• Asparagine, however, is not well transported to the brain via the blood-brain barrier," said senior co-author of the study Dr Jacques Michaud, who found that brain cells depend on the local synthesis of asparagine to function properly. (health24.com)
  • We provide independent and unbiased information on manufacturers, prices, production news and consumers for the global and regional (North America, Asia and Europe) market of DL-Asparagine monohydrate. (reportsnreports.com)
  • Asparagine was first isolated in 1806 in a crystalline form by French chemists Louis Nicolas Vauquelin and Pierre Jean Robiquet (then a young assistant) from asparagus juice, in which it is abundant, hence the chosen name. (wikipedia.org)
  • Traditionally, the name of an amino acid is related to its discovery, and since asparagine was first purified from asparagus juice, it was given a similar name. (fsu.edu)
  • Asparagus contains the highest amount of asparagine, where the name comes from. (foodista.com)
  • Asparagine is produced when sugars react to heat, for example: baked goods, potato chips and roasted coffee. (foodista.com)
  • Structural characterization of asparagine synthetase from mammalian sources have been difficult due to the low abundance and instability of the enzyme during purification procedures. (wikipedia.org)
  • Most mammalian cells express AS and regulate the level of activity in response to the concentration of asparagine in the medium. (novusbio.com)
  • The particularly low-level expression of asparagine synthetase in primary acute lymphoblastic leukemia (ALL) and numerous ALL cell lines, as compared to that of normal cells, makes asparagine depletion an effective method of treatment due to the cells' unusual dependency on circulating serum asparagine as a necessary nutrition for growth. (wikipedia.org)
  • This depletion of serum asparagine leads to a subsequent rapid efflux of cellular asparagine, which is immediately acted upon and destroyed by the L-asparaginase as well. (wikipedia.org)
  • In individuals with the disability, the enzyme is not produced in sufficient quantity, and the resulting asparagine depletion affects the proliferation and survival of cells during brain development. (health24.com)
  • Certain tumor cells in contrast, exhibit little or no AS activity and rely on the surrounding medium as a source of exogenous asparagines (1). (novusbio.com)