IUPAC have recommended that arsenite compounds are to be named as arsenate(III), for example ortho-arsenite is called trioxidoarsenate(III). (wikipedia.org)
NT-26 is a bioenergetic enzyme involved in the oxidation of arsenite to arsenate. (ucl.ac.uk)
Arsenic is found in mainly in two forms: arsenite and arsenate. (easyreport.in)
Both forms are toxic: arsenite disrupts sulfhydryl groups of proteins and interferes with enzyme function, whereas arsenate acts as a phosphate analog and can interfere with phosphate uptake and transport. (easyreport.in)
Resistance to arsenic species in both Gram-positive and Gram-negative organisms results from energy-dependent efflux of either arsenate or arsenite from the cell, mediated by the ars operon [4-6]. (easyreport.in)
For the first time ever, the dynamic (potentially bioavailable) fraction of inorganic arsenite, As(III), and arsenate, As(V), were quantified in this estuary, using an antifouling gel-integrated gold microelectrode interrogated by square wave anodic stripping voltammetry (GIME-SWASV). (irb.hr)
In addition, in a study of CD1 beryllium compounds, cadmium senic is now drinking-water, where mice with "whole-life" exposure to and cadmium compounds, chromi- it is found primarily as the inorgan- multiple levels of sodium arsenite in um(VI) compounds, and nickel and ic forms of arsenite and arsenate. (who.int)
Arsenic9
In chemistry, an arsenite is a chemical compound containing an arsenic oxyanion where arsenic has oxidation state +3. (wikipedia.org)
Filtration is only effective if arsenic is present as particulates, if the arsenite is in solution it passes through the filtration membrane. (wikipedia.org)
Organification of arsenite is an effective way for organisms to cope with arsenic toxicity. (biomedcentral.com)
Microbial communities are vital contributors to the global arsenic biocycle and represent a promising way to reduce arsenite toxicity. (biomedcentral.com)
ICP-MS analysis indicated that arsenite-resistant SK-Mel-28 cells did not accumulate less arsenic than arsenite-sensitive A375 cells, suggesting that resistance was not attributable to reduced arsenic accumulation but rather to intrinsic properties of resistant cell lines. (uky.edu)
Cell cycle analysis revealed arsenite-sensitive cells arrested in mitosis whereas arsenite-resistant cells did not, suggesting that induction of mitotic arrest occurs at lower intracellular arsenic concentrations. (uky.edu)
Microorganisms have evolved a variety of mechanisms for coping with arsenic toxicity, including minimizing the amount of arsenic that enters the cell (e.g., through increased specificity of phosphate uptake), oxidizing the arsenite (through the activity of arsenite oxidase), or arsenite peroxidation with membrane lipids. (easyreport.in)
Chen B, Arnold LL, Cohen SM, Thomas DJ, Le XC (2011) Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. (springer.com)
maternal consumption of sodium of which is an arsenic compound of Multiple studies in humans have arsenite in drinking-water during concern. (who.int)
Sodium9
Well known examples of arsenites include sodium meta-arsenite which contains a polymeric linear anion, (AsO−2)n, and silver ortho-arsenite, Ag3AsO3, which contains the trigonal AsO3−3 anion. (wikipedia.org)
Sodium arsenite is used in the water gas shift reaction to remove carbon dioxide. (wikipedia.org)
A non-malignant human bronchial epithelial cell line, Beas-2B cells were exposed to 100 nM sodium arsenite for 24 weeks. (louisville.edu)
We report on the formation of a molecule-ion adduct of β-cyclodextrin (β-CD) with sodium arsenite (SA) both in solid state and in aqueous solution. (pku.edu.cn)
Preparation, Spectral Properties and Decomposition Behavior of a Novel β -Cyclodextrin and Sodium Arsenite Adduct Formed by Stirring[J]. Acta Phys. (pku.edu.cn)
Increased susceptibility of H-Ras(G12V)-transformed human urothelial cells to the genotoxic effects of sodium arsenite. (sinica.edu.tw)
The present study was adopted to evaluate the antioxidant efficacy of medium chain fatty acid (caprylic, capric and lauric) rich rice bran oils in comparison to rice bran oil in terms of altered biochemical parameters of oxidative stress following sodium arsenite treatment in rats. (caluniv.ac.in)
Lipid peroxidation increased with the administration of sodium arsenite, but again administration of rice bran oil and MCFA rich rice bran oils decreased the lipid peroxidation. (caluniv.ac.in)
Evaluation of the Sodium Arsenite Method for Measurement of NO2 in Ambient Air. (epa.gov)
Exposure9
We hypothesize that chronic exposure of "a physiologically relevant" level of arsenite disrupts the EGFR endocytic trafficking. (louisville.edu)
In conclusion, the impact of chronic arsenite exposure on the EGFR signaling axis can explain arsenite-induced overexpression of the EGFR. (louisville.edu)
Arsenite exposure is known to increase the risk of neurological disorders via alteration of dopamine content, but the detailed molecular mechanisms remain largely unknown. (bvsalud.org)
In this study, using both dopaminergic neurons of the PC-12 cell line and C57BL/6J mice as in vitro and in vivo models, our results demonstrated that 6 months of arsenite exposure via drinking water caused significant learning and memory impairment, anxiety -like behavior and alterations in conditioned avoidance and escape responses in male adult mice . (bvsalud.org)
Our data demonstrated for the first time that arsenite remarkably increased m6A modification, and FTO possessed the ability to alleviate the deficits in dopaminergic neurotransmission in response to arsenite exposure. (bvsalud.org)
Our findings not only provide valuable insight into the molecular neurotoxic pathogenesis of arsenite exposure, but are also the first evidence that regulation of FTO may be considered as a novel strategy for the prevention of arsenite-associated neurological disorders . (bvsalud.org)
Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species. (cri.or.th)
Ingestion is the main route of exposure to other arsenites and arsenates for the general population. (cdc.gov)
Maternal and early life arsenite exposure impairs neurodevelopment and increases the expression of PSA-NCAM in hippocampus of rat offspring. (bvsalud.org)
Suggest that arsenite2
These results suggest that arsenite promotes TF synthesis by activating the Nrf2 pathway in HASMCs and that the induction of TF expression by arsenite may be related to the progression of atherosclerosis. (go.jp)
These data suggest that arsenite has potential for treatment of solid tumors but a functional spindle checkpoint is a prerequisite for a positive response to its clinical application. (uky.edu)
Concentrations of arsenite2
A375 and SK-Mel-2 cells were sensitive to clinically achievable concentrations of arsenite, whereas SK-Mel-3 and SK-Mel-28 cells required supratherapeutic levels for toxicity. (uky.edu)
The concentrations of arsenite in the dynamic fraction, As(III)dyn, ranged from 1.3 to 3.3 nM, contributing almost completely to the dissolved arsenite, As(III)diss, which ranged between 0.9 and 3.1 nM in the 0.2 μm fraction, and between 1.2 and 3.7 nM in the 0.02 μm fraction. (irb.hr)
Oxidase5
In addition, melatonin was found to prevent arsenite-induced decreases in cytochrome c oxidase levels (a biomarker of mitochondrial mass) and elevation in co-localized fluorescent puncta of autolysosomes and cytochrome c oxidase. (greenmedinfo.com)
The arsenite oxidase (Aio) from the facultative autotrophic Alphaproteobacterium Rhizobium sp. (ucl.ac.uk)
The NT-26 Aio, a heterotetramer, shares high overall similarity to the heterodimeric arsenite oxidase from A. faecalis but there are striking differences in the structure surrounding the Rieske 2Fe-2S cluster which we demonstrate explains the difference in the observed redox potentials (+225 mV vs. +130/160 mV, respectively). (ucl.ac.uk)
Cold-adapted arsenite oxidase from a psychrotolerant Polaromonas species. (ucl.ac.uk)
GM1 is an aerobic, psychrotolerant, heterotrophic member of the Betaproteobacteria and is the only isolate capable of oxidising arsenite at temperatures below 10 °C. Sequencing of the aio gene cluster in GM1 revealed the presence of the aioB and aioA genes, which encode the arsenite oxidase but the regulatory genes typically found upstream of aioB in other members of the Proteobacteria were absent. (ucl.ac.uk)
Meta-arsenite3
A number of different arsenite anions are known: AsO3−3 ortho-arsenite, an ion of arsenous acid, with a pyramidal shape (AsO−2)n meta-arsenite, a polymeric chain anion. (wikipedia.org)
Examples of these are the meta-arsenite salts and at low temperature, hydrogen arsenite salts can be prepared, such as Na2H2As4O8, NaAsO2·4H2O, Na2HAsO3·5H2O and Na5(HAsO3)(AsO3)·12H2O. (wikipedia.org)
Fowler's solution first introduced in the 18th century was made up from As2O3 as a solution of potassium meta-arsenite, KAsO2. (wikipedia.org)
Arsenates3
Some species of bacteria obtain their energy by oxidizing various fuels while reducing arsenates to form arsenites. (wikipedia.org)
In 2008, bacteria were discovered that employ a version of photosynthesis with arsenites as electron donors, producing arsenates (just like ordinary photosynthesis uses water as electron donor, producing molecular oxygen). (wikipedia.org)
Bifunctional protein ArsRM contributes to arsenite methylation and resistance in Brevundimonas sp. (biomedcentral.com)
M20 with arsenite and roxarsone resistance was isolated from aquaculture sewage. (biomedcentral.com)
A 3,011-bp arsenite resistance ars cluster arsHRNBC and a 5649-bp methionine biosynthesis met operon were found on the 3.315-Mb chromosome. (biomedcentral.com)
Expression of ArsR M in E. coli increased its arsenite resistance to 1.5 mM. (biomedcentral.com)
Inhibition of glutathione synthesis, glutathione S-transferase (GST) activity, and multidrug resistance protein (MRP) transporter function attenuated arsenite resistance, consistent with studies suggesting that arsenite is extruded from the cell as a glutathione conjugate by MRP-1. (uky.edu)
Inhibits1
In humans, arsenite inhibits pyruvate dehydrogenase (PDH complex) in the pyruvate-acetyl CoA reaction, by binding to the -SH group of lipoamide, a participant coenzyme. (wikipedia.org)
Enzymes1
Results showed that activities of antioxidant enzymes in liver, brain and erythrocyte membrane increased with the administration of rice bran oil and MCFA rich rice bran oils both in normal and arsenite treated cases. (caluniv.ac.in)
Protein5
Furthermore, melatonin significantly attenuated arsenite-induced elevation in microtubule-associated protein light chain 3 (LC3)-II levels, a biomarker of autophagy. (greenmedinfo.com)
Because 3-methyladenine (an autophagic inhibitor) attenuated the arsenite-reducedα-synuclein levels (a protein essential for the neurite outgrowth and synaptic plasticity), melatonin via inhibiting autophagy attenuated the arsenite-reduced α-synuclein levels. (greenmedinfo.com)
At the same time, melatonin ameliorated the arsenite-induced reduction in growth associated protein 43 (a hallmark protein of neurite outgrowth) and discontinuous neurites of rat primary cultured cortical neurons. (greenmedinfo.com)
The lack of arsenite-induced mitotic arrest in resistant cell lines was associated with a weakened spindle checkpoint resulting from reduced expression of spindle checkpoint protein BUBR1. (uky.edu)
The chronic arsenite-treated cells had increased EGFR protein expression levels and activity, increased transcription levels of TGFα, and altered the distribution of the EGFR. (louisville.edu)
Groundwater2
Note that in fields that commonly deal with groundwater chemistry, arsenite is used generically to identify soluble AsIII anions. (wikipedia.org)
We report that MnO4¯-Fe(III) dosing is an effective technique to improve arsenite [As(III)] removal at groundwater treatment plants. (edu.au)
Promotes2
We conclude that ArsR M promotes arsenite methylation and is able to bind to its own promoter region to regulate transcription. (biomedcentral.com)
H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP. (cdc.gov)
Aqueous solution1
Some arsenite salts can be prepared from an aqueous solution of As2O3. (wikipedia.org)
AioA1
The enzyme from the distantly related heterotroph, Alcaligenes faecalis, which is thought to oxidise arsenite for detoxification, consists of a large α subunit (AioA) with bis-molybdopterin guanine dinucleotide at its active site and a 3Fe-4S cluster, and a small β subunit (AioB) which contains a Rieske 2Fe-2S cluster. (ucl.ac.uk)
Electron1
The enzyme contained Mo and Fe as cofactors and had, using the artificial electron acceptor 2,6-dichlorophenolindophenol, a Km for arsenite of 111.70 ± 0.88 μM and a Vmax of 12.16 ± 0.30 U mg(-1), which is the highest reported specific activity for any known Aio. (ucl.ac.uk)
Removal1
We investigated the removal mechanism of arsenite (As(III)) through coprecipitation with ferrihydrite to establish an optimum wastewater treatment method. (elsevierpure.com)
Molecular2
In the present study, we investigated the effect of arsenite on the expression of TF in human aortic smooth muscle cells (HASMCs) and the underlying molecular mechanisms. (go.jp)
The goal of this project is to identify molecular mechanisms and roles of chronic arsenite-induced EGFR overexpression in lung cancer development. (louisville.edu)
Reduction1
Moreover, melatonin prevented arsenite-induced reduction in peroxisome proliferator-activated receptor gamma co-activator 1 α, a transcriptional co-activator of mitochondrial biosynthesis. (greenmedinfo.com)
Found1
We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs. (go.jp)
Activity2
The arsenite methylation activity of ArsR M and its ability to bind to its own gene promoter were confirmed. (biomedcentral.com)
The temperature-activity profiles of the arsenite oxidases from GM1 and the mesophilic betaproteobacterium Alcaligenes faecalis were compared and showed that the GM1 Aio was more active at low temperatures than that of A. faecalis. (ucl.ac.uk)
Effect2
In the present study, the neuroprotective effect of melatonin on arsenite-induced neurotoxicity was investigated in rat primary cultured cortical neurons. (greenmedinfo.com)
We further evaluated the effect of arsenite on the m6A modification and tested if regulation of the m6A modification by demethylase fat mass and obesity -associated (FTO) could affect dopaminergic neurotransmission . (bvsalud.org)
Forms1
This metalloid occurs worldwide and many of its forms, especially arsenite [As(III)], cause various diseases including cancer. (biomedcentral.com)
Cell3
Melatonin prevented arsenite induced neuronal cell loss in a concentration dependent manner. (greenmedinfo.com)
The mode of arsenite-induced cell death was apoptosis. (uky.edu)
Arsenite-induced apoptosis is associated with cell cycle alterations. (uky.edu)
Role1
Assessing the role of arsenite in disrupting the EGFR signaling axis. (louisville.edu)
Levels1
Taken together, melatonin may exert its neuroprotective action via inhibiting arsenite-induced autophagy and enhancing mitochondrial biogenesis and thus restoring α-synuclein levels, neuronal integrity, and mitochondrial mass in rat primary cultured cortical neurons. (greenmedinfo.com)
Structure2
Ortho-arsenite contrasts to the corresponding anions of the lighter members of group 15, phosphite which has the structure HPO2−3 and nitrite, NO−2 which is bent. (wikipedia.org)
Hawthorne, Frank C. "Schneiderhoehnite, Fe2+ Fe3+ 3As3+ 5O 13, a densely packed arsenite structure. (wikipedia.org)
Groups1
five normal groups and five arsenite treated groups. (caluniv.ac.in)