Assay lipoproteins ldl. Medical search. Frequent questions

CHICAGO - The world of cholesterol management and coronary disease prevention has come a long way since 2013, when a major practice guideline document called for radical shifts in strategies for lowering low-density lipoprotein cholesterol (LDL-C), drawing praise, reproach, and puzzlement. (medscape.com)

IIn the 5,830 individuals aged 20 to 70 who were evaluated, dietary GI and GL were significantly associated with HDL-C, LDL-C, LDL-C/HDL-C ratio, and triglycerides serum levels. (hindawi.com)
The L-Type LDL-C is an in vitro assay utilizing a selective protection method for the determination of low-density lipoprotein cholesterol in serum or plasma. (fishersci.com)
PHC settings and barriers to good diabetes metric assay, serum high-density lipopro- care practice. (who.int)
Compared with women, men had higher body mass indices, serum total cholesterol as well as LDL and apoB concentrations. (biomedcentral.com)
Men had smaller LDL size and smaller concentrations of serum HDL and apoA-I than women. (biomedcentral.com)
From our findings, an increased estimated intake of BCAA seems to correlate with diminished serum LDL concentrations. (biomedcentral.com)
The serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in patients were detected by biochemistry. (amegroups.org)
The serum levels of miR-26 in patients were inversely correlated with the levels of blood lipids (TC, TG, and LDL-C), and positively correlated with HDL-C levels. (amegroups.org)
J-a assay response is linear, more than twice as sensitive as a-B assay, and is suppressed only 18 ± 5% by non-Lp(a) O-glycan-containing proteins of serum. (nebraska.edu)
About half of the studied T2DM patients have high serum cholesterol level (52.5%), while 22.5% had low serum HDL- C levels and 39.2% had high serum triglyceride level, most of patients had serum LDL-C levels above normal range (67.5%), so the common patterns of dyslipidemia in this study were LDL-C followed by cholesterol. (heraldopenaccess.us)
Serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) were measured by the clinical chemistry department using commercial kits following the manufacturer instructions. (biomedcentral.com)
Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. (jamanetwork.com)
The lipoproteins in CI-943 individual serum were tagged with [3H] lipid as well as the tagged LDL was isolated by thickness gradient ultracentrifugation as defined (65). (phytid.org)
The assays had been performed by incubating individual serum with or without inhibitors at 37C for 1 h. (phytid.org)
The levels of serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were inversely associated with BMD in both pre- and post-menopausal women. (who.int)

some metabolic studies have observed that diets with a high GI or GL lead to an increase in triglycerides and reduced high density lipoprotein cholesterol (HDL-C) [ 4 - 6 , 12 - 14 ] and cause systemic inflammation [ 15 , 16 ]. (hindawi.com)
2018). The blood lipids measurements in NHANES include total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoproteins cholesterol (LDL-C), and triglycerides. (cdc.gov)
Data on LDL-C and triglycerides are provided in Cholesterol - Low - Density Lipoprotein and Triglycerides (TRIGLY_J) file, and HDL-C data are provided in Cholesterol - High - Density Lipoprotein (HDL_J). (cdc.gov)
SAA levels in T2DM patients also positively correlated with body mass index, triglycerides, fasting plasma glucose, hemoglobin A1c, insulin resistance, C-reactive protein, and interleukin-6, but negatively correlated with high-density lipoprotein cholesterol. (e-enm.org)
Cord blood markers of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, leptin, and adiponectin were used as child mediators. (biomedcentral.com)
Total indirect effects (effects of all mediators combined) for MetS on a child's COM and PSE domain were significant, through all child cord blood mediators of LDL, HDL, triglycerides, adiponectin, and leptin for adjusted models. (biomedcentral.com)

I continued my post-doctoral research in Professor Griffiths lab (2009-2014) that involved isolation and characterisation of modified lipids in low density lipoproteins (LDL) in plasma from cardiovascular patients and Dementia patients. (j-alz.com)

HCV can be an enveloped trojan of the family members (genus the VLDL (suprisingly low thickness lipoprotein) development and secretion pathway [13], [14]. (uawildlifeschool.org)
Therefore, HCV circulates in the plasma of contaminated patients in colaboration with VLDL and LDL (low-density lipoprotein), developing lipo-viral contaminants (LVPs) [15], [16]. (uawildlifeschool.org)
Compounds had been preincubated with CETP and HDL donor contaminants for either 1 or 24 h before addition of VLDL/LDL acceptor contaminants. (phytid.org)

He developed an assay that allows the quantification of low density lipoprotein particle size and concentration (known to the wider world as LDL cholesterol) based on a technique which determines the size of the particle based on physics. (apple.com)
Emerging approaches include measuring the cholesterol content of remnant particles, or TG-rich lipoprotein particle number or composition, although none of these is fully validated for their association with ASCVD risk. (eas-society.org)
Lipoprotein subfraction particle concentrations were measured by ion mobility at baseline, 1, and 2 years and CIMT was measured at baseline and 2 years. (biomedcentral.com)
At 2 years, CCI resulted in a 23% decrease of small LDL IIIb and a 29% increase of large LDL I with no change in total LDL particle concentration or ApoB. (biomedcentral.com)
These panels are offered by various commercial entities and include those which offer LDL particle testing. (medscape.com)
Lipoprotein (a) (Lp[a]) is composed of a low density lipoprotein (LDL) particle with an apolipoprotein B-100 (apo B100) component that is covalently linked via a disulfide bridge to an apolipoprotein (a) molecule, which is highly homologous to plasminogen. (medscape.com)
In short, this assay methods the CE or TG transfer half-reaction utilizing a artificial donor particle very similar in proportions and thickness to HDL-C, which bears a core of fluorescent TG or CE. (phytid.org)
Lp(a) is a low-density lipoprotein (LDL)-like particle that is bound to apolipoprotein(a) and is causally implicated in the pathogenesis of ASCVD. (cdc.gov)

Studying signaling effects of low density lipoproteins (LDL) in vascular smooth muscles (VSMCs), T-cadherin was isolated and identified as new LDL receptor using human aortic media and the ligand-blotting method. (wikipedia.org)
Increasing evidence has demonstrated that oxidized low-density lipoproteins (oxLDL) and lipopolysaccharide (LPS) enhance accumulation of interleukin (IL)-1 beta-producing macrophages in atherosclerotic lesions. (nih.gov)

Indeed, beyond the lipoprotein lipase cofactor apolipoprotein (apo) CII, recent studies have identified the relevance of apoCIII in controlling the efficiency of TG clearance, and angiopoietin-like protein 3 (ANGPTL3) in modulating lipoprotein lipase activity, suggesting potential as therapeutic targets (14,15) . (eas-society.org)
Apolipoprotein B (apoB) is a nonexchangeable lipoprotein that exists in two forms in humans, apoB-100 and apoB-48. (medscape.com)
Apolipoprotein A1 (apoA1) is the major apolipoprotein constituent of the high-density lipoprotein (HDL) and is involved in reverse cholesterol transport [ 15 ]. (biomedcentral.com)
Key proteins involved in lipoprotein metabolism, such as PCSK9, angiopoietin-related protein 3, cholesteryl ester transfer protein and apolipoprotein(a), have been identified as viable targets for therapeutic intervention through observational and genetic studies. (cdc.gov)

Though T-cadherin can mediate weak adhesion in aggregation assays in vitro, the lack of intracellular domain suggests that T-cadherin is not involved in stable cell-cell adhesion. (wikipedia.org)
Some in vitro experiments have previously suggested that high-density lipoprotein (HDL) co-incubated with LDL prevents Cu 2+ -induced oxidation of LDL, while some other studies have observed an opposite effect. (biomedcentral.com)
We conclude that in vitro HDL does not protect LDL from oxidation, but is in fact oxidized fastest of all lipoproteins due to its fatty acid composition, which is oxidation promoting. (biomedcentral.com)
In some reports this finding could not be confirmed, and in fact it has been demonstrated that in vitro HDL is oxidized faster than other lipoproteins [ 4 ]. (biomedcentral.com)
The contradictory findings on the role of HDL on LDL oxidation in vitro may be due to rather small study populations, and the reported heterogeneity of oxidation kinetics between lipoprotein preparations in vitro [ 9 ] which might be due to individual intrinsic properties of the lipoproteins. (biomedcentral.com)
In vitro fluorogenic assays of CETP-mediated TG and CE transfer For perseverance of in vitro CETP transfer activity, a continuing fluorogenic assay defined previously (64) was utilized. (phytid.org)

In that latter group, initiation of nonstatin lipid-lowering therapy should be considered for anyone with an LDL-C that hasn't fallen below 70 mg/dL. (medscape.com)
Using biochemical assays, colorimetry and mass spectrometry techniques, I have shown that LDL isolated from patients with hypercholesterolemia has higher level of lipid and protein oxidation and these lipid affect neuronal cell viability and processing of amyloid beta protein in a neuronal cell line via a redox driven mechanism. (j-alz.com)
A high-fat diet induces lipid metabolism dysfunction by increasing the concentration of total cholesterol (TCHO) and low-density lipoprotein cholesterol (LDL-c), being oxidized to ox-LDL-c which is swallowed by macrophage in the vessels. (hindawi.com)
Plasma lipid subfractions - Apo A-I, apo A-II, apo B, and lipoprotein Lp(a) are measured, using immunoassays for apo A-II and nephelometric assays employing antibodies for apo A-I, apo B, and Lp(a). (medscape.com)
Cholesterol measurement is performed to screen for atherosclerotic risk and in the diagnosis and treatment of disorders involving elevated cholesterol as well as lipid and lipoprotein metabolic disorders. (cdc.gov)
Lipoprotein(a) is collected as part of various panels constituting what is known as "advanced lipid testing. (medscape.com)
Lipid Peroxidation (MDA) Assay Bundle (Colorimetric/Fluorometric) (ab118970) provides a helpful software program for delicate detection of malondialdehyde (MDA). (crn-ccrc.org)
Inside the lipid peroxidation assay protocol, the MDA inside the sample reacts with thiobarbituric acid (TBA) to generate a MDA-TBA adduct. (crn-ccrc.org)
Lipid peroxidation is a extensively identified occasion of oxidative hurt in cell membranes, lipoproteins, and totally different lipid-containing buildings. (crn-ccrc.org)
Bioquochem's LPO assay gear measures MDA and HNE concentrations as an index of lipid peroxidation. (crn-ccrc.org)
Malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) are typically used as markers of lipid peroxidation, and to assay for oxidative hurt / oxidative stress. (crn-ccrc.org)
Moreover see the favored 4-HNE Assay Bundle ab238538 instead marker of lipid peroxidation and oxidative stress. (crn-ccrc.org)
We utilized ELISA kits to measure fasting blood glucose (FBS) and lipid profile markers, and additionally calculated low-density lipoprotein (LDL) and insulin sensitivity markers. (biomedcentral.com)
Furthermore, a higher baseline LDL level provides been shown to become the very best predictor of the suffered virologic response, whereas low lipid amounts correlate with steatosis, progressing fibrosis and nonresponse to treatment [19]. (uawildlifeschool.org)
While some with the highest LDL-C are diagnosed with HoFH in childhood, many others are missed, denying them the opportunity for timely initiation of aggressive lipid-lowering therapies (LLT) and resulting in premature cardiovascular disease. (cdc.gov)

The guideline recommends PCSK9 inhibitors, whose randomized trial underpinnings were established after 2013, primarily for patients with familial hypercholesterolemia (FH), and for patients at very high ASCVD risk with elevated LDL-C despite maximal statins and ezetimibe. (medscape.com)
Severe primary hypercholesterolemia (LDL-C ≥190 mg/dL), often called FH. (medscape.com)
Regarding comorbidities, 53.2% and 61.3% were obese and hypertensive, respectively, and 72% had hypercholesterolemia as defined by low-density lipoprotein cholesterol (LDL-C) ≥100 mg/dL in people with diabetes. (e-dmj.org)

A corresponding increase in concentrations of larger LDL particles was responsible for higher levels of plasma LDL-C. The lack of increase in total LDL particles, ApoB, and in progression of CIMT, provide supporting evidence that this dietary intervention did not adversely affect risk of CVD. (biomedcentral.com)
Enzyme immunoassay for lipoprotein(a) [Lp(a)] using antibodies to both apoB and apo(a) subunits (a-B assay) is shown to be affected by differential masking of apoB by apo(a) and the presence of LDL-Lp(a) adducts. (nebraska.edu)
An apoB-independent immunoassay by capturing Lp(a) through its O-glycans on microplate-coated lectin jacalin and quantitation using peroxidase-labeled anti-apo(a) (J-a assay) is described. (nebraska.edu)

and Interleukin- (IL-) 1 β , IL-37, IL-38, NT-proBNP, hs-cTNI, and Ischemia-modified albumin (IMA) by enzyme-linked immunosorbent assay (ELISA). (hindawi.com)
Plasma FABP3 concentrations were measured by an enzyme-linked immunosorbent assay. (medsci.org)

Therefore, this latest EAS Statement reviewed what is known about the structure, function, metabolism, and atherogenicity of TG-rich lipoproteins and their remnants, with the ultimate aim of identifying targeted therapeutic approaches to address residual cardiovascular risk associated with elevated TG levels (9) . (eas-society.org)
Evaluation the oxidative stress marker and assay info, or the whole metabolism assay info to check additional assays for metabolites, metabolic enzymes, mitochondrial function, and oxidative stress, and as well as how one can assay metabolic function in dwell cells using your plate reader. (crn-ccrc.org)
The Lipoprotein Metabolism Laboratory, led by Dr. Alan T. Remaley, seeks to better understand lipoprotein metabolism and to translate new insights gained from basic biochemistry, cell biology, and transgenic animal models into much-needed clinical advances in the treatment and prevention of cardiovascular disease. (nih.gov)
It takes a village to do a good science" is a motto of Dr. Alan Remaley's team of the Lipoprotein Metabolism Laboratory. (nih.gov)

The laboratory method used to measure total cholesterol is an enzymatic assay. (cdc.gov)
In this enzymatic assay, esterified cholesterol is converted to cholesterol by cholesterol esterase. (cdc.gov)

The membrane-bound form of CXCL16 binds and internalizes oxidative low-density lipoprotein (oxLDL) and promotes adhesion of cells expressing its cognate receptor, CXCR6 [ 6 , 7 ] . (medsci.org)
Oxidative modification of low-density lipoprotein (LDL) is a key event in the oxidation hypothesis of atherogenesis. (biomedcentral.com)
Some studies have shown that co incubation of LDL with HDL in the presence of divalent copper prevents the oxidative modification of LDL [ 3 ]. (biomedcentral.com)

When the isolated LDL was subjected to Cu 2+ -induced oxidation, both HDL 2 and HDL 3 particles increased the rate of appearance and the final concentration of conjugated dienes similarly in both genders. (biomedcentral.com)
Epidemiological studies show an inverse correlation between high-density lipoprotein (HDL) concentration and the risk of developing coronary artery disease [ 1 ]. (biomedcentral.com)
Concordance of a High Lipoprotein(a) Concentration Among Relatives. (cdc.gov)
In this cross-sectional study, 1607 of 3420 (47.0%) first-degree relatives of UK Biobank participants with a lipoprotein(a) concentration at least 125 nmol/L were similarly affected, compared with 4974 of 30 258 (16.4%) unrelated individuals. (cdc.gov)
Treatment is based on lowering low density lipoprotein (LDL) cholesterol concentration, with a target of at least 50% reduction from baseline. (cdc.gov)
When Is a High Lipoprotein (a) Concentration Too High? (cdc.gov)

Consumption of a very low carbohydrate diet with nutritional ketosis for 2 years in patients with type 2 diabetes lowered levels of small LDL particles that are commonly increased in diabetic dyslipidemia and are a marker for heightened CVD risk. (biomedcentral.com)
High prevalence of dyslipidemia among type 2 diabetes mellitus in Mukalla city were observed and so the common patterns of dyslipidemia is LDL-C followed by cholesterol. (heraldopenaccess.us)

LDL cholesterol levels are estimated using the formula proposed by DeLong and colleagues. (medscape.com)

The properties of T-cadherin as an LDL receptor were markedly different from the presently known types of LDL receptors. (wikipedia.org)
CXCL16, which was originally described as a scavenger receptor for phosphatidylserine and oxidized low-density lipoprotein (SR-PSOX), is one of the few scavenger receptors that has two distinct forms: membrane-bound and soluble. (medsci.org)

Plasma levels of TG-rich lipoproteins depend on the rate of production, the efficiency of removal of TG content by lipolysis, and hepatic clearance. (eas-society.org)
however, in most studies, Lp(a) has predictive value for those already known to be at high risk because of the presence of other risk factors, in particular elevated LDL-C levels. (medscape.com)
The observation of extremely high levels of Lp(a) seem to be almost entirely limited to patients with concomitantly high levels of LDL cholesterol brings into question the use of Lp(a) as an independent marker of increased cardiovascular risk and highlights the limitations presented by interactions with LDL cholesterol. (medscape.com)
Additionally, there was a noted association between greater estimated BCAA intake and reduced LDL levels. (biomedcentral.com)
Second-hand" cigarette smoke decreases plasma high density lipoprotein levels in the blood and also decreases the ratios between high density lipoprotein and low density lipoprotein, high density lipoprotein and triglyceride, and high density lipoprotein and total cholesterol. (biomedcentral.com)
METHODS: Expression levels of circ_HECW2, microRNA (miR)-942-5p, and toll-like receptor 4 (TLR4) were analyzed by quantitative real-time PCR (qRT-PCR) and western blot assays. (semcs.net)
From the abstract: 'What is the prevalence of high lipoprotein(a) concentrations (=125 nmol/L) in first- and second-degree relatives of individuals with high lipoprotein(a) levels? (cdc.gov)
Cascade screening of first-degree relatives of individuals with high lipoprotein(a) levels, if implemented at scale, is likely to identify a substantial number of additional high-risk individuals. (cdc.gov)
The levels of high-density lipoprotein cholesterol (HDL-C) were not associated with BMD values at any of the sites in the pre- and post-menopausal subjects. (who.int)

100 mg/dL showed an increase in NCM, IL-1 beta, LPS-binding protein (LBP), and Castelli's atherogenic risk index as compared to controls (n = 65) with optimal LDL-C concentrations (≤100 mg/dL). (nih.gov)
The functional mechanism of circular RNA (circRNA) HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (circ_HECW2, hsa_circ_0057583) in ox-LDL-treated human cardiac microvascular endothelial cells (hCMECs) is still unclear. (semcs.net)

The change in proportion of smaller and larger LDL was reflected by reversal of the small LDL subclass phenotype B in a high proportion of CCI participants (48.1%) and a shift in the principal component (PC) representing the atherogenic lipoprotein phenotype characteristic of T2D from a major to a secondary component of the total variance. (biomedcentral.com)

Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults. (cdc.gov)

Plasma TG is, however, merely a surrogate for estimating the critical lipoproteins - TG-rich lipoproteins and their remnants. (eas-society.org)
First, there is clarification of what is meant by TG, TG-rich lipoproteins, and remnants. (eas-society.org)
Second, this EAS Statement provides a framework for understanding how remnants of TG-rich lipoproteins are generated and cleared from the circulation. (eas-society.org)
This EAS Statement provides a state-of-the art review of current thinking on how TG-rich lipoproteins and their remnants are retained in the arterial wall and promote maladaptive responses central to plaque initiation and progression. (eas-society.org)
There is also exploration of the relative atherogenicity of TG-rich lipoproteins and their remnants versus LDL, with the caveat that precise definition of the nature of remnant particles is currently uncertain. (eas-society.org)
Two key gaps in knowledge about TG-rich lipoproteins and remnants are highlighted. (eas-society.org)
First, there is an unmet need for a standardised, readily applicable assay to measure remnants and to relate this to their atherogenic properties. (eas-society.org)
The Panel concludes that clinicians should continue to use plasma TG (either fasting or nonfasting) as a surrogate for quantitating TG-rich lipoproteins and remnants, as recommended by the 2019 European Society of Cardiology/EAS dyslipidaemia guidelines (12,16) . (eas-society.org)

Oxidation rate was positively associated with polyunsaturated fatty acid content of the lipoproteins in that it was positively related to the content of linoleate and negatively related to oleate. (biomedcentral.com)
Oxidatively modified HDL is no longer capable of removing cholesterol from cells, and it enhances LDL oxidation [ 8 ]. (biomedcentral.com)
In the present paper we report the results of a study of the effect of HDL subtractions and gender on ex vivo oxidation of LDL from a population of 61 healthy free-living human subjects. (biomedcentral.com)
The oxidation of LDL of all subjects gave rise to typical conjugated diene vs. time -curves, where the different phases of hydro peroxide formation were clearly discernible. (biomedcentral.com)
Co incubations of LDL with either HDL 2 or HDL 3 produced biphasic profiles with faster oxidation in the beginning, followed by a slower rate and finally a faster propagation phase. (biomedcentral.com)
In spite of all the evidence that cigarette smoke stimulates atherogenesis and lipoprotein oxidation may play an important role [ 9 ], very little is known about the biological processes induced by smoke that contribute to increased cardiovascular disease. (biomedcentral.com)

Zheng SM, Chen H, Sha WH, Chen XF, Yin JB, Zhu XB, Zheng ZW, Ma J. Oxidized low-density lipoprotein stimulates CD206 positive macrophages upregulating CD44 and CD133 expression in colorectal cancer with high-fat diet. (wjgnet.com)

these accumulate if there is overproduction of TG-rich lipoproteins or compromised (albeit not absent) lipase action. (eas-society.org)

Monocytes in the arterial wall differentiate into activated macrophages that are efficient scavengers of oxidized low density lipoprotein (LDL). (biomedcentral.com)

[ 5 ] confirmed that inflammatory cytokines contribute to foam cell formation by modifying cholesterol-mediated LDL receptor regulation in mesangial cells. (medsci.org)

Principal component analysis (PCA) was used to assess changes in independent clusters of lipoprotein particles. (biomedcentral.com)
The increase in LDL-C in the CCI group was mainly attributed to larger cholesterol-enriched LDL particles. (biomedcentral.com)

The low-density lipoprotein (LDL) cholesterol level is determined in the supernatant after plasma precipitation with magnesium chloride-phosphotungstic acid. (medscape.com)

Concomitantly, there was strong interest in high-density lipoprotein cholesterol (HDL-C) as a protective risk factor, supported by extensive epidemiological evidence (4) . (eas-society.org)
Dr. Remaley's research has focused on the beneficial role of high-density lipoprotein (HDL), the so-called "good cholesterol. (nih.gov)

hence its cellular and whole body distribution is subject to complex, dynamic regulation by circulating lipoproteins and enzymes. (nih.gov)

Although LDL-C has been a mainstay for CVD risk prediction and management for decades, it is not characteristically elevated in patients with diabetes. (biomedcentral.com)

Flow cytometry assays revealed that nLDL significantly decreases the classical monocyte (CM) percentage and increases the non-classical monocyte (NCM) subset. (nih.gov)

From the abstract: 'Lipoprotein(a) is an independent risk factor for cardiovascular disease. (cdc.gov)

This assay detects MDA ranges as little as 1 nmol/successfully colorimetrically and 0.1 nmol/successfully fluorometrically. (crn-ccrc.org)

Cell proliferation and apoptosis were analyzed by 5-ethynyl-2'-deoxyuridine (EdU) assay, cell counting kit-8 (CCK8) assay, and flow cytometry, respectively. (semcs.net)

There were no gender differences in the total amounts of saturated, monounsaturated and polyunsaturated fatty acids of LDL, HDL 2 and HDL 3 . (biomedcentral.com)

In our assay an indol (Reagent A) reacts quickly with MDA and HNE in acidic medium, yielding a chromophore (C) with a extreme molar extinction coefficient at its maximal absorption wavelength of 586 nm. (crn-ccrc.org)

Reference ranges of lipoprotein (a) (Lp[a]) vary and depend on assay and reporting laboratories. (medscape.com)

Preclinical, epidemiologic, and genomic studies identify lipoprotein (a) (Lp[a]) as a risk factor for atherosclerotic cardiovascular disease (ASCVD). (cdc.gov)

Hence, the current study aimed to identify signaling pathways associated with SPA1413 using lipopolysaccharides (LPS)-stimulated BV2 cells as the experimental model via biological assays, Western blotting, and quantitative (q)RT-PCR. (bvsalud.org)

Largely filling the influence gap are limited restoration of LDL-C treatment targets, especially in higher-risk groups, and a pervasive investment in doctor-patient communication for shared decision-making, especially for intermediate-risk primary prevention patients. (medscape.com)
As noted by Davidson, the odds ratio for significant coronary heart disease on angiography in patients with a Lp(a) level greater than 30 mg/dL versus a level less than or equal to 5 mg/dL increased from 1.67 to 6.0, as LDL concentrations increased as well. (medscape.com)

How are elevated TG-rich lipoproteins linked to cardiovascular risk? (eas-society.org)
These factors contribute to residual risk of CVD following statin treatment for lowering of LDL-cholesterol (LDL-C) [ 10 ]. (biomedcentral.com)

Peroxidative modification of unsaturated phospholipids, glycolipids, and ldl ldl cholesterol can occur in a number of reactions. (crn-ccrc.org)

Anatomy5

Organisms1

Diseases15

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Psychiatry and Psychology1

Phenomena and Processes12

Technology, Industry, Agriculture1

Information Science1

Health Care1

Lowering low-density lipoprotein cho1

Serum15

Triglycerides6

Lipids1

VLDL3

Particle8

Density lipoproteins2

Apolipoprotein4

Vitro6

Lipid15

Hypercholesterolemia3

ApoB3

Enzyme-linke2

Metabolism4

Enzymatic2

Oxidative3

Concentration6

Dyslipidemia2

Cholesterol levels1

Receptors2

Levels9

Protein2

Participants1

Atherosclerosis1

Remnants8

Oxidation6

Stimulates1

Accumulate1

Macrophages1

Receptor1

Particles2

Plasma1

High2

Enzymes1

Diabetes1

Significantly1

Abstract1

Nmol1

Flow1

Total1

Maximal1

Depend1

Atherosclerotic1

Quantitative1

Patients2

Risk2

Modification1