Asct autologous bone marrow transplant bone marrow transplantation. Medical search. Frequent questions

The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)

Biol Blood Marrow Transplant. (gitmo.it)

Bazarbachi AH, Al Hamed R, Malard F, Bazarbachi A, Harousseau JL, Mohty M. Induction therapy prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma: an update. (gitmo.it)
Would you recommend autologous stem cell transplantation (ASCT) for transplant-eligible patients with newly diagnosed multiple myeloma (NDMM)? (targetedonc.com)

High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)

METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)

Impact of the SARS-CoV-2 pandemic on hematopoietic cell transplantation and cellular therapies in Europe 2020: a report from the EBMT activity survey. (gitmo.it)
The first-ever online and open-access education e-course, brought to you by The EBMT Trainee Committee, designed to cover all aspects surrounding hematopoietic cell transplantation and cellular therapy with a focus on trainee-relevant knowledge and skills. (ebmt.org)

Multiple myeloma is diagnosed based on blood or urine tests finding abnormal antibody proteins - (often using electrophoretic techniques revealing the presence of a monoclonal spike in the results - termed an m-spike), bone marrow biopsy finding cancerous plasma cells, and medical imaging finding bone lesions. (wikipedia.org)

Identifying and understanding acute complications after allogeneic haematopoietic cell transplantation (alloHCT). (ebmt.org)

7 In the recently completed LenaRIC study patients undergoing allo-SCT with reduced-intensity conditioning received lenalidomide for 12 months from day 35 post-transplantation, with DLI for mixed chimerism or persistent disease. (medicalupdateonline.com)
Donor/sponsor chimerism was regularly performed every 3 months for the 1st yr post transplantation using short-tandem repeat (STR) amplified by polymerase chain reaction (PCR). (bio-cavagnou.info)
Life-threatening infections required vasopressors and/or intubation and included Sobetirome any viral end-organ disease EBV-post-transplantation lymphoproliferative disorder (EBV-PTLD) or infections. (bio-cavagnou.info)

lenalidomide-dexamethasone [KRd] or with cyclophosphamide-dexamethasone [KCd], with half the patients getting KRd, just continuing without a transplant, and the others doing a stem cell transplant and then getting some further therapy afterward. (targetedonc.com)
After ASCT, lenalidomide maintenance is considered for standard risk patients especially in those who are not in very good partial response or better, while maintenance with a bortezomib-based regimen is needed for patients with intermediate or high-risk disease. (elsevierpure.com)
PI) and immunomodulatory (IMiD) [eg, bortezomib thalidomide and dexamethasone (VTd), lenalidomide, bortezomib and dexamethasone (RVd)] with or without a CD38 monoclonal antibody, or Velcade® (bortezomib), cyclophosphamide, dexamethasone (VCd), and followed by a single or tandem autologous stem cell transplantation (ASCT). (who.int)

Although multiple myeloma patients younger than 66 years of age have an aggressive presentation, this did not translate into an inferior overall survival, particularly in those undergoing autologous hematopoietic stem cell transplantation. (scielo.br)
We determined the incidence and the prognostic significance of HZ and its correlation with VZV serology in 191 consecutive myeloma patients undergoing high-dose melphalan chemotherapy with ASCT. (nature.com)
Finally, OS was better in myeloma patients with HZ after ASCT compared with patients without HZ ( P =0.007). (nature.com)
The implication of these results would be that myeloma-specific T cell subfamilies might be positively selected from the donor inoculum and infused to myeloma patients post ASCT, to afford separation of allo- from tumor-reactive T cells without the prior need to define specific target antigens. (biomedcentral.com)

1,2 One of the issues is that three-quarters of the patients who did not receive ASCT initially had a stem cell transplant at first relapse. (targetedonc.com)
Despite chemo-induction therapy and autologous stem cell transplantation (ASCT), the vast majority of patients with Multiple Myeloma (MM) relapse within 7 years and the disease remains incurable. (biomedcentral.com)
We first demonstrated that myeloma bearing-Balb/c mice initially respond clinically to irradiation and auto-BMT but eventually relapse, similar to MM patients undergoing induction therapy and ASCT. (biomedcentral.com)
Standard risk patients can opt for delayed ASCT at first relapse. (elsevierpure.com)
Progressive disease or clinical relapse (as defined by IMWG response criteria) following ASCT with or without consolidation or is not responsive to primary therapy. (who.int)

The primary objective is to demonstrate that intensified chemotherapy followed by consolidating HCT-ASCT is superior to conventional chemotherapy with rituximab, MTX, procarbazine (R-MP) followed by maintenance with procarbazine in terms of progression free survival (PFS). (biomedcentral.com)
Multivariable analysis revealed that creatinine ≥2 mg/dl, extramedullary disease, ≤very good partial remission and non-autologous hematopoietic stem cell transplantation are independent risk factors for shorter survival. (scielo.br)
Our data indicate that VZV reactivation after ASCT is a frequent event carrying a significant disease burden and it is associated with improved survival. (nature.com)
3 Although the higher CR rates did not translate into a survival benefit in this study, longer follow-up periods of up to 9 years show a significant OS and PFS benefit in favour of allo-SCT over double ASCT including in patients with high-risk cytogenetics. (medicalupdateonline.com)
After 90 months of follow-up, the study found an advantage in progression-free survival [PFS] at 47 months vs 35 months for patients who did not receive ASCT. (targetedonc.com)
OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
Though untreated the disease is uniformly fatal, newer advances in treatment like autologous hematopoietic stem cell transplantation, mini-transplants and advances in chemotherapy have improved the quality of life and increased survival (Gupta et al. (journalcra.com)
These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
Survival of patients with multiple myeloma (MM) beyond 7 years remains rare even after autologous stem cell transplantation (ASCT) and treatment with novel agents [ 1 ]. (biomedcentral.com)
Research shows that ASCT is a lot of toxicity aka causes short, long-term, late stage side effects considering the overall survival (length of life) you will gain. (peoplebeatingcancer.org)
Endpoints of the study were overall survival (OS) progression-free survival (PFS) transplant-related mortality (TRM) engraftment cumulative incidence of illness and GVHD. (bio-cavagnou.info)
High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
Progression-free survival for people who have received an HDT-ASCT combination therapy is around 3.5 years. (janssen.com)
Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)

Other promising developments to improve outcomes in allo-SCT include conditioning with radiolabelled anti-CD66, as well as salvage therapy with daratumumab 8 or newer imids which suggest that allo-SCT has the potential to enhance the efficacy of other therapies that may have been less effective pre-transplantation. (medicalupdateonline.com)
Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
Fifty-five out of 72 patients (75%) who received any therapy were treated with immunomodulators (IMiDs) and/or proteasome inhibitors (PIs), and 14/72 (19%) underwent salvage autologous stem cell transplantation (ASCT). (wustl.edu)
These findings suggest that patients with sPCL may benefit from salvage ASCT- and PI-based regimens. (wustl.edu)
TRANSFORM is a randomized pivotal global multicenter phase 3 trial testing liso-cel against the standard of care, which is salvage chemotherapy followed by an autologous stem cell transplant in patients with primary relapsed/refractory LBCL in the second-line setting. (oncdata.com)
On the other hand, patients in the standard-of-care arm received the standard three cycles of salvage chemotherapy followed by autologous transplant if they were to respond. (oncdata.com)
On the other hand, in the standard-of-care arm, only about 46% of patients responded to salvage and went on to get an autologous transplant. (oncdata.com)

Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
Is radioimmunotherapy before a donor peripheral blood stem cell transplant an effective treatment for non-Hodgkin's Lymphoma? (ucdavis.edu)
This phase II trial studies how well ibritumomab tiuxetan before donor peripheral blood stem cell transplant works in treating patients with relapsed or refractory non-Hodgkin lymphoma. (ucdavis.edu)
Giving rituximab, antithymocyte globulin, and total-lymphoid irradiation (TLI) before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells and helps stop the patient's immune system from rejecting the donor's stem cells. (ucdavis.edu)
Statistical Analysis This study was designed as a single center non-randomized phase II trial to investigate the feasibility and security of a non-myeloablative conditioning routine plus an unmodified peripheral blood stem cell transplant in individuals with hematologic malignancies who are not candidates for myeloablative conditioning by virtue of age prior organ toxicity or intensity of prior therapy. (bio-cavagnou.info)

Complications such as renal failure, infections, anemia, lytic bone lesions and amyloidosis lead to morbidity as well as mortality (UK myeloma forum, 2001). (journalcra.com)
Progression of intramedullary myeloma is associated with increasingly severe secondary features (lytic bone lesions, anaemia, immunodeficiency and renal impairment) and also, in a fraction of patients, the occurrence of tumour cells in extramedullary sites, such as the blood, pleural fluid and skin. (touchoncology.com)

Combination vincristine, doxorubicin, and dexamethasone (VAD) is considered a standard infusional induction therapy for younger MM patients prior to HDT and ASCT. (haematologica.org)

High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
Tandem haematopoietic stem cell transplantation versus single cell transplant and BV maintenance in relapsed/refractory Hodgkin lymphoma: A matched cohort analysis from the LYSA. (canceropole-est.org)
This randomized phase III trial studies ibrutinib to see how well it works compared to placebo when given before and after stem cell transplant in treating patients with diffuse large B-cell lymphoma that has returned after a period of improvement (relapsed) or does not respond to treatment (refractory). (ucdavis.edu)
It is not yet known whether adding ibrutinib to chemotherapy before and after stem cell transplant may help the transplant work better in patients with relapsed or refractory diffuse large B-cell lymphoma. (ucdavis.edu)

Additional data presented in an oral presentation at ASCO (Abstract #8013) demonstrate that adding BEXXAR to BEAM (BCNU, etoposide, ara-C, and melphalan) chemotherapy as a conditioning regimen prior to autologous stem cell transplant (ASCT) in patients with relapsed or high-risk chemosensitive diffuse large B-cell lymphoma (DLBCL) resulted in 78% of the patients achieving a complete remission following the transplant. (salesandmarketingnetwork.com)
Axicabtagene ciloleucel in large B cell lymphoma ineligible for autologous stem cell transplantation: the phase 2 ALYCANTE trial. (canceropole-est.org)
This phase I/II trial studies the side effects and best dose of gene therapy in treating patients with human immunodeficiency virus (HIV)-related lymphoma that did not respond to therapy or came back after an original response receiving stem cell transplant. (ucdavis.edu)
Within ACVR1B this cohort of high-risk lymphoma individuals alemtuzumab comprising RIC resulted in a low risk of GVHD and a high incidence of POD especially in those with poor-risk features defined by elevated LDH pre-allo-SCT and earlier HDT-ASCT. (bio-cavagnou.info)

In this month's Pharmacy SIG Literature Update: Impact of anti-T-lymphocyte globulin dosing on GVHD in MUD SCT, impact of MRD status before alloHCT on outcomes in secondary AML, low-dose post- transplant cyclophosphamide with low-dose antithymocyte globulin for prevention of GVHD in MUD SCT and more. (astct.org)

The following chapter describes the underlying biology and clinical techniques involved in the process of stem and progenitor cell identification, enumeration, mobilization, and collection prior to autologous stem cell transplantation (ASCT). (wustl.edu)

Han CS, Miller W, Haake R, Weisdorf D . Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications. (nature.com)
Familiarize trainees with important clinical aspects of stem cell transplant and cellular therapy, including pharmacology, patient monitoring, and recognition and basic management of complications. (ebmt.org)

Remissions may be brought about with steroids, chemotherapy, targeted therapy, and stem cell transplant. (wikipedia.org)

Atkinson K, Meyers J, Storb R, Prentice RL, Thomas ED . Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. (nature.com)

Earlier high-dose therapy and autologous stem cell transplantation (HDT-ASCT) and elevated LDH at the time of allo-SCT resulted in inferior Sobetirome OS. (bio-cavagnou.info)
Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. (haematologica.org)

National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
2 The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 study showed that patients receiving an autologous SCT (ASCT) followed by an allo-SCT had significantly higher CR rates that patients receiving double ASCTs. (medicalupdateonline.com)
BEXXAR is also currently being tested in a Phase III trial in the Bone Marrow Transplant Clinical Trials Network (BMT/CTN) of Rituximab + BEAM vs. BEXXAR + BEAM in patients with relapsed DLBCL. (salesandmarketingnetwork.com)
The common clinical symptom were bone pain seen in 83.33% of patients followed by weakness/fatigue (53.33%), renal failure (20%), polyuria/polydipsia (13.33%), infections/fever (10%), isolated bony swelling (6.67%) and neurological features seen in 3.33% of cases. (journalcra.com)

Bisphosphonates and radiation therapy are sometimes used to reduce pain from bone lesions. (wikipedia.org)
Introduction: Multiple myeloma is characterized by proliferation of a clone of plasma cells that manifest by one or more lytic lesions, monoclonal (M) protein in the blood or urine and bone marrow involvement, ( Sirohi and Powles, 2004) having varying presentation and hematological features. (journalcra.com)
At diagnosis, MM is characterised by having a high intramedullary tumour-cell content (>10%), osteolytic bone lesions and/or an increasing tumour mass. (touchoncology.com)

Provide trainees with a basic knowledge and understanding of bone marrow transplant and cellular therapies. (ebmt.org)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)

Even if they do respond and go through an autologous transplant, among patients who have relapsed within 12 months after receiving chemoimmunotherapy, only a quarter of these patients actually experience durable remission. (oncdata.com)

26%) received ASCT from December 2000 to May 2011. (smw.ch)

Conclusion: Overall response rate (ORR) was 86.67%, 56.67 % patients achieved ≥VGPR hence VTD is highly active induction therapy before ASCT. (journalcra.com)
Much of the curative potential of allografts is attributed to the graft-versus-tumor (GvT) response that aims to destroy residual tumor cells that persist after induction therapy and ASCT [ 5 ]. (biomedcentral.com)
Participants within 12 months from initiation of induction therapy who achieved at least a partial response (PR) after autologous stem cell transplantation (ASCT) with or without consolidation, according to International Myeloma Working Group (IMWG 2016) criteria. (who.int)

Multiple Myeloma Diagnosis- Too Old for Stem Cell Transplant? (peoplebeatingcancer.org)

Multiple myeloma is a bone marrow disease characterized by the presence of malignant plasma cells, & abnormal serum &/or urine immunoglobulin secondary to clonal plasma cell expansion. (mims.com)

Stem cell transplant is a procedure in which a patient receives healthy blood-forming cells to replace their own stem cells that have been destroyed by treatment. (survivornet.com)
Patient usually presents with bone pain & nonspecific symptoms, or due to abnormalities in laboratory exams. (mims.com)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)

Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)

Transplanting only tumor reactive donor T cells that mediate a graft-versus-myeloma (GvM) but not GvHD may overcome this problem. (biomedcentral.com)
Results Using the 5TGM1-Kalw/RijHSD immunocompetent in vivo model we have demonstrated that reovirus reduces both MM tumor burden and myeloma-induced bone disease. (bmj.com)
Multiple myeloma (MM) is a tumor of terminally differentiated plasma cells which expand in the bone marrow (BM). (bmj.com)

High-dose chemotherapy and autologous stem cell transplantation (HCT-ASCT) after high-dose methotrexate (MTX)-based immuno-chemotherapy has become an increasingly used treatment approach in eligible elderly PCNSL patients with promising feasibility and efficacy, but has not been compared with conventional chemotherapy approaches. (biomedcentral.com)
Patients judged transplant eligible will be randomized (1:1). (biomedcentral.com)
During a Targeted Oncology case-based roundtable event, Robert A. Vescio, MD, discussed the results of several key trials related to new treatments for patients with transplant-eligible multiple myeloma. (targetedonc.com)
6 , 9 The demonstrated efficacy, lack of myelosuppression, and overall tolerability of thalidomide provide a strong rationale for its incorporation in standard induction regimens for patients presenting with NDMM who may be eligible for ASCT. (haematologica.org)
In eligible patients, initial therapy is given for approximately 3-4 months followed by autologous stem cell transplantation (ASCT). (elsevierpure.com)

The efficacy of allo-SCT in MM relies on the transplanted immune system having an anti-tumour effect on the host bone marrow, the so-called graft-versus-myeloma (GvM) effect. (medicalupdateonline.com)
10 Data from the European Society for Blood and Marrow Transplantation (EBMT) megafile database indicates that the graft-versus-tumour effect achieved with allo-SCT is weaker and PFS rates lower in MM than in other types of haematological cancers. (medicalupdateonline.com)
Reduced-intensity conditioning (RIC) regimens for allogeneic stem cell transplantation (allo-SCT) have used alemtuzumab to abrogate the risk of graft-versus-host disease (GVHD). (bio-cavagnou.info)

Autologous stem cell transplant in 716 patients with multiple myeloma: low treatment-related mortality, feasibility of outpatient transplant, and effect of a multidisciplinary quality initiative. (gitmo.it)
In its early era allo-SCT was associated with transplant-related mortality (TRM) rates of around 40%, 1 and in Dr Cook's opinion this has left a lingering perception in many MM clinicians' minds that allo-SCT outcomes are poor. (medicalupdateonline.com)

This trial confirmed the results of other trials that demonstrated a substantial incidence of symptomatic hypotension in MM patients in the peri-transplant period following ASCT. (astct.org)
People whom experienced ocular floor treatments such as limbal hair loss transplant prior to BKPRo implantation had a decrease incidence associated with corneal melting/thinning (p=0.3 years ago), of course this wasn't statistically considerable. (ikksignaling.com)

0.5 x 109 cells/kg and being transplanted in CR1 versus CR/PR from second-line therapy were identified as independent predictors for OS and PFS. (astct.org)

All patients will be treated with a pre-phase rituximab-MTX (R-MTX) cycle followed by re-assessment of transplant eligibility. (biomedcentral.com)

CONCLUSIONS: Conditioning with CBV or BEAM and subsequent ASCT was feasible and effective. (smw.ch)
These results compare favorably with previous studies of BEAM alone followed by ASCT. (salesandmarketingnetwork.com)

Patients not candidates for transplant are treated with Rd until progression, or alternatively, a triplet regimen such as VRD for approximately 12-18 months. (elsevierpure.com)

People had proposed that if you test for MRD, and it's negative, then maybe you don't have to do a transplant, but this study showed that it was better if patients had the transplant, at least for their PFS. (targetedonc.com)

European Society for Blood and Marrow Transplantation (EBMT). (gitmo.it)
A predictive model of varicella-zoster virus infection after autologous peripheral blood progenitory cell transplantation. (nature.com)
Shea, TC & DiPersio, JF 2016, Mobilization of Peripheral Blood Hematopoietic Cells for Autologous HCT . (wustl.edu)

Before transplant, stem cells are taken from patients and stored. (ucdavis.edu)
If If my doctor feels that I am a candidate for stem cell they plan to harvest stem cells at the end of Feb. The current plan is to postpone stem cell transplant until early summer because of COVID. (peoplebeatingcancer.org)
Harvesting your stem cells, regardless if you think you will have an ASCT or not, is a good idea. (peoplebeatingcancer.org)

Are unable or unwilling to undergo a stem cell transplant or CAR-T cell therapy. (survivornet.com)

In addition atovaquone or trimethoprim-sulfamethoxazole was prescribed for prevention of toxoplasmosis infections after transplantation in seropositive individuals or those with seropositive donors. (bio-cavagnou.info)

Anatomy27

Organisms12

Diseases62

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment71

Psychiatry and Psychology2

Phenomena and Processes35

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science5

Named Groups3

Health Care16

Therapy and autologous bone marrow tra2

Biol Blood Marrow Transplant1

Newly diagnosed multiple2

Chemotherapy with autologous1

Conditioning regimens1

Hematopoietic cell transplantation and cellular2

Biopsy1

Haematopoietic Cell Transplantation1

Post-transplantation3

Lenalidomide3

Myeloma patients4

Relapse5

Survival15

Salvage7

Peripheral blood stem5

Lytic bone lesions2

Dexamethasone1

Refractory6

Lymphoma4

Cyclophosphamide1

Progenitor1

Complications2

Targeted therapy1

Aplastic1

High-dose therapy2

Clinical6

Lesions3

Therapies2

Remission1

20001

Induction therapy3

Diagnosis1

Clonal1

Patient3

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Eligible5

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Mortality2

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Versus1

Rituximab1

BEAM2

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Study showed1

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Infections1