• Three of 14 wipe samples were positive for cyclophosphamide (1.6-3.9 ng/sample) while simultaneously being ND for doxorubicin, vincristine, methotrexate, and epirubicin. (cdc.gov)
  • Dogs initially treated with COP protocol for induction (combination protocol with cyclophosphamide, vincristine and prednisone) or COAP (same as COP plus cytosine arabinoside) for a period of 8 weeks, are followed with LMP protocol for maintenance (methotrexate, chlorambucil and prednisone) for the period where the remission time is sustained. (vin.com)
  • Toxicity of vincristine another chemotherapy agent, may be more likely if vincristine and L-asparaginase are given at the same time. (marvistavet.com)
  • Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster-based intensive chemotherapy. (unimib.it)
  • Purpose: To assess the effect of treatment intensification and that of extended intrathecal methotrexate substitution for cranial irradiation in intermediate-risk acute lymphoblastic leukemia (ALL) children treated with a Berlin-Frankfurt-Munster (BFM)-based intensive chemotherapy. (unimib.it)
  • On protocol Total XII, 182 children achieved remission and received weekly methotrexate 40 mg/m 2 parenterally and daily oral 6MP, interrupted every 6 weeks during the first year by pulse chemotherapy. (ashpublications.org)
  • Asparaginase as a single agent induces in the majority of the cases a complete remission, but because this time is usually short, the administration of other chemotherapy agents is needed. (vin.com)
  • When used to treat cancer, methotrexate works by blocking an enzyme process in cancer cells so they cannot grow. (medbroadcast.com)
  • The enzyme L-Asparaginase destroys asparagine outside the cells forcing the cells to rely completely on what they can produce on their own. (marvistavet.com)
  • L-asparaginase is an enzyme produced by bacteria. (marvistavet.com)
  • L-asparaginase may interfere with blood clotting, may raise blood sugar levels, may raise liver enzyme blood tests, and may cause liver disease in some patients. (marvistavet.com)
  • Asparaginase is an enzyme that is used as a medication and in food manufacturing. (wikipedia.org)
  • Another useful antimetabolite is L-asparaginase, an enzyme that inhibits lymphoma cells with an absolute requirement for the pre-formed amino acid asparagine. (vin.com)
  • Enzyme: asparaginase 8. (present5.com)
  • V. To collect pharmacodynamic (PD) data for asparaginase activity following pegaspargase administration in infants. (iu.edu)
  • The dose of methotrexate varies depending on the type of cancer being treated and body weight or size. (medbroadcast.com)
  • If your doctor recommends the injectable form of methotrexate, the appropriate dose is usually injected one or more times weekly, either in cycles (i.e., some weeks no injections are given) or on a regular basis, depending on the type of cancer being treated. (medbroadcast.com)
  • The usual adult dose of methotrexate is 7.5 mg taken as one dose once weekly by mouth or 2.5 mg taken every 12 hours for 3 doses once weekly. (medbroadcast.com)
  • The usual adult starting dose of methotrexate is 10 mg to 25 mg per week in one dose (tablet or injection) or 2.5 mg (tablet) to 5 mg taken every 12 hours for 3 doses once weekly. (medbroadcast.com)
  • Check specific protocol for precise asparaginase product and dose. (medscape.com)
  • June 3, 2011 (Chicago, Illinois) - A regimen of high-dose methotrexate appears to be superior to the standard protocol of escalating methotrexate in children and young adults with high-risk B-precursor acute lymphoblastic leukemia (ALL). (medscape.com)
  • We feel that it is the standard of care to receive high-dose methotrexate in this population," said lead author Eric C. Larsen, MD, director of the Maine Children's Cancer Program and the division of pediatric hematology/oncology at the Barbara Bush Children's Hospital at Maine Medical Center in Portland, adding that he hopes to see it incorporated into practice guidelines. (medscape.com)
  • High-dose methotrexate will be incorporated in current and future Children's Oncology Group trials. (medscape.com)
  • Dr. Larsen noted that adverse events were closely monitored, and high-dose methotrexate appeared to be safe with no increase in toxicity. (medscape.com)
  • High-dose methotrexate was actually less toxic than the Capizzi regimen," he said. (medscape.com)
  • Even though methotrexate has been used for more than 5 decades and is an essential part of the treatment regimen for children with ALL, the optimal dose and schedule have not been fully established. (medscape.com)
  • The Capizzi regimen, which involves the administration of escalating-dose methotrexate and L-asparaginase, has been the standard treatment for ALL for the past 20 years. (medscape.com)
  • In their study, Dr. Larsen and colleagues randomized 2426 patients to receive dexamethasone or prednisone during induction, and then to receive high-dose methotrexate (5 g/m 2 biweekly for 4 weeks) or escalating-dose methotrexate plus PEG-L-asparaginase during interim maintenance. (medscape.com)
  • Possible reasons for the plateau in event-free survival (including type and dose of induction steroid, dropping of induction anthracycline, type and dose of asparaginase, gaps early in therapy following intensification, and overall lack of compliance in maintenance) are being explored in the latest protocol ALL '97. (ox.ac.uk)
  • Our objective was to evaluate whether MTXPGs, TGNs, and the dose intensity of administered methotrexate and 6MP were prognostic in the setting of a treatment protocol in which all treatment was coordinated through a single center, and the weekly doses of methotrexate were given parenterally. (ashpublications.org)
  • A total of 709 TGN, 418 MTX-PG, and 267 thiopurine methyltransferase (TPMT) measurements, along with complete dose intensity information (dose received divided by protocol dose per week) for 19,046 weeks of 6MP and methotrexate, were analyzed. (ashpublications.org)
  • In univariate analyses, only higher dose intensity of 6MP and of weekly methotrexate were significant predictors of overall EFS ( P = .006 and .039, respectively). (ashpublications.org)
  • I. To determine if the administration of post-Induction age-adjusted intrathecal triple therapy (ITT) on a Modified Berlin-Frankfurt-Munster (MBFM) interim maintenance high-dose methotrexate (IMHDM) backbone will improve 5-year disease-free survival (DFS) of children with high-risk (HR) B-acute lymphoblastic leukemia (ALL) compared to age-adjusted intrathecal (IT) methotrexate (MTX). (uchicagomedicine.org)
  • If a complete remission is achieved when a rescue protocol is started, the dose of the asparaginase may be "saved" for the future, but if only a partial remission is obtained, intensification with asparaginase may be necessary). (vin.com)
  • Methotrexate is an antimetabolite of the folic acid analogue type. (medscape.com)
  • Methotrexate, a folic acid analog/antimetabolite, can be curative for women with choriocarcinoma and is also useful for non-Hodgkin lymphomas and acute lymphocytic leukemias (ALLs) in children. (medquizzes.net)
  • Indicated as part of a multiagent chemotherapeutic regimen as a substitute for asparaginase (Elspar), which was discontinued by the manufacturer in August 2012. (medscape.com)
  • L-asparaginase works by exploiting the unusually high requirement tumor cells have for the amino acid "asparagine. (marvistavet.com)
  • When L-asparaginase destroys asparagine, ammonia is a by-product. (marvistavet.com)
  • Asparaginase works by breaking down the amino acid known as asparagine without which the cancer cells cannot make protein. (wikipedia.org)
  • L-asparaginase starves cancer cells without affecting normal cells, which are capable of making asparagine from other amino acids, whereas the lymphoma cells generally cannot. (vin.com)
  • myelosuppression and gastrointestinal toxicity (especially methotrexate). (vin.com)
  • This essential technique to reduce host cell toxicity in response to methotrexate (MTX) therapy is often referred to as leucovorin (folinic acid) rescue. (medquizzes.net)
  • As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). (wikipedia.org)
  • One of the primary concerns in acute lymphoblastic leukemia treatment is the occurrence of adverse events (AEs) associated with asparaginase therapy. (wikipedia.org)
  • Relapse risk following truncation of PEG-asparaginase in childhood acute lymphoblastic leukemia. (cancercentrum.se)
  • Determine whether treatment with a regimen without methotrexate maintains the same disease-free survival as NHL/BFM 90 in these patients. (knowcancer.com)
  • Eryaspase treatment for children and young adults with leukemia and hypersensitivity to PEG-asparaginase. (clinicaltrialsregister.eu)
  • It is also indicated for use in patients with hypersensitivity to native forms of L-asparaginase. (medscape.com)
  • The main uses of methotrexate (MTX) for conditions other than responsive cancers are management of rheumatoid arthritis (RA) and psoriasis that is usually not responsive to other drugs. (medquizzes.net)
  • To determine the incidence of osteonecrosis (ON), defined by magnetic resonance (MR) imaging, and to characterize the natural history of clinically silent ON in children, adolescents, and young adults 10 years of age and greater and to assess the role of drugs (i.e., asparaginase and methotrexate) in addition to corticosteroids, in the risk for development of ON. (uchicagomedicine.org)
  • and asparaginase intramuscularly (IM) on days 3, 5, and 7 and then 3 times a week for 9 doses (during days 8-21). (knowcancer.com)
  • Maintenance (84 day course): Patients receive same therapy as localized lymphoblastic lymphoma patients, except methotrexate IT is administered on day 0 and 28 (for first 4 courses). (knowcancer.com)
  • In studies of oral 6MP and methotrexate, indices of chronic systemic exposure to active metabolites of these agents, namely, red blood cell (RBC) concentrations of methotrexate polyglutamates (MTXPGs) and thioguanine nucleotides (TGNs) have positively correlated with event-free survival (EFS). (ashpublications.org)
  • Anaphylactic reactions to L-asparaginase are much more common in dogs than in cats. (marvistavet.com)
  • Methotrexate is used to treat certain types of cancer such as leukemia, non-Hodgkin's lymphoma, breast cancer, head and neck cancer, stomach cancer, bladder cancer, bone cancer, and choriocarcinoma (a type of uterine cancer). (medbroadcast.com)
  • The use of L-asparaginase has been associated with pancreatitis . (marvistavet.com)
  • The main efficacy outcome measure was demonstration of the achievement and maintenance of nadir serum asparaginase activity (NSAA) above the level of 0.1 U/mL. (wikipedia.org)