hopkinsmedicine.org)

Using data from the cohort, Harris published a 2019 study showing that prior dengue virus infection can grant a small amount of protection against Zika, and other studies now support this conclusion. (sciencedaily.com)
Zika virus transmission worldwide-9 April 2019. (radiopaedia.org)
As of December 2019, no new cases of locally transmitted Zika virus have been reported in the continental United States. (msdmanuals.com)
As of December 2019, there are no areas with Zika outbreaks. (msdmanuals.com)
Coronavirus-induced disease 2019 (COVID-19) is caused by a zoonotic virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has rapidly spread during the last year and a half, infecting over 100 million humans and causing more than two million deaths worldwide. (nature.com)

Potential sexual transmission of Zika virus. (springer.com)

FDA has recommended that whole blood and blood components for transfusion be obtained from U.S. areas without active Zika virus transmission. (cdc.gov)
Puerto Rico is experiencing active Zika virus transmission and also performs local blood collections. (cdc.gov)
The Centers for Disease Control and Prevention monitors and lists those countries with known active Zika virus transmission. (familydoctor.co.nz)

This is not the first time that officials have identified a case of sexual transmission of the Zika virus. (theverge.com)
There are some other mosquito species implicated in the transmission of the Zika virus, though they are implicated relatively infrequently. (familydoctor.co.nz)
There is a potential risk of transmission of the Zika virus through blood transfusion. (familydoctor.co.nz)

At the beginning of the Zika outbreak in South America, my colleagues in Colombia contacted me with concern about the increasing number of patients with neurological complications in their hospitals," says Carlos A. Pardo, M.D., associate professor of neurology and pathology at the Johns Hopkins University School of Medicine, who earned his medical degree in Colombia and is an expert in neuroimmune and infectious diseases, including Guillain-Barré. (hopkinsmedicine.org)
The research team, he says, continues to collect clinical data and samples from the Colombian hospitals' patients, but the work is constrained by the limited availability of resources, which is further strained by the severe and ongoing Zika outbreak in South America. (hopkinsmedicine.org)
But unlike South America, South-East Asia has not recorded widespread Zika outbreaks. (medindia.net)
We are pretty sure that there were no strains circulating in South America before 2013 and that the virus has now largely gone" explains Henrik Salje. (medindia.net)
The first is that changes may have occurred to the Zika virus - and its transmissibility - when the virus migrated to South America. (medindia.net)

Intracranial calcifications resulting from congenital Zika virus infections are typically more florid than caused by the TORCH infections and also characteristically at the grey-white matter interface, which is unusual for other congenital viral diseases. (radiopaedia.org)
Interpret revised testing guidance for newborns with possible congenital Zika virus infection. (cdc.gov)

The findings, published in JNeurosci , suggest children exposed to the virus during the 2015 - 16 epidemic may harbor increased risk for developmental disorders. (sfn.org)
Although it is not currently epidemic, there is a concern that the virus can still reemerge since the male genital tract might harbor persistent reservoirs that could facilitate viral transmission over extended periods, raising concerns among public health and assisted reproductive technologies (ART) experts and professionals. (springer.com)
These data include all four regions of the country affected by the epidemic in that period, with prenatal infection confirmed at a laboratory level through genetic tests and evaluation of potential adverse effects on an individual level. (fiocruz.br)
Although there has never been report on this issue, it is no doubt that the co-infection already occurred in many tropical countries that presently have the problem of Zika virus epidemic. (oaepublish.com)
Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic? (wikipedia.org)

This information can help pediatric healthcare providers better understand the appropriate tests and clinical approaches for evaluating and managing infants, born to mothers in the United States and its territories, with laboratory evidence of Zika virus infection. (cdc.gov)
Discuss clinical evaluation of infants born to mothers with laboratory evidence of Zika virus infection. (cdc.gov)

When this FOA was originally released, the effects of Zika virus infection on the developing fetus, or possible effects on neonatal/infant immunity, were not appreciated. (nih.gov)
Those infected with Zika virus may cultivate an immunity that bars future infections, according to a recent study published in the journal Nature Medicine. (beckershospitalreview.com)
I'm interested in how viruses engage with these pathways with respect to cellular antiviral immunity, to develop novel avenues for therapeutic intervention. (gla.ac.uk)
My research focuses on companion animal virology and immunology with a view to understanding disease pathogenesis, correlates of immunity to infection and the development of novel approaches to the diagnosis, prevention and treatment of viral diseases. (gla.ac.uk)

1) A volunteer has been inoculated with the Eastern Nigerian strain of Zika virus. (paho.org)
SARAH C. OGDEN Laboratory-grown human neural progenitor cells, which can give rise to the kind of neurons and glia found in the brain, can be infected and killed by a strain of Zika virus, according to a report published today (March 4) in Cell Stem Cell . (the-scientist.com)

Some observational studies looking at health outcomes in areas where there have been Zika virus outbreaks e.g. the Pacific and the Americas have demonstrated an increased occurrence of a demyelinating neuropathy known as Guillain-Barré syndrome (3) . (familydoctor.co.nz)
However, it has been unclear whether there represented a true absence of the virus in the region or if outbreaks have simply not been detected. (medindia.net)

2017) Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. (radiopaedia.org)
As of May 2017, cases of locally transmitted Zika virus infection were reported in Miami-Dade County in southeastern Florida and Brownsville, Texas. (msdmanuals.com)

Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. (springer.com)
Guillain-Barré syndrome associated with Zika virus infection. (springer.com)
There's also evidence that Zika might be related to increased incidences of Guillain-Barre Syndrome, which can affect individuals of any sex or age. (oviahealth.com)
While the majority of cases of Zika virus infections will resolve without difficulty in 2 to 7 days, some patients might go on to develop a problem with the nervous system called Guillain-Barre Syndrome. (sundominica.com)
Zika virus footprints tracked to Guillain-Barré syndrome. (hopkinsmedicine.org)
Biological tests support association of Zika and Guillain-Barré syndrome. (hopkinsmedicine.org)
In a collaborative effort with scientists at six Colombian hospitals, Johns Hopkins Medicine researchers report what they believe to be the strongest biological evidence to date linking Zika virus infection and Guillain-Barré syndrome. (hopkinsmedicine.org)

Hence, World Health Organization document Zika virus infection as an important problem that needs urgent attention and management. (oaepublish.com)

Zika virus and complications: Questions and answers. (oviahealth.com)
The researchers are also investigating the frequency of miscarriage and stillbirth, two of the most common complications associated with Zika. (atmph.org)
This infection is associated with several complications. (atmph.org)

The virus is named after the Zika (or Ziika) Forest (near Lake Victoria) in Uganda, as the virus was first isolated in a monkey at this location in 1947 6 . (radiopaedia.org)
In 1947, the Zika virus was first identified in monkeys in the Zika Forest of Uganda. (msdmanuals.com)
The Zika virus was identified in 1947 in Rhesus monkeys in the Republic of Uganda and isolated in humans in 1952 in the same country. (bvsalud.org)
Discovered in Uganda in 1947, the Zika virus has long been thought to be a virus of little importance to humans from a health perspective. (familydoctor.co.nz)

Hypothesis-based studies designed to understand the impact of Zika virus infection on the developing immune system, including characterization of immune responses to childhood vaccines post-Zika virus infection are encouraged. (nih.gov)
Multiple vaccines are also being developed using safe, non-pathogenic, viruses as vectors for immunogenic Zika virus proteins. (wikipedia.org)
Vaccines and antiviral drugs have not yet been developed for Zika, and there are no effective treatments. (atmph.org)
While there are no vaccines against this disease, it is essential to have a good understanding of the virus and the mechanisms of transmission. (atmph.org)

Based on what we know now, the best way to avoid Zika virus infection is to prevent mosquito bites AND to avoid exposure to semen from someone who has been exposed to Zika virus or has been ill from Zika virus infection,' the CDC says. (theverge.com)
Though most news coverage has focused on the risk of mosquito bites transmitting Zika, it has also been determined that the virus can be transmitted sexually . (oviahealth.com)
Can the Zika virus be spread in ways other than mosquito bites? (familydoctor.co.nz)

The infection was confirmed by the Centers for Disease Control and Prevention (CDC). (sdaho.org)

However, after a person has been infected with two types of dengue viruses, they usually gain some degree of immune protection against future dengue disease severity. (sciencedaily.com)

As an immune evasion strategy, the virus inhibits activation of intracellular receptors that detect viral RNA and trigger type I interferon production, such as RIG-I, IRF-3 and MAVS. (news-medical.net)
The antibody, with the virus loosely attached, then shuttles into an immune cell. (imperial.ac.uk)
This immune cell would normally then kill the virus, but because the virus is not properly attached, it breaks free once it gains entry to the human immune cell. (imperial.ac.uk)
Here it hijacks the immune cell's machinery to replicate more viral particles, enhancing the infection. (imperial.ac.uk)
he added that the team also found that a type of antibody may help protect against the phenomenon of ADE, and prevent the virus from hijacking the immune cells. (imperial.ac.uk)
But he cautions that although the study demonstrates a biological and viral association between Zika infection and Guillain-Barré, it does not reveal the biological mechanisms through which Zika might initiate an immune attack on the nerves. (hopkinsmedicine.org)
Forty-five days after being infected and Zika was no longer detectable, the virus was reintroduced to six of the primates, all of which were protected from infection due to immune responses incited by the initial infection. (beckershospitalreview.com)
Dengue and Zika virus infection has been found to up against a human and mosquito immune defense mechanism and highjack specific host proteins for virus replication. (medindia.net)
We explore the intricate structural interactions between viruses and host complexes during virus infection and immune response, which is crucial for exploiting them and uncovering new avenues for the development of therapeutics. (gla.ac.uk)

108 mothers who were seropositive for Zika virus infection but whose children were born healthy served as controls. (charite.de)
Infected mothers should consult a doctor for the diagnosis of Zika. (atmph.org)

Louse- that is endemic to Africa and South- nese encephalitis virus, yellow fever and flea-borne rickettsioses: biological and east Asia. (cdc.gov)
Dengue fever has risen dramatically over recent decades and the virus is thought to cause around 390 million infections each year - with 40 per cent of the world's population living in areas of risk. (imperial.ac.uk)
This has been previously identified in dengue fever, and is thought to be why a second infection with dengue is often more serious than the first. (imperial.ac.uk)
There is no specific treatment for Zika virus infection, but rest, plenty of fluids, and acetaminophen to relieve fever and pain can help. (msdmanuals.com)
[ 3 ] The acute hemorrhagic fever can be the first presentation of Zika virus infection. (oaepublish.com)
[ 8 , 9 ] In fact, Zika virus is usually included in differential diagnosis of acute febrile illness due to arbovirus infections including to yellow fever. (oaepublish.com)
5) A rise in serum antibody to both Zika and yellow fever viruses was demonstrated by both mouse protection and haemagglutination inhibition tests. (paho.org)
The next most common diagnoses were Zika virus infection, Rocky Mountain spotted fever, and dengue. (health.mil)
This is the same mosquito species known to carry other viruses such as the Dengue fever and Yellow fever virus. (familydoctor.co.nz)
The dengue virus, which is responsible for dengue fever and is widely spread across Latin America, was suspected to be one such cofactor. (charite.de)

There are limited reports on liver pathology in Zika virus infection. (oaepublish.com)
In infected death fetus, the molecular pathology also revealed no observed virus in liver tissue. (oaepublish.com)
[ 10 ] Hence, the question whether there is any interrelationship between Zika virus infection and liver pathology is still a topic for further research. (oaepublish.com)
As already noted, the evidence on liver pathology in Zika virus infection is extremely limited. (oaepublish.com)

Studying virus entry using a multidisciplinary toolkit encompassing basic virology, computational/mathematical analysis, structural biology, and advanced microscopy. (gla.ac.uk)

In up to 80% of adult cases, Zika disease is asymptomatic. (radiopaedia.org)
Therefore, animal models are important to test interventions against in utero infection and health sequelae in symptomatic and likely more widespread asymptomatic offspring. (uea.ac.uk)
If not efficiently prevented, asymptomatic infections in combination with reduced mask wearing and social distancing could result in significant continuing circulation of the virus 5 . (nature.com)
Although younger individuals are less prone to develop severe disease, they are susceptible to mild COVID-19 or asymptomatic infection and may facilitate circulation of the virus and the potential for further mutation. (nature.com)

The atypical clinical manifestations can add difficulty in diagnosis of the Zika virus infection. (oaepublish.com)
Developing high throughput methods for generating and analysing virus genomic sequences from clinical samples. (gla.ac.uk)

[ 1 ] The infection can be serious and can cause neurological complication. (oaepublish.com)
Guillain-Barré, which affects an estimated one or two out of 100,000 people after infections, is diagnosed with electrodiagnostic neurological tests that measure the conductive speed and activity of nerve signals. (hopkinsmedicine.org)
The Committee agreed that Zika virus infection and its associated congenital and other neurological disorders continues to be a Public Health Emergency of International Concern (PHEIC). (who.int)

The key thing that our study establishes is that prior Zika infection does significantly increase your risk of both symptomatic and more severe forms of dengue disease," said study first author Leah Katzelnick, who performed the research as postdoctoral scholar at the University of California, Berkeley's School of Public Health. (sciencedaily.com)
I wonder if previous infection with Zika is pushing people into symptomatic disease? (sciencedaily.com)
The protein interferon helps inhibit replication of the virus and is an extremely important part of the response to any viral disease,' she said. (news-medical.net)
Zika virus disease: interim case definitions. (springer.com)
Mackay added that the iPSC-derived neural cells grown in culture "may not yield infection results that accurately reflect disease processes in humans. (the-scientist.com)

Importation of blood products from nonaffected areas might serve a role in prevention of transfusion-transmitted Zika virus. (cdc.gov)
The role and responsibility of executive-level oversight in infection prevention is growing. (infectioncontroltoday.com)
The possibility that cells are not uniformly affected by virus exposure may lead to new therapies or prevention strategies. (eneuro.org)

It can be triggered by a number of bacterial or viral infections. (familydoctor.co.nz)

By mid-autumn, the researchers had enough evidence to prove that having a prior Zika infection made a person more likely to have a symptomatic dengue infection. (sciencedaily.com)
The public health researchers exposed mice to the virus during a period analogous to the third trimester in humans and report different effects depending on the sex and strain of the mouse. (sfn.org)
Women who have previously been infected with dengue virus may be at risk for increased damage to their fetuses and placentas if they should later become infected with the Zika virus, researchers from the Department of Microbiology at the Icahn School of Medicine at Mount Sinai report. (infectioncontroltoday.com)
Researchers from Charité - Universitätsmedizin Berlin and the German Centre for Infection Research (DZIF) have now shown that prior dengue infection protects against damage associated with Zika. (charite.de)
It means that the researchers' initial suspicion - that the dengue virus might act as a cofactor for severe Zika virus infection in the unborn child - could not be confirmed. (charite.de)
After some evaluation, the researchers found urine to be the most reliable fluid to diagnose Zika infection in patients with Guillain-Barré. (hopkinsmedicine.org)
For the study, researchers sought to better understand the molecular dynamics of Zika infection by monitoring the virus in macaques, primates which are highly susceptible to a type of Zika infection genetically similar to the Zika lineages currently infecting humans in the Western Hemisphere. (beckershospitalreview.com)
Researchers detected Zika in the saliva, urine, cerebrospinal fluid and semen of the macaques one day after they were infected with the virus. (beckershospitalreview.com)
Researchers will also enroll women not infected with either virus. (beckershospitalreview.com)

This was the research on the subject with the highest number of participants, managing to detect more clearly the relation between the zika virus and possible congenital conditions. (fiocruz.br)

Arboviruses Arbovirus, arenavirus, and filovirus are viruses that are spread from animals to people and, with some viruses, from people to people. (msdmanuals.com)
This arbovirus infection can cause acute illness and affect fetus in utero. (oaepublish.com)
Zika virus is an arbovirus that can cause acute febrile illness. (oaepublish.com)

The new study suggests the same phenomenon occurs when a person who has previously been exposed to dengue encounters Zika. (imperial.ac.uk)

This research provides a first step toward studying the full range of possible outcomes in individuals exposed to the Zika virus in the womb. (sfn.org)

The study showed that these evasion strategies enabled the virus to persist in placenta, facilitating its replication and transmission to the fetus. (news-medical.net)
An autopsy performed at the time of delivery revealed the fetus to have been infected with Zika virus. (atmph.org)
Although there are no signs of this virus in the mother, the infection is dangerous for the fetus. (atmph.org)

The team, who were also supported by the National Institute for Health Research Imperial Biomedical Research Centre , added them to human cell cultures, together with the Zika virus. (imperial.ac.uk)

Mice exposed to the Zika virus during later stages of gestation present behaviors reminiscent of attention-deficit/hyperactivity disorder, according to a study of genetically diverse animals . (sfn.org)
Prior infection with the genetically related dengue virus had been assumed to enhance the effects of subsequent Zika virus infection. (charite.de)
By producing a phylogenetic tree of the Zika virus in Thailand, the scientists discovered that the viral strains within Thailand were genetically very different from each other, and their ancestor seems to have appeared in the country in 2002. (medindia.net)

The Zika virus outbreak in Latin America has so far affected more than 60 million people. (charite.de)
For one thing, he said, the virus strain used in the study differs to the one responsible for the ongoing outbreak in Latin America. (the-scientist.com)

Applications that include studies of neonates (0-28 days), infants (29 days-1 year) or relevant animal models infected with Zika virus in utero or postnatally are responsive to this FOA. (nih.gov)

Getting sick with one type of dengue virus can increase the likelihood that a person will develop a second, more severe illness when infected with a separate type of dengue virus. (sciencedaily.com)
People with prior dengue infection therefore need not worry about subsequently developing more severe forms of Zika infection. (charite.de)

Unlike humans, viruses do not have a genetic repair system," says Henrik Salje. (medindia.net)

Since November 2015, Puerto Rico has reported active mosquito-borne transmission of Zika virus ( 1 ). (cdc.gov)

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