• Furthermore, the field of cardiac ion channel trafficking is challenged to apply new concepts from basic cell biology that focus on the general structure and basic mechanisms of intracellular transport toward the level of individual ion channels. (frontiersin.org)
  • Balse and Boycot provide a review on the basic mechanisms of ion channel trafficking, their interdependence on basal cellular (e.g., local lipid composition) and extracellular (e.g., potassium concentration) factors, and some examples of modifying ion channel trafficking in order to counteract arrhythmias. (frontiersin.org)
  • Genetically modified mice rapidly appeared as promising tools for understanding the pathophysiological mechanisms of cardiac SCN5A -related arrhythmic syndromes and several mouse models have been established. (frontiersin.org)
  • After joining MMRL, he began investigating and publishing scholarly articles on the mechanisms underlying ventricular arrhythmias, including parasystole and reentry. (wikipedia.org)
  • Investigators are exploring new techniques of detecting and understanding the underlying mechanisms of sudden cardiac death in these patients without pathological evidence of underlying heart disease. (wikipedia.org)
  • After an incidence has been detected, members of the patient's close family are examined to detect possible arrhythmias. (hus.fi)
  • Magnesium supplementation may reduce the incidence of postoperative arrhythmias in pediatric patients undergoing cardiopulmonary bypass. (greenmedinfo.com)
  • To determine the incidence of arrhythmias and their importance 22 patients with accidental hypothermia (core temperature less than 35 degrees C) were studied by 12 lead electrocardiography and continuous recording of cardiac rhythm. (bmj.com)
  • Lower serum concentrations of magnesium were found to be associated with a higher incidence of arrhythmia in a large population study. (peacehealth.org)
  • The incidence and clinical significance of cardiac arrhythmias during long-term exposure to microgravity experienced on the International Space Station (ISS) or during a prolonged (that is, up to 3 years) sojourn to Mars or on the Moon are a concern for the National Aeronautics and Space Administration (NASA). (wikipedia.org)
  • When asked to contribute to the series 'Current Status of Clinical Cardiology' we felt that the clinical aspects of cardiac arrhyth- mias should be emphasized, and that the text should be as comprehensive as possible within the limitations of a single volume in this series. (springer.com)
  • The modellers used nine million core hours on GENCI's supercomputers , including Turing, Occigen and Curie , and worked closely with cardiologists as well as with biologists, physiologists and other specialists to cover all the different aspects of cardiac arrhythmias. (hpcwire.com)
  • We welcome experts on this research topic to share their original research on cardiac ion channel trafficking from the basic science lab and the clinic, to submit solid review papers on the intricate aspects of cardiac ion channel trafficking and to bring forward hypotheses that provide new avenues in this fascinating field with extraordinary clinical implications. (frontiersin.org)
  • A detailed analysis of the phenomenon of delayed anti-anginal action revealed that PgI2-pretreatment protected against consequences of ischaemia, such as early morphological changes, early and late postocclusion and reperfusion arrhythmias due to coronary artery occlusion or ouabain intoxication. (wikipedia.org)
  • In reentry, cardiac tissue is repetitively excited by a propagating wave circulating around an obstacle (anatomical reentry) or circulating freely in the tissue as a spiral or scroll wave (functional reentry). (scholarpedia.org)
  • Gene therapy to develop a genetically engineered cardiac pacemaker. (cogprints.org)
  • Our electrophysiologists offer an array of treatments that target the source of the arrhythmia, from pacemaker implantation to ablation procedures. (seton.net)
  • This chapter will review sex differences in different cardiac arrhythmias with an emphasis on clinical evaluation, treatment, and outcomes. (springer.com)
  • Although the epidemiology of clinical arrhythmias is difficult to dis- cover, it is widely appreciated that arrhythmias are commonplace. (springer.com)
  • The book then devotes specific chapters to various arrhythmias, including technical innovations in treatment and insights from clinical trials of and current guidelines for permanent pacemakers and implantable cardioverter-defibrillators. (springer.com)
  • This work took place at IHU Liryc, a research institute dedicated to cardiac arrhythmias, with one of the largest clinical teams in the world specialising in the treatment of these diseases. (hpcwire.com)
  • Alterations in ion channel function or trans-sarcolemmal ionic electrochemical gradients lead to alteration in ionic current and action potential which can cause arrhythmias. (springer.com)
  • People using such drugs are usually advised to take potassium supplements because potassium deficiency can cause arrhythmias. (medicalcityhospital.com)
  • Studies evaluating pathophysiology, disease course, and therapeutic options for cardiac arrhythmias have been performed in predominantly male patients. (springer.com)
  • All these results and literature on epidemiology and pathophysiology of sudden cardiac death as well as on possible therapeutic measures were summarized in a monograph. (wikipedia.org)
  • Since the electrical characteristics of the infarcted tissue change (see pathophysiology section), arrhythmias are a frequent complication. (wikipedia.org)
  • conducting a microwave signal through said catheter to said cardiac tissue. (google.com)
  • Phenytoin was given intravenously in 37 patients with cardiac arrhythmias-21 had acute myocardial infarction and 16 had other conditions. (bmj.com)
  • The research, which is published today (Wednesday) in the European Heart Journal , is the first study to investigate the link between acute alcohol consumption and cardiac arrhythmias in a large number of people in a prospective fashion i.e. examining them as they were drinking, rather than asking them to remember at some point afterwards how much they had drunk, when, and for how long. (eurekalert.org)
  • Heavy drinking over a short period of time (acute alcohol consumption) has been linked to "Holiday heart syndrome" in which people without any previous history of heart problems develop arrhythmias and sometimes atrial fibrillation, but the evidence for this has tended to come from small, retrospective studies. (eurekalert.org)
  • Search for methods to prevent sudden cardiac death due to acute myocardial infarction. (wikipedia.org)
  • Studies (notably the Cardiac Arrhythmia Suppression Trial) have shown an increased mortality when flecainide is used to suppress ventricular extrasystoles in the setting of acute myocardial infarction. (wikipedia.org)
  • 2. This Article Has Been Brought to You for Free by www.freud-sigmund.compropagation does not follow the normal Stored in both normal cardiac impulseroute. (slideshare.net)
  • The purpose of this fine text is to help inform physicians and surgeons about recent advances in the diagnosis and management of patients with cardiac arrhythmias, and to describe how electrophysiologists can best assist in the care of their patients. (springer.com)
  • These are specially equipped operating rooms that usually contain a Fluoroscope, Recording System, Cardiac Stimulator, Ablation Equipment, a Cardiac Mapping System and the necessary cables, catheters and sheaths. (wikipedia.org)
  • emphasize on the involvement of autophagy pathways in cardiac ion channel trafficking under disease conditions and the impact of drugs, including antiarrhythmics, on autophagy and subsequent arrhythmic outcomes. (frontiersin.org)
  • Procainamide works as an anti-arrhythmic agent and is used to treat cardiac arrhythmia. (wikipedia.org)
  • Available anti-arrhythmic agents (AAD) used for the maintenance of AF are often accompanied with the risk of developing ventricular pro-arrhythmias, as they are often limited to targeting a single ion channel (i.e. (wikipedia.org)
  • Hyperkalaemic cardiac arrhythmia caused by potassium citrate mixture. (bmj.com)
  • Browning J J , Channer K S . Hyperkalaemic cardiac arrhythmia caused by potassium citrate mixture. (bmj.com)
  • Management may include avoiding strenuous exercise, getting sufficient potassium in the diet, the use of beta blockers, or a implantable cardiac defibrillator. (wikipedia.org)
  • The product of the KCNQ1 gene is thought to produce an alpha subunit that interacts with other proteins (in particular, the minK beta subunit) to create the IKs ion channel, which is responsible for the delayed potassium rectifier current of the cardiac action potential. (wikipedia.org)
  • In some patients, the cause of extrasystoles may be heart disease, while others may be at risk of severe attacks of arrhythmia. (hus.fi)
  • July 30, 2018 - A team of researchers lead by Mark Potse from Inria Bordeaux Sud-Ouest is using high performance computing resources to study heart arrhythmias and help doctors in the diagnosis and treatment of patients. (hpcwire.com)
  • Whether anyone was able to do this I do not know but Bretylium was one of the Cardiac arrhythmia drugs recommended by the American Heart Association in the manuals. (salem-news.com)
  • More serious forms of heart arrhythmia may occur as well. (medicalcityhospital.com)
  • Heart arrhythmias are far too dangerous for self-treatment. (medicalcityhospital.com)
  • Although the use of fish oil to help prevent dangerous heart arrhythmias has received considerable research attention, 1-2,15-17,20,22,23,24,25 the evidence for its effectiveness remains conflicted. (medicalcityhospital.com)
  • The mineral magnesium tends to stabilize the heart, and intravenous infusions of magnesium are sometimes given to people in cardiac intensive care. (medicalcityhospital.com)
  • People with congestive heart failure (CHF) are likely to use both digoxin and loop diuretics (another type of diuretic that depletes magnesium), and the net result can be cardiac arrhythmias 5-8 One small double-blind, placebo-controlled study found that magnesium supplements reduced episodes of ventricular arrhythmia in people with CHF. (medicalcityhospital.com)
  • Arrhythmias can be caused by genetics, as well as lifestyle choices that contribute towards heart disease. (seton.net)
  • They can also lead to more serious problems such as heart failure , stroke or cardiac arrest (a heart attack ). (seton.net)
  • Correcting your arrhythmia will depend on what type of heart problem you have. (seton.net)
  • Cameron Health's approach avoided implanting transvenous leads into the heart, which had been the usual procedure for cardiac devices. (wikipedia.org)
  • Cardiac arrhythmia is any abnormality in the electrical activity of the heart. (wikipedia.org)
  • Flecainide works by regulating the flow of sodium in the heart, causing prolongation of the cardiac action potential. (wikipedia.org)
  • Treatment of flecainide cardiac toxicity involves increasing the excretion of flecainide, blocking its effects in the heart, and (rarely) institution of cardiovascular support to avoid impending lethal arrhythmias. (wikipedia.org)
  • Flecainide works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. (wikipedia.org)
  • Rupture is usually a catastrophic event that may result a life-threatening process known as cardiac tamponade, in which blood accumulates within the pericardium or heart sac, and compresses the heart to the point where it cannot pump effectively. (wikipedia.org)
  • Cardiogenic shock is defined as a hemodynamic state in which the heart cannot produce enough of a cardiac output to supply an adequate amount of oxygenated blood to the tissues of the body. (wikipedia.org)
  • This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart that coordinates the heart's beating (i.e., the hERG channel mediates the repolarizing IKr current in the cardiac action potential). (wikipedia.org)
  • In particular, his work helped lead to the FDA approval of the drugs dronedarone and amiodarone which help restore normal heart beat patterns in patients with arrhythmia. (wikipedia.org)
  • Additionally, with cardiac researcher Jose Di Diego, MD, Antzelevitch is exploring the heart-related therapeutic applications of human induced pluripotent stem cells and progenitor cells, including a possible role in the engineering of bioartificial hearts suitable for heart transplantation. (wikipedia.org)
  • One useful classification that will be utilized here is reentrant versus non-reentrant arrhythmias. (scholarpedia.org)
  • Thus, there is a strong spatial component to reentrant arrhythmias: either a sufficiently large spatial extent is needed to support the initiation and continuation of the arrhythmia, or an appropriate geometry must be present to allow a reentrant circuit. (scholarpedia.org)
  • Taneja T, Mahnert BW, Passman R, Goldberger J, Kadish A. Effects of sex and age on electrocardiographic and cardiac electrophysiological properties in adults. (springer.com)
  • 1. This Article Has Been Brought to You for Free by WHAT IS www.freud-sigmund.com CARDIAC ARRHYTHMIA atrioventricular node, the junction between the atria and ventricles. (slideshare.net)
  • Anextra systole interrupts normal Atria arrhythmias originate in the atria:sequence of activation of cardiac - Ectopic atria - ectopic impulsesmuscle. (slideshare.net)
  • Moreover, in the next decade cardiac ion channel trafficking research has to transit from ectopic cell expression systems, via isolated adult cardiomyocytes and tissue explants into in vivo approaches. (frontiersin.org)