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AnaphaseAnaphase-Promoting Complex-CyclosomeUbiquitin-Protein Ligase ComplexesCdc20 ProteinsCdh1 ProteinsMitosisApc3 Subunit, Anaphase-Promoting Complex-CyclosomeCell Cycle ProteinsApc1 Subunit, Anaphase-Promoting Complex-CyclosomeSpindle ApparatusSecurinCyclin BF-Box ProteinsMetaphaseGenes, APCLigasesM Phase Cell Cycle CheckpointsChromosome SegregationCyclin A2Mad2 ProteinsApc5 Subunit, Anaphase-Promoting Complex-CyclosomeCyclin B1Ubiquitin-Protein LigasesCell CycleHeLa CellsPrometaphaseCDC2 Protein KinaseMolecular Sequence DataMeiosisAmino Acid SequenceUbiquitinationSaccharomyces cerevisiae ProteinsMutationSchizosaccharomyces pombe ProteinsGemininFungal ProteinsProtein BindingProtein-Serine-Threonine KinasesSchizosaccharomycesCyclin AApc2 Subunit, Anaphase-Promoting Complex-CyclosomeNocodazoleNuclear ProteinsSeparaseApc8 Subunit, Anaphase-Promoting Complex-CyclosomeMicrotubulesAurora KinasesProtein SubunitsTelophaseXenopus ProteinsSaccharomyces cerevisiaeChromatidsOocytesProto-Oncogene Proteins c-mosVirus AssemblyG1 PhaseGenes, cdcXenopusKinetochoresUbiquitinRecombinant Fusion ProteinsUbiquitin-Conjugating EnzymesModels, BiologicalApc6 Subunit, Anaphase-Promoting Complex-CyclosomeSKP Cullin F-Box Protein LigasesPhosphorylationAmino Acid MotifsProteasome Endopeptidase ComplexUbiquitinsRNA InterferenceChromosomesCytokinesisDrosophila ProteinsS PhaseCalcium-Binding ProteinsCarrier ProteinsCell LineCentromereMacromolecular SubstancesProtein Processing, Post-TranslationalProtein KinasesSubstrate SpecificityBase SequenceG2 PhaseChromosomal Proteins, Non-HistoneRepressor ProteinsDrosophilaCadherinsRNA, Small InterferingProtein Structure, TertiaryApc11 Subunit, Anaphase-Promoting Complex-CyclosomeProtein StabilitySequence Homology, Amino AcidAdenomatous Polyposis Coli ProteinCyclinsMicrotubule-Associated ProteinsTubulinCyclin-Dependent KinasesKinesinApc7 Subunit, Anaphase-Promoting Complex-Cyclosome
CullinUbiquitin ligaseCellStructure
Cullin2
  • The human genome contains eight cullin genes CUL1, part of SCF complex CUL2, part of ECS complex (Elongin C - CUL2 - SOCS-box) CUL3, part of CUL3-BTB complex CUL4A CUL4B CUL5 CUL7 CUL9, also known as PARC There is also a more distant member called ANAPC2 (or APC2), part of the Anaphase-promoting complex. (wikipedia.org)
  • Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae (Baker's yeast), and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. (wikipedia.org)
Ubiquitin ligase1
  • The anaphase-promoting complex or cyclosome (APC/C) is an unusually large E3 ubiquitin ligase responsible for regulating defined cell cycle transitions. (ox.ac.uk)
Cell1
Structure1
  • Three conserved tetratricopeptide repeat (TPR) subunits (Cdc16, Cdc23 and Cdc27) share related superhelical homo-dimeric architectures that assemble to generate a quasi-symmetrical structure. (ox.ac.uk)