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  • embryos
  • Acclimation to a low Cl - environment increased mRNA expression of both clc-2c and ncc2b , and also the protein expression of CLC-2c in embryos and adult gills. (ijbs.com)
  • stem cell
  • Stem cell technologies : basics and applications / chief editor, Kaushik D. Deb. (princeton.edu)
  • Stem cell research in the United States remains at the center of controversy and was a hotly debated topic during the recent election. (tinnitusformula.com)
  • Spheres are cloned cell colonies generated from a single stem cell and are made up primarily of progenitor cells that are capable of differentiating into different cell types. (tinnitusformula.com)
  • The next step is to integrate the growth of stem cell-derived hair cells with the recovery of neural synapses to complete the auditory pathway. (tinnitusformula.com)
  • What can stem cell technology offer to IVF patients? (ed.ac.uk)
  • Fujita, 1962 ) and that immense efforts are currently invested worldwide in stem cell research and regenerative medicine, it comes as a surprise that cell cycle studies during adulthood, contrary to development, are extremely limited with only a handful addressing the diseased brain. (frontiersin.org)
  • somatic cell nuc
  • The long-tailed macaques are the first primates to be cloned using the somatic cell nuclear transfer technique, which theoretically allows for a limitless amount of clones to be produced. (e-flux.com)
  • unlike
  • This consideration appeared to be challengeable because, unlike Mb-expressing cells, which are highly contractile (e.g., cardiac and skeletal muscle cells), the hitherto-known functions of HSCs and their activation were not fully discussed from the viewpoint of the intracellular [O.sub.homeostasis of HSCs. (thefreelibrary.com)
  • However, unlike mammalian or avian systems, testing for learning and memory in a reptile species is difficult. (jove.com)
  • nuclei
  • Adult amphibians, though, have been successfully cloned for many years from embryo nuclei. (encyclopedia.com)
  • In this technique, nuclei from cells of an early embryo are extracted using a very fine glass pipette and placed in egg cells that have been shed by a female amphibian such as a frog (after removing the unfertilized egg cell nucleus). (encyclopedia.com)
  • In order to use this technology effectively, all three of these elements, including the DNA repair template, must be efficiently and safely delivered to the nuclei of target cells. (umassmed.edu)
  • fetal
  • This finding provides direct evidence to overturn a long-held dogma in reproductive biology, that female mice generate egg cells only during fetal development and thus are born with a finite stock of eggs that declines throughout life. (bio-medicine.org)
  • Medical Center in Boston, Massachusetts, investigated the fetal cells that remained in the maternal blood stream after pregnancy. (asu.edu)
  • genome
  • Since the nucleus of virtually every animal cell contains the entire genome of the animal, it might seem easy enough to clone an animal by placing the nucleus in an egg cell from which the nucleus has been removed. (encyclopedia.com)
  • If a corrected copy of the disease mutation is also delivered when the cut is made, the cell can stitch the genome back tighter with the corrected gene, leading to permanent repair of the genome and correction of the disease gene. (umassmed.edu)
  • Without the Cas9 messenger RNA to cut the genome, the CRISPR guide and repair template remain inactive in the cells. (umassmed.edu)
  • bodies
  • The cell bodies of sensory neurons are located in the structures just next to the spinal cord, ie, the dorsal root ganglia, or in the cranial ganglia, while the cell bodies of the motor neurons are located within the central nervous system (spinal cord or brainstem). (pubmedcentralcanada.ca)
  • Intelligence
  • Using advanced molecular and artificial intelligence technologies, they identified pathways that they believe may provide means of unlocking this profound biology in human medicine. (nextbigfuture.com)
  • membrane
  • We also show that phospholipid vesicles without the bead supports and biomembranes from cellular sources can be arrayed with the same method and cell-specific membrane lipids can be identified. (jove.com)
  • Previous studies demonstrated that one major pathway by which Cl - crosses the basolateral cell membrane is via a member of the CLC family of Cl - channels. (ijbs.com)
  • Epithelial-like cells exhibit a plasma membrane with two sub-areas differing in structure and function. (leica-microsystems.com)
  • apoptosis
  • By initiating suppressive effects through induction of apoptosis, cell senescence, or transient cell-cycle arrest, p53 plays an important role in cancer suppression, developmental regulation, and aging. (asu.edu)
  • molecular
  • This is the first study to provide proof that the CRISPR/Cas9 gene editing system can be administered in a therapeutically applicable formulation to repair genes in live, adult animals," said Wen Xue, PhD, assistant professor of molecular medicine and a member of the RNA Therapeutics Institute at UMass Medical School. (umassmed.edu)
  • mice
  • A new report published in the Ear, Nose & Throat Journal (October, 2004) describes the significant progress being made in the growth of cochlear hair cells generated from stem cells in mice. (tinnitusformula.com)
  • To address questions along this front in anesthetized mice, we employ an artificial respiration strategy that decouples airflow through the nasal passages from gas exchange with the lungs. (bio-protocol.org)
  • A study published in Nature Biotechnology shows that administering the treatment by combining two delivery mechanisms already in clinical trials for other diseases led to correction of the mutated gene that causes the rare liver disorder in 6 percent of liver cells-enough to effectively cure the disease in mice. (umassmed.edu)
  • Just 24 hours after a transplant, the sterilized mice had new egg cells and follicles, the nurturing group of cells that encloses each egg cell. (bio-medicine.org)
  • findings
  • The results of these animal experiments corroborated the artificial environment findings. (tinnitusformula.com)
  • These findings were recently translated to the adult brain in an attempt to identify the overall principles governing stemness in the two contexts and allowing us to manipulate the expansion of NSC for regenerative therapies. (frontiersin.org)
  • clones
  • By using neuroblastoma cell clones lacking the expression of all neurotrophin receptors or engineered to express full-length or various truncated forms of p75(NTR), we could show that p75(NTR) is involved in the direct signaling of cell death by Abeta via the function of its death domain. (jove.com)
  • Type
  • 8) The discovery of CYGB led us to study its biological and pathophysiological importance in the histological homeostasis of the liver and to rethink the biological features of HSCs as a cell type that harbors [O.sub.bearing globin, especially in relation to their activation upon hepatic insult. (thefreelibrary.com)
  • 9) in which HSCs were recognized as an "[O.sub.sensing cell type" because these cells are activated under hypoxic conditions. (thefreelibrary.com)
  • Another differentiator of mammalian cell culture systems is the cell type which is used. (leica-microsystems.com)
  • nerve
  • In this paper, basic concepts of peripheral nerve injury, types of artificial and natural guides, and methods to improve the performance of tubes, such as orientation, nanotechnology applications for nerve reconstruction, fibers and nanofibers, electrospinning methods, and their application in peripheral nerve reconstruction are reviewed. (pubmedcentralcanada.ca)
  • similar
  • This study provides baseline methylation and gene transcription profiles for a healthy adult pig, reports similar patterns to those observed in humans, and supports future porcine studies related to human disease and development. (biomedcentral.com)
  • Previous studies in zebrafish identified Na + -Cl - cotransporter (NCC) 2b-expressing cells in the gills and skin as the major ionocytes responsible for Cl - uptake, similar to distal convoluted tubular cells in mammalian kidney. (ijbs.com)
  • liver
  • A week later, after the liver cells have had time to begin producing the RNA guide strand and the DNA template, a lipid nanoparticle is used to deliver the Cas9 messenger RNA. (umassmed.edu)