Arsenic induces. Medical search. Frequent questions

Inorganic arsenic is generally more toxic than organic arsenic. (cdc.gov)
However, animal studies have shown that other organic arsenic compounds (methyl and phenyl arsenates, for example) can produce health effects similar to those produced by inorganic arsenic [ATSDR 2007]. (cdc.gov)
Some studies in arsenic metabolism suggest that methylation of inorganic arsenic may be a toxification, rather than a detoxification pathway and that trivalent methylated arsenic metabolites, particularly monomethylarsonous acid and dimethylarsinous acid, have a great deal of biological activity [Kitchin 2001]. (cdc.gov)
Millions of people in the U.S. and worldwide are exposed to unsafe levels of inorganic arsenic (iAs) in drinking water. (usda.gov)
Inorganic arsenic causes apoptotic and necrotic damage to hepatocytes and capillarization of liver sinusoidal endothelial cells (LSECs), an important preceding event upon exposure. (iium.edu.my)
In other cell types, including hepatocytes, inorganic arsenic causes inhibition of DNA repair. (iium.edu.my)
Chronic exposure to inorganic arsenic (iAs) elevates reactive oxygen species (ROS) generation and up-regulates TGF-β signalling. (jcpjournal.org)
Arsenic compounds exist in a number of inorganic and organic forms. (cdc.gov)
Other inorganic arsenic compounds may vary somewhat in relative toxicity, and organic arsenic compounds appear to be essentially nontoxic. (cdc.gov)
the guidelines for decontamination and medical treatment are applicable for exposure to arsenic and inorganic arsenic compounds, including arsenic trioxide. (cdc.gov)
Arsenic occurs naturally in soil and many kinds of rock (especially minerals and ores that contain copper and lead) as inorganic arsenic. (cdc.gov)
Inorganic arsenic compounds have been used as pesticides, but can no longer be used in agriculture. (cdc.gov)
OSHA PEL (permissible exposure limit) = 10 µg/m 3 as an 8-hour TWA concentration (as As) for inorganic arsenic (OSHA 2006). (cdc.gov)
None had elevated urinary inorganic arsenic levels. (cdc.gov)
They found that organic brown rice syrup, which is used in organic food products as an alternative to high fructose corn syrup, can contain significant concentrations of inorganic arsenic, the form classified as a human carcinogen. (nih.gov)
Interestingly, inorganic arsenic is found to be more potent than the organic form and trivalent compounds are found to be more toxic than pentavalent ones [ 10 ]. (biomedcentral.com)
The greatest threat to public health from arsenic comes from drinking water, typically through consumption over long periods of water containing low concentrations of inorganic arsenic. (who.int)
Exposure to inorganic arsenic through the food chain is limited, although absorption by crops irrigated with water highly contaminated with arsenic warrants further research. (who.int)
We were advised that the NIOSH recommended standard for occupational exposure to arsenic does not distinguish between organic and inorganic arsenic and recommends a standard of 0.002 mg (As)/m(3). (cdc.gov)

Overexposure may result from relatively high levels of arsenic in drinking water and foods. (cdc.gov)
Groundwater with high levels of arsenic in southwestern and northeastern Taiwan received much attention. (routledge.com)
A third study by Margaret Karagas, Ph.D. and colleagues, also at the Dartmouth University SRP, showed rice consumption was associated with increased urinary levels of arsenic in pregnant women. (nih.gov)
In some regions of the world, for example Bangladesh, Chile, and Taiwan, populations are exposed to levels of arsenic reaching thousands of micrograms per liter [ 8 ]. (biomedcentral.com)
Many of these HMs, such contaminated with low levels of arsenic can be harmful as copper, chromium, iron, manganese and zinc, are es- for the respiratory system ( 10 ), and a high blood level of sential to health. (who.int)

Our group previously reported that arsenic (As) exposure induced apoptosis in hippocampus neurons. (springer.com)
Exposure to arsenic in drinking water is a global health problem and arsenic-induced skin lesions are hallmark of chronic arsenic toxicity. (nih.gov)
Some deletions had stronger effect in a specific gender (ZNF658 in males, SGCZ in females) and some had stronger effect in higher arsenic exposure (lincRNA CTD-3179P9.1) suggesting a possible gene-environment interaction. (nih.gov)
Our study highlights the vital role of the miR-218-5p/EGFR signaling pathway in arsenic-induced carcinogenesis and angiogenesis, which may be helpful for the treatment of lung cancer induced by chronic arsenic exposure in the future. (jefferson.edu)
Eye exposure to arsenic pentoxide can cause irritation, but it is not associated with systemic toxicity. (cdc.gov)
The World Health Organisation (WHO) permissible limit for the concentration of arsenic in drinking water is currently at 10 μg/L. The long-term effect on low dose exposure is also not established. (iium.edu.my)
Therefore, this study aimed to investigate the changes to liver functions, its cellular morphology and selected gene expressions involved in apoptosis and DNA inhibition pathways following chronic low dose organic arsenic exposure. (iium.edu.my)
In the 6- month group, only base excision repair (Mpg) was significantly up-regulated by 5 folds.The organic arsenic cause reduction in liver enzymes and increased apoptotic-related gene at sub-chronic exposure but increased DNA repair gene expression at chronic exposure. (iium.edu.my)
Arsenic exposure: The literature supports an association between Bowen disease and arsenic exposure, often occurring after a time lag of 10 years. (medscape.com)
Ingestion is the most important route of acute exposure of arsenic trioxide. (cdc.gov)
Contaminated soil may also be a source of significant arsenic exposure in children, although it is not likely that children would ingest sufficient arsenic-contaminated soil to cause significant acute toxicity. (cdc.gov)
Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. (harvard.edu)
Arsenic exposure was a concern due to the reported use of an arsenic containing ant-killer and chromated copper arsenate (CCA) treated lumber. (cdc.gov)
The studies reveal unexpected sources of arsenic exposure, demonstrate that adverse health effects are linked to low levels of exposure, show the mechanisms behind some of its health effects, and suggest a strategy for reducing exposure from well water. (nih.gov)
Brian Jackson, Ph.D., and colleagues at the Dartmouth University SRP, identified a previously under recognized source of arsenic exposure - common foods. (nih.gov)
In a second study, Jackson's research team showed that infant formula and jarred baby foods are a significant source of arsenic exposure. (nih.gov)
In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate i n utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. (biomedcentral.com)
These associations were sex-dependent, suggesting that in utero arsenic exposure differentially impacts male and female fetuses. (biomedcentral.com)
Multivariable linear regression analysis was used to examine their relationship with arsenic exposure and with key developmental genes, after stratification by fetal sex. (biomedcentral.com)
We found that maternal arsenic exposure was strongly associated with expression of the AQP9 gene, encoding an aquaglyceroporin transporter, in female but not male fetal placenta. (biomedcentral.com)
Our results suggest that AQP9 is upregulated in response to arsenic exposure in female, but not male, fetal placenta. (biomedcentral.com)
Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
Thus, this study suggests that AQP9 may play a role in the sex-specific effects of in utero arsenic exposure. (biomedcentral.com)
However, the exact molecular events leading to reproductive dysfunctions as a result of arsenic exposure are yet to be ascertained. (biomedcentral.com)
This report evaluates the effect and mode of action of chronic oral arsenic exposure on the uterine physiology of mature female albino rats. (biomedcentral.com)
The effect of chronic oral exposure to arsenic at the dose of 4 microg/ml for 28 days was evaluated on adult female albino rats. (biomedcentral.com)
As some affects of arsenic exposure are irreversible, the core public health measure is prevention of human exposure. (who.int)
The suggested control limit for Lewisite is equivalent to 0.001 mg/m(3), measured as arsenic and is thus lower than both the OSHA Permissible Exposure Level and NIOSH's more protective recommendation. (cdc.gov)
greater than 5 g/cm3 which are found naturally on the Chronic exposure to arsenic by drinking groundwater earth in very small amounts. (who.int)

Arsenic Toxicity: How Does Arsenic Induce Pathogenic Change? (cdc.gov)
Interference with cellular respiration explains the potent toxicity of arsenic. (cdc.gov)
Arsenic toxicity may vary by form. (cdc.gov)
The type of organic arsenic found in certain seafood (arsenobetaine and arsenocholine) appears to have low toxicity. (cdc.gov)
Two mechanisms of arsenic toxicity that impair tissue respiration are described below. (cdc.gov)
The toxicity of a particular arsenic compound depends in part on its solubility. (cdc.gov)
Arsenic trioxide dust is readily absorbed from the lungs, but inhaled quantities are usually insufficient to cause acute systemic toxicity. (cdc.gov)
Raindrop Pigmentation in Chronic Arsenic Toxicity. (harvard.edu)
Mechanisms of action for arsenic in cardiovascular toxicity and implications for risk assessment. (harvard.edu)
Monitor patients with severe hepatic impairment (Child-Pugh Class C) for toxicity when treated with arsenic trioxide. (nih.gov)
The aim of the present study was to demonstrate astaxanthin's attenuating effects against cisplatin (CIS)-induced gastrointestinal toxicity in a rat model. (springermedizin.at)
Based on the data in this study, astaxanthin might play a protective role against cisplatin-induced gastrointestinal toxicity in rats. (springermedizin.at)
Zurück zum Zitat Shahid F, Farooqui Z, Khan F. Cisplatin-induced gastrointestinal toxicity: an update on possible mechanisms and on available gastroprotective strategies. (springermedizin.at)

The present view of arsenic carcinogenesis is that there are many possible chemical forms of arsenic that may be causal in carcinogenesis. (cdc.gov)
In addition, arsenic induced carcinogenesis may have different mechanisms in different tissues with contributions from all species present in that tissue [ROM 2007]. (cdc.gov)
A scientific consensus has not yet been reached on the many suggested modes of arsenic carcinogenesis that exist in the literature. (cdc.gov)
MiR-218-5p/EGFR Signaling in Arsenic-Induced Carcinogenesis" by Ranakul Islam, Lei Zhao et al. (jefferson.edu)
and Liu, Ling-Zhi, "MiR-218-5p/EGFR Signaling in Arsenic-Induced Carcinogenesis" (2023). (jefferson.edu)

The results indicated that Tau supplement markedly ameliorates As-induced apoptosis by mitochondria-related pathway in mouse hippocampus. (springer.com)
Das J, Ghosh J, Manna P, Sil PC (2010) Protective role of Tau against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. (springer.com)
Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
We report that necroptosis, autophagy, NF-ƘB and MAPK signalling pathway are not involved in ATO-induced apoptosis. (lu.se)
Together, the results indicate that arsenic disrupted the circulating levels of gonadotropins and estradiol, led to degeneration of luminal epithelial, stromal and myometrial cells of the rat uterus and downregulated the downstream components of the estrogen signaling pathway. (biomedcentral.com)

The present study was aimed to study protective role of N-acetyl cysteine (NAC) was assessed against arsenic (As)-induced hepatotoxicity in rats. (jnsbm.org)
The study revealed that arsenic induces hepatotoxicity by inducing oxidative stress and supplementation of NAC is beneficial in countering the adverse effects. (jnsbm.org)
Arsenic, hepatotoxicity, N-acetyl cysteine. (jnsbm.org)
The manifestations of drug-induced hepatotoxicity are highly variable, ranging from asymptomatic elevation of liver enzymes to fulminant hepatic failure. (medscape.com)

Induction of differentiation rescues HL-60 cells from Rana catesbeiana ribonuclease-induced cell death. (eurogentec.com)
We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5. (hindawi.com)
Arsenic trioxide (As2O3) has been shown to induce apoptosis and differentiation in NPC xenografts. (scielo.br)
Patients with acute promyelocytic leukemia (APL) treated with arsenic trioxide have experienced symptoms of differentiation syndrome, which may be life-threatening or fatal. (nih.gov)
Aresenic trioxide (ATO) is proven to be active against leukaemia cells by inducing apoptosis and differentiation. (lu.se)

Aly HA, Khafagy RM (2014) Tau reverses endosulfan-induced oxidative stress and apoptosis in adult rat testis. (springer.com)
Das J, Ghosh J, Manna P, Sil PC (2012a) Tau protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis. (springer.com)
A high-fat and high-cholesterol diet induces overt and latent oxidative damage in hippocampus of mice lacking apolipoprotein E. Open Neuro 12 , 12-18. (uml.edu)

A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh. (harvard.edu)
Individual susceptibility to arsenic poisoning also differs significantly, depending on age, nutritional status, social conditions and other poorly understood factors. (who.int)

Even though organic arsenic is believed to be less dangerous, the postulation is hard to prove since the evidence is still lacking. (iium.edu.my)
Some organic arsenic compounds may be used as pesticides or as additives in animal feed. (cdc.gov)
Toddler formula, cereal bars, and energy foods aimed at athletes that contained organic brown rice syrup had higher total arsenic concentrations than similar products that didn't contain the syrup. (nih.gov)

Supporting the notion of noncanonical autophagy, we found that ATRA-induced autophagy was Beclin1-independent compared to starvation- or arsenic trioxide- (ATO-) induced autophagy. (hindawi.com)
The ULK1 protein complex including ULK1, ATG13, and FIP200 coordinates the autophagy initiation from different upstream signaling pathways to induce autophagy [ 6 , 7 ]. (hindawi.com)

Mitochondria are considered to be the major source of intracellular reactive oxygen species (ROS), which are known to be associated with As 2 O 3 -induced cell damage. (biomedcentral.com)

A small molecule that can easily get into cells, arsenic can cause cell injury and death by multiple mechanisms. (cdc.gov)
Arsenic is a known human carcinogen, but the specific mechanisms by which it causes cancer are less well understood. (cdc.gov)
Mechanisms of arsenic-induced prolongation of cardiac repolarization. (nih.gov)

Arsenic trioxide is a human carcinogen. (nih.gov)

Arsine gas poisoning results in a considerably different syndrome from that caused by other forms of arsenic. (cdc.gov)
Arsenic trioxide (an odorless, tasteless, white or transparent, nonflammable solid) is one of the most toxic and prevalent forms of arsenic. (cdc.gov)

Histological evaluation revealed degeneration of luminal epithelial cells and endometrial glands in response to arsenic treatment, along with reduction in thickness of the longitudinal muscle layer. (biomedcentral.com)
Downregulation of the estrogen receptor and estrogen-responsive genes in response to arsenic indicates a mechanism of suppression of female reproductive functions by an environmental toxicant that is contra-mechanistic to that of estrogen. (biomedcentral.com)

Arsenic trioxide can cause QTc interval prolongation, complete atrioventricular block and torsade de pointes, which can be fatal. (nih.gov)
Withhold arsenic trioxide until resolution and resume at reduced dose for QTc prolongation. (nih.gov)
We propose that pentamidine, like arsenic trioxide, produces QT prolongation and torsades de pointes in patients by inhibition of hERG trafficking. (aspetjournals.org)

Chang CY, Shen CY, Kang CK, Sher YP, Sheu WH, Chang CC, Lee TH (2014) Tau protects HK-2 cells from oxidized LDL-induced cytotoxicity via the ROS-mediated mitochondrial and p53-related apoptotic pathways. (springer.com)
Furthermore, apoptosis and cytotoxicity induced by As 2 O 3 in glioma cells were decreased after silencing the mitoferrin-2 gene. (biomedcentral.com)

However, cell proliferation and the induction of IFN-γ by arsenic were found to be abolished in DT-treated Langerin-DTR mice. (eur.nl)

Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. (medscape.com)

A higher level of ambient nickel with allergic diseases of humans are arsenic, cadmium, was associated with increased respiratory symptoms lead, nickel, chromium and manganese ( 8,9 ). (who.int)

Physical and chemical properties vary among the various arsenic compounds of toxicological concern. (cdc.gov)
1 See for example, Gomez-Caminero A. Arsenic and arsenic compounds . (who.int)

The results of this study, the first to study oral arsenic polarization of Th1 responses in epicutaneous protein sensitization through CCL21-mediated LC migration, suggest the chronicity of As-BD without invasion might result from enhanced Th1 responses and altered LC migrations by arsenic. (eur.nl)

Arsenic trioxide is produced during the smelting of ores that contain arsenic. (cdc.gov)
Pots and jars of skin creams also could contain arsenic. (wkbw.com)

Rhamnaceae) on cisplatin-induced damage to kidney epithelial LLC-PK1 cells via mitogen-activated protein kinase (MAPK) and apoptosis pathways. (mdpi.com)
Cisplatin-induced LLC-PK1 cell death was most significantly reduced following treatment with 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME). (mdpi.com)

All these modulations were found to be reversed by BTE, which inhibits iAs induced SCC of skin by quenching excess ROS, promoting Smad mediated TGF-β signalling, downregulating signalling intermediates of PI3K-AKT and MAPK pathways and inhibiting EMT. (jcpjournal.org)

To investigate the protective effects of Mucuna (M.) pruriens against arsenic-induced testicular impairment in albino mice. (manipal.edu)

In the 1950s, the residents of the southwestern coastal areas of Taiwan suffered greatly from Blackfoot disease (BFD) due to the consumption of arsenic-contaminated groundwater. (routledge.com)
After arsenic-safe tap water was utilized for drinking instead of groundwater in the 1970s, BFD cases decreased greatly. (routledge.com)
However, arsenic is still present in the groundwater. (routledge.com)
It deals with constraints on the mobility of arsenic in groundwater, its uptake from soil and water by plants, arsenic-propagation through the food chain, human health impacts, and arsenic-removal technologies. (routledge.com)
Arsenic enters aquifers through the dissolution of minerals and ores, resulting in high concentrations in groundwater in some areas. (who.int)
Drinking-water from surface sources does not normally contain high concentrations of arsenic, unless those supplies come from arsenic-contaminated irrigation groundwater. (who.int)

Arsenic is hazardous to health and strongly associated with carcinogenic effects, cardiovascular and liver diseases. (iium.edu.my)

Arsenic, a major pollutant of water as well as soil, is a known endocrine disruptor, and shows adverse effects on the female reproductive physiology. (biomedcentral.com)

It further investigates the possibility that arsenic alters LC migration and polarizes Th responses. (eur.nl)

The aim of the present study was to clarify the protective capacity of taurine (Tau) on As-induced neuronal apoptosis and the related mechanism in mouse hippocampus. (springer.com)
Synaptic Signals from Glutamate-Treated Neurons Induce Aberrant Post-Synaptic Signals in Untreated Neuronal Networks. (uml.edu)

Metalloid arsenic is generally regarded as nonpoisonous due to its insolubility in water and body fluids. (cdc.gov)

According to Dr. Cheryl Kinney, a national board member of the Jane Austen Society of North America, many things contained arsenic during the author's lifetime: "Water, the soil, homemade wine (which Jane Austen refers to in her letters), wallpaper, clothing that had green pigment, glue, and medicines (Fowler's Solution would have been. (wkbw.com)

Since development and functional maintenance of the uterus is under the influence of estradiol, arsenic-induced structural degeneration may be attributed to the reduction in circulating estradiol levels. (biomedcentral.com)

The study aims to investigate the role of BTE in prevention of iAs-induced SCC of skin in Swiss albino mice via the modulation of TGF-β signalling and EMT. (jcpjournal.org)

Chen Y, Ahsan H (2004) Cancer burden from arsenic in drinking water in Bangladesh. (springer.com)
Regulation of birthweight by placenta-derived miRNAs: evidence from an arsenic-exposed birth cohort in Bangladesh. (harvard.edu)
In 1983, the first cases of arsenic-induced skin lesions in India were identified in patients from West Bengal, but by 1987 several cases had been identified in patients from neighbouring Bangladesh. (who.int)

Leon R, Wu H, Jin Y, Wei J, Buddhala C, Hu WJ (2009) Protective function of Tau in glutamate-induced apoptosis in cultured neurons. (springer.com)

Ferreccio C, Gonzalez C, Milosavjlevic V, Marshall G, Sancha AM, Smith AH (2000) Lung cancer and arsenic concentrations in drinking water in Chile. (springer.com)
To do this, we patch-sensitized Balb/c mice or DT-treated Langerin-DTR mice (conditional depletion of Langerin + cells) with OVA or PBS, and fed them water containing 300 ppb arsenic or regular water for 200 μl for five days. (eur.nl)
Water: Arsenic pentoxide can be used to contaminate water. (cdc.gov)
The water solubility of arsenic salts varies depending on the salt. (cdc.gov)
After all, some 19th-century English water supplies and medicines, which Austen might have taken, were contaminated with -- cue the dramatic music -- arsenic. (wkbw.com)
But the arsenic theory just doesn't hold water, Kinney says. (wkbw.com)
Although some recent studies from Asia have shown a loose association of chronic arsenic poisoning in water with cataract formation, the studies only show association, not causation. (wkbw.com)
Absorption of arsenic through the skin is minimal and thus, for example, washing hands or clothes and bathing in water containing arsenic or working in paddy fields with arsenic-contaminated waters do not pose risks to human health. (who.int)
Mitigation strategies should therefore focus primarily on reducing consumption of arsenic-rich drinking-water. (who.int)
Factors that severely limit the ability to determine the extent of the consequences of drinking arsenic-contaminated water include the delayed onset of illness, a lack until recently of common definitions, limited local awareness and poor reporting. (who.int)
The unavailability of a test that is simple, applicable in the field and low cost continues to be a significant limit to better understanding of the extent and severity of arsenic contamination of drinking-water and the development of the potential of community-based water- quality testing. (who.int)
About 1 in 100 people who drink water containing more than 0.05 mg/l of arsenic for a long period may eventually die from arsenic-related cancers. (who.int)

Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. (mbl.edu)

Arsenics, including arsenic pentoxide, naturally exist at low concentrations in the environment and the body. (cdc.gov)

Arsenic pentoxide is readily absorbed into the body via ingestion, inhalation, and through mucosal membranes. (cdc.gov)
Arsenic trioxide is readily absorbed if ingested or inhaled, but only slowly absorbed through the skin. (cdc.gov)

Substance-induced psychosis (commonly known as toxic psychosis or drug-induced psychosis) is a form of psychosis that is attributed to substance use. (wikipedia.org)
This Medical Management Guideline focuses on arsenic trioxide (As 2 O 3 ), one of the most toxic and prevalent forms. (cdc.gov)
Accumulation of Toxic Arsenic by Cherry Radish Tuber (Raphanus sativus var. (cas.cz)

Twenty four male Wistar rats were divided into 4 groups of 6 animals each and treated as follows: Group 1: sham control, 2: arsenic control (sodium arsenite @ 10 mg/kg b. wt orally for 4 wks), 3: Pre-treatment with NAC (@ 300 mg/kg orally for 2 wks) followed by sodium arsenite along with NAC (as per above doses) and 4: Sodium arsenite + NAC (as per above doses for 4 wks). (jnsbm.org)

With considerable advances in therapy, including the introduction of ATRA initially as a single agent and then in combination with anthracyclines, and more recently by development of arsenic trioxide (ATO)-containing regimens, APL is now characterized by complete remission rates of 90% and cure rates of ∼ 80%, even higher among low-risk patients. (nature.com)
In the past two decades, therapy for newly diagnosed APL has evolved from an all- trans retinoic acid (ATRA)+chemotherapy backbone for all patients to the addition of arsenic trioxide (ATO) to ATRA with omission of chemotherapy in low-risk patients as a new standard of care. (nature.com)

Therefore, we investigated whether mitoferrin-2, a mitochondrial iron uptake transporter, participates in As 2 O 3 -induced cell killing in human gliomas. (biomedcentral.com)
Therefore, we hypothesized that the mitochondrial iron transporter may participate in As 2 O 3 -induced excessive ROS production. (biomedcentral.com)

From a large prospectively followed-up cohort, exposed to arsenic, we randomly selected 2171 subjects without arsenic-induced skin lesions at enrollment and genotyped their whole blood DNA samples on Illumina Cyto12v2.1 SNP chips to generate DNA copy number. (nih.gov)
This first genome-wide CNV study in a prospectively followed-up large cohort, exposed to arsenic, suggests that DNA deletion in several genes and lincRNA genes may predispose an individual to a higher risk of development of arsenic-induced skin lesions. (nih.gov)

Arsenic-induced Bowen's disease (As-BD) is generally an indolent cutaneous intraepithelial carcinoma in susceptible people. (eur.nl)

Serious encephalopathy, including Wernicke's, has occurred with arsenic trioxide. (nih.gov)
If Wernicke's encephalopathy is suspected, immediately interrupt arsenic trioxide and initiate parenteral thiamine. (nih.gov)

Unless it is mixed with a solvent to enhance absorption, arsenic pentoxide is minimally absorbed through intact skin. (cdc.gov)
Arsenic pentoxide can be absorbed through broken skin. (cdc.gov)
Persons whose clothing or skin is contaminated with arsenic may secondarily contaminate others by direct contact or through release of inhalable dust. (cdc.gov)
Direct contact with arsenic trioxide dust can cause localized skin irritation, but systemic absorption through the skin is negligible. (cdc.gov)
A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women. (harvard.edu)

The results showed that Tau treatment induced the decrease of TUNEL-positive cells, prohibited the disturbance of Bcl-2 and Bax expression, and inhibited Cyt C release and caspase-8 and caspase-3 activation significantly. (springer.com)
Ninety-six hours after OVA sensitization, Langerin +EpCAM + cells in arsenic-treated WT mice were significantly increased in draining lymph nodes and decreased in epidermis without changes in the dermis. (eur.nl)

Effect of aqueous seed extract of Mucuna pruriens on arsenic-induced t" by Preethi Concessao, Laxminarayana Bairy et al. (manipal.edu)

Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)
Moreover, AQP9 expression associated with that of a subset of female-specific arsenic-responsive genes. (biomedcentral.com)
Expression of the estrogen receptor and estrogen-induced genes was studied at the mRNA level by RT-PCR and at the protein level by immunohistochemistry and western blot analysis. (biomedcentral.com)

Kadeyala PK, Sannadi S, Gottipolu RR (2013) Alterations in apoptotic caspases and antioxidant enzymes in arsenic exposed rat brain regions: reversal effect of essential metals and a chelating agent. (springer.com)

Anatomy2

Organisms1

Diseases5

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Psychiatry and Psychology1

Phenomena and Processes3

Disciplines and Occupations1

Technology, Industry, Agriculture4

Health Care4

Geographicals3

Inorganic19

Levels of arsenic5

Exposure29

Toxicity13

Carcinogenesis5

Pathway7

Hepatotoxicity4

Differentiation5

Oxidative3

Susceptibility2

Organic3

Autophagy2

Reactive oxygen1

Mechanisms3

Human carcinogen1

Forms of arsenic2

Response to arsenic2

Prolongation3

Cytotoxicity2

Cell proliferation1

Hepatic1

Cadmium1

Compounds2

Oral arsenic1

Contain arsenic2

Cisplatin-induced2

Pathways1

Impairment1

Groundwater6

Diseases1

Adverse1

Alters1

Neuronal2

Metalloid1

Soil1

Reduction1

Albino1

Bangladesh3

Neurons1

Water12

Toxicant1

Naturally1

Readily absorbed2

Toxic3

Rats1

ATRA2

Mitochondrial2

Cohort2

Carcinoma1

Encephalopathy2

Skin5

Significantly2

Aqueous1

Genes3

Enzymes1