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  • binds
  • a mAb binds to a target (e.g., receptors, soluble antigens, etc.) and induces either antagonistic (i.e., blocking or neutralizing) or agonistic effects (i.e., activating), triggering down-stream pharmacological effects, leading to efficacy and/or unwanted side effects. (springer.com)
  • Structural
  • We applied these methods to the actual biologically important systems, including chemokine-chemokine receptors, the cell adhesion molecule CD44, and the photosynthesis complex, and successfully obtained the structural information of the transiently formed complex of those molecules, which are related to their function. (nii.ac.jp)
  • vitro
  • We will address these hypotheses with the following specific aims: In initial studies, the recognition and binding of T lymphocytes to the hepatocyte ASGP receptor will be characterized in vitro. (grantome.com)
  • surfaces
  • The kinetics of appearance of newly synthesized wild-type and mutant receptor protein at the apical and basolateral surfaces indicate that these proteins are sorted intracellularly and are transported directly to the respective domains. (uzh.ch)
  • abnormal
  • Furthermore, as a consequence of ethanol-mediated alterations to the ASGP receptor, altered clearance of T cells occurs leading to abnormal lymphocyte accumulation, events that could contribute the development of hepatitis and the progression of ALD. (grantome.com)
  • regulation
  • Recently it has been suggested that the recognition and subsequent regulation of immune cells could be a potential physiological role of the ASGP receptor. (grantome.com)
  • Primary
  • Nevertheless, it was not until 1984 when the first Cyp, specifically cyclophilin A (Cyp A), was purified from bovine thymocytes, and it was confirmed as the primary intracellular receptor of the immunosuppressive drug CsA ( 2 ). (frontiersin.org)