Moving forward, larger randomized controlled trials are required comparing TAPT versus DAPT (clopidogrel, prasugrel or ticagrelor on top of aspirin). (nih.gov)
The addition of prasugrel to aspirin for dual antiplatelet therapy has been shown to reduce the ischemic outcomes compared with clopidogrel and aspirin in combination. (jabfm.org)
Elderly patients ≥75 years, patients who weigh ≥60 kg, and patients with a history of stroke or transient ischemic attack are at a higher risk of bleeding complications when prasugrel is used in combination with aspirin. (jabfm.org)
Thienopyridines include ticlopidine (first generation), clopidogrel (second generation), and the most recent addition, prasugrel (third generation). (jabfm.org)
Triple versus dual antiplatelet therapy in acute coronary syndromes: adding cilostazol to aspirin and clopidogrel? (nih.gov)
Cilostazol, a phosphodiesterase III inhibitor, has been shown to significantly improve high on-treatment platelet reactivity in patients receiving both aspirin and clopidogrel and has antiproliferative effects (inhibiting neointimal hyperplasia and smooth muscle proliferation), thus reducing the risk of restenosis after coronary stent implantation. (nih.gov)
Further, cilostazol in addition to aspirin and clopidogrel versus DAPT in patients undergoing percutaneous coronary intervention showed that triple antiplatelet therapy (TAPT) was associated with a significantly greater platelet inhibition, reduced major adverse cardiovascular events, target lesion revascularization, and target vessel revascularization with no increased risk for a hemorrhagic event. (nih.gov)
However, suboptimal clinical outcomes with aspirin monotherapy resulted in the use of dual antiplatelet therapy with the addition of thienopyridines. (jabfm.org)
5 While dual antiplatelet therapy with aspirin and clopidogrel is more effective than aspirin monotherapy, the added benefit is accompanied by an equivalent absolute increase in major bleeding. (acc.org)
For patients with "intermediate" risk (CHA 2 DS 2 -VASc score of 1), the option of anticoagulation, aspirin monotherapy, or no therapy is left to a consensus decision between the provider and patient. (acc.org)
1 - 5 Dual antiplatelet therapy, consisting of aspirin and a thienopyridine, has been used for more than a decade because aspirin monotherapy turned out to be insufficient. (ajnr.org)
Between years 1 and 2, high platelet reactivity was not associated with the very late ST and in patients on aspirin monotherapy, aspirin hyporesponsiveness was not associated with adverse outcomes. (duke.edu)
Dual antiplatelet therapy with aspirin plus thienopyridines has become the standard treatment of patients undergoing coronary stenting. (hindawi.com)
Coronary5
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor antagonist is the standard of care in acute coronary syndromes. (nih.gov)
Following percutaneous coronary intervention (PCI), short-term clopidogrel therapy in addition to aspirin leads to greater protection from thrombotic complications than aspirin alone. (nih.gov)
Coronary angiogram, performed after administration of aspirin (100 mg) and of a 300 mg loading dose of clopidogrel, showed a critical stenosis of the left anterior descending artery involving the origin of the first diagonal branch and a severe short stenosis of a large, dominant circumflex artery at the level of the first marginal branch. (hindawi.com)
Aspirin alone or in combination with a thienopyridine (dual antiplatelet therapy) reduces the risk of coronary ischemic events in patients with ACS. (jabfm.org)
Aspirin helps to prevent the formation of clots in the coronary arteries. (speedyremedies.com)
Nicotinamide1
11 Other drugs that have been used are clofazimine, 12 ticlopidine 13 and nicotinamide. (racgp.org.au)
The retrospective registry study evaluated different types of management against the development of post-thrombotic syndrome and recurrent deep vein thrombosis, including standard management, aspirin, pine bark extract, ticlopidine, and sulodexide. (nutritionaloutlook.com)
Results showed that 137 patients took pine bark extract with no tolerability issues and had a significantly lower incidence of post-thrombotic syndrome and recurrent deep vein thrombosis compared to the standard management and aspirin groups. (nutritionaloutlook.com)
Platelet reactivity1
OBJECTIVES: In this analysis of 2-year outcomes in the ADAPT-DES (Assessment of Dual AntiPlatelet Therapy with Drug-Eluting Stents) study, the authors sought to examine the independent associations between platelet reactivity to both aspirin and clopidogrel and subsequent outcomes. (duke.edu)
Loading dose3
To evaluate the benefit of long-term (12-month) treatment with clopidogrel after PCI and to determine the benefit of initiating clopidogrel with a preprocedure loading dose, both in addition to aspirin therapy. (nih.gov)
Our preferred antiplatelet regimen was aspirin (325 mg daily) and clopidogrel (300 mg of loading dose followed by 75 mg daily) starting 5-10 days before the procedure. (ajnr.org)
6 , 7 The combination of aspirin (75-325 mg daily) and clopidogrel (75 mg daily following a loading dose of 300 mg) has become the widely accepted standard regimen for stent-placement procedures. (ajnr.org)
Therapy2
Aspirin, which exerts its antiplatelet effects by inhibiting thromboxane A2 production, has been the mainstay of antiplatelet therapy in patients with ACS. (jabfm.org)
BACKGROUND: Concurrent therapy with a proton-pump inhibitor is a standard treatment for patients receiving aspirin who are at risk for ulcer. (hku.hk)
Prevention4
The benefits of aspirin have been limited to the Stroke Prevention in Atrial Fibrillation Trial. (acc.org)
We compared clopidogrel with aspirin plus esomeprazole for the prevention of recurrent bleeding from ulcers in high-risk patients. (hku.hk)
CONCLUSIONS: Among patients with a history of aspirin-induced ulcer bleeding whose ulcers had healed before they received the study treatment, aspirin plus esomeprazole was superior to clopidogrel in the prevention of recurrent ulcer bleeding. (hku.hk)
At discharge, 92% of patients were receiving aspirin, 76% clopidogrel (or ticlopidine), and 80% statins. (acc.org)
It is not uncommon for patient to use combinations of medications with anticoagulation or anti-platelet properties and this increased risk of bleeding may be increased if an SSRI is added to a patients regimen of aspirin or clopidogrel. (rxeconsult.com)
We reviewed our neurovascular prospectively collected data base for consecutive patients pretreated with aspirin and/or clopidogrel for planned or expected stent-placement procedures by the nature of the patient's vascular lesion. (ajnr.org)
Scholars@Duke publication: Impact of Aspirin and Clopidogrel Hyporesponsiveness in Patients Treated With Drug-Eluting Stents: 2-Year Results of a Prospective, Multicenter Registry Study. (duke.edu)
Current U.S. guidelines also recommend clopidrogel for patients who have major gastrointestinal intolerance of aspirin. (hku.hk)
METHODS: We studied patients who took aspirin to prevent vascular diseases and who presented with ulcer bleeding. (hku.hk)
After the ulcers had healed, we randomly assigned patients who were negative for Helicobacter pylori to receive either 75 mg of clopidogrel daily plus esomeprazole placebo twice daily or 80 mg of aspirin daily plus 20 mg of esomeprazole twice daily for 12 months. (hku.hk)
RESULTS: We enrolled 320 patients (161 patients assigned to receive clopidogrel and 159 to receive aspirin plus esomeprazole). (hku.hk)
Recurrent ulcer bleeding occurred in 13 patients receiving clopidogrel and 1 receiving aspirin plus esomeprazole. (hku.hk)
Our finding does not support the current recommendation that patients with major gastrointestinal intolerance of aspirin be given clopidogrel. (hku.hk)
We investigated the in-vitro effects of E5555 on platelet function beyond PAR-1 blockade in healthy volunteers and CAD patients treated with aspirin (ASA) with or without clopidogrel. (uea.ac.uk)
Medications1
On the adult questionnaire, aspirin was moved to the non-prescription medications sections unless the strength or brand name reported was only available by prescription (e.g. (cdc.gov)
Recurrent1
4. Rothwell PM, Algra A, Chen Z, Diener HC, Norrving B, Mehta Z. Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials. (bvs.br)
Adult1
The most popular and effective way is to give an adult asprin and take the patient to hospital as soon as possible. (speedyremedies.com)
Adverse1
Clopidogrel has mostly replaced the use of ticlopidine due to its more favourable adverse event profile. (hindawi.com)
Commonly1
Aspirin is the most commonly used antiplatelet medicine. (chnola.org)
Treatment2
After the procedure, clopidogrel (75 mg/day) and aspirin (100 mg/day) were prescribed as chronic treatment. (hindawi.com)
Current or recent (within 10 days of enrolment) use of aspirin (>325 mg/day) or treatment with dipyramidole, ticlopidine, clopidogrel, or clostazol. (who.int)
Groups1
Both groups received aspirin throughout the study. (nih.gov)
Results1
The test results were reported as aspirin-reaction unit (ARU) for aspirin and P2Y 12 reaction units (PRU), baseline (BASE), and percentage inhibition for the P2Y 12 assay and were summarized as mean ± SD of the values. (ajnr.org)