• Osteoarthritis (OA) and rheumatoid arthritis (RA) are common joint disorders that are considered to be different diseases due to their unique molecular mechanisms and pathogenesis. (researchsquare.com)
  • Here, we found that both diseases feature elevated levels of CXCL1 and interleukin (IL)-6, an important proinflammatory cytokine that participates in OA and RA pathogenesis. (researchsquare.com)
  • Our findings help to explain the pathogenesis of arthritis. (researchsquare.com)
  • The course Advanced Medical Microbiology will provide you with detailed insight in epidemiology, pathogenesis, prevention and treatment of important infectious diseases. (uva.nl)
  • Patients with the disease have immune responses to native type II collagen (4), but whether collagen reactivity participates in the primary pathogenesis of rheumatoid arthritis or reflects tissue degradation is unknown. (bronsonvitamins.com)
  • The purpose of our exploratory research is to increase our knowledge of the genesis and pathogenesis of chronic and infectious diseases. (bprc.nl)
  • Therefore, it is imperative to explore the underlying pathogenesis and identify novel therapeutic targets to more effectively prevent and treat autoimmune diseases [ 3 ]. (biomedcentral.com)
  • Consequently, dyslipidemia may be implicated in the pathogenesis and progression of autoimmune diseases, but the effects of various lipid-lowering drugs on autoimmune diseases warrant further investigation. (biomedcentral.com)
  • These findings suggest that PCSK9i may be involved in the pathogenesis of autoimmune diseases through pathways other than lipid-lowering. (biomedcentral.com)
  • CONCLUSION:Although antibodies to specific citrullinated proteins may have distinct genetic and environmental risk factors, the similarity in clinical phenotype suggests that they share common pathways in the pathogenesis of joint disease in RA. (shengsci.com)
  • Although the etiological role of microorganisms in the pathogenesis of this disease is clear, the host's immune-inflammatory response can lead to protective and/or destructive effects on periodontal tissues 1 . (bvsalud.org)
  • Rheumatoid arthritis (RA) is an autoimmune disease of the joint synovial membranes. (nih.gov)
  • Genetic risk factors play an important role in autoimmune disease susceptibility. (hindawi.com)
  • In particular, we are interested in papers describing novel genetic associations with autoimmune disease, genetic factors which predict disease outcome, or disease phenotype and papers which characterize the molecular or biological function of a known autoimmune disease risk variant. (hindawi.com)
  • Oral tolerization to autoantigens suppresses animal models of T cell-mediated autoimmune disease, including two models of rheumatoid arthritis. (bronsonvitamins.com)
  • The work shines new light on the workings of autoimmune disease. (uchealth.org)
  • New research suggests a bacterial strain in the gut may trigger rheumatoid arthritis, an autoimmune disease that attacks the joints. (uchealth.org)
  • She cautioned that the findings, while promising, leave many questions yet to be answered about RA specifically and autoimmune disease in general. (uchealth.org)
  • Kuhn is a researcher in RA and other forms of arthritis and autoimmune disease who also practices in the UCHealth Rheumatology Clinic - Anschutz Medical Campus . (uchealth.org)
  • Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. (medscape.com)
  • Specific treatment of autoimmune disease is needed. (lu.se)
  • The main risk factors for osteoarthritis are age and body mass index, as such, OA is predominantly considered a disease of aging. (wikipedia.org)
  • In addition, osteoarthritis has a number of heritable factors, and there may be genetic risk factors for the disease. (wikipedia.org)
  • Gene augmentation, gene replacement, and novel transgene gene therapy strategies for the potential medical management of osteoarthritis are under preliminary research to define pathological mechanisms and possible treatments for this chronic disease. (wikipedia.org)
  • Primary Osteoarthritis (OA) is a degenerative joint disease which is the western world's leading cause of pain and disability. (wikipedia.org)
  • Chemokines and chemokine receptors are critical players in the disease processes of two inflammatory joint diseases: rheumatoid arthritis (RA) and osteoarthritis (OA) (1). (researchsquare.com)
  • Celebrex is a new medication for the treatment of the inflammation and pain of the two most common forms of arthritis , rheumatoid arthritis and osteoarthritis . (medicinenet.com)
  • Indomethacin has been shown to be an effective anti-inflammatory agent, appropriate for long-term use in rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. (nih.gov)
  • Dr. Jarjour's specialty interests include rheumatoid arthritis, vasculitis, Lupus, connective tissue diseases and osteoarthritis with research focused on autoimmunity. (osu.edu)
  • Its underlying causes are not well understood but genetic factors are believed to account for half to two thirds of human arthritis cases, including the most common types such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, says Kingsley. (stanford.edu)
  • The incidence of osteoarthritis, the most common joint disease of humans, increases with age and is most frequent in people greater than 60 years old. (stanford.edu)
  • But many of the mouse symptoms are similar to those found in human arthritic diseases, including cartilage erosion and bony outgrowths seen in osteoarthritis and fusion of the vertebrae seen in ankylosing spondylitis. (stanford.edu)
  • uses a concentrated form of autologous adipose-derived adult stem cells to treat traumatic and degenerative diseases, including bowed tendons, ligament injuries, osteoarthritis, and osteochondral defects in horses, dogs, and cats. (vetstem.com)
  • At the large American congress ACR Convergence on rheumatological diseases held in 2021, results from a large study were presented indicating that the diabetes medication metformin can reduce the risk of osteoarthritis. (lu.se)
  • In this current study, PEMF decreased paw inflammation in a collagen-induced arthritis (CIA) murine model. (nih.gov)
  • To determine the therapeutic efficacy and immunomodulatory effect of an anti-human death receptor 5 (DR5) antibody, TRA-8, in eliminating macrophage subsets in a mouse model of type II collagen-induced arthritis (CIA). (nih.gov)
  • Combined collagen-induced arthritis and organic dust-induced airway inflammation to model inflammatory lung disease in rheumatoid arthritis. (cdc.gov)
  • The collagen-induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone/joint-lung inflammatory outcomes. (cdc.gov)
  • An easy to use protocol incorporating contactless image acquisition and computer-assisted data analysis was developed to detect disease-related temperature changes in a collagen-induced arthritis (CIA) mouse model and validated by comparison with two conventional methods, clinical arthritis scoring and paw thickness measurement. (mendeley.com)
  • Humans and other animals have differences in nerve anatomy, so electrodes and stimulation patterns that show results in non-human models often don't translate well for humans in clinical trials. (nih.gov)
  • Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans. (nih.gov)
  • In its capacity as Europe's one of the largest largest non-commercial primate research centre, BPRC plays a vital part in biomedical research on serious diseases affecting humans. (bprc.nl)
  • The results of these experiments challenge the longstanding scientific presumption holding that animal experiments are of direct relevance to humans. (proanima.fr)
  • The new results arise from basic medical research, which itself rests heavily on the idea that treatments can be developed in animals and transferred to humans. (proanima.fr)
  • The research originated when investigators noted that in their medical specialism of inflammatory disease (which includes diabetes, asthma and arthritis), drugs developed using mice have to date had a 100% failure rate in almost 150 clinical trials on humans. (proanima.fr)
  • In summary, repeated experiments confirmed that, when it comes to inflammation, mice and humans have little in common, a finding important enough in itself given the prevalence of inflammation-related diseases in humans. (proanima.fr)
  • Like arthritis in humans, the condition becomes more severe with increasing age. (stanford.edu)
  • According to Kingsley, the type of arthritis from which the ank mice suffer is not exactly the same as any single form of human arthritis - it is much more severe and widespread than that typically seen in humans. (stanford.edu)
  • New targeted drugs have come from this work, but the similarity in function and physiology between humans and rodents makes it easier for the laboratory to use this technology and process to mimic human disease. (connectusfund.org)
  • The results of animal experiments cannot be reliably transferred to humans. (aerzte-gegen-tierversuche.de)
  • A consequence of this unscientific extrapolation from laboratory animals to humans is that drugs have had to be withdrawn from the market because of unforeseen hazards or even lethal side-effects in humans - effects which were not seen in animals. (aerzte-gegen-tierversuche.de)
  • Results from animal tests do not allow conclusions about effectiveness, tolerance nor safety for humans. (aerzte-gegen-tierversuche.de)
  • The reason why many drugs and medical procedures are relatively safe cannot be put down to animal experiments, but to the fact that all drugs have to be tested on humans, in the so-called clinical trials required by law. (aerzte-gegen-tierversuche.de)
  • Several studies have shown that B. burgdorferi becomes tolerant to antimicrobials and may persist in both animals and humans after exposure to the currently recommended antimicrobial treatment. (lymediseaseassociation.org)
  • These findings in humans, although not definitive, are consistent with observations found in animal models (mice and non-human primates) as well as a wide range of in vitro studies. (lymediseaseassociation.org)
  • Creutzfeldt-Jacob disease (nvCJD) in humans. (who.int)
  • Birds are often reservoirs for arboviruses, which are transmitted by mosquitoes to horses, other domestic animals, and humans. (msdmanuals.com)
  • These viruses may spread to humans from nonhuman reservoirs, but most arboviral diseases are not transmissible by humans, perhaps because the typical viremia is inadequate to infect the arthropod vector. (msdmanuals.com)
  • indicate tative comparisons of carcinogens been narrowed and their therapeutic that no agents classified as carci- with respect to potency in humans use has declined, with the possible nogenic to humans (Group 1) are and in experimental animals are exception of cyclophosphamide. (who.int)
  • Background Anti-tumour necrosis factor (anti-TNF) therapy has been associated with reports of rapid severe progression of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). (bmj.com)
  • 7 Following the introduction of anti-tumour necrosis factor (anti-TNF) therapies for patients with RA, there have been a number of case reports and case series documenting either a rapid progression of pre-existing RA-ILD or the development of new-onset interstitial disease. (bmj.com)
  • In the context of a recent work in the magazine PNAS The team developed a new protein-based vaccine to stimulate the production of 14-3-3-zeta antibodies and successfully prevented disease progression in several animal models. (bioprepwatch.com)
  • Extended report: Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. (bmj.com)
  • Additionally, we administered daily intraperitoneal CB treatment to arthritic mice to evaluate its effects on circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, as indicators of disease progression. (frontiersin.org)
  • Furthermore, CB treatment in a mouse model of collagen-induce arthritis resulted in a significant decrease in circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, leading to a reduction in disease progression. (frontiersin.org)
  • We established echocardiography and cMRI with T2 mapping as a method to determine lupus-mediated disease progression in these mice. (osu.edu)
  • Arthritis News : What is the Relationship of RA Disease Activity to Radiographic Progression of Joint Damage? (hopkinsarthritis.org)
  • These questions are not readily answered by conventional statistical analysis methods which use time-averaged estimates of radiographic progression and disease activity over a study interval. (hopkinsarthritis.org)
  • Time-averaged estimates do not take into account the variability of disease within an individual patient, and also assume a linear rate of radiographic progression. (hopkinsarthritis.org)
  • Regression models using GEE were constructed to evaluate trends in radiographic progression. (hopkinsarthritis.org)
  • Then baseline variables thought to be predictive of radiographic progression (age at baseline, sex, rheumatoid factor, baseline Sharp score, baseline DAS score) were entered into the model. (hopkinsarthritis.org)
  • Using GEE, the rate of radiographic progression was found to slow slightly with increasing disease duration. (hopkinsarthritis.org)
  • Thus, periods of higher disease activity (mean interval DAS) or fluctuating disease activity (SD of mean interval DAS) were associated with more radiographic progression. (hopkinsarthritis.org)
  • The time averaged radiographic progression in this cohort was 7.7 Sharp points per year, but the rate of radiographic progression tended to slightly slow with increasing disease duration. (hopkinsarthritis.org)
  • Outcomes measured were C-reactive protein, erythrocyte sedimentation rate, visual analogue scales for pain and global assessment of disease activity, Health Assessment Questionnaire, physician's assessment, swollen and tender joint counts and radiological progression. (shengsci.com)
  • Taking into account the extensive presence of C. verbenacea in Brazilian folk medicine, and considering the anti-inflammatory activity previously reported 12-17 our group was prompted to assess the impact of C. verbenacea in modulating periodontal disease progression. (bvsalud.org)
  • Our data provide preclinical evidence that TRA-8 is a potential novel biologic agent for rheumatoid arthritis therapy. (nih.gov)
  • This game isn't therapy, but above all a tool that can help children to better cope with their disease. (uu.nl)
  • An ideal therapy would decrease inflammation in the joint by a disease-specific mechanism and would lack toxicity. (bronsonvitamins.com)
  • In patients with major organ involvement, such as lymphocytic interstitial lung disease, consider therapy with steroids and immunosuppressive agents, such as cyclophosphamide. (medscape.com)
  • People already place a high value on both quality and length of life, which is why children are immunized against infectious diseases. (the-scientist.com)
  • Immunology is the science that investigates how complex multicellular organisms (mostly mammals) defend themselves against infectious diseases. (uva.nl)
  • The work, which included contributions from 10 other CU School of Medicine faculty from the CU School of Medicine divisions of Rheumatology and Infectious Disease and the Department of Pathology, also drew attention from the school's Dean, Dr. John J. Reilly . (uchealth.org)
  • The potential for residual infectious risk from EBOV persistence is further highlighted by recovery of infectious EBOV in cerebrospinal fluid collected at 282 days after onset of Ebola disease from a survivor who experienced late onset of meningoencephalitis signs and symptoms 1 , and isolation of EBOV from an intraocular fluid specimen of an eye affected by panuveitis collected at 14 weeks after onset of Ebola disease 16 . (cdc.gov)
  • In these communities, a high prevalence of both poor diet and infectious disease exist in a vicious circle [ 1 ]. (who.int)
  • Both diseases are characterized by the extravasation of leukocytes from the vascular endothelium into the synovial tissue, a process that involves numerous chemokines and their receptors acting as synovial chemotactic mediators (5). (researchsquare.com)
  • This study details how we found that CXCL1 promoted interleukin (IL)-6 expression in RA and OA synovial fibroblasts (SFs), worsening the inflammatory status in the joints of both diseases. (researchsquare.com)
  • Rheumatoid arthritis is an inflammatory synovial disease thought to involve T cells reacting to an antigen within the joint. (bronsonvitamins.com)
  • Rheumatoid arthritis (RA) is a common chronic illness in which the synovial membrane of multiple joints becomes inflamed, causing damage to cartilage and bone. (bronsonvitamins.com)
  • It is unknown whether EBOV can persist in synovial fluid with or without accompanying arthritis. (cdc.gov)
  • Now, imagine an intervention that does all these things, and at the same time reduces your risk of everything else undesirable about growing older: including heart disease, diabetes, Alzheimer and Parkinson disease, hip fractures, osteoporosis, sensory impairments, and sexual dysfunction. (the-scientist.com)
  • An emerging wave of bioelectronic medicine is changing the way we treat disease, targeting everything from arthritis and diabetes to cancer and Crohn's disease. (theengineer.co.uk)
  • Now a new wave of biomedical companies is seeking to expand the field, hacking the body's codes to treat everything from arthritis and diabetes to cancer, cardiovascular disease and asthma. (theengineer.co.uk)
  • Oral tolerization, a method of inducing antigen-specific tolerance, suppresses animal models of the autoimmune diseases multiple sclerosis, uveitis, and diabetes (6-11). (bronsonvitamins.com)
  • The reasons why the immune systems of people with various forms of arthritis, Type 1 diabetes, lupus, multiple sclerosis and many other diseases go awry and cause the body-as-boxer to attack itself remain murky and the subject of intense investigation. (uchealth.org)
  • This protects against heart disease, and is also likely to reduce risk of other lifestyle diseases such as Type 2 Diabetes and stroke. (weightlosshelpandtips.net)
  • With the risk of coronary heart disease as a positive control, primary outcomes included the risk of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), myasthenia gravis (MG), multiple sclerosis (MS), asthma, Crohn's disease (CD), ulcerative colitis (UC), and type 1 diabetes (T1D). (biomedcentral.com)
  • Using animal testing, in spite of millions of animal victims and enormous economic investments the medical research system has failed to make real breakthroughs in the fight against the main diseases of today (e.g. cancer, heart and vascular diseases, diabetes, rheumatoid arthritis, allergies, AIDS, etc.), contrary to its countless promises. (aerzte-gegen-tierversuche.de)
  • CU Division of Rheumatology head Dr. Kristi Kuhn, senior author of the paper, believes the new finding is another step toward understanding the riddle of what triggers rheumatoid arthritis. (uchealth.org)
  • Far from being a stand-alone, the study is an extension of many years of work by specialists in the Division of Rheumatology on autoimmune diseases and how mucosal surfaces throughout the body - mouth, lungs, and gut among them - may be involved, said senior author and Division of Rheumatology head Dr. Kristi Kuhn . (uchealth.org)
  • Because AS is a systemic inflammatory disease, systemic features are common. (medscape.com)
  • I have long term research interests in the study of the molecular basis of alterations in the signaling of T and B lymphocytes in patients with autoimmune diseases, systemic lupus erythematosus or SLE, and psoriasis. (csic.es)
  • This means that age-associated B-cells develop more frequently, such as with rheumatoid arthritis (RA), scleroderma, and systemic lupus erythematosus . (medscape.com)
  • Data also support suppression of the lung inflammatory response, but increases in extracellular matrix protein deposition/interstitial disease in the setting of arthritis. (cdc.gov)
  • Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a non-neoplastic disorder resulting from damage to the lung parenchyma by varying patterns of inflammation and fibrosis. (bmj.com)
  • Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a sometimes life-threatening complication in RA patients. (biomedcentral.com)
  • Interstitial lung disease (ILD) is sometimes a complication of rheumatoid arthritis (RA), in which case it is called rheumatoid arthritis-associated ILD (RA-ILD). (biomedcentral.com)
  • To stop the damage done by rheumatoid arthritis we need to selectively kill the B-cells making the rogue antibodies," says Pitzalis. (thenakedscientists.com)
  • Specifically, the team found that arthritis appeared in the animals along with a loss of 14-3-3-zeta antibodies. (bioprepwatch.com)
  • They collected blood from people at risk for the disease and isolated the relevant disease-linked antibodies. (uchealth.org)
  • The most common transgenic animals that you will see in the world today are mice that have received genetic modifications so that they naturally produce human antibodies. (connectusfund.org)
  • We use antibodies from mice and other rodents to create new medical therapies that can reduce or eliminate the impact of illness and disease. (connectusfund.org)
  • METHODS:Anti-CEP-1 and anti-CCP2 antibodies were measured in two prospective cohorts of patients (Karolinska n=272, Norfolk Arthritis Register (NOAR) n=408) with early rheumatoid arthritis (RA). (shengsci.com)
  • The antifetal cartilage antibodies were found in 6 of 9 patients and only 4 (1.5%) of 260 patients with RA, exclusively in long-standing disease. (medscape.com)
  • 2023. A review on experimental surgical models and anesthetic protocols of heart failure in rats. (awionline.org)
  • These experimental findings provided the rationale for a pilot, open-label dose-escalation and safety study in 10 patients with recalcitrant rheumatoid arthritis. (bronsonvitamins.com)
  • This dose was extrapolated from experiments in the rat adjuvant arthritis model where feeding 3 to 30 p.g of collagen attenuated disease (14) and the rat experimental autoimmune encephalomyelitis (EAE) model where feeding 500 to 1000 p.g of MBP was suppressive (6,10). (bronsonvitamins.com)
  • An experimental model has demonstrated that the mechanical overloading of a single compartment of the knee leads to degenerative change in that compartment. (medscape.com)
  • As a result, the linkage between the autoimmune experimental arthritis phenotype and the genomic region, that is, the quantitative trait locus, can cover several hundred genes. (medscape.com)
  • The CGC tool was developed by combining genomic regions in the rat, associated with the autoimmune experimental arthritis phenotype, with rat/human gene homology data, and with descriptions of phenotypic gene effects and selected keywords. (medscape.com)
  • The CGC application ranks gene candidates for 37 rat genomic regions associated with autoimmune experimental arthritis phenotypes. (medscape.com)
  • Rats are very useful for this purpose because autoimmune experimental arthritis phenotypes can be induced in susceptible strains by several agents, such as collagen, pristane, oil, streptococcal cell wall and even adjuvant alone. (medscape.com)
  • An additional source of quantita- erations for compounds that cause of tumour-free animals by 50% (Gold tive data on cancer risks is the group cancer in experimental animals. (who.int)
  • Such data chal enge the "ca- and in experimental animals, with The four anticancer agents dis- nonical" site-specificity of carcino- reference to the possible underlying cussed here were first used in clin- ical practice in the 1960s, but since genesis. (who.int)
  • This chronic disease not only affects the articular cartilage but also the subchondral bone, the synovium, and periarticular tissues. (wikipedia.org)
  • Most patients have mild chronic disease or intermittent flares with periods of remission. (medscape.com)
  • But play is not self-evident for all children, for instance, those with a chronic disease. (uu.nl)
  • Children with a chronic disease can experience lasting consequences for their social, cognitive and emotional development. (uu.nl)
  • What is the relationship between play behaviour and the development of children with a chronic disease? (uu.nl)
  • Developing an applied game focusing on loneliness in children with a chronic disease. (uu.nl)
  • Patients with cardiovascular disease or risk factors for cardiovascular disease may be at a greater risk. (nih.gov)
  • Recent epidemiologic evidence suggests an association between olive oil consumption and a lower incidence of cardiovascular disease and certain cancers. (researchgate.net)
  • A new discovery has shed light on the mechanism by which joints are damaged by rheumatoid arthritis, scientists announced this week. (thenakedscientists.com)
  • Writing in this week's edition of the journal PLoS Medicine Barts and the London Medical school researcher Constantino Pitzalis and his colleagues collected samples from the inflamed joints of patients affected by the disease, which affects about 1% of the adult population and occurs when the immune system mistakes healthy joints for hostile tissue and attacks them. (thenakedscientists.com)
  • Joint involvement tends to occur most commonly in the hips, shoulders, and joints of the chest wall, including the acromioclavicular and sternoclavicular joints, and often occurs in the first 10 years of disease. (medscape.com)
  • In this randomized, double-blind trial involving 60 patients with severe, active rheumatoid arthritis, a decrease in the number of swollen joints and tender joints occurred in subjects fed chicken type II collagen for 3 months but not in those that received a placebo. (bronsonvitamins.com)
  • STANFORD - A substance commonly added to toothpaste to prevent tartar build-up on our teeth may be the same material our bodies use to prevent calcium and minerals accumulating in our joints and forming the deposits associated with arthritis. (stanford.edu)
  • Kingsley's group uses genetics to study the development of bones and joints in vertebrates, or animals with backbones. (stanford.edu)
  • The resulting mineralization of cartilage, deposition of bone in and around joints and eventual joint destruction are classic symptoms of arthritis. (stanford.edu)
  • Arthritis and Rheumatism. (ncl.edu.tw)
  • In a prospective study of 78 patients with primary Sjögren syndrome treated with rituximab, significant improvement in extraglandular manifestations was reported, as measured by EULAR [European League Against Rheumatism] Sjögren Syndrome Disease Activity Index (ESSDAI) (disease activity score) and overall good tolerance reported. (medscape.com)
  • British Heart Foundation, Arthritis and Rheumatism Council), School of Medicine and Dentistry. (bioethics.ac.uk)
  • LEIPZIG, GERMANY - With age comes illness: Cancer, cardiovascular and neurodegenerative diseases, increased infections, and autoimmune diseases such as rheumatism become more common. (medscape.com)
  • Undifferentiated spondyloarthropathy (USpA) is used to describe patients with predominantly peripheral features and may represent an early phase or incomplete form of AS or another spondyloarthropathy such as psoriatic arthritis. (medscape.com)
  • It may delay development of conditions such as dementia and Alzheimer's disease and improve cognitive function. (weightlosshelpandtips.net)
  • Rheumatoid arthritis (RA) is associated with extra-articular manifestations in around 40% of patients. (bmj.com)
  • The outcome in patients with axial spondyloarthritis, including AS, is generally good compared with that in patients with a disease such as rheumatoid arthritis. (medscape.com)
  • The risk of complications is higher in elderly patients, rheumatoid arthritis sufferers, patients taking blood thinning medications ( anticoagulants such as Coumadin and heparin ) or prednisone (cortisone medication), and patients with heart disease or a prior history of bleeding ulcers. (medicinenet.com)
  • Apart from providing new insights into the mechanisms of rheumatoid arthritis, which costs the NHS more than £1.2 billion per year to treat affected patients, the new research may also help with the development of better drugs and better use of the drugs we do have to control the disease. (thenakedscientists.com)
  • Targeting rheumatoid arthritis (RA), the trial will see patients implanted with Galvani's neuromodulation system, sending pulses to the splenic nerve. (theengineer.co.uk)
  • Four patients in the collagen group had complete remission of the disease. (bronsonvitamins.com)
  • Indomethacin may enable the reduction of steroid dosage in patients receiving steroids for the more severe forms of rheumatoid arthritis. (nih.gov)
  • In investigating the role of estrogen receptors and estrogen in SLE and other autoimmune diseases, our team has identified novel targets of estrogen that are significantly up-regulated in SLE patients and play a critical role in regulating inflammation. (osu.edu)
  • However, in addition to anti-VEGF pharmacotherapy, intravitreal administered anti-inflammatory substances, such as triamcinolone acetonide (TA) [ 11 - 13 ], a widely used anti-inflammatory drug, and infliximab [ 14 ], an antibody of tumor necrosis factor α (TNF- α), have also shown positive effects in treating CNV in patients and animal models. (molvis.org)
  • It is crucial that we continue to develop new therapies for use in uveitis that aim to suppress disease activity, prevent accumulation of damage, and preserve visual function for patients with the minimum possible side effects. (dovepress.com)
  • Of the eleven patients with Ebola disease who were managed in U.S. healthcare facilities during 2014-2015, nine survived. (cdc.gov)
  • Patients who recover from acute Ebola disease and later become ill with neurologic or ocular symptoms might have persistent ebolavirus replication in the CNS or eye respectively. (cdc.gov)
  • Appropriate infection control practices, such as those recommended for evaluating patients with suspect Ebola disease, should be adhered to until testing is negative. (cdc.gov)
  • Patients with RA associated with Sjögren syndrome likely require other disease-modifying agents. (medscape.com)
  • [ 84 ] In a randomized, placebo-controlled, parallel-group study of 120 patients with primary Sjögren syndrome, treatment with rituximab did not alleviate disease activity or symptoms at week 24, although it did alleviate some symptoms at weeks 6 and 16. (medscape.com)
  • Here, Welsing et al ( Arthritis Rheum 50(7):2082, 2004 ) use GEE to investigate the longitudinal relationship of RA disease activity to radiographic damage in two different cohorts of RA patients. (hopkinsarthritis.org)
  • Patients are treated according to the discretion of their treating rheumatologist, but have regular assessments of disease activity (reported as DAS (disease activity scores) collected at baseline and every 3 months) and radiographs of hands and feet obtained at baseline and every three years. (hopkinsarthritis.org)
  • The baseline characteristics of patients enrolled in each of the cohorts was remarkably similar except that the COBRA group had higher disease activity at baseline (as required by the study protocol) and was followed for a longer period of time. (hopkinsarthritis.org)
  • Extensive studies with patients and healthy people have shown the impact of life-style on the cause and process of different diseases. (aerzte-gegen-tierversuche.de)
  • This antibiotic persistence/tolerance has also been documented in clinical reports describing efficacy of repeated and extended antimicrobial treatment that resolve some cases of Lyme arthritis and improve other symptoms in some patients. (lymediseaseassociation.org)
  • While most patients with pemphigus vulgaris have oral lesions, which usually are the first manifestation of this disease, only a few patients with bullous pemphigoid have oral lesions. (medscape.com)
  • Passive transfer experiments have demonstrated that purified autoantibodies from patients with the pemphigus group of diseases can induce blister formation when delivered to newborn mice. (medscape.com)
  • Symptoms of AS include those related to inflammatory back pain, peripheral enthesitis and arthritis, and constitutional and organ-specific extra-articular manifestations. (medscape.com)
  • In contrast, acute onset of pain, exacerbation of symptoms with activity, and radicular radiation of pain suggest a mechanical or degenerative process such as disc disease. (medscape.com)
  • Ebola disease survivors who have any new or recurrent ocular or neurologic symptoms should seek care for complications associated with potential virus persistence. (cdc.gov)
  • Apart from some symptoms these „models" have hardly any similarities with the human diseases. (aerzte-gegen-tierversuche.de)
  • Compared with male mice, female mice showed less articular and pulmonary disease. (cdc.gov)
  • The interaction of inhalation-induced airway inflammation and arthritis induction resulted in compartmentalized responses with the greatest degree of arthritis and bone loss in male mice with combined exposures. (cdc.gov)
  • 2023. Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington's disease. (awionline.org)
  • Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. (awionline.org)
  • When mice were deprived of 14-3-3 zeta, the development of the induced disease accelerated. (bioprepwatch.com)
  • SKG mice develop not only arthritis but also an ILD resembling RA-ILD. (biomedcentral.com)
  • We previously reported that tofacitinib, a JAK inhibitor, facilitates the expansion of myeloid-derived suppressor cells (MDSCs) and ameliorates arthritis in SKG mice. (biomedcentral.com)
  • We also showed that tofacitinib facilitated the expansion of MDSCs in the spleen and bone marrow (BM) and ameliorated the arthritis in SKG mice [ 10 ]. (biomedcentral.com)
  • All mice were kept in specific pathogen-free conditions at the Institute of Laboratory Animals, Graduate School of Medicine, Kobe University. (biomedcentral.com)
  • All mice were handled in accordance with the guidelines for animal care approved by the Animal Experimentation Committee of Kobe University. (biomedcentral.com)
  • In addition I studied CD38-deficient mice (Cd38KO) for phenotypic, functional and proteomic studies in animal models of autoimmune diseases (arthritis reumatoide and pristane induced-lupus). (csic.es)
  • Official assurances of the safety of these chemicals are based largely on animal experiments that use rabbits, mice, rats and dogs. (proanima.fr)
  • Mice carrying the defective ank gene have long been studied as a model of arthritis. (stanford.edu)
  • 95% of the animals who fall into this category are rodents, with most of them being mice. (connectusfund.org)
  • We invite authors to submit original research articles about diverse autoimmune diseases which will advance our knowledge in this important group of conditions. (hindawi.com)
  • This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research. (awionline.org)
  • Longitudinal studies on mouse models related to Alzheimer disease (AD) pathology play an important role in the investigation of therapeutic targets to help pharmaceutical research in the development of new drugs and in the attempt. (awionline.org)
  • Animal welfare considerations are an essential part of scientific research. (awionline.org)
  • If animals may suffer, then even 26 the most promising research plans can be delayed or rejected and the resulting data may be questionable. (awionline.org)
  • According to her, these findings open an entirely new avenue for future research into new treatments for arthritis, having recently been linked to an imbalance in the gut microbiota. (bioprepwatch.com)
  • Our scientific research institute is located in Rijswijk and employs more than one hundred people, ranging from animal care workers and animal behaviour experts to vets and geneticists. (bprc.nl)
  • The Biomedical Primate Research Centre (BPRC) is a scientific research institute that conducts biomedical research on life-threatening diseases, e.g. (bprc.nl)
  • What role does BPRC play in research on life-threatening diseases? (bprc.nl)
  • The purpose of our applied research is to contribute to the development of new medications or therapies for serious diseases. (bprc.nl)
  • Published in Independent Science News (May6, 2013) the article "The Experiment Is on Us : Science of Animal Testing Thrown into Doubt" by Pat Dutt and Jonathan Latham describes important new research that strongly suggests animal testing does not meaningfully protect us from unsafe food additives, pesticide contaminants, and other industrial chemicals. (proanima.fr)
  • This process is used routinely in laboratory models as part of the biomedical research process. (connectusfund.org)
  • Researchers use this method of research to understand human disease better, look at gene functionality with regards to disease susceptibility, and determine the necessary response for a therapeutic intervention. (connectusfund.org)
  • The pros and cons of transgenic animals often try to balance the ethics of treating an animal appropriately with the potential benefits that the research can produce. (connectusfund.org)
  • Researchers can take advantage of three common methods of producing transgenic animals for their research. (connectusfund.org)
  • 3. It allows us to research human diseases more effectively. (connectusfund.org)
  • In research laboratories animals are downgraded to disposable tools and testing systems. (aerzte-gegen-tierversuche.de)
  • Animal based research leads to an overvaluing of the natural sciences in medicine. (aerzte-gegen-tierversuche.de)
  • In many fields of medical research, using in vitro tests (including cell cultures, human tissue, microorganisms, and biochips) as well as epidemiological studies make a substantial contribution to understanding and curing human diseases. (aerzte-gegen-tierversuche.de)
  • These new avenues of research by far ourstrip the limited possibilities of animal-based research. (aerzte-gegen-tierversuche.de)
  • Some early research suggests that taking high doses of CBD might make muscle movement and tremors worse in some people with Parkinson disease. (medlineplus.gov)
  • Knowledge of the genetic basis of disease provides us with a unique window into human pathophysiology, which will facilitate improved diagnostic and therapeutic strategies and enable personalized medicine. (hindawi.com)
  • Employing IRT in longitudinal preclinical setting to monitor arthritis onset, disease activity and therapeutic efficacies requires a standardized framework to provide reproducible quantitative data as a precondition for clinical studies. (mendeley.com)
  • These inflammatory myopathies are part of a heterogeneous group of diseases with diverse etiologies and clinical manifestations. (osu.edu)
  • Over the last few decades, many other autoimmune blistering diseases have been delineated, and some of these newly identified diseases have oral manifestations. (medscape.com)
  • This article discusses the oral manifestations of several well-characterized autoimmune blistering diseases, including pemphigus vulgaris, bullous pemphigoid, linear immunoglobulin A (IgA) bullous dermatosis, and paraneoplastic pemphigus (PNP). (medscape.com)
  • Oral lesions are observed commonly in autoimmune blistering skin diseases. (medscape.com)
  • As a group, autoimmune blistering skin diseases are recognized as autoantibody-mediated diseases. (medscape.com)
  • IRT was found to be superior over the conventional techniques specially at early arthritis onset, when it is difficult to observe subclinical signs and measure structural changes. (mendeley.com)
  • At first, Ritu Chakravarti and colleagues from University of Toledo It is assumed that if the latter played an important role in the emergence of Rheumatoid arthritis , it was expected that gene deletion in mouse models of arthritis would prevent disease onset. (bioprepwatch.com)
  • According to the SUN criteria, disease is further classified according to onset (sudden or insidious), duration (limited or persistent), and course (acute, recurrent, or chronic). (dovepress.com)
  • The timing of onset, severity, and duration of complications among Ebola disease survivors are variable. (cdc.gov)
  • EBOV was isolated from a semen specimen collected 82 days after acute onset of Ebola disease from a male survivor 13 . (cdc.gov)
  • Molecular evidence suggested sexual transmission of EBOV from an asymptomatic male survivor to a female partner 179 days after the survivor's disease onset 14 . (cdc.gov)
  • Surprised by the consistently poor correlations between the two species, the authors then tested other human/mouse models of inflammatory diseases. (proanima.fr)
  • With this map, scientists will create digital models that can be used to simulate the effects of different nerve anatomies, types of electrodes, and stimulation intensities and patterns. (nih.gov)
  • Transgenic animals make it possible for scientists to study the functioning of particular genes at the level of the entire organism. (connectusfund.org)
  • We explored the effects of Segmented Filamentous Bacteria (SFB) on the lupus disease manifestation in NZM2410. (osu.edu)
  • Baharav E., Mor F., Halpern M., and Weinberger A., (2003) Lactobacillus GG Bacteria ameliorate arthritis in Lewis rats. (ncl.edu.tw)
  • Lyme disease bacteria) and Post treatment Lyme Disease Syndrome (PTLDS). (lymediseaseassociation.org)
  • Success in numerous animal models of disease and emerging success in human clinical trials for Crohn's fistulas 1 and stroke, 2 along with hundreds of ongoing clinical trials (see sidebar) support the rationale for stem cell use, and now success, in veterinary medicine. (vetstem.com)
  • Animal models provide a valuable tool for finding genes contributing to the susceptibility to and severity of RA. (medscape.com)
  • The researchers tested ASCENT with digitized models of real samples from human, pig, and rat vagus nerves found in the neck, along with corresponding data on nerve stimulation thresholds from real-world experiments. (nih.gov)
  • Animal experiments have to be rejected for ethical reasons. (aerzte-gegen-tierversuche.de)
  • Even if animal experiments had any benefit - which is not the case - they would still be ethically wrong. (aerzte-gegen-tierversuche.de)
  • Animal experiments cannot lead to a reliable conclusion about whether and to what extent the human and animal will react in the same way. (aerzte-gegen-tierversuche.de)
  • Researching the real causes of our illnesses is much more useful and promising and is even cheaper than more and more experiments on innocent animals. (aerzte-gegen-tierversuche.de)
  • Conclusion: Animal experiments are not only cruel and therefore unethical, they are also unscientific and unsafe and must be abolished immediately in the interest of man and animals and replaced by meaningful and humane procedures. (aerzte-gegen-tierversuche.de)
  • AIDS, malaria, hepatitis, tuberculosis and autoimmune diseases such as MS. At the same time, we also expend a great deal of energy on the development of testing methods that do not involve animal testing. (bprc.nl)
  • BPRC researchers are working hard to develop methods which will help us preserve endangered species in an animal-friendly manner. (bprc.nl)
  • For this reason, BPRC is very active in the development of alternative methods which do not involve animal testing. (bprc.nl)
  • 2. There are three different methods available to use to create transgenic animals. (connectusfund.org)
  • Among immune cells, activated monocytes play a detrimental role in chronic and viral-induced inflammatory pathologies, particularly in Juvenile Idiopathic Arthritis (JIA), a childhood rheumatoid arthritis (RA) disease. (frontiersin.org)
  • Innumerous biological systems have been suggested as alternatives to modulate the host's immune-inflammatory response involved in periodontal disease 2 . (bvsalud.org)
  • Some of the peripheral arthritis occurs at sites in which the major component is local enthesitis, as suggested by magnetic resonance imaging (MRI). (medscape.com)
  • Current treatments are inadequate in that they only partially control established rheumatoid arthritis. (bronsonvitamins.com)
  • are not a valid method of researching the different causes of human diseases nor of developing treatments for such diseases. (aerzte-gegen-tierversuche.de)
  • Intuitively, the answer to this would seem to be yes but data from the ATTRACT trial and studies on bone erosion in animal models of RA have suggested that there may be a disconnect between the two. (hopkinsarthritis.org)
  • Moreover, our laboratory has developed a myositis mouse model that combines synaptotagmin VII null with FoxP3 mutations, resulting in a mouse with impaired membrane resealing and regulatory T-cell deficiency. (osu.edu)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications for the inflammation of arthritis and other body tissues, such as in tendonitis and bursitis . (medicinenet.com)
  • It's not a perfect mimic of any particular form of arthritis but we thought it an interesting mutation to study because what's happening in the animals has lots of similarities to the pathological process that occurs in many forms of human arthritis,' Kingsley said. (stanford.edu)
  • Animals are artificially damaged to create so-called „models" which are used to mimic human diseases. (aerzte-gegen-tierversuche.de)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The anti-human DR5 antibody TRA-8 was efficacious in reducing the severity of arthritis via targeted depletion of macrophages and immunomodulation. (nih.gov)
  • A non-invasive method of drug delivery, intranasal atomization, has shown positive results in human medicine and in some animal species. (awionline.org)
  • Although the pathogenetic mechanisms underlying the disease are unknown, rheumatoid arthritis is associated with human lymphocyte antigen (HSA)-DR4 and considered to be an autoimmune disorder in which activated T cells participate (1). (bronsonvitamins.com)
  • This study has significant implications for human disease. (osu.edu)
  • This mouse displays robust inflammatory myositis that recapitulate, in part, the human disease ( Aberrant Muscle Antigen ). (osu.edu)
  • The researchers also identified the human version of the gene and confirmed that it lies in a region of DNA previously implicated in human joint disease, suggesting that disruptions in this gene may underlie arthritis in many different animals. (stanford.edu)
  • Arthritis is one of the most common human health problems. (stanford.edu)
  • We are also exploring this science to see if livestock and farm animals could produce complex human proteins that would provide benefits in the treatment of human disease. (connectusfund.org)
  • This study is demonstrated using UVA-induced cellular aging model of human dermal fibroblast. (researchgate.net)
  • The human body is regarded as a sort of bio-machine and diseases as biochemical or physiological deviations which can be repaired using chemical, surgical or radiological means. (aerzte-gegen-tierversuche.de)
  • Instead human beings and their diseases should be considered holistically. (aerzte-gegen-tierversuche.de)
  • at least 80 cause human disease. (msdmanuals.com)
  • Spontaneous animal homologues of human autoimmune blistering diseases have been identified in the last 2 decades. (medscape.com)
  • The histopathologic and immunopathologic findings usually are the same as that of human diseases and are not discussed here. (medscape.com)
  • Also, combining such test systems allows the properties of substances to be studied in detail, for instance toxicity, or their potential to cause cancer, genetic disorders or congenital diseases. (aerzte-gegen-tierversuche.de)
  • PEMF treatment at 10 Hz was more effective in ameliorating arthritis than at 75 Hz. (nih.gov)
  • US researchers have developed a potential new treatment for rheumatoid arthritis. (bioprepwatch.com)
  • Therapies that stimulate nerves with electrodes within the body hold promise for the treatment of many diseases, and vagus nerve stimulation (VNS) is already approved to treat epilepsy and depression. (nih.gov)
  • whilst both may present with similar clinical features, they are best considered as distinct disease entities since the underlying pathophysiology and treatment strategies are very different. (dovepress.com)
  • The incidence of autoimmune diseases accounts for about 5-9% of the global population, and their treatment is still a thorny clinical problem that imposes a great burden on society and families [ 1 ]. (biomedcentral.com)
  • The goal of treatment of rheumatoid arthritis (RA) is to prevent pain and disability. (hopkinsarthritis.org)
  • 356 disease terms (MeSH) has been reported with IL8 gene. (cdc.gov)
  • If the gene is defective, the animals have severe arthritis. (stanford.edu)
  • Researchers are looking at these animals as a potential source for organs to transplant, which would allow us to reduce severe donor shortages. (connectusfund.org)
  • Survivors can experience complications after surviving acute Ebola disease. (cdc.gov)
  • Among the debilitating complications of foodborne disease are reactive arthritis and paralysis. (who.int)
  • Sanne Nijhof is a paediatrician at UMC-WKZ, treating children with juvenile arthritis, childhood cancer or cystic fibrosis. (uu.nl)
  • Because the vaccine has been shown to be effective in preliminary animal studies, clinical trials can begin quickly. (bioprepwatch.com)
  • No animal has to suffer and die to investigate these important factors. (aerzte-gegen-tierversuche.de)
  • Millions of children die annually from diarrhoeal diseases, while hundreds of millions suffer from frequent episodes of diarrhoea and its debilitating consequences. (who.int)