• Elevated anti-recoverin antibodies were detected by immunoblot postmortem. (cdc.gov)
  • The anti-recoverin antibodies induced by the primary tumor may on contact with intraretinal recoverin initiate a photoreceptor degeneration and trigger photoreceptor death by apoptosis, thus causing blindness. (univmed.org)
  • Antibodies to recoverin induced apoptosis of photoreceptor and bipolar cells in vivo. (univmed.org)
  • E1A.NR3 retinal cells pretreated with 40 μM resveratrol were grown in the presence of anti-recoverin (Rec-1), anti-enolase (Enol-1) antibodies, and normal purified immunoglobulins. (biomedcentral.com)
  • Spectrophotometric titration of Ca2+-loaded recoverin gave 7.6 for the pKa value of Cys38 thiol, suggesting partial deprotonation of the thiol in vivo conditions. (usf.edu)
  • An ability of recoverin to form a disulfide dimer and thiol-oxidized monomer under mild oxidizing conditions was found using SDS-PAGE in reducing and nonreducing conditions and Ellman's test. (usf.edu)
  • The Ca2+ modulated susceptibility of the recoverin thiol to reversible oxidation may be of potential importance for functioning of recoverin in photoreceptor cells. (usf.edu)
  • We demonstrate that on the one hand MMTS can modify functional cysteines in the thiol enzyme GAPDH, thereby preventing thiol oxidation and reversibly inhibiting the enzyme, while on the other hand it can protect the redox-sensitive thiol group of recoverin from oxidation and such modification produces no impact on the activity of the protein. (bvsalud.org)
  • Like all members of the NSC family, recoverin contains a conserved cysteine (Cys38) in nonfunctional EF-hand 1. (usf.edu)
  • In this study we report examples of MMTS application in experiments involving oxidoreductase (glyceraldehyde-3-phosphate dehydrogenase, GAPDH), redox-regulated protein (recoverin) and cysteine protease (triticain-α). (bvsalud.org)
  • In a visual cycle of photoreceptor cells, recoverin regulates activity of rhodopsin kinase in a Ca2+-dependent manner. (usf.edu)
  • One retinal antigen implicated in the autoimmune mechanism of CAR is recoverin, a 23 kDa photoreceptor-specific calcium-binding protein modulating the activity of photoreceptor guanylyl cyclase. (univmed.org)
  • Maeda A, Ohguro H, Maeda T, Wada I, Sato N, Kuroki Y, Nakagawa T. Aberrant expression of photoreceptor-specific calcium-binding protein (recoverin) in cancer cell lines. (univmed.org)
  • Polans AS, Witkowska D, Haley TL, Amundson D, Baiz-er L, Adamus G. Recoverin, a photoreceptor-specific calcium binding protein is expressed by the tumor of a patient with cancer-associated retinopathy. (univmed.org)
  • Recoverin is a member of the neuronal calcium sensor (NCS) family of EF-hand calcium binding proteins. (usf.edu)
  • It is similar to neuronal Ca 2+ sensors, like recoverin, which regulate their binding partners through a calcium acyl switch mechanism. (northwestern.edu)
  • Recoverin as a Redox-sensitive Protein" by Sergei E. Permyakov, Aliya A. Nazipova et al. (usf.edu)
  • and Permyakov, Eugene A., "Recoverin as a Redox-sensitive Protein" (2007). (usf.edu)
  • The most common autoantibodies found in association with vision loss are against recoverin and α-enolase [ 5 ]. (biomedcentral.com)
  • Although formation of the disulfide dimer takes place only for Ca2+-loaded recoverin, accumulation of the oxidized monomer proceeds more effectively for apo-recoverin. (usf.edu)
  • We hypothesized that, like recoverin, FCaBP projects its acyl groups in the presence of Ca 2+ , permitting flagellar membrane and binding partner association and that it sequesters the acyl groups in low Ca 2+ , disassociating from the membrane and releasing its binding partner to perform a presumed enzymatic function. (northwestern.edu)
  • This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • 7. Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells. (nih.gov)
  • The high expression of recoverin and arrestin-1 in kidney tumors suggests the use of these proteins in future as a marker for the diagnosis or even as a potential target for immunotherapy. (eco-vector.com)
  • 5. Frequent detection of anti-recoverin cytotoxic T-lymphocyte precursors in peripheral blood of cancer patients by using an HLA-A24-recoverin tetramer. (nih.gov)
  • 8. Role of anti-recoverin autoantibodies in cancer-associated retinopathy. (nih.gov)
  • We also studied serum recoverin levels in patients with various brain tumors and compared these to controls. (medscape.com)
  • Using GCAPs/recoverin-deficient mice, we show that mammalian cones possess another Ca 2+ -dependent mechanism promoting light adaptation. (wustl.edu)
  • 4. Establishment of a novel small cell lung carcinoma cell line with specific recoverin expression from a patient with cancer-associated retinopathy. (nih.gov)
  • 10. Effects of cytotoxic T lymphocyte antigen 4 (CTLA4) signaling and locally applied steroid on retinal dysfunction by recoverin, cancer-associated retinopathy antigen. (nih.gov)
  • 17. Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer-associated retinopathy. (nih.gov)
  • 20. The cancer-associated retinopathy antigen is a recoverin-like protein. (nih.gov)
  • Recoverin is a detectable serologic protein that is expressed in patients with cancer-associated retinopathy, a paraneoplastic syndrome. (medscape.com)
  • Whitcup SM, Vistica BP, Milam AH, Nussenblatt RB, Gery I. Recoverin-associated retinopathy: a clinically and immunologically distinctive disease. (ijcrr.com)
  • Recoverin is a recently discovered 26 kDa calcium-binding protein, which activates guanylate cyclase in retinal photoreceptors when the intracellular concentration of free calcium drops upon photoexcitation. (nih.gov)
  • 2. Aberrant expression of photoreceptor-specific calcium-binding protein (recoverin) in cancer cell lines. (nih.gov)
  • No immunocytochemical staining was observed after preabsorption of the recoverin antibody with the recombinant protein. (nih.gov)
  • We report on two potential novel tumor markers, vascular endothelial growth factor (VEGF) and recoverin (protein A). VEGF is a highly specific endothelial cell activator that induces angiogenesis both in vivo and in vitro. (medscape.com)
  • This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. (nih.gov)
  • Jensen Lab generated fractional counting score for the prevalence of this gene in Pubmed articles. (nih.gov)
  • Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)
  • 12. Stimulation of the aberrant expression of a paraneoplastic antigen, recoverin, in small cell lung cancer cell lines. (nih.gov)
  • 1. Clinicopathological roles of aberrantly expressed recoverin in malignant tumor cells. (nih.gov)
  • Recoverin is detectable in serum and may be a useful glioma tumor marker, especially for recurrent active disease. (medscape.com)
  • Cite this: Cerebrospinal Fluid (Vascular Endothelial Growth Factor) and Serologic (Recoverin) Tumor Markers for Malignant Glioma - Medscape - May 01, 2004. (medscape.com)
  • In this study we examined the distribution of recoverin in retinae and pineal organs of Xenopus laevis larvae, 1-day-old chicken, adult pigeon, albino rat, sheep and man by means of immunocytochemistry. (nih.gov)
  • In our recoverin study, an immunoenzymetric assay was used to measure the serum recoverin levels patients with glioma and compared with controls. (medscape.com)
  • Recoverin levels were 10-fold higher in patients with recurrent GBM relative to controls. (medscape.com)
  • This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • Below is an excerpt of their introduction along with a list of articles in the special issue. (usc.edu)