Articular damage. Medical search. Frequent questions

Intra-articular hemarthroses affect approximately 90% of patients with severe hemophilia, with the most frequently involved joints being the ankles, knees, and elbows. (medscape.com)
Intra-articular bleeding produces a direct chemical effect on the synovium, cartilage, and bone. (medscape.com)
The intra-articular structures include the medial and lateral menisci and the anterior and posterior cruciate ligaments ( Figure 1 ) . (aafp.org)
Frequent intra-articular injections may result in damage to joint tissues. (pdr.net)
Dexamethasone sodium phosphate injection is particularly recommended for use in conjunction with one of the less soluble, longer-acting steroids for intra-articular and soft tissue injection. (pdr.net)

Cartilage injury assays were performed using avulsed immature hips from wild-type or genetically modified mice or by explanting articular cartilage from porcine joints preinjected with pharmacologic inhibitors. (ox.ac.uk)

Since articular cartilage does not have a blood supply and chondrocytes (cells in articular cartilage) have limited mobility, the articular cartilage has very limited ability to heal itself. (wikipedia.org)
Articular cartilage is made up of specialized cells called chondrocytes. (nutritionjoint.com)
In contrast to the cost- and labor-intensive cultivation and propagation of cells such as MSCs or articular chondrocytes, the clinical use of "minimally processed" autologous BMA that can be prepared in the operation room as a single-step procedure appears straightforward. (hindawi.com)
This study used etoposide, to induce DNA damage-related senescence or chronic exposure to IL-1β to entail inflammation-related senescence in human OA chondrocytes. (aging-us.com)
On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. (aging-us.com)
That joint preservation technology developed at USC is a therapeutic bio-implant, called Plurocart, composed of a scaffold membrane seeded with stem cell-derived chondrocytes-the cells responsible for producing and maintaining healthy articular cartilage tissue. (scienceblog.com)
Evseenko said molecular characterization studies showed the bio-implant mimicked natural articular cartilage, with more than 95 percent of implanted cells being identified as articular chondrocytes. (scienceblog.com)
Light microscopic findings indicated progressive damage with increasing duration of treatment and included, in various degrees of severity, clefts in articular cartilage containing collagen strands, pyknotic nuclei in necrotic chondrocytes, cartilaginous flaps, and vesicles. (cdc.gov)

eBook authored by Dr Sheila Strover (Clinical Editor), explaining the difference between articular cartilage and meniscus cartilage. (kneeguru.co.uk)
Arthritis also occurs when a patient's meniscus cartilage has been damaged or removed following a sports injury, leaving the knee exposed to increased forces that wear off the articular cartilage-bearing surface. (stoneclinic.com)
A surgeon's evaluation, including an MRI and x-ray, can determine the degree and extent of any cartilage damage and also establish the injury or underlying mechanical problems that may have caused it, such as a missing or damaged meniscus cartilage. (stoneclinic.com)
It is vital that we understand the outcomes of our biologic surgical procedures to treat articular cartilage, meniscus cartilage, and the ligaments and tendons. (stoneclinic.com)

2006) found that small articular cartilage defects can progress to osteoarthritis over time if left untreated. (wikipedia.org)
Articular cartilage can naturally wear down as a person ages, but it can also wear down prematurely from repetitive motions, injury, or disease-like osteoarthritis. (nutritionjoint.com)
Exposure to excessive stress is associated with the pathogenesis of osteoarthritis, a joint disease involved in the degeneration of articular cartilage. (elsevierpure.com)
Although the mechanisms underlying mechanically induced osteoarthritis are still elusive, those results suggest a correlation between local chondrocyte death and transient strain rates in a depth dependent manner, and the surface layer played a crucial role in regulating chondrocyte damages and local strains in middle and deep layers. (elsevierpure.com)
Meniscal damage and meniscectomy lead to subsequent osteoarthritis (OA) of the knee joint through multiple and diverse mechanisms, yet the interaction of these mechanisms remains unknown. (nih.gov)
A long-term study of 49 meniscus transplant patients found that athletes who replace their damaged or missing meniscus with donor tissue can recover well enough to get back to sports, for up to 15 years, even if they had already developed osteoarthritis. (stoneclinic.com)
These injuries damage the menisci and the articular cartilage, eventually leading to osteoarthritis and osteoarthrosis. (medscape.com)
Moreover, chronic cartilage damage has been described at 13-year follow up with patellofemoral osteoarthritis in 22% in patellar instability knees compared to 11% in contralateral healthy knees [ 6 ]. (springer.com)

citation needed] When the damage increases and the chondral defect reaches the subchondral bone, the blood supply in the bone starts a healing process in the defect. (wikipedia.org)
X-rays show only bone injuries and are therefore not very helpful in diagnosing cartilage damage, especially not in early stages. (wikipedia.org)
In some cases, where the bone has been damaged or the injury has been caused by a more serious injury such as a ligament tear, surgery may be required. (nsmi.org.uk)
Once pain-related behavior was established, RNA was extracted from either whole joints or microdissected tissue samples (articular cartilage, meniscus, and bone). (ox.ac.uk)
When tissue samples from articular cartilage, meniscus, and bone were analyzed separately, NGF was consistently regulated in the articular cartilage. (ox.ac.uk)
TY - JOUR T1 - Nitrite and nitrotyrosine concentrations in articular cartilage, subchondral bone, and trabecular bone of normal juvenile, normal adult, and osteoarthritic adult equine metacarpophalangeal joints. (unboundmedicine.com)
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder characterised by synovitis and progressive damage to articular cartilage and subchondral bone. (bmj.com)
Damage to the bone and articular cartilage appears later. (medscape.com)
Arthritis the degenerative condition: characterized by cartilage damaged as the result of an injury or broken down over time by wear exposing the underlying bone. (stoneclinic.com)
The pathologic changes in OA joints include degradation of the articular cartilage, especially at the superficial zones, thickening of the subchondral bone, osteophyte formation, and variable degrees of synovial inflammation 11 . (nature.com)
A typical distinction of KBD from OA or other bone and joint diseases is the damage of epiphyseal cartilage and hyaline cartilage in the deep zones of cartilage 11 , 14 . (nature.com)
When this cartilage is damaged, bone can rub painfully against bone. (scoi.com)
Without adequate treatment, disease activity can lead to permanent joint and bone damage. (medscape.com)
Articular cartilage is the smooth, rubbery material that covers the bone surfaces in most joints. (eorthopod.com)
Furthermore, post-traumatic OA experienced by military personnel injured on the battlefield is a highly accelerated process, likely because these combat injuries are complicated by factors that are associated with greater risk including bone loss, surrounding soft tissue damage, and infection. (dtic.mil)
Joint fusion entails removing the damaged articular cartilage and inserting small pieces of bone between the joint surfaces. (lu.se)
AS is the prototypical member of the family of spondyloarthropathies, and is characterized by seronegativity, axial predominance and new bone formation, which underlie symptoms of inflammatory back pain, enthesopathy and extra-articular manifestations, including anterior uveitis, psoriasis and colitis. (medscape.com)
[ 2 ] Patients with AS typically present with inflammatory back pain with varying degrees of associated enthesopathy (inflammation at sites where tendons, ligaments and joint capsule fibres attach to bone), peripheral arthritis and extra-articular manifestations. (medscape.com)
[ 6 , 7 ] Diagnosis of AS has long relied on evidence of structural damage to the bone via radiographic imaging. (medscape.com)

Lesions can appear in the surface, damaging the articular cartilage. (zehrcenter.com)
2006. "Articular cartilage paste grafting to full-thickness articular cartilage knee joint lesions: a 2- to 12-year follow-up. (stoneclinic.com)
In some patients joint degeneration starts with posttraumatic focal lesions, which are lesions in the articular (joint) cartilage ranging from 1 to 8 cm 2 in diameter," Evseenko said. (scienceblog.com)
Articular cartilage damage is common, with 44.6% cartilage lesions of the patellofemoral joint reported in knee arthroscopies [ 4 ]. (springer.com)
Knowing the distribution of the Flexor digitorum superficialis muscle nerve's branches, its origin levels and points of penetration, it makes the treatment of these lesions easier, mainly in cases of surgery where without the adequate anatomic knowledge the nerve's branches could be even more damaged. (scielo.cl)
The model involved the induction of degenerative articular lesions in New-Zealand-White-rabbits by the injection of nalidixic-acid (389082) (NA). (cdc.gov)
Histochemical changes in the cartilaginous matrices within the articular lesions were seen at all stages of lesion development. (cdc.gov)
Standard radiographs, a computed tomography scan, and magnetic resonance imaging of the affected foot showed symmetrical para-articular marginal erosion in the third and fourth metatarsophalangeal joints, with local inflammation and multiple subcutaneous nodular lesions containing small low-signal foci. (cdc.gov)

Microfracture surgery of the knee is indicated to resurface well-defined, small to medium size areas of full-thickness articular cartilage damage of the knee. (drrobertlaprademd.com)
1997. "Surgical technique for articular cartilage transplantation to full thickness cartilage defects in the knee joint. (stoneclinic.com)

It is damage to the articular cartilage which is called 'arthritis' and in the knee all efforts are geared towards preventing any damage or breakdown of this all-essential joint surface, as it has a poor blood supply and does not heal well if damaged. (kneeguru.co.uk)
Because of its avascular nature (absence of blood supply), cartilage cannot repair itself and therefore surgical treatment is usually required to restore cartilage function and prevent progression of the damage into arthritis. (jonwhitehurstmd.com)
Objectives (1) To compare spontaneous and stimuli-induced adipocytokine secretion by articular adipose tissue (AAT) and synovial membrane (SM) explants obtained from patients with rheumatoid arthritis (RA). (bmj.com)
Traumatic arthritis comes from an injury that damages the articular cartilage. (stoneclinic.com)
To prevent the arthritis returning, you must address the underlying cause of the damaged articular cartilage. (stoneclinic.com)
Damage to the articular cartilage eventually leads to degenerative arthritis . (eorthopod.com)
Like the meniscus, articular cartilage can get damaged as a result of injury or diseases such as arthritis. (cromwellhospital.com)
Rheumatoid arthritis causes damage mediated by cytokines, chemokines, and metalloproteases. (msdmanuals.com)

If left untreated, knee articular cartilage injuries may lead to the development of widespread degenerative joint disease. (researchgate.net)

When cartilage is damaged, it can cause severe pain, inflammation, stiffness, and decreased range of motion of the knee. (jonwhitehurstmd.com)
Again, these components can be placed into the injured cartilage to help repair the damage and reduce inflammation. (nutritionjoint.com)
There is evidence of structural, mechanical, and biological changes after meniscal damage, all of which can be greatly affected by the presence of local or systemic inflammation. (nih.gov)
The evidence suggests that the addition of elevated inflammation at the time of meniscal damage or meniscectomy results in an accelerated progression toward cartilage degradation. (nih.gov)
1-4) ROS react with cells initiating chain reactions that result in tissue damage causing inflammation, spasm, pain and disease. (life-enthusiast.com)
Loss of cell and tissue function results in further inability to repair damage, leading to increased tendency to bruising, excessive inflammation, spasm, joint stiffness, digestive abnormalities and respiratory distress. (life-enthusiast.com)

The extra-articular muscle-tendon units include the quadriceps and patellar tendons (responsible for knee extension), medial and lateral hamstrings (chiefly responsible for knee flexion), gastrocnemius muscle, popliteal ligament and iliotibial band ( Figure 2 ) . (aafp.org)
The extra-articular ligamentous structures include the tibial and fibular collateral ligaments ( Figure 1 ) . (aafp.org)
These ligaments act as the principal extra-articular static stabilizing structures (i.e., they provide stability for the medial and lateral aspects of the knee). (aafp.org)
Extra-articular involvement of organs such as the skin, heart, lungs, and eyes can also occur and markedly affect quality of life. (medscape.com)

Dr. Karen Hambly, Articular Cartilage Repair of the Knee MRI-scans are becoming more valuable in the analysis of articular cartilage but their use is still expensive and time-consuming. (wikipedia.org)

Articular cartilage reduces friction when bones glide over each other, making the movements smooth and painless. (jonwhitehurstmd.com)

Articular cartilage damage in the knee may be found on its own but it will more often be found in conjunction with injuries to ligaments and menisci. (wikipedia.org)
There are two types of cartilage in the knee - the thick, rubbery pads of cartilage known as the menisci and the cartilage that coats the end surfaces of the bones in the joint, known as articular cartilage. (cromwellhospital.com)

Articular cartilage covers the ends of the bones in your knee joint. (zehrcenter.com)
Articular cartilage has a smooth, slippery surface that allows the bones to slide over each other without rubbing. (zehrcenter.com)
Articular cartilage is the white gristle covering the ends of joint bones, where they articulate. (kneeguru.co.uk)
Articular cartilage is the smooth, shiny, white tissue covering the ends of bones that form a joint. (jonwhitehurstmd.com)
Articular cartilage is a connective tissue that cushions bones and protects joints from impact. (nutritionjoint.com)
The damaged cartilage at the ends of your bones can be regenerated using an advanced surgical technique called a paste graft that stimulates the body's natural healing powers. (stoneclinic.com)
Articular cartilage covers the ends of all bones. (stoneclinic.com)
When the articular cartilage is worn away over time, the bones begin to rub against each other. (eorthopod.com)
The bones of the knee are covered with a smooth, glistening layer called articular cartilage and connected by strong ligaments and powerful muscles that are attached to the thigh and calf by tendons, and which provide side-to-side stability. (hss.edu)
Damaged cartilage causes a roughened joint surface and may lead to bones rubbing directly together. (hss.edu)
Healthy articular cartilage can be seen on X-ray as a pronounced spacing between the bones. (hss.edu)
Our bones and joints need load and movement, otherwise, they become weak, risking damage. (lu.se)

It is also important to remember that although the amount of damage is an important factor, the location of the defect(s) can also influence the symptoms you are getting in terms of pain and function and their repair options available. (wikipedia.org)
What Are The Symptoms Of An Articular Cartilage Injury That Can Be Treated With Microfracture Surgery? (drrobertlaprademd.com)
If you have symptoms like joint pain, swelling, or clicking/grinding, you should reach out to your doctor to see if your articular cartilage has been damaged. (nutritionjoint.com)
However, PRP stem cell therapy can be a great alternative to surgery since it is minimally invasive and can reduce symptoms of articular cartilage loss. (nutritionjoint.com)
A group of rare autosomal dominant diseases, commonly characterized by atypical URTICARIA (hives) with systemic symptoms that develop into end-organ damage. (bvsalud.org)

However, it lacks the smooth, glassy surface of the articular cartilage that normally covers the surface of the knee joint. (zehrcenter.com)
Knee cartilage restoration is a surgical technique to repair damaged articular cartilage in the knee joint by stimulating new growth of cartilage or by transplanting cartilage into areas with defects in order to relieve pain and restore normal function to the knee. (jonwhitehurstmd.com)

citation needed] Articular cartilage does not usually regenerate (the process of repair by formation of the same type of tissue) after injury or disease leading to loss of tissue and formation of a defect. (wikipedia.org)
50) have well-localized articular cartilage damage with good articular cartilage edges of the remaining cartilage present (well-shouldered) and who have good ligament stability of their knee (or who are undergoing concurrent ligament reconstruction), have normal lower extremity alignment, and who have good remaining meniscal tissue (the protective cushioning material for the articular cartilage). (drrobertlaprademd.com)
Articular cartilage thin shell grafting holds the promise of using donor cartilage tissue loaded with patient stem cells to replace extensively or totally destroyed articular cartilage surface. (stoneclinic.com)
This is the first time an orthopaedic implant composed of a living cell type was able to fully integrate in the damaged articular cartilage tissue and survive in vivo for up to six months," Evseenko said. (scienceblog.com)
inevitably, damage to membranes diminishes cellular ability to repair damaged tissue. (life-enthusiast.com)

The dislocation of the humeral head to antero-inferior causes damage to the antero-inferior rim of the glenoid in the 3 - 6 o'clock position (marked in red). (radiologyassistant.nl)

SnCs exhibit irreversible growth arrest accompanied by increased expression of cyclin-dependent kinase inhibitors (CDKi) such as p16 INK4a , and p21 Cip1 , accumulation of DNA damages, and secretion of diverse bioactive molecules known as the senescence-associated secretory phenotype (SASP). (aging-us.com)

Articular cartilage damage can occur from normal wear and tear of the knee joints, increasing age, injury, or other disease conditions. (jonwhitehurstmd.com)

Several surgical techniques have been developed in the effort to repair articular cartilage defects. (wikipedia.org)
Articular cartilage has a very limited capacity for self repair. (wikipedia.org)
Small damage does not repair itself and can often get worse over time. (wikipedia.org)
Mesenchymal stem cells (MSCs) play a key role in articular cartilage repair. (hindawi.com)
Native and concentrated BMA have been intensively studied in the context of articular cartilage repair. (hindawi.com)
Such enhanced techniques of marrow stimulation have been shown to improve articular cartilage repair in both animal models and patients. (hindawi.com)
Long-term survival of concurrent meniscus allograft transplantation and articular cartilage repair: A PROSPECTIVE TWO- TO 12-YEAR FOLLOW-UP REPORT. (stoneclinic.com)
With this technique, a patch of cartilage cells is used to repair the damage. (scoi.com)
But what if doctors could intervene and repair damaged cartilage before surgery is needed? (scienceblog.com)
The study resulted in the long-term repair of articular cartilage defects. (scienceblog.com)

It tends to be diagnosed only after other structures have been ruled out - well if it isn't your meniscus or ligaments, what else could it be, perhaps we should look at the articular cartilage? (wikipedia.org)

acuna Conjugada parents) have a 3:2 fold increased risk for neurologic events compared DTP vaccine and permanent neurologic damage. (who.int)

The effect of the collagen fibrils network on the damage behaviour of articular cartilage: a comp. (rwth-aachen.de)

Roosendaal and Lafeber found that the articular cartilage is sensitive to the presence of blood and that damage may occur to the cartilage independent of the synovial changes caused by bleeding. (medscape.com)

Most of the procedures are designed to remove the articular cartilage from the joint surfaces of the hinge joint and then bind the two surfaces together until they heal. (eorthopod.com)

Articular cartilage is also called joint cartilage or hyaline cartilage . (kneeguru.co.uk)

Knee articular cartilage injuries present a great challenge for musculoskeletal clinicians and scientists, leading to substantial morbidity and significant time lost from work and sport and even permanent disability. (researchgate.net)

If articular cartilage is damaged enough, then patients may have to consider surgery, such as microfracture surgery or chondrocyte transplantation. (nutritionjoint.com)

Because articular cartilage doesn't heal on its own, patients may have to rely on a number of different treatments to find relief, such as cortisone injections and over-the-counter pain relievers. (nutritionjoint.com)

Chondropathy is the umbrella term for pathological changes in the articular cartilage. (ottobock.com)

Mechanical properties of mature articular cartilage are known to be depth zone-dependent. (elsevierpure.com)
Although chondrocyte death was observed in articular cartilage after excessive stress loading in vitro, few studies have investigated the correlation between chondrocyte death and local mechanical strains in a depth dependent manner. (elsevierpure.com)

Cartilage structures and functions can be damaged. (wikipedia.org)
Nutricol reinforces membrane and matrix structures (halts damage that initiates inflammatory and spasmodic reactions). (life-enthusiast.com)

As you can see, articular cartilage loss is an issue since the cartilage cells don't heal easily and repairs may involve surgery. (nutritionjoint.com)

Although the method is similar to microfracture, it is less precise, and the heat produced during drilling may damage other tissues. (jonwhitehurstmd.com)
Nociceptive Sensitizers Are Regulated in Damaged Joint Tissues, Including Articular Cartilage, When Osteoarthritic Mice Display Pain Behavior. (ox.ac.uk)
CONCLUSION: Damaged joint tissues produce proalgesic molecules, including NGF, in murine OA. (ox.ac.uk)

A surgical procedure to smooth the surface of the articular cartilage to restore movement in the knee. (cromwellhospital.com)
Chondroplasty involves smoothing the surface of the articular cartilage by either shaving the articular cartilage, making drill holes into the defect in the cartilage to generate fibrocartilage, or treating it with a radio frequency probe. (cromwellhospital.com)
The articular cartilage is either cut away, shaved until the surface is smooth, or drilled with holes in order to generate fibrocartilage. (cromwellhospital.com)

An articular cartilage defect that initially may be small still has the potential to have a physical and chemical "domino effect" on the surrounding "normal" articular cartilage. (wikipedia.org)

The white articular cartilage has a very special internal structure, with the cartilage cells suspended in pockets within a background matrix . (kneeguru.co.uk)

If articular cartilage is torn or damaged, the ragged edges can catch within the joint, causing stiffness, pain and swelling, locking, and giving way. (cromwellhospital.com)

anterior cruciate ligament damage is a common contributor to articular cartilage damage. (nsmi.org.uk)

In 1868, the physician Volkmann defined the role of hemorrhage in the pathogenesis of the articular findings in hemophilia. (medscape.com)

Several hallmarks of cellular senescence, such as cell cycle arrest, expression of cyclin-dependent kinase inhibitors, DNA damages, and senescence-associated secretory profile were evaluated. (aging-us.com)

In an effort to mitigate damage due to incessant hemorrhage, Prof. Ashok Kumar and team have developed a cryogel with profound fluid absorption ability, rapid blood clotting and good antibacterial activity that can effectively inhibit bleeding from irregular and differently-compressible wound sites. (iitk.ac.in)

In conclusion, our results demonstrated that compared with OA, the differential abundance proteins and signaling pathways may contribute to the occurrence and development of joint damage in KBD. (nature.com)
Unfortunately, there is no universal "cure" for OA in the sense of there being a specific treatment undoing or stopping joint damage. (lu.se)

In contrast to popular perception, pain is not a good indicator for determining the extent of articular cartilage damage. (wikipedia.org)

Plurocart represents a practical, inexpensive, one-stage therapy that may be more effective in restoring damaged cartilage and improve the outcome of such procedures. (scienceblog.com)

This is a slow, progressive in which the articular cartilage of the femur, tibia, or patella wears down over time. (hss.edu)

Diseases2

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes3

Intra-articular5

Explanting articular cartilage1

Chondrocytes8

Meniscus cartilage4

Osteoarthritis8

Bone19

Lesions8

Full thickness2

Arthritis8

Left untreated1

Inflammation6

Extra-articular4

Karen Hambly1

Friction1

Menisci2

Bones12

Symptoms5

Knee joint2

Tissue5

Dislocation1

Secretion1

Joints1

Repair10

Ligaments1

Neurologic1

Collagen1

Synovial1

Surfaces1

Hyaline cartilage1

Injuries1

Transplantation1

Injections1

Pathological1

Mechanical2

Structures2

Heal1

Tissues3

Surface3

Defect1

Cartilage cells1

Edges1

Anterior1

Findings1

Inhibitors1

Hemorrhage1

Joint damage2

Extent1

Outcome1

Patella1