• Consecutive patients with stable coronary heart disease who received IVUS examination between January 2011 and January 2014 were retrospectively screened. (hindawi.com)
  • It is the most common primary disease of the arterial vascular system and is responsible for coronary heart disease, the leading cause of death worldwide. (lecturio.com)
  • Reduces the risk of coronary heart disease, with risk falling sharply 1 to 2 years after cessation and then declining more slowly over the longer term. (cdc.gov)
  • It is the principal underlying pathology of coronary heart disease and stroke. (ac.ir)
  • A particularly strong association between vitamin K2 and peripheral arterial disease was found in patients with diabetes or hypertension. (nutritionaloutlook.com)
  • Despite the availability of specific therapies targeting multiple pathways involved in the development and progression of pulmonary arterial hypertension (PAH), and the improved survival observed in PAH patients in recent years, it remains a progressive, devastating disease [ 1 ]. (ersjournals.com)
  • NEW YORK (GenomeWeb News) - A team led by researchers at Columbia University Medical Center uncovered a new gene linked with pulmonary arterial hypertension, and as the group reported in The New England Journal of Medicine this week, the effects of some mutations in this gene may be mitigated by drug treatment. (genomeweb.com)
  • Pulmonary arterial hypertension is a rare, progressive, and fatal disorder marked by increased pulmonary artery pressure, which leads to decreased blood flow from the heart to the lungs. (genomeweb.com)
  • 3 Wood units is a criterion of the haemodynamic definition of pulmonary arterial hypertension (PAH). (ersjournals.com)
  • Pulmonary arterial hypertension (PAH) is a haemodynamic consequence of obstructive remodelling of the small pulmonary arteries and patients can progress to right-heart failure and death [ 1 ]. (ersjournals.com)
  • The fundamental physiological disturbance in pulmonary hypertension is an increase in right ventricular (RV) afterload, regardless of disease aetiology. (bmj.com)
  • The risk factors for peripheral arterial disease parallel those for ischemic heart disease in patients with hypertension. (aao.org)
  • All hospitalisations for pulmonary arterial hypertension (PAH) in the Scottish population were examined to determine the epidemiological features of PAH. (ersjournals.com)
  • Hospitalisation data from the Scottish Morbidity Record scheme gave higher prevalences of pulmonary arterial hypertension than data from the expert centres (Scotland and France). (ersjournals.com)
  • The hospitalisation data may overestimate the true frequency of pulmonary arterial hypertension in the population, but it is also possible that the expert centres underestimate the true frequency. (ersjournals.com)
  • Max Planck scientists find a way of treating pulmonary arterial hypertension . (medicalnewstoday.com)
  • Patients with pulmonary arterial hypertension struggle with severe symptoms, which include shortness of breath, exhaustion and a lack of vitality. (medicalnewstoday.com)
  • A malfunction of the vascular endothelium arises at an early stage in the development of pulmonary arterial hypertension. (medicalnewstoday.com)
  • With pulmonary arterial hypertension, the malfunctioning of the vascular epithelium results in the contraction and narrowing of the blood vessels. (medicalnewstoday.com)
  • According to Pullamsetti, these combined effects caused a reduction in the arterial hypertension. (medicalnewstoday.com)
  • Odds ratios for hypertension, heart diseases and related subjective symptoms among local truck drivers were significantly increased by job career, twisting posture, vibration and driving stress. (cdc.gov)
  • The logistic regression analysis within the subpopulation of truck drivers showed that the odds ratio for arterial hypertension was 3.20, for smoking-2.48. (cdc.gov)
  • In Australia, PAH therapy could be prescribed solely on mean pulmonary arterial pressure (PAP) and pulmonary arterial wedge pressure (PAWP) criteria. (ersjournals.com)
  • Peripheral arterial disease, specifically lower limb peripheral arterial disease, can be defined as atheromatous narrowing or occlusion of an artery or arteries in the lower limb. (intechopen.com)
  • This is important because there is a misconception that daily recommended intake (RDI) of the vitamin K1 is sufficient to protect the arteries from developing arterial diseases," says Hogne Vik, chief medical officer, NattoPharma. (nutritionaloutlook.com)
  • Peripheral arterial disease results in reduced blood flow in the arteries of the trunk, arms, and legs. (msdmanuals.com)
  • However, peripheral arterial disease can affect other arteries, such as those in the arms, and can have other causes. (msdmanuals.com)
  • Occlusive peripheral arterial disease is due to something that physically narrows or blocks arteries. (msdmanuals.com)
  • In functional peripheral arterial disease, blood flow is decreased because the arteries do not function properly. (msdmanuals.com)
  • Raynaud Syndrome Raynaud syndrome, a functional peripheral arterial disease, is a condition in which small arteries (arterioles), usually in the fingers or toes, narrow (constrict) more tightly than normal in. (msdmanuals.com)
  • Arterial emboli occasionally detach from primary sites and travel via circulation to occlude secondary arteries, causing multiple ischemic sites. (wikipedia.org)
  • Thrombi can occlude veins (venous thrombosis) or arteries (arterial thrombosis). (wikipedia.org)
  • Coronary Artery Disease (CAD) results from the stenosis of coronary arteries by an atherosclerotic plaque. (wikipedia.org)
  • Nuclear Resonance Imaging) gives a very complete picture of the thickening or narrowing of the arteries, their blockage, aneurysms, arterial calcification. (clinica-vasculara.ro)
  • Peripheral arterial disease can also cause symptoms from narrowed arteries to the heart or brain. (healthiack.com)
  • Peripheral Arterial Disease (PAD) occurs when blood flow through the arteries is reduced due to plaque buildup. (nevadaheart.com)
  • Many patients with blockages in the arteries in their legs (peripheral arterial disease, 'PAD') suffer from pain in their legs when walking. (inclinicaltrials.com)
  • Presently, clinicians would include "selected" patients with intermittent claudication who have disabling symptoms and proximal disease above the inguinal ligament. (nih.gov)
  • Various disease processes mimic claudication symptoms and must be excluded before a diagnosis of peripheral arterial occlusive disease (PAOD) can be made. (medscape.com)
  • The commonest symptom of arterial occlusion is intermittent claudication, which consists of a painful, aching sensation in the affected muscle. (wikipedia.org)
  • Initially patients may be able to walk through the pain, but as the disease progresses further, this is not possible and the claudication pain causes limping and can only relieved by resting. (vascularcarecentre.com)
  • In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)
  • Depending on the extent of ischemia, symptoms of arterial occlusion range from simple soreness and pain that can be relieved with rest, to a lack of sensation or paralysis that could require amputation. (wikipedia.org)
  • Signs and symptoms of arterial occlusion depend on several factors, including the location, extent, and onset of blockage. (wikipedia.org)
  • What are the Peripheral Arterial Disease symptoms? (clinica-vasculara.ro)
  • The most common symptoms of peripheral arterial disease are cramps in the leg, calf and thigh muscles when walking or exercising. (clinica-vasculara.ro)
  • Talk to your doctor if you are experiencing symptoms of peripheral arterial disease. (clinica-vasculara.ro)
  • Peripheral arterial disease, or PAD, reduces blood flow to the arms and legs to such a degree that the person has symptoms. (healthiack.com)
  • What are the signs and symptoms of the disease? (healthiack.com)
  • This study sought to determine the effect of consuming a high-fat meal (Δ = 51 g fat) in conjunction with prolonged uninterrupted sitting (180 min) on measures of central and peripheral arterial stiffness. (nature.com)
  • Yongho Bae is principal investigator on a grant from the National Heart, Lung and Blood Institute to study how arterial stiffness contributes to cardiovascular disease. (buffalo.edu)
  • A UB researcher has been awarded a National Heart, Lung and Blood Institute grant to explore how changes in arterial stiffness elicit vascular smooth muscle cell (VSMC) behaviors that contribute to cardiovascular disease. (buffalo.edu)
  • We are mainly interested in understanding the effects and molecular mechanisms by which changes in arterial stiffness modulate VSMC biology and mechanics in many types of pathologies, such as in vascular and cardiovascular diseases," he says. (buffalo.edu)
  • Arterial stiffness is a key risk factor for cardiovascular disease events, according to Bae. (buffalo.edu)
  • The new study draws upon newly collected preliminary data that show a novel role for the protein survivin as a key regulator of stiffness-mediated VSMC growth and migration, and an effector of arterial stiffening and remodeling. (buffalo.edu)
  • The researchers identified the stiffness-sensitive induction of survivin as a key mechanism for stimulating VSMC proliferation and migration, and found that survivin inhibition decreases the induction of major ECM proteins directly responsible for arterial stiffness. (buffalo.edu)
  • This new grant will test survivin's role in regulating both ECM production and arterial stiffness using an in vivo animal model," Bae says. (buffalo.edu)
  • The aim is to reveal a completely new aspect of survivin biology in VSMCs and in the pathology of arterial stiffness," Bae says. (buffalo.edu)
  • Currently, the acute effects of these behaviors performed in combination on arterial stiffness, a marker of cardiovascular health, are unknown. (nature.com)
  • Smoking, smoking status, and risk for symptomatic peripheral artery disease in women: a cohort study. (medscape.com)
  • Other clinical scenarios requiring IVUS examination (restenosis, acute coronary syndrome, left main disease, and chronic total occlusion) were excluded. (hindawi.com)
  • Arterial occlusion is a condition involving partial or complete blockage of blood flow through an artery. (wikipedia.org)
  • These three types of occlusion underlie various common conditions, including coronary artery disease, peripheral artery disease, and pulmonary embolism, which may be prevented by lowering risk factors. (wikipedia.org)
  • Arterial occlusion is diagnosed by exercise testing, ultrasonic duplex testing, and multi-detector coronary tomography angiography. (wikipedia.org)
  • The pathophysiology of diseases of arterial occlusion depends on the type of occlusion, the severity of blockage, and the location of the occluded artery. (wikipedia.org)
  • Common diseases of arterial occlusion include Coronary Artery Disease, Peripheral Artery Disease, and Pulmonary Embolism. (wikipedia.org)
  • Angiography is the criterion standard arterial imaging study for the diagnosis of PAOD. (medscape.com)
  • Diagnosis and prompt treatment are key as the effects of untreated peripheral arterial disease can be dire. (intechopen.com)
  • Despite the extensive research demonstrating the benefits of lipid lowering therapy in occlusive arterial disease, there is a paucity of data on the rheological effects of such treatment. (iospress.com)
  • We have investigated the rheological effects of gemfibrozil in 50 patients with angiographically documented but stable peripheral occlusive arterial disease. (iospress.com)
  • is an example of occlusive peripheral arterial disease caused by abnormalities in the cells in the vessel wall. (msdmanuals.com)
  • One Sampling-based free angiography in cerebro arterial occlusive diseases including computer tomography is to let nationwide problem about the love, page, and HOW of elastic over too as own settings as a type for future typesetting in images high-resolution. (subjectmatters.com.ph)
  • For the free angiography in cerebro arterial occlusive diseases including computer tomography and radionuclide download request, are Internal Revenue Code way. (subjectmatters.com.ph)
  • Treatment of coronary intermediate lesions remains a controversy, and the role of arterial remodeling patterns determined by intravascular ultrasound in intermediate lesion is still not well known. (hindawi.com)
  • Randomized studies done on a very large number of subjects in different centers around the world have shown it to be as effective as the surgical method for many types of arterial blockages. (clinica-vasculara.ro)
  • Such changes in arterial wall structure may significantly alter arterial wall mechanical properties, and thus cause abnormal arterial haemodynamics. (bmj.com)
  • May reduce the risk of atrial fibrillation, sudden cardiac death, heart failure, venous thromboembolism, and peripheral arterial disease. (cdc.gov)
  • There is also some evidence that nocturnal arterial hypotension may play a role in the development of nonarteritic anterior ischemic optic neuropathy (NAION), which has been associated with obstructive sleep apnea syndrome (OSAS). (aao.org)
  • P = 0.001), 38.1% (8/21) had ischemic heart disease in patients who developed PAD, while in the absence of PAD the presence of ischemic heart disease was 9.5% (6/63). (bvsalud.org)
  • Methods and Results: In 1994-1995 and 1993-1997, 81 687 subjects were included in the Tromsø Study and in the Diet, Cancer and Health Study and followed to the date of incident venous and arterial events (MI or ischemic stroke), death or migration, or to the end of the study period (2010 and 2008, respectively). (uit.no)
  • Ninety-three patients with severe chronic obstructive pulmonary disease (COPD) of the bronchitic (n = 74) or emphysematous type (n = 19), who all had arterial hypoxemia, underwent 2 right cardiac catheterizations in a clinical steady state, with a delay of 5 yr or more between the first and the last catheterization. (nih.gov)
  • The aim of this study was to investigate the impact of arterial remodeling of intermediate coronary lesions on long-term clinical outcomes. (hindawi.com)
  • Furthermore, previous studies have shown that arterial remodeling assessed by IVUS in vivo affects hemodynamic stress on the lesion site [ 8 - 10 ] and is correlated with clinical presentation [ 11 , 12 ]. (hindawi.com)
  • Its clinical manifestations depend on the specific vessels affected and include most notably coronary artery disease, carotid disease, and peripheral vascular disease. (lecturio.com)
  • Her clinical and research work is focused on arterial, venous and inflammatory vascular disease. (vascular-medicine.org)
  • His research interests are focused mainly on the clinical pharmacology of vasoactive and antithrombotic drugs, the investigation of capillary permeability and microcirculation, and on clinical aspects of arterial and venous diseases. (vascular-medicine.org)
  • Pulmonary arterial compliance: a physiological variable still searching for clinical relevance? (bmj.com)
  • Although a complete description of the arterial afterload can be constructed using complex impedance analysis in the frequency domain, more simple measures are required for clinical use. (bmj.com)
  • Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial. (inclinicaltrials.com)
  • Half of the patients with PAD 52.38% (11/21) obtained a score greater than 3 in the Rutherford Clinical Classification , which corresponds to severe disease . (bvsalud.org)
  • ABC of arterial and venous disease: Acute limb ischaemia. (qxmd.com)
  • Smoking cessation not only will help with PAD progression but also reduce risk of other cardiac diseases such as stroke, CAD, MI. (vascularinstitute.com)
  • Systemic arterial haemodynamics were investigated by measuring aortic input impedance during cardiac catheterisation. (bmj.com)
  • It manifests itself as vessel stenosis and a source of thromboembolic disease. (lecturio.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Endovascular interventions are best used in patients with proximal disease with short-segment stenoses. (nih.gov)
  • What Is Peripheral Artery Disease? (medlineplus.gov)
  • Accordingly, we sought to investigate the impact of arterial remodeling of intermediate lesions on long-term prognosis in patients with stable coronary artery disease. (hindawi.com)
  • Diagonal lobular and anterior tragal ear creases have been associated with coronary artery disease, but they have not yet been investigated in patients with peripheral arterial disease. (scielo.br)
  • 4 ( Figure 1 ), were identified as factors independently associated with coronary artery disease, 5-7 but they have not yet been studied in patients with PAD. (scielo.br)
  • This is a multicenter, open-label trial that included a total fo 2,236 patients with arterial fibrillation who had undergone coronary artery bypass grafting (GAFT) or percutaneous coronary intervention (PCI). (physiciansweekly.com)
  • The research concluded that antithrombotic rivaroxaban monotherapy was non-inferior to combination therapy for efficacy and superior to the combination therapy for safety in patients with arterial fibrillation and stable coronary artery disease. (physiciansweekly.com)
  • Plaque deposition both physically narrows an artery and impairs the function of endothelial cells, potentiating their production of vasoconstrictive chemicals to constrict the arterial lumen. (wikipedia.org)
  • The treatment of carotid artery disease is an effort to prevent strokes when possible. (vsafl.com)
  • In most cases carotid artery disease can be followed with appropriate medical therapy including risk factor control. (vsafl.com)
  • Aneurysm disease is when an artery becomes wider than it should be. (vsafl.com)
  • Balloon angioplasty and stenting has generally replaced invasive surgery as the leading treatment recommendation for Peripheral Artery Disease (PAD). (clinica-vasculara.ro)
  • In some countries, coronary artery disease (CAD) is the cause of nearly half (48%) of the deaths and, loss of productivity life. (ac.ir)
  • Results: We found intracranial arterial abnormalities in 13/21 patients (62 %), of whom: 2/21 patients (9.5 %) showed an unruptured intracranial aneurysm (respectively 2 and 4 mm), 10/21 (47 %) had a vertebrobasilar dolichoectasia (VBD) and 1/21 a basilar artery fenestration. (unime.it)
  • To assess myocardial perfusion (stress, rest) and late gadolinium enhancement in adult patients with known or suspected coronary artery disease (CAD). (nih.gov)
  • FDA approves first drug-coated angioplasty balloon catheter to treat vascular disease [press release]. (medscape.com)
  • The US FDA has approved the first drug-coated balloon (DCB) for the treatment of peripheral arterial vascular disease, the Lutonix 035 Drug Coated Balloon Percutaneous Transluminal Angioplasty Catheter (Lutonix DCB). (medscape.com)
  • Reduced blood flow from this condition can be a red flag for other diseases of the vascular system. (clinica-vasculara.ro)
  • Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke. (medlineplus.gov)
  • CONCLUSIONS: Ear creases are independently associated with peripheral arterial disease and may be an external marker for risk identification. (scielo.br)
  • Detection of external signs associated with PAD can assist in risk stratification and identification of patients who would benefit from early intervention or modification of risk factors related to disease progression. (scielo.br)
  • Stable coronary disease is often associated with an increased risk of arterial fibrillation. (physiciansweekly.com)
  • The association between peripheral arterial disease and risk for hip fractures in elderly men is not explained by low hip bone mineral density. (lu.se)
  • Introduction: To examine if peripheral arterial disease (PAD) is associated with an increased risk for hip fracture in men independent of hip BMD. (lu.se)
  • Those that smoke not only put themselves at risk for developing arterial disease but also undermine attempts at treatment. (vascularcarecentre.com)
  • If you or your family has a history of heart disease, you are at higher risk of developing PAD. (vascularcarecentre.com)
  • Reduces the risk of disease and death from CVD. (cdc.gov)
  • Reduces the risk of disease and death from stroke, with risk approaching that of never smokers after cessation. (cdc.gov)
  • Persons with PAD have a risk of heart disease and stroke that is three to six times higher than that of other people. (healthiack.com)
  • A reduction in levels of plasma HDL-C is associated with elevated risk of atherosclerotic disease. (ac.ir)
  • Consuming a high-fat meal prior to 180 min of uninterrupted sitting augments markers of cardiovascular disease risk more than consuming a low-fat meal prior to sitting. (nature.com)
  • We aimed to study the association between VTE and future arterial events, and to determine the population attributable risk (PAR%) of arterial events by VTE in a large prospective cohort recruited from the general population. (uit.no)
  • Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. (medlineplus.gov)
  • Werner Seeger, Director of the Department of Lung Development and Remodelling at the MPI and Director of the Department of Internal Medicine at University Hospital Giessen sees the potential of the study as relating to the fact that 'for the first time, the progression of the disease was not only halted but the structural changes in the blood vessels were also reversed using a locally administered substance. (medicalnewstoday.com)
  • OBJECTIVES: To evaluate the prevalence of ear creases among patients with peripheral arterial disease of the lower limbs, compared with patients without documented atherosclerotic disease. (scielo.br)
  • The objective of this research is to evaluate the efficacy of antithrombotic therapy for arterial fibrillation in patients with stable coronary disease. (physiciansweekly.com)
  • These are the substitute tests that McKeever et al set out to evaluate against the gold-standard arterial blood analysis. (bmj.com)
  • To Evaluate the Introduction of a Public Health Approach to Peripheral Arterial Disease (PAD) Using National Centre for Sport and Exercise Medicine Facilities. (inclinicaltrials.com)
  • Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease. (inclinicaltrials.com)
  • The Vascular Medicine Department of Montpellier University Hospital is a referral centre for the management of peripheral arterial disease, venous thromboembolic disease and Vascular Rare diseases which include lymphatic and vascular anomalies including arterial fragility such as the Ehlers-Danlos syndrome. (vascular-medicine.org)
  • The centre is part of the RIETE Cohort study led by Pr Manuel Monreal on venous thromboembolic disease since the beginning of the project. (vascular-medicine.org)
  • In the later stages, arterial supply to the leg may be so poor that pain occurs in the toes and feet during periods of inactivity or rest. (vascularcarecentre.com)
  • The aim of this study was to define the presence and type of intracranial arterial abnormalities in a cohort of late onset Pompe disease (LOPD) patients. (unime.it)
  • Peripheral arterial disease (PAD) is an under-recognized complication of diabetes. (nih.gov)
  • Diabetic management is important in preventing the progression of disease. (vascularinstitute.com)
  • Scientists from the Max Planck Institute for Heart and Lung Research and Giessen University have now succeeded for the first time in an animal model in not only halting the progression of the disease, but also in reversing it with the help of an inhalation therapy. (medicalnewstoday.com)
  • Not only was the disease progression halted, we were also able to observe a clear improvement in all areas,' explains Soni Pullamsetti, first author of the study. (medicalnewstoday.com)
  • however, there has long been concern about their use in people with chronic obstructive pulmonary disease (COPD) due to fear of symptomatic worsening of breathlessness. (edgehill.ac.uk)
  • Patients with chronic kidney disease (CKD) on hemodialysis present high cardiovascular comorbidity . (bvsalud.org)
  • 30 mmHg on exercise in the absence of significant lung or left heart disease. (ersjournals.com)
  • Arterial remodeling patterns were assessed in 212 deferred intermediate lesions from 162 patients after IVUS examination. (hindawi.com)
  • Overall, this proposal is unique in its ability to identify potential new therapeutic targets for the treatment of cardiovascular disease. (buffalo.edu)
  • It provides key insights into the management of patients presenting with severe disease, with particular focus on their treatment with multiple PAH-specific therapies. (ersjournals.com)
  • Peripheral arterial disease (PAD) is associated with higher mortality and the interest in its early detection and treatment is increasing. (bvsalud.org)
  • This material is deposited in the form of platelets, arterial plaque, and the tissue in question will no longer receive enough blood to function normally. (clinica-vasculara.ro)
  • Other drugs that prevent blood clots or arterial plaque formation can treat peripheral arterial disease. (clinica-vasculara.ro)
  • Arterial thromboses significantly narrow or completely block arterial blood flow and oxygen delivery to tissues. (wikipedia.org)
  • As McKeever et al have observed, the pain associated with arterial blood sampling is significantly greater than that for venous sampling, and failed attempts are more numerous. (bmj.com)