Assess endothelial function. Medical search. Frequent questions

Endothelial dysfunction is an early marker of atherosclerosis and levels of vascular relaxation are an indicator of endothelial health. (escardio.org)
Moreover, endothelial dysfunction has been shown in varied populations to be a predictor of cardiovascular events. (escardio.org)
In patients with endothelial dysfunction, this process is disturbed and results in decreased vasodilation, thus demonstrating the dysfunction. (escardio.org)
Atherosclerosis and endothelial dysfunction are diffuse disease processes affecting coronary and peripheral arteries, hence, the physiological basis in assessing endothelium-dependent vasomotion in peripheral vessels. (escardio.org)
A lack of vasodilation would suggest decreased release of endogenous vasodilators and therefore, endothelial dysfunction, thus indicating future cardiovascular risk: increased risk for future cardiovascular events and a potential need for revascularisation (5). (escardio.org)
In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium. (wikipedia.org)
Endothelial dysfunction may be involved in the development of atherosclerosis and may predate vascular pathology. (wikipedia.org)
Endothelial dysfunction can also lead to increased adherence of monocytes and macrophages, as well as promoting infiltration of LDL in the vessel wall. (wikipedia.org)
Dyslipidemia and hypertension are well known to contribute to endothelial dysfunction, and lowering blood pressure and LDL has been shown to improve endothelial function, particularly when lowered with ACE inhibitors, calcium channel blockers, and statins. (wikipedia.org)
A feature of endothelial dysfunction is the inability of arteries and arterioles to dilate fully in response to an appropriate stimulus, such as exogenous nitroglycerine, that stimulates release of vasodilators from the endothelium like NO. Endothelial dysfunction is commonly associated with decreased NO bioavailability, which is due to impaired NO production by the endothelium or inactivation of NO by reactive oxygen species. (wikipedia.org)
A non-invasive method to measure endothelial dysfunction is % Flow-Mediated Dilation (FMD) as measured by Brachial Artery Ultrasound Imaging (BAUI). (wikipedia.org)
Since NO maintains low tone and high compliance of the small arteries at rest, a reduction of age-dependent small artery compliance is a marker for endothelial dysfunction that is associated with both functional and structural changes in the microcirculation. (wikipedia.org)
Calcium channel blockers and selective beta 1 antagonists may also improve endothelial dysfunction. (wikipedia.org)
More specifically, proinflammatory adipokines from visceral adipose tissue may initiate the development of insulin resistance, microvascular dysfunction, and endothelial dysfunction. (hindawi.com)
Insulin resistance and endothelial dysfunction have both been implicated in the pathogenesis of hypertension [ 3 - 7 ] and atherosclerosis [ 8 , 9 ]. (hindawi.com)
and endothelial dysfunction measured with the increase in forearm blood flow from resting baseline to maximal vasodilation (FBF % increase). (hindawi.com)
The study was designed to evaluate the role of inflammation markers in the development of insulin resistance, microvascular dysfunction, and endothelial dysfunction and eventually the progression to (pre)diabetes and (pre)hypertension. (hindawi.com)
Endothelial dysfunction, as an early pivotal event in cardiovascular disease, is strongly associated with the pathogenesis of DM [ 1 , 2 ]. (hindawi.com)
There is evidence that the endothelial dysfunction induced by hyperglycemia is associated with the enhanced nitrooxidative stress. (hindawi.com)
Both TP and TP-H topically penetrate and function in skin or mucosa, protecting and treating radiation burns and hair loss or smoking-induced cutaneous vascular dysfunction. (frontiersin.org)
Endothelial arginase 1 was ablated to assess whether this prevents hyperglycemia-induced endothelial dysfunction by improving arginine availability for nitric oxide production. (nih.gov)
Several studies provide evidence to support the association between postprandially elevated triglyceride concentrations and endothelial dysfunction. (nature.com)
This triglyceride-induced endothelial dysfunction is likely due to a combination of both acute morphological and cellular changes. (nature.com)
Inflammation has emerged as a central mediator of endothelial dysfunction, and by extension, vascular disease ( 1 ). (frontiersin.org)
Conclusions: This study has identified dysfunction of the systemic vascular endothelial cell in patients with normal pressure glaucoma. (bmj.com)
Endothelial dysfunction is regarded as a precursor and a surrogate marker of atherosclerosis and coronary artery disease. (nepjol.info)
One hundred subjects with various cardiovascular risk factors were selected and endothelial dysfunction was assessed by measuring flow-mediated dilation of brachial artery. (nepjol.info)
The rates of endothelial dysfunction was compared between subjects with and without metabolic syndrome. (nepjol.info)
Only age and hypertension were associated with endothelial dysfunction. (nepjol.info)
The association between metabolic syndrome and endothelial dys-function was not significantly different than the association between multiplex of risk factors and endothelial dysfunction. (nepjol.info)
Alterations of vascular smooth muscle function have been implicated in the development of vascular complications and circulatory dysfunction in diabetes. (diabetesjournals.org)
One of the sentinel features of atherosclerosis is endothelial cell dysfunction that manifests itself in a variety of ways including poor nitric oxide production, poor vasodilatory response, and increased adhesiveness to leukocytes ( 1 ). (diabetesjournals.org)
Another potential endothelial dysfunction commonly observed in diabetes is altered permeability to macromolecules. (diabetesjournals.org)
Atherogenesis and endothelial dysfunction contribute to cardiovascular risk and vitamin D has been implemented in endothelial repair. (bvsalud.org)
More evidence is required before recommendations for management of endothelial dysfunction can be made. (bvsalud.org)
Diabetes is a disease characterized by endothelial dysfunction and premature vascular aging, [ 6 ] and the adverse endothelial effects of PPIs [ 1 ] could accelerate diabetes-associated angiopathy and contribute to complications and death. (medscape.com)
ABSTRACT This study assessed changes in serum levels of cytokines IFN and IL-10 (biomarkers of in ammatory changes) and soluble biomarkers sICAM-1 and sE-selectin (biomarkers of endothe- lial dysfunction) in diabetic patients with and without nephropathy. (who.int)
haemodialysis (HD), dysfunction of the The purpose of the present study was to host defences against infection has major assess the changes in serum levels of the clinical and socioeconomic implications. (who.int)
However, the biomarkers sICAM-1 and sE-selectin (as mechanism of this immune dysregulation markers of endothelial dysfunction) in dia- is still unclear. (who.int)

Treatment of hypertension and hypercholesterolemia may improve endothelial function in people taking statins (HMGCoA-reductase inhibitor), and renin angiotensin system inhibitors, such as ACE inhibitors and angiotensin II receptor antagonists. (wikipedia.org)
Life style modifications such as smoking cessation have also been shown to improve endothelial function and lower the risk of major cardiovascular events. (wikipedia.org)
In an exploratory way, quercetin supplementation could also improve endothelial function by eliminating senescent vascular endothelial cells. (frontiersin.org)
In older HIV-positive people with or at risk of cardiovascular disease, 24 weeks of low-dose methotrexate (LDMTX) reduced CD8-cell numbers and activation but did not quell other markers of inflammation or improve endothelial function [1]. (natap.org)
They hypothesized (1) that LDMTX would cause no more than a 15% increase in probability of "safety events" (including drops in CD4 count and virologic failure) compared with the background rate, and (2) that reducing inflammation would improve endothelial function assessed by flow-mediated vasodilation of the brachial artery. (natap.org)

VEGF, produced in large amounts by cancer cells during tumor growth, interacts with its receptors VEGFR1 and VEGFR2 thereby causing endothelial cell survival, proliferation, and sprouting [7] . (plos.org)

Additionally, there is considerable debate regarding what is the most appropriate method for assessing endothelial function. (escardio.org)

However, the effects of NAC on LPS‑induced apoptosis of human umbilical vein endothelial cells (HUVECs) and the associated mechanisms are not well characterized. (spandidos-publications.com)

Objective -To develop and assess the reproducibility of a protocol to noninvasively test endothelial function in dogs on the basis of the flow-mediated vasodilation (FMD) procedure used in humans. (avma.org)
Sixteen healthy, nonsmoking women were studied, each on four occasions during one 24-h period (2:00 PM, 8:00 PM, 2:00 AM, and 8:00 AM). Endothelial function was assessed by ultrasound determinations of flow-mediated vasodilation (FMD%) in the brachial artery. (lu.se)

It activates endothelial cells and stimulates nitric oxide release. (escardio.org)
Atherosclerosis Endothelial activation Nitric oxide endothelial nitric oxide synthase Prostacyclin Endothelium-derived relaxing factor Endothelin Integrin network Endothelial shear stress Sitia, S. (wikipedia.org)
Oxidative damage, inflammation markers and signalling pathways for nitric oxide synthesis were also assessed. (nutraingredients.com)
The pigs on high cholesterol diets showed up to a 50% reduction in dilating function, as expected, as well as a diminished capacity to synthesise nitric oxide. (nutraingredients.com)
Acitvity of the eNOS enzyme (endothelial nitric oxide synthase), an enzyme involved in the synthesis of nitric nxide, was also preserved. (nutraingredients.com)
The expression of caspase‑3, Bax, Bcl‑2, phosphorylated (p)‑p38MAPK/total (t‑)p38MAPK and p‑endothelial e nitric oxide synthase (eNOS)/t‑eNOS proteins were determined by western blotting. (spandidos-publications.com)

The data show that endothelial ablation of arginase 1 in mice does not markedly modify smooth muscle and endothelial functions of a resistance artery under normo- and hyperglycemic conditions. (nih.gov)
Therefore, smooth muscle and endothelial cell function were assessed in 20 patients with diabetes and compared with 41 age-matched control subjects. (diabetesjournals.org)

Physiologically, in patients with a normal endothelial response, acetyl-choline will cause released access to the vasodilators, and result in dilation of blood vessels and hyperaemia. (escardio.org)
Furthermore, a negative correlation between percent flow mediated dilation and baseline artery size is recognised as a fundamental scaling problem, leading to biased estimates of endothelial function. (wikipedia.org)
The flow mediated dilation (FMD) test is the most commonly utilized, non-invasive, ultrasound assessment of endothelial function in humans. (jove.com)
The flow-mediated dilation, or FMD test, can be used to answer key questions in the cardiovascular field, with the potential for standardized clinical monitoring of vascular function in patients. (jove.com)
Endothelial function was evaluated by flow mediated dilation and myocardial fibrosis by soluble ST2. (nih.gov)
For the first study, they assessed the effect of different doses of blueberry flavonoids (766, 1278, and 1791 mg total blueberry polyphenols) on flow-mediated dilation (FMD) - a measure of the elasticity of blood vessels - at different times (1, 1, 2, 4, and 6 hours). (nutraingredients.com)

Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. (plos.org)
Moreover, we found that glioblastoma cells, notorious for their VEGF production, elicited a similar response when co-cultured with endothelial cells [11] . (plos.org)
Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). (nature.com)
We characterize the role of increased Lyn kinase activity in neutrophils, endothelial cells and lesional liver biopsies and utilized an iPSC-derived endothelial cell platform for disease modeling of neutrophilic vasculitis and to screen and evaluate drug efficacy. (nature.com)
Neutrophil migration in response to factors secreted by the treated endothelial cells was then assessed. (bl.uk)
This response was probably initiated by reactive oxygen species (ROS) generated by the endothelial cells. (bl.uk)
Soluble factor (s) from hypoxia/reoxygenated endothelial cells also had a powerful neutrophil chemoattractant ability. (bl.uk)
When neutrophils were exposed to both hypoxic/reoxygenated endothelial cells and the soluble factor (s) released by them a large oxidative burst was elicited. (bl.uk)
The secretory products from hypoxia/reoxygenated endothelial cells also affected smooth muscle contractility having an anti-vasoconstrictor or relaxation property, similar to that exerted by PAF. (bl.uk)
However, few studies have investigated LPS-induced apoptosis of vascular endothelial cells. (spandidos-publications.com)
Furthermore, periodontitis has been shown to be associated with systemic cardiovascular disease ( 5 - 7 ), which suggests its close association with vascular endothelial cells. (spandidos-publications.com)
The apoptosis of endothelial cells is a key event that may impair the integrity of the vessel wall and lead to the formation of atherosclerotic plaques ( 9 ). (spandidos-publications.com)
The secondary endpoint is the assessment of endothelial (dys) function by looking at ex vivo vascular reactivity and mRNA expression of endothelial cells from the wall of discarded segments of internal mammary artery. (frontiersin.org)
The research, led by Dr Jeremy Spencer from the University of Reading, investigated the impact of blueberry flavonoids on the function of the cells lining blood vessels (endothelium) in healthy men. (nutraingredients.com)
Results: The in vitro experiment results showed that SBP could significantly increase the expression of mRNAs and proteins associated with angiogenesis in endothelial cells by activating macrophages to release pro-angiogenic factors such as Vegf-a. (visualsonics.com)
Altered functional and molecular responses of endothelial cells treated with serum collected from rats exposed to different welding fumes. (cdc.gov)
Because vascular endothelial cells play a pivotal role in cardiovascular disorders, we used serum collected from exposed animals to assess its molecular and functional effects on in vitro cultures of primary cardiac microvascular endothelial (PCME) cells or ex vivo cultured aortas from naïve rats as a strategy for evaluating altered endothelial cell function. (cdc.gov)
As an initial screen, PCME cells from rats were challenged for 4 h with serum from WF or vehicle-exposed animals, and 84 genes related to endothelial cell biology were analyzed from the mRNA isolated from challenged cells. (cdc.gov)
IPA predicted that serum from animals exposed to MMA-SS, and not GMA-MS or PBS, had influence on several functional aspects of endothelial cells, including angiogenesis and migration. (cdc.gov)
The oxygen saturation, fraction of red blood cells and speed-resolved microcirculatory perfusion (% red blood cells x mm/s) divided into three speed regions: 0-1, 1-10 and above 10 mm/s, were assessed during baseline and after local heating of the foot with a new device integrating diffuse reflectance spectroscopy and laser Doppler flowmetry. (diva-portal.org)
Cholinergic mechanisms are important in the control of peripheral skin perfusion and, in part, are regulated by endothelial cells. (meresearch.org.uk)
Potential mechanisms underlying the diabetes-related changes in the blood-brain barrier (BBB) include altered expression of key structural and enzymatic proteins, alterations in the lipid composition and fluidity of the membranes, alterations in the neurotransmitter activity, and increased oxidative damage of the endothelial cells ( 2 , 6 ). (diabetesjournals.org)
It has been particularly difficult to measure changes in electrical functions of cells grown within Organ Chips that are normally electrically active, such as neuronal cells in the brain or beating heart cells, both during their differentiation and in response to drugs. (harvard.edu)
These electrically active Organ Chips help to open a window into how living human cells and tissues function within an organ context, without having to enter the human body or even remove the cells from our chips," said Ingber. (harvard.edu)
Epithelial cells form tissue layers that cover our skin and the inner surfaces of most of our internal organs, while endothelial cells line the adjacent blood-transporting vessels and capillaries that support their functions. (harvard.edu)
The availability of C4bBP regulates the proportion of the free and bound forms of protein S. Synthesis of protein S occurs in the liver, endothelial cells, and megakaryocytes. (medscape.com)

This study manifests that enriching a diet with pomegranate polyphenols can help in preventing and retarding endothelial dysfunctions, among the first signs of atherosclerosis and cardiovascular diseases. (nutraingredients.com)

The discovery of de novo gain-of-function (GOF) mutations in IL-1 activating inflammasomes (NLRP3, NLRC4, pyrin, and NLRP1) and Type-1 IFN activating viral sensors (STING, RIG-I, and IFIH1/MDA5) linked key innate immune pathways to sterile inflammation. (nature.com)
We assessed the effects of omega-3 PUFAs supplements on inflammation, fibrosis, left ventricle performance and endothelial function of ischemic heart failure (HF) patients. (nih.gov)
It is therefore possible that inhibiting complement activation would reduce inflammation, lead to reduced fibrosis and preservation of renal function. (wjgnet.com)
During Q&A question by Jens Lundgren raised the question that under powering may not have detected benefits, Hsue said when we designed the study safety was the primary endpoint, although we also wanted to look at the impact on inflammation, and because of the greater variability in IL-6 measurement and FMD we may have been underpowered to assess the impact on these single biomarker measurements. (natap.org)
The aim of the present study was to determine the pro-angiogenic effects and mechanism of SBP during inflammation or ischemic pathological conditions and elucidate its regulatory effects on endothelial cell function and signaling pathways mediated by macrophages. (visualsonics.com)

We also performed cell proliferation, cell migration and tubule formation in vitro experiments to assess the effects of SBP on endothelial cell function and signaling pathways by stimulating macrophage activity. (visualsonics.com)
Activation of macrophages by SBP eventually led to endothelial cell proliferation, migration and tubule formation and increased the expression of p-Akt and p-Erk1/2 proteins in the downstream PI3K/Akt and MAPK/Erk1/2 signaling pathways related to angiogenesis, respectively. (visualsonics.com)

Therefore a study was designed to evaluate the role of metabolic syndrome as a cardiovascular risk factor by assessing endothelial function in subjects with it. (nepjol.info)
Similarly the rates of metabolic syndrome was calculated in subjects with and without endothelial dys-function in this cohorts of cardiovascular risk factors. (nepjol.info)
We have examined this hypothesis and also assessed PPI effects on renal function and cardiovascular risk by using longitudinal observational data from the representative community-based Fremantle Diabetes Study Phase II (FDS2). (medscape.com)

The genesis of an inappropriate oxidative burst by the neutrophil upon exposure to endothelial chemoattractants and adhesion molecules was also measured. (bl.uk)

Whether in coronary or peripheral arteries, response to pharmacological agents and/or to hemodynamic provocation tests is assessed as a measure of endothelial function (2). (escardio.org)
Numerous methods for evaluating the peripheral arterial system have emerged as alternatives to coronary endothelial function testing. (escardio.org)
citation needed] In the coronary circulation, angiography of coronary artery responses to vasoactive agents may be used to test for endothelial function, and venous occlusion plethysmography and ultrasonography are used to assess endothelial function of peripheral vessels in humans. (wikipedia.org)
After the trial period, the researchers analysed each pig's capacity to dilate its coronary artery, known as the endothelial function. (nutraingredients.com)

All studies assessed EF using commonly applied methods including ultrasound, plethysmography, and pulse wave analysis. (naturalmedicinejournal.com)

In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)

Current measurements of endothelial function via FMD vary due to technical and physiological factors. (wikipedia.org)
To accomplish this mission, the ACNC has the following objectives and as appropriate, others as mutually agreed upon: A. Determine how maternal/parental diet, exercise, and metabolic health associate with psychological/behavioral, neurologic and physiological function and development in children. (usda.gov)
B. Understand how postnatal diet, childhood physical activity, and nutrition associate with psychological/behavioral, neurologic and physiological function and development in children. (usda.gov)
The plan shall be divided into the following areas: A. Determine how dietary components, dietary patterns, and metabolic health influence psychological-behavioral outcomes, neurodevelopment, and physiological function in children. (usda.gov)
Children will be studied longitudinally and cross-sectionally to evaluate the effects of child/parental diet, metabolic health, and body composition on psychological-behavioral, neurologic and physiological function. (usda.gov)
B. Determine how physical activity and fitness influence psychological-behavioral outcomes, neurodevelopment, and physiological function in children. (usda.gov)

However, in real world scenario, this is just a combination of multiple CV risk factors and its separate existence is somehow regarded as a myth in endothelial function assessment. (nepjol.info)

Skin and kidney microvascular functions may be affected independently in diabetes mellitus. (diva-portal.org)

This analysis highlights the positive impact vitamin C has on endothelial function, which is good news for some of our most vulnerable patients-those with heart disease and diabetes. (naturalmedicinejournal.com)
We investigated skin microcirculatory function in 79 subjects with diabetes type 2, where 41 had microalbuminuria and 38 not, and in 41 age-matched controls. (diva-portal.org)
Diabetes in humans and in animal models has been found to cause significant alterations in endothelial permeability in various vascular beds ( 2 - 5 ). (diabetesjournals.org)
To assess the impact of PPI use on nephropathy and cardiovascular disease (CVD) risk in type 2 diabetes. (medscape.com)
Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)
Diabetic group ( n = 17): patients with in patients with chronic renal failure and type 2 diabetes without renal involve- under HD, and disturbances in endothelial ment (normoalbuminuria). (who.int)
The diagno- function may play a role in vascular com- sis of type 2 diabetes was established plications such as stroke or ischaemic heart before they were screened for the study disease. (who.int)

We will investigate the effects of exenatide on vascular endothelial injury and nitrooxidative stress in hyperglycemia both in vivo and in vitro and explore the role of nitrooxidative stress in endothelium-protective action of exenatide. (hindawi.com)
Recent evidence has indicated that the vascular endothelial injury induced by hyperglycemia is associated with the enhanced nitrooxidative stress both in vivo and in vitro [ 3 - 6 ]. (hindawi.com)
In vitro , the sprouting and migratory properties of primary endothelial cell cultures were reduced by inhibiting EZH2 through up-regulation of miR-101, siRNA-mediated knockdown of EZH2, or treatment with 3-Deazaneplanocin-A (DZNep), a small molecule inhibitor of EZH2 methyltransferase activity. (plos.org)
A recent in vitro study found that prolonged exposure to the proton pump inhibitor (PPI) esomeprazole impaired endothelial function and accelerated human endothelial senescence by reducing telomere length. (medscape.com)
The material from each step isscreened using acellular and in vitro assays for evaluating general toxicity, mechanisms of toxicity, and macrophage function. (cdc.gov)

He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)

In addition, it has also shown beneficial effects on both cardiac [ 11 - 13 ] and vascular endothelial functions [ 14 - 19 ]. (hindawi.com)
Airflow obstruction has profound effects on cardiac function and gas exchange with systemic consequences. (ersjournals.com)

Effect of vitamin D supplementation on endothelial function - An updated systematic review with meta-analysis and meta-regression. (bvsalud.org)
This systematic review , meta-analysis and meta-regression aims to establish the effect of vitamin D supplementation on endothelial function. (bvsalud.org)
Vitamin D supplementation showed no improvement in endothelial function. (bvsalud.org)

Impaired peripheral endothelial function has also independently predicted adverse outcomes in specific patient cohorts, such as heart failure cohorts (6). (escardio.org)
Independently, prolonged uninterrupted sitting and the consumption of a meal high in saturated fats acutely disrupt normal cardiovascular function. (nature.com)

Subjects were categorized renal function [ 4 ]. (who.int)

That suggests increased resilience, because it shows some better functioning and movement back toward baseline. (wildmind.org)
TEER measurements that are based on restriction of ion passage or electrical resistance, can thus be used to assess both the baseline functional integrity of these cell layers and damage responses that are triggered by drugs or other toxic agents. (harvard.edu)

Methods were initially developed to examine the adhesion of neutrophils to monolayers of a cultured endothelial cell line (ECV304) after periods of hypoxia and reoxygenation. (bl.uk)
Finally to appraise how tissue function might be affected by endothelial cell hypoxia the contractility of vascular smooth muscle was examined. (bl.uk)

iii) absence of several haematopoietic and endothelial markers (ie, CD45, CD34, CD11b or CD14, CD79 or CD19 and HLA-DR in human MSCs). (bmj.com)

Arterial stiffness was assessed as carotid-femoral pulse wave velocity. (diva-portal.org)

Short term treatment with omega-3 PUFAs in subjects with stable ischemic HF improved inflammatory and fibrotic status as well as endothelial function in parallel with systolic and diastolic performance of left ventricle. (nih.gov)

Ashor AW, Lara J, Mathers JC, Siervo M. Effect of vitamin C on endothelial function in health and disease: a systematic review and meta-analysis of randomized controlled trials. (naturalmedicinejournal.com)

We previously showed that VEGF signaling in primary endothelial cell cultures caused overexpression of VEGFR2 in a positive feed-forward loop, which is at least partly regulated by loss of miRNA-mediated control of VEGF receptor degradation. (plos.org)
Analysis of the supernatant from hypoxic/reoxygenated endothelial cell cultures and studies using inhibitors of secretion suggested platelet activating factor (PAF) may be a major component in this overall sequence of events. (bl.uk)

Endothelial Arg1-deficient mice (Arg1-KO T ie2 ) were generated by crossing Arg1 fl/fl (controls) with Tie2Cre tg/- mice and analyzed by immunohistochemistry, measurements of hemodynamics, and wire myography. (nih.gov)
The endothelial vasodilatation function of mesenteric arteries was assessed with the use of wire myography. (aspetjournals.org)

Measurements made at 15, 30, and 60 seconds following release of the occlusion were compared with measurements made immediately prior to each occlusion to assess the FMD response. (avma.org)

Sirolimus eluting stents were previously used because they showed low rates of in-stent restenosis, but further investigation showed that they often impair endothelial function in humans and worsen conditions. (wikipedia.org)

As predicted, both functional endpoints were significantly changed when challenged with serum from MMA-SS but not GMA-MS, suggesting that pulmonary MMA-SS exposure has the potential to cause altered endothelial function systemically. (cdc.gov)
Although low in intensity, this [exposure] is sufficient to set off a series of events that eventually lead to vascular endothelial injury, changes to neurons and astrocytes, and damage to the neuropil. (medscape.com)
There isno alteration in macrophage function after BNNT exposure with all purity grades. (cdc.gov)
As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)

The replacement of functioning nephrons by fibrosis is characteristic of progressive disease. (wjgnet.com)

Conclusion: Shexiang Baoxin Pills can promote angiogenesis by activating macrophages to regulate endothelial cell function and signal transduction pathways. (visualsonics.com)

9 Impaired systemic vascular function has been demonstrated in patients with NPG in whom blood flow in the fingers is reduced 10, 11 (both under basal conditions and following cold provocation) and endothelium dependent vasodilatation in the forearm is impaired. (bmj.com)
Flavonoids from blueberries may improve vascular function in healthy men, according to findings of two randomized, controlled, double-blind, crossover human-intervention trials from Europe. (nutraingredients.com)
The improvements in vascular function in healthy men were linked to both the time and dose of blueberry flavonoids, report scientists from the University of Reading (UK), the University Düsseldorf (Germany), and the University of Northumbria (UK). (nutraingredients.com)
In sum, this is a well-designed human study showing that blueberry intake improves vascular function in male volunteers. (nutraingredients.com)

This study aimed to determine whether the function of systemic resistance arteries was altered in patients with NPG. (bmj.com)
Methods: Contractile and relaxant function was assessed in arteries dissected from gluteal fat biopsies (11 NPG, 12 control) using small vessel myography. (bmj.com)
The experiment assesses whether test articles cause vasoconstriction in human subcutaneous resistance arteries with PDA-angiotensin 1 as a reference compound. (reprocell.com)

Vessels are then challenged with an appropriate vasoconstrictive agent before endothelial function is assessed by the addition of the appropriate endothelial dependent vasorelaxant agent. (reprocell.com)

Studies were designed to assess vitamin C's effect on EF in healthy volunteers and in atherosclerotic, diabetic, and/or heart failure patients. (naturalmedicinejournal.com)

In conclusion, this study demonstrates that exenatide treatment can alleviate the vascular endothelial injury, as well as attenuating the nitrooxidative stress in hyperglycemia, implying that the endothelium-protective effect of exenatide might be related to the reduction of nitrooxidative stress. (hindawi.com)

and Obesity and its Effects on Cellular and Physiologic Function in mothers, infants and children. (usda.gov)

Statins may have favorable effects on endothelial barrier function. (diabetesjournals.org)

12 The relatively small number of studies to have assessed vascular reactivity and blood flow in the systemic circulation of these patients, however, prevents identification of the mechanisms underlying these abnormalities. (bmj.com)

The overall goal of this noninvasive technique is to assess endothelial function in humans. (jove.com)

Carotid-femoral (cf) and femoral-ankle (fa) pulse wave velocity (PWV), aortic-femoral stiffness gradient (af-SG), superficial femoral PWV beta (β), and oscillometric pulse wave analysis outcomes were assessed pre and post sitting. (nature.com)
The purpose of this study was to investigate the relationship between trait mindfulness assessed in the first or early second trimester to health outcomes throughout pregnancy. (researchgate.net)
Other studies indicate that individuals with periodontitis have worse outcomes on various neuropsychological tests of cognitive function. (medscape.com)

Albuminuria is considered to reflect widespread endothelial damage [ 7 , 8 ] and could be used as an in vivo marker of PPI effects on the vasculature. (medscape.com)

According to Leira, "There are currently several research groups in the United States and Europe, including ours, that are performing clinical trials to assess the impact of periodontal treatment on recurrent vascular events in patients with cerebrovascular disease. (medscape.com)

ROS generation in turn caused the release of a soluble factor (s) which induced a conformational change on the neutrophil surface allowing it to bind to the intercellular adhesion molecule 1 (ICAM-1) on the endothelial cell. (bl.uk)

Currently, it is not known what the effects of prolonged uninterrupted sitting with and without a high-fat meal are on cardiovascular function. (nature.com)
Dietary Factors and Physical Activity Effects on Health, Development and Function of Organ Systems (skeleton, gastrointestinal and hepatic tissues, immune system, cardiovascular, and muscle, e.g. (usda.gov)

Anatomy32

Organisms12

Diseases28

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes38

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture7

Health Care15

Geographicals1

Dysfunction39

Improve endothelial function5

Causing endothelial cell1

Method for assessing endothelia1

Human umbilical vein endothelial cells1

Flow-mediated vasodilation2

Nitric6

Smooth muscle and endothelial2

Dilation6

Cells26

Atherosclerosis1

Inflammation5

Proliferation2

Cardiovascular risk3

Oxidative1

Coronary4

Ultrasound1

Proteins1

Physiological6

Assessment1

Microvascular1

Diabetes7

Vitro5

Migration1

Cardiac2

Supplementation3

Independently2

Renal function1

Baseline2

Hypoxia2

Markers1

Arterial1

Ischemic1

Systematic review1

Cell cultures2

Wire myography2

Occlusion1

Impair1

Exposure4

Fibrosis1

Macrophages1

Vascular function4

Arteries3

Vessels1

Diabetic1

Endothelium1

Cellular1

Statins1

Systemic1

Humans1

Outcomes3

Vivo1

Clinical1

Adhesion1

Effects2