Loading...
  • sequences
  • These repeated sequences also create ambiguities in the formation of contigs in genome assembly, while ambiguities in transcriptome assembly contigs usually correspond to spliced isoforms, or minor variation among members of a gene family. (wikipedia.org)
  • Official website Tutorials Gene Designer Webinar: demonstrates how to design gene sequences, how to remove or add restriction sites or other motifs, primer design, cloning scheme, and other features. (wikipedia.org)
  • locus
  • Basically, the antibody paratope is polygenic, made up of three genes, V, D, and J. Each paratope locus is also polymorphic, such that during antibody production, one allele of V, one of D, and one of J is chosen. (wikipedia.org)
  • variants
  • Third, transcriptome assembly is more challenging because transcript variants from the same gene can share exons and are difficult to resolve unambiguously. (wikipedia.org)
  • cells
  • More than 20 different partner genes with MLL have been cloned from leukemia cells with translocations involving chromosome 11 band q23 (11q23). (aacrjournals.org)
  • This is usually used when you want just a short sequence from a single gene that you want to use for something such as transfecting into cells in vitro. (physicsforums.com)
  • Synthetic morphology extends this idea by adding output modules that alter the shape or social behaviour of cells in response to the state of the artificial gene network. (wikipedia.org)
  • It has been argued that the formation of properly-shaped tissues by mammalian cells involves mainly a set of about ten basic cellular events (cell proliferation, cell death, cell adhesion, differential adhesion, cell de-adhesion, cell fusion, cell locomotion, chemotaxis, haptotaxis, cell wedging). (wikipedia.org)
  • Zoology (1991-96), Trends in Cell Biology (1991-97), Molecular and Cellular Biology (1992-98), Genes to Cells (1994-98). (wikipedia.org)
  • vector
  • They are one of the most efficient methods of a gene delivery vector. (gentaur.com)
  • The chosen genes were amplified by PCR methodology and cloned into pAE, an E. coli vector. (nih.gov)
  • E. coli strains carrying promoter fusion plasmids along with a RepR-expressing plasmid (pETRepR) or vector (pET22-b) were grown and assayed for β-glucuronidase activity. (nih.gov)
  • Genome
  • The information generated from the Genome Projects will be of the greatest value if it can be converted into functional data, particularly if this increases our understanding of normal gene function and allows strategies to be developed for prevention and treatment of human disease. (pubmedcentralcanada.ca)
  • Unlike genome sequence coverage levels - which can vary randomly as a result of repeat content in non-coding intron regions of DNA - transcriptome sequence coverage levels can be directly indicative of gene expression levels. (wikipedia.org)
  • Deletion
  • ncRNAs are also thought to regulate gene expression, so deletion studies have a hard time distinguishing effects of ncRNA loss from effects of gene misregulation due to the deletion. (wikipedia.org)
  • Chromosome
  • It was also by means of cell fusion that Harris and Goss devised the first systematic method for determining the order of genes along the human chromosome and the distances between them. (wikipedia.org)
  • molecular
  • Gene Designer enables molecular biologists to manage the full gene design process in one application, using a range of design tools. (wikipedia.org)
  • novel
  • In this paper, we propose a novel denoising method for high ISO JPEG images via deep fusion of collaborative and convolutional filtering. (bioportfolio.com)
  • In the present study, we have identified human gephyrin as a novel fusion partner of MLL from a patient who presented with a de novo acute monoblastic leukemia with t(11;14)(q23;q24). (aacrjournals.org)
  • functional
  • Experimentally derived functional knowledge of the majority of gene products in oomycetes in a comparable depth as for model species like Saccharomyces cerevisiae and Arabidopsis ( Arabidopsis thaliana ) will likely not be accessible in the near future. (plantphysiol.org)
  • The functional significance of this de facto truncated MLL gene product is not clear. (aacrjournals.org)
  • different
  • They demonstrated that cell fusion provided a general method for the amalgamation of different cell types across the barriers imposed by species differences and by the process of differentiation. (wikipedia.org)
  • The regions where the genes are randomly recombined together is the hyper variable region used to recognise different antigens on a clonal basis. (wikipedia.org)
  • It is also possible that they represent different genes within the same gene family, or even genes that share only a conserved domain, depending on the degree of variation. (wikipedia.org)
  • intelligence
  • This study established and validated a universal artificial intelligence (AI) platform for collaborative management of cataracts involving multi-level clinical scenarios and explored an AI. (bioportfolio.com)
  • Carnegie Mellon University announces "Libratus", an artificial intelligence program designed to beat humans at poker. (wikipedia.org)
  • methods
  • Microarray data analysis methods and their applications to gene expression data analysis for Saccharomyces cerevisiae under oxidative stress (PhD thesis). (wikipedia.org)
  • Human
  • We were able to identify two MLL -human gephyrin fusion products, presumably attributable to the alternative splicing of human gephyrin . (aacrjournals.org)
  • To identify potential toxicities, we consulted the existing evidence from AAV gene therapy for other nervous system disorders (animal toxicology and human studies) and from the clinical pharmacology of conventional analgesic drugs. (biomedcentral.com)
  • A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (ageing-map.org)
  • scientists
  • In a breakthrough for nuclear fusion research, scientists at China's Experimental Advanced Superconducting Tokamak (EAST) reactor have produced temperatures necessary for nuclear fusion on Earth. (bigthink.com)
  • Still, scientists have many other obstacles to pass before fusion technology becomes a viable energy source. (bigthink.com)
  • sequence
  • That site you linked to refers to a research tool where instead of cloning genes, you can have a DNA sequence synthesized. (physicsforums.com)
  • near
  • Reverse transcriptase PCR analyses of (a) PaLoc genes (a), C. difficile genes near the integration site of the phage (b), and ΦCD119 genes (c) in strains 602 (parent), 602ΦA, and 602ΦB. (nih.gov)
  • studies
  • Recent studies have shown that plant pathogenic oomycetes have expanded gene families that are possibly linked to their pathogenic lifestyle. (plantphysiol.org)
  • Therefore, the subsequent review on clinical translation and preclinical toxicology studies is predicated on a future plan to translate AAV gene therapy first in the palliative oncology setting. (biomedcentral.com)
  • A set of assembled transcripts allows for initial gene expression studies. (wikipedia.org)
  • Data
  • Data integration and Data fusion systems biology and metabolic engineering produces large amounts of data that originated in a diversity of techniques. (wikipedia.org)
  • The Mendes group works on integrating biochemical data and also works on data fusion, numerical issues of data integration. (wikipedia.org)
  • networks
  • Mendes group has created artificial networks to benchmark these problems. (wikipedia.org)
  • Using this approach, synthetic biologists have demonstrated the ability of their gene networks to perform Boolean computation, to hold a memory, and to generate pulses and oscillation. (wikipedia.org)
  • study
  • The purpose of this study is to register the precision of image fusion between live sonography and CT, MRI or PET/CT of liver lesions and other focal lesions in the abdomen. (bioportfolio.com)
  • application
  • Students create and complete projects which manage the full gene design process in one application, using a range of design tools. (wikipedia.org)
  • recessive
  • recessive genes are also more likely to be expressed, and to produce undesirable traits, including loss of general vigor and fertility. (thefreedictionary.com)
  • Ben also discovers that himself, his first cousin Gwen, his father Carl, and Uncle Frank, have alien history, from a species called Anodite, though he doesn't possess "the spark" like Gwen, as it is a recessive gene within him. (wikipedia.org)
  • occurs
  • This is likely a phenomenon that occurs in many types of cancers when oncogenic fusion genes are over-expressed," says the study's senior author, Dr. Mark A. Rubin, The Homer T. Hirst Professor of Oncology in Pathology and vice chair for experimental pathology at Weill Cornell Medical College. (freedomsphoenix.com)
  • mutant
  • The herpes simplex virus type 1 (HSV-1) mutant 1716 lacks both copies of the ICP34.5 gene, and as a result is no longer able to replicate in terminally differentiated and non-dividing cells but will infect and cause lysis very efficiently in cancer cells, and this has proved to be an effective tumour-targeting strategy. (wikipedia.org)
  • regulation
  • Noonan, D.J.;Lou, D.;Griffith, N.;Vanaman, T.C. "A calmodulin binding site in the tuberous sclerosis 2 gene product is essential for regulation of transcription events and is altered by mutations linked to tuberous sclerosis and lymphangioleiomyomatosis. (uky.edu)
  • human
  • Lottick tells Strasheim that the Mycora have apparently been stealing human gene sequences and may develop resistance to the coldness of the outer system, which incites concern. (wikipedia.org)
  • process
  • The phage gene and insert DNA hybrid is then inserted (a process known as "transduction") into Escherichia coli (E. coli) bacterial cells such as TG1, SS320, ER2738, or XL1-Blue E. coli. (wikipedia.org)
  • interest
  • Phage display was first described by George P. Smith in 1985, when he demonstrated the display of peptides on filamentous phage by fusing the peptide of interest onto gene III of filamentous phage. (wikipedia.org)
  • create
  • Thus if one is able to create a DSB at a desired gene in multiple samples, it is very likely that mutations will be generated at that site in some of the treatments because of errors created by the NHEJ infidelity. (wikipedia.org)
  • types
  • Users can design a rAAV vector to any target genomic locus and perform both gross and subtle endogenous gene alterations in mammalian somatic cell-types. (wikipedia.org)
  • devices
  • While thought-capable artificial beings appeared as storytelling devices in antiquity, the idea of actually trying to build a machine to perform useful reasoning may have begun with Ramon Llull (c. 1300 CE). (wikipedia.org)
  • The "detectors" they have by this time dropped on Mars, Earth, and Luna can actually be repurposed as "cascade fusion" devices. (wikipedia.org)
  • technology
  • The Broad Institute and Rockefeller University disagree over which scientists should be named as inventors on certain patents involving the gene-editing technology. (the-scientist.com)
  • allows
  • By scanning a pair of Ultra Capsules (ウルトラカプセル, Urutora Kapuseru), it allows Geed to Fusion Rise (フュージョンライズ, Fyūjon Raizu) into preferred forms: Primitive (プリミティブ, Purimitibu): Geed's default form based on Ultraman and Ultraman Belial. (wikipedia.org)
  • made
  • Non-medical applications of nanotechnology now under development include tiny semiconductor chips made out of strings of single molecules and miniature computers made out of DNA, the material of our genes. (euvolution.com)