1.11Beta-semialdehyde dehydrogenaseKinaseOxidoreductaseDimerisation domainSuccinicAminotransferaseEscherichiaPathwayFamily of aminoInvolved in the biosynthesisEnzymePeriplasmic componentMeSHGenesProfilesNadpAminotransferaseAspartic beta-semialdehydeGlutamateHomoserineSaccharopine dehydrogenaseGeneIdentificationFoundRole
1.111
- In enzymology, an aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) is an enzyme that is very important in the biosynthesis of amino acids in prokaryotes, fungi, and some higher plants. (wikipedia.org)
Beta-semialdehyde dehydrogenase1
- Other names in common use include aspartate semialdehyde dehydrogenase, aspartic semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde:NADP+ oxidoreductase, (phosphorylating), aspartic beta-semialdehyde dehydrogenase, and ASA dehydrogenase. (wikipedia.org)
Kinase2
- Besides, the aspartate kinase mutant LysCT311I from Corynebacterium glutamicum and aspartate semialdehyde dehydrogenase from Halomonas elongata were overexpressed to increase precursors supply. (bvsalud.org)
- Aspartate/glutamate/uridylate kinase [Interproscan]. (ntu.edu.sg)
Oxidoreductase1
- The systematic name of this enzyme class is L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating). (wikipedia.org)
Dimerisation domain1
- All proteins in this entry contain a dimerisation domain of semialdehyde dehydrogenase. (wikipedia.org)
Succinic12
- Establishment and validation of a clinical severity scoring system for succinic semialdehyde dehydrogenase deficiency. (harvard.edu)
- Understanding the Molecular Mechanisms of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): Towards the Development of SSADH-Targeted Medicine. (harvard.edu)
- Development of a Quality-of-Life Survey for Patients With Succinic Semialdehyde Dehydrogenase Deficiency, a Rare Disorder of GABA Metabolism. (harvard.edu)
- Transcranial Magnetic Stimulation in Succinic Semialdehyde Dehydrogenase Deficiency: A Measure of Maturational Trajectory of Cortical Excitability. (harvard.edu)
- aminobutyric acid B (GABA-B) Receptor Antagonist, for Succinic Semialdehyde Dehydrogenase Deficiency. (harvard.edu)
- Speech Motor Function and Auditory Perception in Succinic Semialdehyde Dehydrogenase Deficiency: Toward Pre-Supplementary Motor Area (SMA) and SMA-Proper Dysfunctions. (harvard.edu)
- Postmortem Analyses in a Patient With Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): II. (harvard.edu)
- Magnetic Resonance Imaging (MRI) and Spectroscopy in Succinic Semialdehyde Dehydrogenase Deficiency. (harvard.edu)
- Succinic semialdehyde dehydrogenase deficiency (SSADHD), also known as 4-hydoxybutyric aciduria or gamma-hydoxybutyric aciduria , is a rare autosomal recessive disorder [1] of the degradation pathway of the inhibitory neurotransmitter γ-aminobutyric acid , or GABA . (wikidoc.org)
- However, because of the deficiency, the final intermediate of the GABA degradation pathway, succinic semialdehyde, accumulates and cannot be oxidized to succinic acid and is therefore reduced to gamma-hydroxybutyric acid (GHB) by gamma-hydroxybutyric dehydrogenase. (wikidoc.org)
- Succinic semialdehyde dehydrogenase deficiency has an autosomal recessive pattern of inheritance. (wikidoc.org)
- GABA is metabolized by successive transamination and oxidation to yield succinic semialdehyde and succinic acid respectively via the catalyzing effects of GABA transaminase . (wikidoc.org)
Aminotransferase1
- Erythrocyte aspartate aminotransferase (EAST) and the EAST activation coefficient are long-term indicators of functional pyridoxine status. (medscape.com)
Escherichia1
- Yang, S., 'Mutagenesis of Key Residues in the Binding Center of l-Aspartate-b-Semialdehyde Dehydrogenase from Escherichia coli Enhances Utilization of the Cofactor NAD(H)', ChemBioChem , 2016 , 17(1), 56-64. (sioc-ccbg.ac.cn)
Pathway1
- It forms an early branch point in the metabolic pathway forming lysine, methionine, leucine and isoleucine from aspartate. (wikipedia.org)
Family of amino1
- 10 out of 23 sequenced clones, contained transposons inserted within genes involved in the biosynthesis of the aspartate family of amino acids (lysine. (whiterose.ac.uk)
Involved in the biosynthesis2
- This domain contains both N-acetyl-glutamine semialdehyde dehydrogenase (AgrC), which is involved in arginine biosynthesis, and aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. (wikipedia.org)
- dihydrodipicolinate dehydrogenase (dapA), and cystathionine y-synthase (yjcf) , involved in the biosynthesis oflysine and methionine respectively. (whiterose.ac.uk)
Enzyme3
- citation needed] The enzyme catalyzes the reversible chemical reaction L-aspartate 4-semialdehyde + phosphate + NADP+ ⇌ {\displaystyle \rightleftharpoons } L-4-aspartyl phosphate + NADPH + H+ The 3 substrates of this enzyme are L-aspartate 4-semialdehyde, phosphate, and NADP+, whereas its 3 products are L-4-aspartyl phosphate, NADPH, and H+. (wikipedia.org)
- The 3rd example is normally aspartate-semialdehyde dehydrogenase, which can be an important enzyme of this creates some main amino metabolites and acids [10,11]. (bio-biz-navi.com)
- An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. (harvard.edu)
Periplasmic component1
- 1069\930\BAD95974.1\Azospirillum brasilense\Azospirillum brasilense genes for dihydrodipicolinatesynthase/N-acetylneuraminate lyase, L-Arabinose 1-dehydrogenase,ABC-type sugar transport system periplasmic component, partial andcomplete cds. (or.jp)
MeSH1
- Succinate-Semialdehyde Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Genes1
- Aspartate-semialdehyde dehydrogenase may be cis-regulated by an Asd RNA motif found in the 5' UTR of some Asd genes. (wikipedia.org)
Profiles2
- This graph shows the total number of publications written about "Succinate-Semialdehyde Dehydrogenase" by people in Harvard Catalyst Profiles by year, and whether "Succinate-Semialdehyde Dehydrogenase" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Succinate-Semialdehyde Dehydrogenase" by people in Profiles. (harvard.edu)
Nadp2
- An enzyme that catalyzes the conversion of L-aspartate 4-semialdehyde, orthophosphate, and NADP + to yield L-4-aspartyl phosphate and NADPH. (nih.gov)
- Saccharopine dehydrogenase C-terminal domain, Saccharopine dehydrogenase NADP binding domain [Interproscan]. (ntu.edu.sg)
Aminotransferase2
- Erythrocyte aspartate aminotransferase (EAST) and the EAST activation coefficient are long-term indicators of functional pyridoxine status. (medscape.com)
- Serum aminotransferases such as aspartate aminotransferase, AST and alanine transaminase, ALT have been used as clinical markers of tissue damage, with increasing serum levels indicating an increased extent of damage. (tdmuv.com)
Aspartic beta-semialdehyde1
- Other names in common use include aspartate semialdehyde dehydrogenase, aspartic semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde:NADP+ oxidoreductase, (phosphorylating), aspartic beta-semialdehyde dehydrogenase, and ASA dehydrogenase. (wikipedia.org)
Glutamate2
- Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. (tdmuv.com)
- A pair of principal enzymes, glutamate dehydrogenase and glutamine synthatase, are found in all organisms and effect the conversion of ammonia into the amino acids glutamate and glutamine, respectively. (tdmuv.com)
Homoserine1
- The different * steps are catalysed by aspartate kinases I and III (AK I and * AK III), aspartate semialdehyde dehydrogenase (ASD), homoserine * dehydrogenase (HDH), homoserine kinase (HK) and threonine synthase * (TS). (nih.gov)
Saccharopine dehydrogenase1
- It can be associated with saccharopine dehydrogenase . (wikidoc.org)
Gene1
- Using a balanced lethal system, the kanamycin resistance gene of expressing eukaryotic plasmids pVAX1 and pVAXD were replaced by the aspartate β-semialdehyde dehydrogenase ( asd ) gene. (ojvr.org)
Identification1
- 4. Identification of anti-filarial leads against aspartate semialdehyde dehydrogenase of Wolbachia endosymbiont of Brugia malayi: combined molecular docking and molecular dynamics approaches. (nih.gov)
Found1
- Aspartate-semialdehyde dehydrogenase may be cis-regulated by an Asd RNA motif found in the 5' UTR of some Asd genes. (wikipedia.org)
Role1
- The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. (cathdb.info)