AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHumanitiesInformation ScienceNamed GroupsHealth Care
Arthritis, RheumatoidArthritisHLA AntigensAntigensArthritis, ExperimentalArthritis, InfectiousHLA-B27 AntigenArthritis, ReactiveHLA-B44 AntigenHLA-B AntigensAntigens, BacterialArthritis, JuvenileAntigens, NeoplasmAntigens, SurfaceArthritis, PsoriaticSpondylitis, AnkylosingAntigens, ViralHLA-B8 AntigenHLA-B37 AntigenHLA-DR AntigensSynovial MembraneHLA-A AntigensJointsUveitis, AnteriorAntigens, ProtozoanSpondylarthropathiesEpitopesSynovial FluidAntigens, Polyomavirus TransformingAntigens, CDAntibodies, MonoclonalSacroiliac JointHistocompatibility TestingHLA-B35 AntigenAntigens, FungalH-2 AntigensHLA-C AntigensAntigens, HelminthImmunoglobulin GHLA-B7 AntigenAutoantibodiesHistocompatibility Antigens Class IICross ReactionsT-LymphocytesRheumatoid FactorHLA-DQ AntigensHistocompatibility Antigens Class IArthritis, GoutyCarcinoembryonic AntigenMice, Inbred DBAAntigens, Viral, TumorAwards and PrizesHistocompatibility AntigensReceptors, Antigen, T-CellEnzyme-Linked Immunosorbent AssaySkin Window TechniqueHLA-A2 AntigenHLA-B51 AntigenMolecular Sequence DataHLA-DRB1 ChainsRheumatologyHLA-D AntigensAllelesT-Lymphocytes, CytotoxicSynovitisAmino Acid SequenceProliferating Cell Nuclear AntigenHLA-DR4 AntigenLymphocyte ActivationHIV Long-Term SurvivorsAntibodies, BacterialReceptors, Antigen, B-CellOsteoarthritisProstate-Specific AntigenO AntigensMice, Inbred BALB CAntigens, CD8Interferon-gammaEpitopes, T-LymphocyteAntibody SpecificityAntigens, CD3Antigens, CD15CD8-Positive T-LymphocytesAntigens, Tumor-Associated, CarbohydrateB-LymphocytesCollagen Type IIRats, Inbred LewAntibody FormationCells, CulturedAutoantigensHepatitis B Surface AntigensKlebsiella pneumoniaeBlood Group AntigensSeverity of Illness IndexMice, Inbred C57BLAutoimmune DiseasesAntibodiesReceptors, Antigen, T-Cell, alpha-betaFluorescent Antibody TechniqueMethotrexate
RheumatoidPsoriatic arthritisAbility of HLA-B27 to formOrder the HLA-B27 testReactiveUveitisClass I alleleHumanAlleleHomodimersGeneticInflammationHeavy-chain homodimerJointsJuvenile idiopathiGenotypeReiter's SyndromeSymptomsGeneInfectious ArthritisInfectionAnkylosingSeptic arthritisPositivePrevalenceDisordersAxialProteinSpondyloarthritisSurfaceTesting was performedProteinsSpondyloarthropathyType of arthritisMusculoskeletalSacroiliitisOccurAntibodiesAsymmetricEnthesitis-related arthritisSubtypeBacterialAdultDiseasesForm of arthritisDiseaseNegativeGenes
Rheumatoid43
Psoriatic arthritis12
  • Imaging showed that 54% of patients had sacroiliitis, mostly in those with ERA and psoriatic arthritis (PsA). (medpagetoday.com)
  • Clinical assessment of sacroiliitis and HLA-B27 are poor predictors of sacroiliitis diagnosed by magnetic resonance imaging in psoriatic arthritis. (ox.ac.uk)
  • OBJECTIVE: To determine the frequency and clinical predictors of sacroiliitis diagnosed by magnetic resonance imaging (MRI) in a psoriatic arthritis (PsA) population. (ox.ac.uk)
  • If you have psoriatic arthritis , youre probably familiar with the symptoms that affect your joints. (arthritisdaily.net)
  • People with psoriatic arthritis are at a higher risk of developing this inflammation of the eye, says John M. Davis, III, MD , a rheumatologist at the Mayo Clinic in Rochester, Minnesota. (arthritisdaily.net)
  • People with the gene for the human leukocyte antigen HLA-B27 may have a higher risk of certain autoimmune conditions, including psoriatic arthritis and uveitis, according to the U.S. National Library of Medicine . (arthritisdaily.net)
  • Our main research goal is to understand the molecular mechanisms causing inflammation, particularly in Ankylosing Spondylitis and other forms of inflammatory arthritis including Psoriatic Arthritis, and to translate this understanding into new patient therapy. (ox.ac.uk)
  • Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. (ox.ac.uk)
  • The patient had no evidence of rheumatic disease known to cause ankylosis, such as ankylosing spondylitis, psoriatic arthritis, or diffuse idiopathic skeletal hyperostosis. (faoj.org)
  • The European Commission has approved bimekizumab (Bimzelx) for the treatment of active psoriatic arthritis (PsA) and active axial spondylarthritis (axSpA) in adults. (medscape.com)
  • The approval of bimekizumab in psoriatic arthritis provides rheumatologists and dermatologists in the European Union with a new treatment option, " said Iain McInnes, MD, PhD, from the Institute of Infection, Immunity, and Inflammation at the University of Glasgow, Glasgow, Scotland, in a UCB press release. (medscape.com)
  • Cite this: EU Approves Bimekizumab for Psoriatic Arthritis and Axial Spondyloarthritis - Medscape - Jun 08, 2023. (medscape.com)
Ability of HLA-B27 to form2
  • The KG-1 dendritic-like cell line was transfected with HLA-B27 cDNA constructs, and the cellular distribution, intracellular assembly and ability of HLA-B27 to form heavy-chain homodimers was compared with human monocyte-derived dendritic cells after stimulation with bacterial lipopolysaccharide (LPS). (northumbria.ac.uk)
  • We first described the ability of HLA-B27 to form homodimers and have shown that these homodimers are present on the surface of spondyloarthritis patients' cells as well as in B27 transgenic models of disease, and identified cellular receptors for B27 homodimers including KIR3DL2. (ox.ac.uk)
Order the HLA-B27 test2
Reactive29
  • Another chronic condition that may be associated with Campylobacter infection is reactive arthritis. (wikipedia.org)
  • Reactive arthritis is a complication strongly associated with a particular genetic make-up. (wikipedia.org)
  • Most often, the symptoms of reactive arthritis will occur up to several weeks after infection. (wikipedia.org)
  • Possible complications of campylobacteriosis include Guillain-Barré syndrome and reactive arthritis. (wikipedia.org)
  • An association between Human Leukocyte Histocompatibility Antigen B-27 (HLA-B27) and major arthritis syndromes such as Ankylosing Spondylitis and Reactive Arthritis is well documented (Khan et al. (cdc.gov)
  • The term reactive arthritis refers to an inflammation of one or more joints, following an infection localized at another site distant from the affected joints. (marlerblog.com)
  • The reactive arthritis associated with Reiter's may develop after a person eats food that has been tainted with bacteria. (marlerblog.com)
  • [3] Reiter's syndrome, a form of reactive arthritis, is an uncommon but debilitating syndrome caused by gastrointestinal or genitourinary infections. (marlerblog.com)
  • Although the initial infection may not be recognized, reactive arthritis can still occur. (marlerblog.com)
  • Salmonella has been the most frequently studied bacteria associated with reactive arthritis. (marlerblog.com)
  • [6] In addition, individuals of Caucasian descent may be more likely those of Asian descent to develop reactive arthritis, [7] and children may be less susceptible than adults to reactive arthritis following infection with Salmonella . (marlerblog.com)
  • A clear association has been made between reactive arthritis and a genetic factor called the human leukocyte antigen (HLA) B27 genotype. (marlerblog.com)
  • [9] HLA-B27 has been shown to be a predisposing factor in one-half to over two-thirds of individuals with reactive arthritis. (marlerblog.com)
  • Autoimmune disorders like ankylosing spondylitis, reactive arthritis is progressive in nature. (metropolisindia.com)
  • One type of infectious arthritis is reactive arthritis. (medlineplus.gov)
  • Sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. (medlineplus.gov)
  • Another form of reactive arthritis starts with eating food or handling something that has bacteria on it. (medlineplus.gov)
  • What Is Reactive Arthritis? (medlineplus.gov)
  • Reactive arthritis is a sterile inflammatory process that usually results from an extra-articular infectious process. (medscape.com)
  • Thus, this antigen can be detected in 90-95% of patients with ankylosing spondylitis (Bekhterev's disease), 75% of patients with reactive arthritis (Reiter's syndrome), 50-60% of patients with psoriatic arthropathy, 80-90% of patients with juvenile ankylosing spondylitis and 60-90% of patients with enteropathic arthritis. (lab24.pl)
  • You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis. (tidelandshealth.org)
  • Age, sex, symptom duration, smoking, body mass index, human leukocyte antigen (HLA)-B27 positive rate, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) among the four groups were compared by one-way analysis of variance (ANOVA) and Chi-square test. (bvsalud.org)
  • HLA B27 positivity is associated with a variety of diseases like ankylosing spondylitis, psoriasis, inflammatory bowel disease, reactive arthritis etc. (punerheumatologist.com)
  • Reactive arthritis is strongly associated with HLA-B27 ANTIGEN. (bvsalud.org)
  • Historically characterized by a triad of inflammation involving the eye (CONJUNCTIVITIS), the bone (POST-INFECTIOUS ARTHRITIS), and the urethra (URETHRITIS), it is now thought to be nearly synonymous with reactive arthritis. (bvsalud.org)
  • Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis. (cdc.gov)
  • Lack of association between the HLA-DRB1 locus and post-streptococcal reactive arthritis and acute rheumatic fever in Italian children. (cdc.gov)
  • Solute carrier family 11 member A1 gene polymorphisms in reactive arthritis. (cdc.gov)
  • Toll-like receptor 2 variants are associated with acute reactive arthritis. (cdc.gov)
Uveitis6
  • Approximately half of sudden-onset (acute) anterior uveitis cases are associated with the Human Leukocyte Antigen B27 (HLA-B27) allele. (allaboutvision.com)
  • If your doctor determines that you have acute anterior uveitis, they may recommend a special blood test that looks for the HLA-B27 protein on the surface of white blood cells. (allaboutvision.com)
  • Associations of the HLA-B27 antigen and acute anterior uveitis, aortic valve insufficiency, acute leukemia, IgA nephropathy and psoriasis are of greatest importance. (lab24.pl)
  • About 60% of pediatric uveitis cases are diagnosed as idiopathic uveitis, followed by juvenile idiopathic arthritis (JIA)-associated anterior uveitis [ 17 ]. (biomedcentral.com)
  • This is thought to be due to the association that both AS and uveitis have with the inheritance of the HLA-B27 antigen. (findzebra.com)
  • Peripheral manifestations of disease were more common among patients from South American countries, those with current or prior history of psoriasis, individuals with a history of uveitis, and those with absence of the HLA-B27 antigen. (rheumatologyadvisor.com)
Class I allele2
  • INTRODUCTION: Ankylosing spondylitis (AS) is a severe, chronic inflammatory arthritis, with a strong association to the human major histocompatibilty complex (MHC) class I allele human leucocyte antigen (HLA) B27. (northumbria.ac.uk)
  • Development of a number of common forms of inflammatory arthritis (the spondyloarthritides), which include Ankylosing Spondylitis is strongly associated with possession of the Human Leukocyte Antigen (HLA) class I allele HLA-B27. (ox.ac.uk)
Human21
  • That is, persons who have the human leukocyte antigen B27 (HLA-B27) are most susceptible. (wikipedia.org)
  • There is a strong link between the disease and specific human leukocyte antigen (HLA) phenotypes. (progressivehealth.com)
  • Why take HLA B27 (Human Leucocyte Antigen B27)? (metropolisindia.com)
  • This test helps determine whether you have human leukocyte antigen B27 (HLA-B27) on the surface of your cells and in turn it helps assess the likelihood that you may be suffering from an autoimmune disorder. (metropolisindia.com)
  • The full form of HLA is Human Leukocyte Antigen and helps the body identify between its own cells and foreign body. (metropolisindia.com)
  • The human leukocyte antigen-B27 (HLA-B27) allele is more common in this form of JIA. (msdmanuals.com)
  • Human leukocyte antigen (HLA) B27 is a strong genetic risk factor for AS. (deepdyve.com)
  • We have studied the formation of HLA-B27 heavy-chain homodimers in human dendritic cells, which are key antigen-presenting cells and regulators of mammalian immune responses. (northumbria.ac.uk)
  • Significantly, the formation of HLA-B27 homodimers in transfected KG-1 cells is induced by maturation, with a transient induction also seen in LPS-stimulated human monocyte-derived dendritic cells expressing HLA-B27. (northumbria.ac.uk)
  • We have studied the formation of HLA-B27 heavy-chain homodimers in human dendritic cells, which are key antigen-presenting cells and regulators of mammalian immune responses.METHOD: Both an in vitro dendritic-like cell line and monocyte-derived dendritic cells from peripheral blood were studied. (northumbria.ac.uk)
  • Seronegative spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases with common clinical and aetiological features, including axial and peripheral inflammatory arthritis, enthesitis, extra-articular manifestations and a close link to the presence of the human leucocyte antigen (HLA)-B27 epitope. (jaipurrheumatologist.com)
  • Screening laboratory tests consisting of complete blood cell count, erythrocyte sedimentation rate, antinuclear antibody testing, human leukocyte antigen (HLA), B-27 antigen screening, and automated blood chemistry testing should be performed if the diagnosis of spondylolisthesis is in question to help rule out other causes of pain. (seekhealthz.com)
  • Human leukocyte antigen B27 (HLA-B27) is a protein located on the surface of white blood cells. (labtestsguide.com)
  • Human leukocyte antigens (HLA) are proteins commonly found on white blood cells. (labtestsguide.com)
  • Onset is typically in the third decade, with a higher incidence in Caucasians and an association with human leucocyte antigen (HLA)-B27. (hospitalprofessionalnews.ie)
  • Although (like most autoimmune and autoinflammatory diseases) the "cause" is not known, AS is associated with the gene for human leukocyte antigen B27 (HLA-B27). (walkyourasoff.com)
  • HLA B27 (human leukocyte antigen) is not a disease. (punerheumatologist.com)
  • [14] In addition, a direct relationship between AS and the major histocompatibility human leukocyte antigen (HLA)-B27 has also been determined. (physio-pedia.com)
  • More than 85% of those affected in the UK have a specific human leukocyte antigen known as the HLA-B27 antigen. (findzebra.com)
  • Being male and being HLA-B27 [human leukocyte antigen B27] positive are examples of that. (consultantlive.com)
  • The disease appears to be associated with the human leukocyte antigen B27 (HLA-B27) haplotype. (medscape.com)
Allele2
  • The cross-linked sample DNA was hybridized with sequence-specific oligonucleotide probes to identify HLA-B27 allele sequences. (cdc.gov)
  • The weak association of wildtype HLA-B*2705 with the transporter associated with antigen processing could also be enhanced by mutation of residues at position 114 and 116 in the peptide-binding groove to those present in the HLA-B*2706 allele. (northumbria.ac.uk)
Homodimers9
  • Disulfide-linked HLA-B27 heavy-chain homodimers have been implicated as novel structures involved in the aetiology of AS. (northumbria.ac.uk)
  • RESULTS: Immature KG-1 cells expressing HLA-B27 display an intracellular source of MHC class I heavy-chain homodimers partially overlapping with the Golgi bodies, but not the endoplasmic reticulum, which is lost at cell maturation with phorbyl-12-myristate-13-acetate (PMA) and ionomycin. (northumbria.ac.uk)
  • Cell-surface expression and immune receptor recognition of HLA-B27 homodimers. (ox.ac.uk)
  • We undertook this study to ascertain if patients with spondylarthritis express beta(2)-microglobulin-free HLA-B27 heavy chains in the form of homodimers and receptors for HLA-B27 homodimers. (ox.ac.uk)
  • Fluorescence-labeled tetrameric complexes of HLA-B27 heavy-chain homodimers were constructed in which each dimer comprised one His-tagged heavy chain and one biotinylated heavy chain, and were used to stain patient and control mononuclear cells and transfected cell lines. (ox.ac.uk)
  • RESULTS: Patients with spondylarthritis expressed cell-surface HLA-B27 homodimers. (ox.ac.uk)
  • Populations of synovial and peripheral blood monocytes, and B and T lymphocytes from patients with spondylarthritis, and controls carried receptors for HLA-B27 homodimers. (ox.ac.uk)
  • Experiments with transfected cell lines demonstrated that KIR3DL1 and KIR3DL2, and immunoglobulin-like transcript 4 (ILT4), but not ILT2, are receptors for HLA-B27 homodimers. (ox.ac.uk)
  • CONCLUSION: Patients with spondylarthritis express both HLA-B27 heavy-chain homodimers and receptors for HLA-B27 homodimers. (ox.ac.uk)
Genetic5
  • Spondyloarthropathies (SpA) encompass a group of chronic inflammatory diseases sharing common genetic and clinical features, including the association with HLA-B27 antigen, the involvement of both the axial and the peripheral skeleton, the presence of dactylitis, enthesitis, and typical extra-articular manifestations such as psoriasis, inflammatory bowel disease, and acute anterior uveitis (AAU). (hindawi.com)
  • Spondyloarthropathies (SpA) embrace different chronic inflammatory diseases sharing common genetic (association with HLA-B27 antigen) and clinical features. (hindawi.com)
  • HLA-B27 is a normal genetic variant. (punerheumatologist.com)
  • [14] Studies have shown factors such as genetic background gene called ( HLA-B27), microbial infection, endocrinal abnormalities and immune reaction related to the occurrence of AS. (physio-pedia.com)
  • Approximately 85% of people with AS express the HLA-B27 genotype, meaning there is a strong genetic association. (findzebra.com)
Inflammation7
  • Enthesitis-related arthritis involves arthritis and enthesitis (painful inflammation at the insertion of tendons and ligaments). (msdmanuals.com)
  • Arthritis is a term that refers to joint inflammation (pain, swelling, and stiffness). (perfectsvasthya.com)
  • Arthritis joint damage incurred previously, such as joint inflammation or fracture can also cause osteoarthritis. (perfectsvasthya.com)
  • Asides from worsening the pain in the arthritis joint, continuous inflammation can lead to permanent damage of the joints, lack of balance, deformity, and issues in other organs of the body. (perfectsvasthya.com)
  • The presence of HLA-B27 gene causes a gene product that promotes inflammation, says Mandi D. Conway, MD , professor and interim chair of ophthalmology at the University of Arizona College of Medicine-Phoenix. (arthritisdaily.net)
  • Reducing inflammation across your whole body is key to preventing eye conditions that arise from arthritis. (arthritisdaily.net)
  • The major musculoskeletal features are inflammation and arthritis of the sacroiliac joints and spine, hip, shoulder, and other peripheral joint involvement, costochondral (in between the ribs) inflammation, and enthesitis (inflammation at points of attachment of tendons and ligaments to the bone). (walkyourasoff.com)
Heavy-chain homodimer2
  • CONCLUSION: We have demonstrated that HLA-B27 heavy-chain homodimer formation can be induced by dendritic cell activation, implying that these novel structures may not be displayed to the immune system at all times. (northumbria.ac.uk)
  • OBJECTIVE: HLA-B27 is capable of forming in vitro a heavy-chain homodimer structure lacking beta(2)-microglobulin. (ox.ac.uk)
Joints9
  • The principal symptoms are inflammatory chronic back pain, peripheral arthritis (typically asymmetric monoarthritis or oligoarthritis predominantly affecting the joints of the lower extremities), dactylitis, and enthesitis [ 1 ]. (hindawi.com)
  • Most kinds of arthritis cause pain and swelling in your joints. (medlineplus.gov)
  • In both types, arthritis can be symmetric and frequently involves the small joints. (msdmanuals.com)
  • The pattern of arthritis is typically an asymmetric oligoarthri-tis that involves the large joints of the lower extremities. (deepdyve.com)
  • Because of the increasing use of prosthetic joints, infection associated with these devices have become the most common and challenging type of septic arthritis encountered by most clinicians. (medscape.com)
  • One of the arthritis facts is that it can affect either one joint or several joints at the same time. (perfectsvasthya.com)
  • Arthritis nodes are bony hard lumps at the joints of your finger. (perfectsvasthya.com)
  • To differentiate arthritis versus arthrosis, the doctor can run physical tests to check for tenderness, swelling, and redness in the joints. (perfectsvasthya.com)
  • Ankylosing spondylitis (pronounced ank-kih-low-sing spon-dill-eye-tiss), or AS, is a form of inflammatory arthritis that primarily affects the spine, although other joints can become involved. (walkyourasoff.com)
Juvenile idiopathi7
  • What Happens When Patients with Juvenile Idiopathic Arthritis Become Adults? (medpagetoday.com)
  • Reclassifying adults with juvenile idiopathic arthritis may have the advantage of exposing them sooner to a wider spectrum of disease-modifying drugs, possibly improving long-term outcomes. (medpagetoday.com)
  • Arthritides beginning before 16 years of age and of unknown etiology comprise the category of juvenile idiopathic arthritis (JIA). (medpagetoday.com)
  • Juvenile idiopathic arthritis is a group of rheumatic diseases that begins by age 16. (msdmanuals.com)
  • Juvenile idiopathic arthritis (JIA) is uncommon. (msdmanuals.com)
  • Juvenile Idiopathic Arthritis (JIA) is the most common chronic heterogenous rheumatological disorder that manifests in patients aged less than 16 years and, in some cases, can cause severe impairment and disability. (biomedcentral.com)
  • Our methodology for searching the NCBI PubMed database included the following search strings: "((juvenile idiopathic arthritis) OR JIA) AND (Africa OR (Middle East) OR AfME) AND prevalence. (biomedcentral.com)
Genotype1
Reiter's Syndrome2
  • Reiter's syndrome is characterized by a triad of arthritis, conjunctivitis, and urethritis, although not all three symptoms occur in all affected individuals. (marlerblog.com)
  • In a Washington State study, while 29% developed arthritis, only 3% developed the triad of symptoms associated with Reiter's syndrome. (marlerblog.com)
Symptoms2
  • Hence, veterans may receive a 10% arthritis VA rating if symptoms appear within one year of discharge. (perfectsvasthya.com)
  • Further, the presence of psoriasis and absence of the HLA-B27 antigen are both associated with the development of peripheral symptoms, according to results from an ancillary analysis of the observational, cross-sectional, multicenter, international Assessment in Spondyloarthritis International Society-Comorbidities in Spondyloarthritis (ASAS-COMOSPA) study published in The Journal of Rheumatology . (rheumatologyadvisor.com)
Gene1
  • If you look indiscriminately at the whole population, only 10-15% of those with this HLA-B27 gene will end up developing ankylosing spondylitis or another type of spondyloarthritis. (punerheumatologist.com)
Infectious Arthritis3
  • Infectious arthritis is an infection in the joint. (medlineplus.gov)
  • To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. (medlineplus.gov)
  • Septic arthritis, also known as infectious arthritis, may represent a direct invasion of joint space by various microorganisms, most commonly caused by a variety of bacteria .However, viruses, mycobacteria, and fungi have been implicated. (medscape.com)
Infection6
  • [10] While HLA-B27 does not appear to predispose to the initial infection itself, it increases the risk of developing arthritis that is more likely to be severe and prolonged. (marlerblog.com)
  • [ 1 ] The incidence of arthritis due to disseminated gonococcal infection is 2.8 cases per 100,000 person-years. (medscape.com)
  • [ 7 , 8 ] Staphylococcus aureus infection is the cause of the vast majority of cases of acute bacterial arthritis in adults and in children older than 2 years. (medscape.com)
  • On the other hand, the presence of HLA-B27 also plays a certain protective role: some viral infections (influenza, herpes virus type 2 infection, infectious mononucleosis, hepatitis C and HIV) occur in a milder form in HLA-B27 carriers. (lab24.pl)
  • These antigens help your Immune System identify the differences between healthy body tissue and foreign substances that can cause an infection. (labtestsguide.com)
  • An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. (bvsalud.org)
Ankylosing7
  • Determination of the HLA-B27 antigen is of the greatest importance in the diagnosis of early ankylosing spondylitis. (lab24.pl)
  • The presence of HLA-B27 is associated with an increased risk of extra-articular manifestations of ankylosing spondylitis. (lab24.pl)
  • Baines M, Ebringer A, Avakian H et al (1990) The use of enzyme immunoassay (EIA) and radiobinding assay to investigate the cross-reactivity of Klebsiella antigens and HLA-B27 in ankylosing spondylitis patients and healthy controls. (springer.com)
  • Around 80 to 90% of patients with ankylosing spondylitis tests positive for HLA-B27. (punerheumatologist.com)
  • Around 10-20% of patients with proven ankylosing spondylitis will test negative for HLA B27. (punerheumatologist.com)
  • Rs12569232 predisposed to AAU and its subgroups (with ankylosing spondylitis (AS) or HLA-B27 positive). (biomedcentral.com)
  • HLA class I and class II association with ankylosing spondylitis in a southern Indian population. (cdc.gov)
Septic arthritis6
  • Several bacteria, including Salmonella , induce septic arthritis. (marlerblog.com)
  • Failure to recognize and to appropriately treat septic arthritis results in significant rates of morbidity and may even lead to death. (medscape.com)
  • Approximately 20,000 cases of septic arthritis occur in the United States each year (7.8 cases per 100,000 person-years), with a similar incidence occurring in Europe. (medscape.com)
  • Septic arthritis is also becoming increasingly common among people who are immunosuppressed and elderly persons. (medscape.com)
  • Fifty-six percent of patients with septic arthritis are male. (medscape.com)
  • See also Pediatric Septic Arthritis, Pediatric Septic Arthritis Surgery, and Septic Arthritis Surgery. (medscape.com)
Positive15
  • Lab testing revealed that 51% of patients tested for HLA-B27 were positive for this antigen (generally in patients with ERA or undifferentiated JIA). (medpagetoday.com)
  • Duplicate interpretations of positive probe hits were uploaded into a laboratory information system which interpreted the hit pattern to determine if the HLA-B27 was positive or negative. (cdc.gov)
  • All HLA-B27 positive specimens and 2.5% of HLA-B27 negative samples were confirmed using a second, independent DNA preparation in order to identify any sample discrepancies. (cdc.gov)
  • If your test results are positive for the HLA-B27 protein, it means that you are at higher risk for certain conditions. (allaboutvision.com)
  • HLAB27-positive patients are more prone to the risk of tuberculosis and malaria. (lab24.pl)
  • Despite the presence of a stable association of the HLA-B27 antigen and the risk of developing spondyloarthritis, a positive test result does not always reflect the real risk of the disease in a particular patient. (lab24.pl)
  • If your HLA-B27 antigen test is positive, you may need other tests to help confirm a diagnosis of an autoimmune disease. (tidelandshealth.org)
  • A positive result means HLA-B27 was found in your blood. (tidelandshealth.org)
  • If you are white, you are more likely to test positive for the HLA-B27 antigens. (tidelandshealth.org)
  • Braun J, Bollow M, Remlinger G et al (1998) Prevalence of spondylarthropathies in HLA B27-positive and negative blood donors. (springer.com)
  • A positive HLA B27 test does not mean you have a disease. (punerheumatologist.com)
  • HLA B27 can be positive in upto 8% of normal population. (punerheumatologist.com)
  • If your HLA B27 test is positive usually there is no need to have this test again. (punerheumatologist.com)
  • In this context, a positive HLA B27 test is useful in making the diagnosis. (punerheumatologist.com)
  • For female patients who are not HLA-B27 positive, they are a little bit more protected in terms of developing the aggressive syndesmophyte formation, the bridging calcification between vertebral bodies that causes the ankylosis phenomenon. (consultantlive.com)
Prevalence4
  • A U.S. national-level HLA-B27 prevalence estimate is required for public health planning purposes because of the recent significant improvements in the medical therapy for HLA-B27 related disorders. (cdc.gov)
  • The B27_F_R data release provides data for the estimation of the U.S. national prevalence of HLA-B27 based on samples collected during the 2009 U.S. National Health and Nutrition Examination Survey (NHANES) survey year. (cdc.gov)
  • The single year examination weight, WTSFM, should be used in estimating the prevalence of and in testing statistical hypotheses concerning HLA B27. (cdc.gov)
  • Results showed that 64.3% (2562 of 3984) reported ≥1 peripheral manifestation - with a prevalence of 51.5% for peripheral arthritis, 37.8% for peripheral enthesitis, and 15.6% for dactylitis. (rheumatologyadvisor.com)
Disorders1
  • 2009). Some studies indicate an increase in mortality among persons who have HLA-B27 associated disorders, however there are no mortality studies that relate directly to the HLA-B27 trait itself (Zochling and Braun, 2008). (cdc.gov)
Axial4
  • It is more common among older boys, and these patients may subsequently develop arthritis of their axial skeleton (sacroiliac and lumbar spine). (msdmanuals.com)
  • The presence of HLA-B27 is associated with a threefold increase in the risk of atlanto-axial subluxation. (lab24.pl)
  • Apart from axial involvement, patients with axSpA may suffer from peripheral musculoskeletal manifestations such as enthesitis, arthritis and dactylitis. (biomedcentral.com)
  • Axial spondyloarthropathy (axSpA) is an autoinflammatory arthritis predominantly involving the axial spine. (hospitalprofessionalnews.ie)
Protein3
  • HLA-B27 is a specific protein that is found on cell surfaces. (metropolisindia.com)
  • The HLAB27 is used to identify the presence or absence of this protein on white blood cells. (metropolisindia.com)
  • HLA-B27 antigen is a specific protein found on the surface of immune cells. (lab24.pl)
Spondyloarthritis2
  • Also in NHANES 2009-10, questionnaire data related to inflammatory back pain and Spondyloarthritis (ARQ_F) and physical examination data for selected arthritis-related body measures (ARX_F) were collected. (cdc.gov)
  • Carrying the HLA-B27 antigen is associated with an increased risk of developing diseases from the group of seronegative spondyloarthritis. (lab24.pl)
Surface1
  • Treatment is based on surface areas of involvement, body site(s) affected, the presence or absence of arthritis, and the thickness of the plaques and scale. (medscape.com)
Testing was performed2
  • HLA-B27 testing was performed on these samples using a polymerase chain reaction (PCR) to specifically replicate the DNA sequences encoding the HLA loci of interest. (cdc.gov)
  • A careful clinical assessment for sacroiliitis was made from history and examination, and HLA-B27 testing was performed. (ox.ac.uk)
Proteins2
Spondyloarthropathy1
  • We hypothesize that the role of HLA-B27 in spondyloarthropathy stems from its function in antigen presentation, either in peptide selection and binding or in other aspects of its cell biology. (ox.ac.uk)
Type of arthritis2
Musculoskeletal1
  • Bringing the Walk with Ease Programme to the UK: A mixed-methods study to assess the relevance, acceptability and feasibility of implementation for people with arthritis and musculoskeletal conditions. (elsevierpure.com)
Sacroiliitis2
  • There was no correlation between HLA-B27 and sacroiliitis diagnosed by MRI. (ox.ac.uk)
  • Determination of the HLA-B27 antigen is indicated when examining a patient with complaints of inflammatory back pain in the absence of radiological signs of sacroiliitis or when examining a patient with asymmetric oligoarthritis. (lab24.pl)
Occur2
  • the term applies to a number of chronic, noninfectious arthritides that occur in children and share certain features. (msdmanuals.com)
  • Arthritis in the hips and shoulders may also occur. (findzebra.com)
Antibodies2
Asymmetric1
Enthesitis-related arthritis1
  • Most of the patients had polyarthritis (33%) or enthesitis-related arthritis (ERA) (20%), and the majority (63.8%) were women. (medpagetoday.com)
Subtype2
  • No allelic or HLA-B27 subtype analysis was performed and none is reported. (cdc.gov)
  • We observed that the most prevalent subtype in the region was oligoarticular arthritis. (biomedcentral.com)
Bacterial3
  • For this reason, the current discussion concentrates on the bacterial septic arthritides. (medscape.com)
  • Bacterial/suppurative arthritis is commonly classified as either gonococcal or nongonococcal. (medscape.com)
  • In addition, the toxin does not appear to be produced at temperatures higher than 30°C. The plasmid-mediated outer membrane antigens are associated with bacterial resistance to opsonization and neutrophil phagocytosis. (diseasesdic.com)
Adult5
  • There are more drugs approved for the treatment of adult-onset arthritis than for childhood-onset arthritis. (medpagetoday.com)
  • Are agents approved for conditions other than JIA used in young adults with JIA, and if so, is this associated with a change in disease classification to adult-onset forms of arthritis? (medpagetoday.com)
  • 1 The primary outcome was the percentage of patients with JIA who met the criteria for adult-onset arthritis and the number of biologics used by these patients. (medpagetoday.com)
  • Of the adults treated with biologics, 41% met the criteria for a diagnosis of adult-onset arthritis, whereas 59% kept their JIA diagnosis. (medpagetoday.com)
  • Ten of the patients were treated with medications that are not guideline-recommended for JIA but are for adult-onset arthritis. (medpagetoday.com)
Diseases1
  • Given this feature, detection of the HLA-B27 antigen is of great diagnostic value in the clinic of rheumatological diseases. (lab24.pl)
Form of arthritis1
  • Osteoarthritis is the most common form of arthritis and is reputed to have the most frequent number of visits to the hospital. (perfectsvasthya.com)
Disease4
Negative2
  • A negative result means you don't have HLA-B27 in your blood. (tidelandshealth.org)
  • Please note a negative HLA-B27 test does not completely rule out the diagnosis of ankylosisng spondylitis. (punerheumatologist.com)
Genes1
  • Effect of HLA-B and HLA-DR genes on susceptibility to and severity of spondyloarthropathies in Mexican patients. (cdc.gov)