Other procedures discussed in this review are the percutaneous left atrial appendage closure as a non-pharmacologic therapy to prevent strokes, and renal denervation for resistant hypertension. (bmj.com)
Other important developments are the percutaneous treatment options for mitral regurgitation (MR) (MitraClip), non-pharmacologic therapy to prevent cerebral embolisation in patients with atrial fibrillation (AF) such as left atrial appendage (LAA) closure and closure of the patent foramen ovale, and renal denervation to treat resistant hypertension. (bmj.com)
He recently completed studies on renal denervation for resistant hypertension and use of a recently FDA-approved agent, patiromer, for controlling serum potassium in high-risk people with advanced kidney disease. (uchicagomedicine.org)
Comparative efficacy and safety of renal denervation (RDN) interventions for uncontrolled (UH) and resistant hypertension (RH) is unknown. (edu.pe)
The last decade has witnessed intense research into minimally invasive sympathetic denervation therapies - from catheter-based drug delivery systems to sonic and RF ablation devices - to treat chronic diseases such as systemic hypertension, metabolic syndrome, sleep apnea, heart failure, liver cirrhosis and rheumatoid arthritis. (cbset.org)
The purpose of the assessment is to assess the effectiveness and safety of renal denervation systems for patients who suffer from treatment-resistant hypertension compared to standard of care (no treatment, additional pharmacological treatment, device-based hypertension therapy and sham treatment). (scubacapsule.fr)
Time in therapeutic range (TTR) of BP is associated with cardiovascular events.OBJECTIVES This study sought to assess the impact of catheter-based RDN on TTR and its association with cardiovascular outcomes in the GSR (Global SYMPLICITY Registry).METHODS Patients with uncontrolled hypertension were enrolled and treated with radiofrequency RDN. (univr.it)
Sympathetic Denervation5
Rushil conducted translational research centered on advancements in Cardiac Magnetic Resonance Imaging, VT Ablation, Atrial Fibrillation, Cardiac Sarcoidosis, Cardiac Sympathetic Denervation and Hypothermia Induction in the animal experiment lab at Johns Hopkins under the supervision of Harikrishna Tandri, MD, FACC. (stanford.edu)
How can we judge sympathetic denervation from the external manifestation in the human skin? (biomedres.info)
The external monitoring indicators of sympathetic denervation are reviewed to facilitate the clinical diagnosis of sympathetic diseases and the results of sympathectomy. (biomedres.info)
Sympathetic denervation can be assessed simply and accurately using many external indicators to diagnose sympathetic-related diseases or evaluate the effectiveness, complications, and prognosis of sympathectomy. (biomedres.info)
Catheter-based2
Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy. (cbset.org)
Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. (cbset.org)
Radiofrequency8
[ 11 ] Many investigators developed techniques to diagnose facet joint pain using intra-articular joint blocks and medial branch nerve blocks, as well as ways to treat such pain with intra-articular steroids, surgical ablation, or radiofrequency (RF) denervation. (medscape.com)
In three randomised trials, treatment of chronic low back pain (CLBP) with radiofrequency denervation resulted in either no improvement or no clinically important improvement in pain, according to a study published by the Journal of the American Medical Association ( JAMA ). (spinalnewsinternational.com)
Even though radiofrequency denervation is a commonly-used treatment, high-quality evidence for its effectiveness is lacking. (spinalnewsinternational.com)
Participants in the intervention group received radiofrequency denervation as well, which is usually a one-time procedure, but the maximum number of treatments in the trial was three. (spinalnewsinternational.com)
The researchers found that two trials assessing radiofrequency denervation for the sacroiliac joints and a combination of the facet joints, sacroiliac joints, or intervertebral disks showed a statistically significant but not clinically important improvement in pain intensity three months after the intervention. (spinalnewsinternational.com)
No clinically important or statistically significant differences between the groups were shown in the trial assessing radiofrequency denervation for facet joint pain. (spinalnewsinternational.com)
The findings do not support the use of radiofrequency denervation to treat chronic low back pain from these sources," the authors write. (spinalnewsinternational.com)
Because the aim of the study was to provide evidence of the added value of radiofrequency denervation in a multidisciplinary setting, as done in daily practice, the study was limited by a lack of both participant and clinician blinding. (spinalnewsinternational.com)
Clinical8
This may help explain recent clinical imaging studies using meta-iodobenzylguanidine (MIBG) and 11C-meta-hydroxyephedrine positron emission tomography (PET) which demonstrate that border zone denervation is strongly associated with a high risk of future arrhythmia. (frontiersin.org)
for therapeutic decisions as well as prognosis, we describe however, the exact etiology of this acute flaccid paralysis the detailed clinical, laboratory, and electrophysiologic has not been systematically assessed. (cdc.gov)
It is likely that a significant proportion of the 4-15% of de novo patients recruited for recent clinical trials with antiparkinsonian drugs who have no evidence of nigrostriatal dopaminedenervation on functional imaging (subjects without evidence of dopaminergic deficit (SWEDDs)) have tremulous syndromes other than PD. (bmj.com)
This is supported by long term follow-up showing minimal clinical deterioration, no response to dopaminergic therapy and in some cases no evidence on repeat functional imaging of dopaminedenervation. (bmj.com)
In this study, the clinical features of patients with tremor and parkinsonism were assessed by two blinded movement disorder specialists (DGG and AJL). (bmj.com)
Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model. (cbset.org)
Patients were assessed for their clinical condition, respiratory disturbances, physical capacity, heart function and laboratory tests. (krakow.pl)
The objective of this study is to assess the safety and initial effectiveness of the TIVUS™ System when used for pulmonary artery denervation in group II PH patients through change in clinical parameters including hemodynamics, exercise tolerance, and quality of life. (ucsd.edu)
Efficacy4
We identified 204 studies (531 experiments) assessing the efficacy of pregabalin in behavioral models of pain. (iasp-pain.org)
We assessed the comparative efficacy and safety of existing RDN interventions for UH and RH. (edu.pe)
Since the inception of this technology, CBSET has led the way in developing animal models for assessing safety, as well as quantitative methods for assessing and understanding efficacy, including biomarker assays, histomorphometry, and even computational modeling. (cbset.org)
Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. (cbset.org)
Ultrasound2
Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity. (cbset.org)
In severity, Treated with Ultrasound or assessed with the Boston carpal tunnel questionnaire, with infiltration, there were two asymptomatic cases and none with Corticosteroid Infiltration. (bvsalud.org)
The tibial nerve transection model is a well-tolerated, validated, and reproducible model of denervation-induced skeletal muscle atrophy in rodents. (mcmaster.ca)
We assess the atrophy of the gastrocnemius muscle, as a representative muscle, at 1, 2, and 4 weeks post-denervation by measuring muscle weights and fiber type specific cross-sectional area on paraffin-embedded histologic sections immunostained for fast twitch myosin. (mcmaster.ca)
Ablation1
The risk of recurrence was significantly decreased compared to pulmonary vein isolation (PVI) alone for PVI with renal denervation (RR: 0.60, CI: 0.38-0.94), PVI with ganglia-plexi ablation (RR: 0.62, CI: 0.41-0.94), PVI with additional ablation lines (RR: 0.8, CI: 0.68-0.95) and PVI in combination with bi-atrial modification (RR: 0.32, CI: 0.11-0.88). (biomedcentral.com)
Lesion2
I found that progressive denervation may alter DA signaling by three independent mechanisms depending on degree of denervation and macroscopic morphology of the lesion. (jneurosci.org)
Data correlating biophysical characteristics of IRE and lesion characteristics are limited.OBJECTIVES: To assess the effect of different procedural parameters (voltage, number of cycles (NoC), and contact) on lesion characteristics in a vegetal and animal model for IRE.METHODS: Two hundred four Russet potatoes were used. (stanford.edu)
Objective1
abstract： OBJECTIVE:The purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age, and other factors. (shengsci.com)
Our study aims to assess the impact of knee arthroscopic debridement coupled with peripatellar denervation on restoring knee function in OA patients and analyze the risk factors affecting treatment outcomes. (biomedcentral.com)
Among them, 116 patients received arthroscopic knee debridement treatment alone as the control group, and 95 in the observation group were combined with denervation treatment based on the control group. (biomedcentral.com)
knee arthroscopic debridement combined with peripatellar denervation has a significant improvement in the restoration of knee function in patients with knee osteoarthritis and reduces their level of pain. (biomedcentral.com)
RDN was safe, but in symptomatic, despite resynchronization, patients it did not lead to any significant improvement in the most important parameters assessing the severity of HFrEF. (krakow.pl)
Muscular1
Muscular denervation changes may also be seen, most commonly in the flexor hallucis brevis muscle. (podiatryarena.com)
Innervation2
As long as the remaining innervation stays anatomically coherent, denervation reduces phasic variations in extracellular DA, but the DA tone is not changed. (jneurosci.org)
Innervation patterns may limit response to endovascular renal denervation. (cbset.org)
Interventional1
CBSET has developed specialized expertise in the development and application of minimally invasive device-based interventional therapies for renal denervation. (cbset.org)
Study2
In the present study TMT was used to assess the detection of the serum polyclonal IgG responses against NFs, measured by ELISA, as a peripheral marker of neurotoxicity. (cdc.gov)
The aim of this study was to clinically assess the incidence of negative pulp sensitivity to cold among maxillary canines in infraocclusion submitted to orthodontic traction. (bvsalud.org)
Muscle4
Strengthening exercises are not possible or effective on a muscle that is experiencing complete denervation. (spine-health.com)
As recent evidence suggests that it may be linked to a muscle membrane defect, these studies are of interest in assessing the functional state of dystrophic muscle membranes. (mun.ca)
Six weeks after initiation of smoke or air exposure, sham surgery or denervation of the agonists of the left plantaris muscle was performed. (ljmu.ac.uk)
Electrodiagnostic studies, however, displayed reduced compound muscle action potentials, normal sensory nerve action potentials, and widespread denervation, consistent with a severe, asymmetric process involving anterior horn cells or motor axons. (cdc.gov)
Physical performance tests-time up and go (TUG) and 6-min walk test (6MWT), blood pressure, insulin resistance, and selected proteins induced by exercise (exerkines) were assessed at baseline and post-exercise intervention. (nature.com)
Nerve4
Electrodiagnostics are done to assess how much of the weakness in the shoulder, arm, or hand is caused by denervation (loss of nerve supply). (spine-health.com)
Once pain levels, strength, biomechanics, and nerve function have been assessed, a physical therapy program can be designed with specific exercises and stretches to best help the patient regain strength and flexibility. (spine-health.com)
We assessed the effects of EQ on peripheral nerve function in the db/db mouse model of type II diabetes. (nature.com)
Carpal tunnel syndrome is the most common compressive peripheral neuropathy of the upper extremity, Evolución clínica en which is caused by compression of the median nerve. (bvsalud.org)
Cardiovascular1
BACKGROUND Renal denervation (RDN) has been shown to lower blood pressure (BP), but its effects on cardiovascular events have only been preliminarily evaluated. (univr.it)
Effect1
Renal denervation had no effect on urinary angiotensinogen/creatinine ratio in the 20% group and no effect on the increased urinary angiotensinogen/creatinine ratio found in programmed rats. (elsevierpure.com)
Tonic2
With 80-99% denervation, a persistent aberrant signal develops in D 2 -regulated pathways caused by random fluctuations in tonic DA release. (jneurosci.org)
The two mechanisms described above appear at stages of denervation where tonic DA levels and tonic receptor occupancy appear normal. (jneurosci.org)
Blood1
He is also on the steering committee of two other international trials involving agents that lower blood pressure or blood sugar and assessing effects on diabetic kidney disease progression. (uchicagomedicine.org)
Responses1
The pharmacologic responses to serotonin and noradrenalin were assessed in vitro ischiatic artery preparations of the chicken. (mun.ca)
Response2
In all of these, my interests include the use of MRI to assess outcomes and response to therapy. (unityhealth.to)
Twelve weeks later, the hypertrophic response was assessed. (ljmu.ac.uk)
Studies1
Studies have been conducted on the effects of applying orthodontic forces to teeth in order to assess the effects of these forces on the dental pulp 1,5,9,13 . (bvsalud.org)
Time2
With a high degree of denervation, l -dopa enhanced another aberrant signal, this time in the D 1 pathway. (jneurosci.org)
However, when denervation reaches 50%, a mismatch between time scales of DA dynamics and bursts and pauses in firing patterns arises ( Grace and Bunney, 1984b ). (jneurosci.org)
High1
This phenomenon appears with moderate denervation (50-80%), and affects mainly signaling by high-affinity DA receptors (e.g., high-affinity D 2 - and D 3 -type receptors). (jneurosci.org)
Shown1
Renal denervation (RDN) has been shown to reduce office brachial and central BP as well as brachial ambulatory BP, but data on central ambulatory BP are limited. (uni-luebeck.de)
Analysis3
Here I provide a theoretical analysis of the pathophysiology and postsynaptic adaptation resulting from striatal DA denervation. (jneurosci.org)
Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation. (cbset.org)
To assess treatments that have not been directly compared in previous trials, we employed a network meta-analysis (NMA). (biomedcentral.com)