Arrest phases halts cell cycle progression. Medical search. Frequent questions

If cells containing damaged DNA were to divide, the errors would be transmitted to daughter cells, generating genomic instability and resulting in tumorigenesis or apoptosis . (tocris.com)
Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)
A substantial synergistic interaction between Amy and Sor was observed (CI 50 = 0.56), which was connected to cell cycle arrest at the S and G2/M stages and increased apoptosis and potential necroptosis. (biomedcentral.com)
This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)
Wu X, Song M, Qiu P, Li F, Wang M, Zheng J, Wang Q, Xu F, Xiao H. A metabolite of nobiletin, 4'-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis. (umassmed.edu)
Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. (umassmed.edu)
Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells. (umassmed.edu)
A key feature of prostate cancer progression is the induction and activation of survival proteins, including the Inhibitor of Apoptosis (IAP) family member survivin. (oncotarget.com)
Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
Numerous harmful factors that affect the human body from birth to old age cause many disturbances, e.g., in the structure of the genome, inducing cell apoptosis and their degeneration, which leads to the development of many diseases, including cancer. (mdpi.com)
Tax regulates cell cycle progression and apoptosis both positively and negatively, however, www.selleckchem.com/products/Rapamycin.html the molecular mechan ism underlying the regulation of these processes by Tax remain obscure. (thrombininhibitors.com)
Using this system for the in vivo analysis of the spatial and temporal patterns of cell cycle dynamics, we demonstrated that Inhibitors,Modulators,Libraries Tax expressing cells arrest in the G1 phase of the cell cycle and proceeded to apop tosis, and we found that Tax induced changes in the expression of genes related to cell cycle regulation and apoptosis correlated well with the morphological changes observed in the cells. (thrombininhibitors.com)
Results Tax induces cell cycle arrest and apoptosis in transfected HeLa cells To examine whether Tax induces cell cycle Inhibitors,Modulators,Libraries arrest at the G1 phase and promotes apoptosis in HeLa cells, chimeric Tax carrying a Flag tag at the carboxyl terminus was transfected into HeLa cells. (thrombininhibitors.com)
Unlike apoptosis, senescence is a state of which cells are still alive and metabolically active. (frontiersin.org)
These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)
It inhibits glucose uptake, suppresses key enzymes and reduces the level of available ATP energy, leading to apoptosis of both parasites and cancer cells. (cancer.news)
As the drug blocked cell cycle progression, it increased p53 protein stability and induced apoptosis of the cancer cells. (cancer.news)
The drug induced oxidative stress on the cancer cells, making them more vulnerable to apoptosis. (cancer.news)
It also induces apoptosis by Beclin-1 and causes cell cycle arrest of cancer cells at the G2/M phase. (cancer.news)
Another study from 2022 provides evidence that benzimidazoles induce apoptosis and pyroptosis of human glioblastoma (GBM) cancer cells. (cancer.news)
Artemisinin - This study demonstrated that artemisinin -tagged transferrins (ART-Tf) conjugate kills the prostate carcinoma cell line DU 145 by the mitochondrial pathway of apoptosis. (compassionateacupuncture.com)
We asked regardless of whether the antiproliferative action of 17-AAG was as a consequence of cell cycle arrest, apoptosis, or each. (hsp90-inhibitors.com)
Annexin-V/PI movement cytometric experiments had been performed to determine if 17-AAG alone or in combination with cisplatin could induce A549 cell apoptosis. (hsp90-inhibitors.com)
In many cases the antiproloferation action is caused by damage to DNA, which initiates apoptosis and cell death [4]. (savedelicious.com)
These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)

Cell cycle checkpoints are control mechanisms in the eukaryotic cell cycle which ensure its proper progression. (wikipedia.org)
Progression through these checkpoints is largely determined by the activation of cyclin-dependent kinases by regulatory protein subunits called cyclins, different forms of which are produced at each stage of the cell cycle to control the specific events that occur therein. (wikipedia.org)
The cell cycle checkpoints play an important role in the control system by sensing defects that occur during essential processes such as DNA replication or chromosome segregation, and inducing a cell cycle arrest in response until the defects are repaired. (wikipedia.org)
The main mechanism of action of the cell cycle checkpoints is through the regulation of the activities of a family of protein kinases known as the cyclin-dependent kinases (CDKs), which bind to different classes of regulator proteins known as cyclins, with specific cyclin-CDK complexes being formed and activated at different phases of the cell cycle. (wikipedia.org)
For a cell to progress through the cycle and replicate, it must pass through checkpoints between phases to ensure that DNA is replicated correctly and that chromosomes segregate. (tocris.com)
These checkpoints may stop the cell cycle after DNA damage, loss of DNA replication or disruption of the mitotic spindle, in order for repair processes to take place. (tocris.com)
Thus, WEE1 inhibition sensitizes cancers have loss-of-function TP53 mutations, meaning that tumor cells to DNA-damaging chemotherapy and can lead to they become more dependent on the G2/M- and S-phase unstable DNA replication, DNA damage and mitotic catas- checkpoints to halt progression of the cell cycle [3, 4]. (sagepub.com)
G1 Phase Cell Cycle Checkpoints" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "G1 Phase Cell Cycle Checkpoints" by people in this website by year, and whether "G1 Phase Cell Cycle Checkpoints" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "G1 Phase Cell Cycle Checkpoints" by people in Profiles. (umassmed.edu)
In Xenopus laevis, early embryonic development consists of twelve rapid cleavage cycles between DNA replication (S) and mitosis (M) without checkpoints or gap phases. (vt.edu)
During the cell cycle, there are two main checkpoints that regulate entrance into S and M phases. (vt.edu)
Transitional checkpoints are therefore crucial for a successful completion of the cell cycle. (janechin.net)

solid tumor (excluding lymphoma), failure to respond to Key Points standard therapy, disease progression despite standard ther- apy, or cancers for which standard therapy did not exist. (sagepub.com)
Ovarian cancer is frequently sensitive to chemotherapy at diagnosis but rapid development of drug resistance leads to disease progression and ultimately death in the majority of patients. (biomedcentral.com)
Conventionally, patients took aspirin or other nonsteroidal anti-inflammatory drugs to soothe their discomfort, but these drugs didn't halt disease progression. (laskerfoundation.org)

Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. (oncotarget.com)

Inhibiting WEE1 abrogates G2 cell cycle arrest, resulting The tyrosine kinase WEE1 regulates cyclin-dependent kinase in premature entry into mitosis and leading to aberrantly 1 (CDK1), which drives cells from the G2 phase into mitosis, high CDK2 activity in S-phase cells, with the deregulated and CDK2, which drives cells into and through the S phase DNA replication resulting in replication stress [1, 5]. (sagepub.com)
Chk1 regulates cell cycle arrest in the presence of unreplicated DNA in somatic cells by phosphorylating Cdc25A and leading to its degradation. (vt.edu)
The conditioned medium from these cells re-expressing ZKSCAN5 could rescue these effects ( Figures?2A, B ). A similar tendency was also detected in HLEC migration analysis ( Figures?2C, D ). Open in a separate window Figure?2 VEGFC secreted by cancer cells, under the influence of ZKSCAN5, regulates HLEC proliferation, migration, and tube formation. (bms-911543.com)

As the eukaryotic cell cycle is a complex process, eukaryotes have evolved a network of regulatory proteins, known as the cell cycle control system, which monitors and dictates the progression of the cell through the cell cycle. (wikipedia.org)
The E2F gene family is a group of transcription factors that target many genes that are important for control of the cell cycle, including cyclins, CDKs, checkpoint regulators, and DNA repair proteins. (wikipedia.org)
The three pocket proteins are Retinoblastoma (Rb), p107, and p130, which bind to the E2F transcription factors to prevent progression past the G1 checkpoint. (wikipedia.org)
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. (tocris.com)
We combined time-lapse microscopy, highly multiplexed single-cell imaging of 48 core cell cycle proteins, and manifold learning to render a visualization of the human cell cycle. (bvsalud.org)
Initially the arrest is due to lack of sufficient cell cycle proteins to allow meiotic progression. (wikipedia.org)
However, as the oocyte grows, these proteins are synthesized, and meiotic arrest becomes dependent on cyclic AMP . (wikipedia.org)
[7] The cells that comprise the follicle, known as granulosa cells, are connected to each other by proteins known as gap junctions, that allow small molecules to pass between the cells. (wikipedia.org)
One of the critical factors for the control of the protein levels during the cell cycle is the Anaphase Promoting Complex/Cyclosome (APC/C). This complex recognises proteins with specific signatures (or degrons) and targets them for degradation via the protein destruction machinery called the proteasome. (europa.eu)
Invadopodia are cancer cell protrusions rich in structural proteins (e.g. (biorxiv.org)
Factors mandating cellular consequence include cell surface-receptors, cytoplasmic proteins, and nuclear proteins. (janechin.net)
In particular, proteins called cytokines, which carry signals between cells to orchestrate the fight against invading microorganisms, act up and provoke ferocious inflammation. (laskerfoundation.org)
In this illness, particular non-immune thyroid cells take on unusual properties, acquiring molecules (such as HLA class II proteins) that allow them to stimulate an immune reaction that leads to inflammation. (laskerfoundation.org)

However, under these microenvironmental conditions, only 15% of tumor cells assemble invadopodia at any given time, while the rest are non-motile. (biorxiv.org)
In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer. (aacrjournals.org)
These data suggest the energy of the KISS1R like a novel biomarker for multiple myeloma, capable of focusing on both tumor cells and sponsor cells of the tumor microenvironment. (onlycoloncancer.com)
There is also evidence that benzimidazole drugs sensitize tumor cells so they can become more susceptible to radiation therapy. (cancer.news)

It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death. (tocris.com)
First, the drug displays anti-mitotic activity, which means it inhibits tubulin polymerization by binding to tubulin sites of rapidly dividing cells. (cancer.news)

and the M (mitosis) phase, during which the duplicated chromosomes (known as the sister chromatids) separate into two daughter nuclei, and the cell divides into two daughter cells, each with a full copy of DNA. (wikipedia.org)
The checkpoint original model represents the activity of Cdc25 phosphatase on the mitosis promoting factor (MPF) that leads the cell into mitosis. (vt.edu)
This advised that 17-AAG induced cell cycle arrest by preventing Ponatinib selleck chemicals A549 cells from entering mitosis. (hsp90-inhibitors.com)
Stages of the cell cycle are G1 (Gap 1), S (Synthesis), G2, M (Mitosis), and G0 (quiescence), with mitosis as the shortest and most visually dramatic process of the cycle after which two daughter cells result, Figure 1-1. (janechin.net)

The microenvironment of the cell and the interactions of many growth factors have a role in tumor development and survival [ 2 , 7 ]. (biomedcentral.com)
Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. (oncotarget.com)
These bone metastases produce osteoblastic lesions that are associated with high morbidity and high mortality [ 8 ] and attempts at delaying this tumor progression with chemotherapeutic agents have only prolonged survival a few months. (oncotarget.com)
Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. (aacrjournals.org)
Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
19,twenty Despite the fact that the results of the phase III trial of vandetanib have recently been presented showing improved progression-free survival, 21 there remains anunmetmedical have inMTC;norandomized trials have still been linked with improved all round survival on this patient population. (hsp90-inhibitors.com)
These heterozygous somatic mutations most regularly consist of a point mutation within exon 21, leading to an amino acid substitution or in-frame deletions within exon 19.Kinase domain mutations result in constitutive activation of EGFR by jak2 inhibitors selleck chemicals destabilization in the autoinhibited conformation on the receptor.In mutant EGFR tumors, cell survival is dependent on EGFR signaling, a phenomenon termed ?oncogene addiction? (hsp90-inhibitors.com)
The Warburg hypothesis was based on the metabolic differences between cancer cells and normal cells, and proposed that increased glycolysis by transformed cells conferred a bio-energetic advantage for survival over normal counterparts under anoxic conditions (Anghileri, 1983). (janechin.net)
In both genetic and diet-induced models of insulin resistance, CHOP deficiency improved β cell ultrastructure and promoted cell survival. (jci.org)

Tumor cell invasion and metastasis require cancer cells to be both proliferative and invasive, i.e. migrate through the tissue and assemble invadopodia. (biorxiv.org)
Metastasis is a complex, multi-step process that is initiated when cancer cells in the primary tumor acquire invasive properties, including motility and the ability to breakdown the extracellular matrix (ECM) 1 , and is responsible for the majority of cancer-related mortalities 2 . (biorxiv.org)
Thus, angiogenesis is a necessary and required step for transition from a small harmless cluster of cells to a large tumour and is also required for the spread of a tumour, invasion and/or metastasis. (biomedcentral.com)

Pope PA, Pryciak PM. Functional overlap among distinct G1/S inhibitory pathways allows robust G1 arrest by yeast mating pheromones. (umassmed.edu)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
When unreplicated or damaged DNA is present, cell cycle checkpoint pathways cause cell cycle arrest by inhibiting cyclin-dependent kinases (Cdks). (vt.edu)
One goal of this work is to understand the developmental role and regulation of checkpoint signaling pathways due to its monitoring of DNA integrity within the cell. (vt.edu)
Reports also suggest that some of the biological effects of anthocyanins and flavonols may be related to their ability to modulate mammalian cell signalling pathways. (chk1inhibitor.com)
High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
In a recent study functional themes associated with Gleason grade include developmental processes, signal transduction, chemokine and embryonic stem cell pathways with specific enrichment of the androgen receptor, EGFR, TNF-alpha, and Notch signaling cascades. (compassionateacupuncture.com)
Here, we review some of the recent advances and studies that highlight the roles of these changes as well as antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. (springer.com)

The majority of cell cycle regulators, including APC/C, as well as the genes regulating cells' responses to external cues, are very similar between Drosophila and mammals, although the genetic circuit in Drosophila is relatively simple and less complex compared to mammals. (europa.eu)
Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)
The genes that have been identified to date have been categorized into two broad categories, depending on their normal functions in the cell. (cancerquest.org)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
This first category also includes genes that contribute to tumor growth by inhibiting cell death. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
Many of these genes are responsible for providing the positive signals that lead to cell division. (cancerquest.org)
As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
This is in contrast with tumor suppressor genes which must BOTH be defective to lead to abnormal cell division. (cancerquest.org)
Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)
A) Luciferase reporter genes were determined in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with Glutaminase-IN-1 different concentrations of reporter and myc-ZKSCAN5. (bms-911543.com)

Embryos treated with aphidicolin, resulting in a halted replication fork and therefore a reduced DNA concentration, were tested for Chk1 activation and Cdc25A degradation. (vt.edu)
They can also cause base mispairing between strands, which interferes with the progression of the replication fork [3]. (savedelicious.com)

Because APE1/Ref-1 is expressed and elevated in prostate cancer, we sought to characterize APE1/Ref-1 expression and activity in human prostate cancer cell lines and determine the effect of selective reduction-oxidation (redox) function inhibition on prostate cancer cells in vitro and in vivo . (oncotarget.com)
Cannabis sativa in particular cannabidiol, we propose it plays important role in helping the body fight cancer through inhibition of pain and cell growth. (biomedcentral.com)
Crataeva Nurvala - (Lupeol is the active compound in Crateva) - Collectively, these data suggest the multitarget efficacy of Lupeol on beta-catenin-signaling network thus resulting in the inhibition prostate cancer cell proliferation. (compassionateacupuncture.com)
This inhibition by 5 HTia agonists, the truth is final results through the direct activation of somatodendritic 5 HTj autoreceptors, located on the serotoninergic cells inside of the dorsal raphe nucleus. (agckinase.com)
The inhibition of angiogenesis is emerging as a new, attractive therapeutic approach to control tumour progression [ 1 ]. (biomedcentral.com)

Immediately prior to ovulation, the combination of E 2 and FSH leads to the production of luteinizing-hormone (LH) receptors on the granulosa cells surrounding the lead follicle. (medscape.com)
Luteinizing hormone acts on receptors in the outer layers of granulosa cells of the follicle, causing a decrease in cyclic GMP in the granulosa cells. (wikipedia.org)
Current and calcium responses were selleckchem Brefeldin A used to quantify the total functional pool of extrasynaptic NMDA receptors for each cell. (thrombininhibitors.com)
Having said that, ketanserin is unable to block the inhibitory action of 4 iodo 2,5 dimethoxyphenyiisopropylamine, a potent 5 HT2 agonist, to the electrical action of those cells, indicating that 5 HT2 receptors, like 5HT3 receptors, will not play any function from the regulation of their firing charge. (agckinase.com)
In contrast to 5 HT2 and 5 HT3 receptors, 5 HTia receptors are involved with the regulation in the firing charge of serotoninergic neurones while in the dorsal raphe nucleus, as more supported while in the present study by the efficacy of your S HT agonist, ipsapirone to inhibit, in vivo as well as in vitro, the electrical activity of these cells by way of a propranolol reversible action. (agckinase.com)
The mammalian cell is furnished with receptors linked to interactive series of cytoplasmic networks for controlling cellular processes. (janechin.net)

In recent years, cell cycle regulators have been shown to exhibit roles in both tumor suppression and tumor promotion, particularly cyclin-dependent kinase inhibitors (CKI) p27 kip1 and p21 cip1 14 . (biorxiv.org)
Increasing evidence indicates that senescent cells could be a promising new target for therapeutic intervention known as senotherapy, which includes depleting senescent cells, modulating SASP and restoration of senescence inhibitors. (frontiersin.org)

Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. (tocris.com)
Some proto-oncogenes work to regulate cell death. (cancerquest.org)

Dysregulation of processes driven by these factors is a severe liability to the cell and therefore represents potential areas for therapeutic intervention. (janechin.net)

At this point, the embryo initiates transcription, acquires gap phases between S and M phases, and establishes a functional apoptotic program. (vt.edu)
These actions block DNA synthesis, causing a block at G2 phase and subsequently apoptotic cell death. (savedelicious.com)

The lysosomal membranes that separate those digestive enzymes from the rest of the cell contain relatively high concentrations of coenzyme Q 10 . (oregonstate.edu)
The presence of a significant amount of CoQ 10 H 2 in cell membranes, along with enzymes capable of reducing oxidized CoQ 10 back to CoQ 10 H 2 (i.e. (oregonstate.edu)

The role of increased oxidative stress is associated with both the incidence and the progression of AMD and is reviewed by Jarrett and Boulton (2012) . (frontiersin.org)
Secondly, the drug induces oxidative stress that disrupts cell metabolic processes. (cancer.news)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)

Chk1 plays a critical but not fully understood role in cell cycle remodeling and early embryonic development. (vt.edu)
Comparative biochemical studies of rapamycin and wortmannin on transforming growth factor-beta 1 (TGF-beta1)-mediated G(1)-S cell cycle progression in C3H-10T1/2 embryonic fibroblasts. (janechin.net)

This system acts like a timer, or a clock, which sets a fixed amount of time for the cell to spend in each phase of the cell cycle, while at the same time it also responds to information received from the processes it controls. (wikipedia.org)
They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM , and divide them equally between two daughter cells. (nih.gov)
If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable. (nih.gov)
These factors couple extracellular signals to intracellular processes to determine cell cycle progression. (janechin.net)

Therefore, understanding how the division of the cells, i.e. the cell cycle, is coordinated with their responses to the external clues is key to understanding the causes of the formation and progression of tumours as well as the pathology of degenerative disorders, which will ultimately help develop new therapeutic strategies to these diseases. (europa.eu)
Lastly, through gene expression profiling we have demonstrated disruption of the spindle assembly checkpoint in the paclitaxel resistant cell lines, indicating a potential therapeutic pathway. (biomedcentral.com)

In this study, using invadopodia- and cell cycle- fluorescent markers, we show in 2D and 3D cell cultures, as well as in vivo , that breast carcinoma cells assemble invadopodia and invade into the surrounding ECM preferentially during the G1 phase of the cell cycle. (biorxiv.org)
The effects of BCRC-3 on cancer cells were explored by transfecting with plasmids in vitro and in vivo. (biomedcentral.com)
Proliferation of BC cells was suppressed by ectopic expression of BCRC-3 in vitro and in vivo. (biomedcentral.com)
The researchers detailed the direct pathway for which the drug caused programmed cell death in vivo and exactly where it caused cell cycle arrest. (cancer.news)

In the absence of active Chk1, Cdc25A activates cyclin dependent kinases (Cdks) allowing the cell to progress into S or M phase. (vt.edu)
Cell cycle progression is governed by a complex network of cyclin-dependent kinases that define not only the phase of the cell cycle, but also the timing of transitions between phases 13 . (biorxiv.org)

For tumour estimation, nude mice were inoculated subcutaneously with 1 107 ZR75-1 cells with different constructs on the right side. (bms-911543.com)

Oocyte meiosis, important to all animal life cycles yet unlike all other instances of animal cell division, occurs completely without the aid of spindle -coordinating centrosomes . (wikipedia.org)
We have generated model systems to explore drug resistance in ovarian cancer, which have revealed a key pathway related to the spindle assembly checkpoint underlying paclitaxel resistance in ovarian cell lines. (biomedcentral.com)

The menstrual cycle is an orderly progression of coordinated hormonal events in the female body that stimulates growth of a follicle to release an egg and prepare a site for implantation if fertilization should occur. (medscape.com)
The mammalian cell cycle is stringently regulated and orderly process by which a cell reproduces. (janechin.net)

On the contrary, M2 is characterized by arginase-1 (Arg1) activity, which promotes tumor development through tissue remodeling, cell proliferation, angiogenesis, and immune regulation ( 6 ). (amegroups.org)

The menstrual cycle can be divided into 3 physiologic phases: follicular, ovulatory, and luteal. (medscape.com)

In the study, " Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics (2023)," researchers found that Fenbendazole has two primary mechanisms of action against cancer cells. (cancer.news)

The drug proves to be less toxic to healthy cells than traditional chemotherapy agents, yet similarly lethal to the cancer cells. (cancer.news)
Modern approaches to treating cancer take advantage of critical biochemical differences between cancer cells and normal cells - from radiation therapy to chemotherapy to experimental gene therapy. (janechin.net)
Table 1 summarises the results from phase II trials utilizing bevacizumab in combination with chemotherapy, many of which are still preliminary. (biomedcentral.com)
Resistance to chemotherapy is when the cancer cells do not respond to the drugs. (savedelicious.com)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Encouraging progress in understanding cell cycle regulation occurred over the past five years. (janechin.net)
Such regulation ensures faithful reproduction of DNA for subsequent distribution to daughter cells. (janechin.net)
The G1 phase is a period of intense metabolic activity and regulation. (janechin.net)

Distinguishing and removing cancer cells from normal cells continue to be key in the experimental design for therapy and prevention. (janechin.net)
An obvious requirement for the stringent control of cell cycle progression is the prevention of deregulated proliferation - loss of control may result in tumors and cancers. (janechin.net)

Regulatory signaling systems that control the progression of the CELL CYCLE through the G1 PHASE and allow transition to S PHASE when the cells are ready to undergo DNA REPLICATION. (umassmed.edu)
Thus, further exploration of genetic regulatory networks involved in BC progression and development of precise strategies are worthy and important. (biomedcentral.com)
In general, the circRNA-miRNA-mRNA axis may function as an extensive regulatory network in progression of some diseases. (biomedcentral.com)
Regulatory signaling systems that control the progression through the CELL CYCLE . (nih.gov)

Following DNA damage, WEE1 inhibits CDK1, leading 1 Introduction to cell cycle arrest and allowing time for DNA repair [4]. (sagepub.com)

The G1 checkpoint, also known as the restriction point in mammalian cells and the start point in yeast, is the point at which the cell becomes committed to entering the cell cycle. (wikipedia.org)
As the cell progresses through G1, depending on internal and external conditions, it can either delay G1, enter a quiescent state known as G0, or proceed past the restriction point. (wikipedia.org)
The Restriction point is also known as a checkpoint, where 'the cell is arrested at a particular phase of the cycle due to a lack of appropriate signals' (Hartwell and Weinert, 1989). (janechin.net)

Paradoxically, progression deeper into cell cycle arrest was accompanied by increases in proliferative effectors such as CDKs and cyclins, which can drive cell cycle re-entry by overcoming p21 induction. (bvsalud.org)
An intrinsic mechanism that through the secretion of a specific molecule called Wingless by the neighbouring cells, instruct the receiving cells to keep their proliferative state. (europa.eu)
In this study we compare the anti-proliferative effects of crude extract of Cannabis sativa and its main compound cannabidiol on different cervical cancer cell lines. (biomedcentral.com)
Therefore, the aim of this study was to evaluate the cytotoxic and anti-proliferative properties of Cannabis sativa and its isolate, cannabidiol in cervical cancer cell lines. (biomedcentral.com)

The mammalian cell cycle typically completes in 24 hours, where dramatic changes occur in cellular metabolism and cytoskeletal physiology. (janechin.net)

FSH is secreted into the circulation and communicates with the granulosa cells surrounding the developing oocytes. (medscape.com)
As FSH increases during the early portion of the follicular phase, it meshes with granulosa cells to stimulate the aromatization of androgens into estradiol. (medscape.com)
The LH surge promotes maturation of the dominant oocyte, the release of the oocyte and then the luteinization of the granulosa cells and the surrounding theca cells of the dominant follicle resulting in progesterone production. (medscape.com)
The granulosa cells produce a small molecule, cyclic GMP , that diffuses into the oocyte through the gap junctions. (wikipedia.org)
[5] Because the granulosa cells and oocyte are connected by gap junctions, cyclic GMP also decreases in the oocyte, causing meiosis to resume. (wikipedia.org)

Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors known as the senescence-associated secretory phenotype (SASP). (frontiersin.org)
We also highlight potential options of targeting senescent cells for the treatment of CKD. (frontiersin.org)
We also highlight potential options for targeting senescent cells in developing therapeutics for CKD patients. (frontiersin.org)
Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
Elimination of senescent cells can counter chronic inflammation, said Steven N. Austad, director of aging studies at the University of Alabama at Birmingham. (qualitycounts.com)

ZKSCAN5-Regulated VEGFC Promotes the Proliferation, Migration, and Tube Formation of HLECs Cancer cell-secreted VEGFC markedly enhanced the proliferation and migration of lymphocyte endothelial cells. (bms-911543.com)
[ 2 ] Diagnosed in 50% of patients with VHL disease, these hemangiomas are composed of endothelial cells and pericytes. (medscape.com)

Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)

Cell cycle progression is faster in cells in which invadopodia are abolished (by Tks5 knockdown), evidenced by earlier induction of cyclins A and B. A close look at the regulators of G1 revealed that the overexpression of p27 kip1 , but not p21 cip1 , causes faster turnover of invadopodia and increased ECM degradation. (biorxiv.org)
Taken together, these findings suggest that invadopodia function is tightly linked to cell cycle progression and is controlled by specific cell cycle regulators. (biorxiv.org)

Objective This open-label Phase Ib study (NCT02341456) investigated the safety, pharmacokinetics, and clinical activity of adavosertib in combination with carboplatin alone or paclitaxel plus carboplatin in Asian patients with advanced solid tumors and defined the recommended Phase II dose. (sagepub.com)
administered in combination with cisplatin, carboplatin, or gemcitabine in patients with advanced solid tumors in a * Yung-Jue Bang [email protected] Phase I study (NCT00648648, PN001) [6]. (sagepub.com)
Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)

The cell division process is dependent on a tightly controlled sequence of events. (cancerquest.org)

These compounds are almost structurally similar or possess identical pharmacological activities and offer various potential applications including the ability to inhibit cell growth, proliferation and inflammation [ 22 ]. (biomedcentral.com)
Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
recent studies have identified measures potentially available to everyone that can minimize the potency of chronic inflammation and stymie - and possibly even reverse - its progression. (qualitycounts.com)

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. (tocris.com)
Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase. (chk1inhibitor.com)

The microenvironment of GBM includes innate immune cells, which are recognized as glioma-associated microglia/macrophages (GAMs) ( 2 ). (amegroups.org)

The decision to commit to a new round of cell division occurs when the cell activates cyclin-CDK-dependent transcription which promotes entry into S phase. (wikipedia.org)
Progression to wet AMD occurs in about 10% of dry AMD patients. (frontiersin.org)

The atherosclerotic process is accelerated by a myriad of factors, such as the release of inflammatory chemokines and cytokines, the generation of reactive oxygen species (ROS), growth factors, and the proliferation of vascular smooth muscle cells. (hindawi.com)
The research showed that fenbendazole induces reactive oxygen species and causes cell death of lymphoma cells but does not harm the normal spleen cells. (cancer.news)

This data-driven approach revealed the comprehensive "structure" of the cell cycle: a continuum of molecular states that cells occupy as they transition from one cell division to the next, or as they enter or exit cell cycle arrest. (bvsalud.org)

Our results caution that this coordination between invasion and cell cycle must be considered when designing effective chemotherapies. (biorxiv.org)
Additionally, the drug inhibited cell migration, preventing further invasion of GBM cells. (cancer.news)

DNA DAMAGE, or the deficiencies in specific cellular components or nutrients may cause the cells to halt before progressing through G1 phase. (umassmed.edu)
This receptor is found in moderate levels on some normal cells and as the gene's name implies, it is involved in cellular responses to growth factors. (cancerquest.org)
Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
Cellular senescence is characterized by an irreversible and permanent cell cycle arrest coupled with altered transcriptome and secretome. (frontiersin.org)
Cellular mechanisms that ensure that all events occuring during specific times in the CELL CYCLE are completed and without mistakes prior to progression to the next phase of the cell cycle. (nih.gov)
Restriction points receive signals from central- and peripheral cellular networks to determine subsequent cell fate. (janechin.net)
Lysosomes are organelles within cells that are specialized for the digestion of cellular debris. (oregonstate.edu)

It was earlier thought that cannabinoids exert their physiologic and behavioral effects via nonspecific interaction with cell membranes. (aacrjournals.org)
Viable cells with intact membranes exclude PI, whereas dead and damaged cells with broken membranes are permeable to PI. (hsp90-inhibitors.com)
It also functions as an antioxidant in cell membranes and lipoproteins . (oregonstate.edu)
Coenzyme Q 10 is soluble in lipids (fats) and is found in virtually all cell membranes , including mitochondrial membranes. (oregonstate.edu)
In its reduced form (CoQ 10 H 2 ), coenzyme Q 10 is an effective fat-soluble antioxidant that protects cell membranes and lipoproteins from oxidation . (oregonstate.edu)
CoQ 10 H 2 has been found to inhibit lipid peroxidation when cell membranes and low-density lipoproteins (LDL) are exposed to oxidizing conditions. (oregonstate.edu)

D) Cytoplasmic and nuclear ZKSCAN5 protein levels in two types of breast cancer cell lines, ZR75-1 and MDA-MB-231. (bms-911543.com)

Human ovarian cancer cell lines TOV21G (representing clear cell ovarian carcinoma) and TOV112D (representing endometrioid adenocarcinoma) were purchased from American Type Culture Collection (Manassas, VA). The human ovarian epithelial-serous cell line COV504 was purchased from Sigma Aldrich (St. Louis, MO). (biomedcentral.com)
Fenbendazole, for example, possesses at least twelve anti-cancer mechanisms of action and has been proven effective against a host of different cancers, including colorectal cancer cells, leukemia, breast cancer, lymphomas and ovarian cancer. (cancer.news)
In the end, the drug decreased cell proliferation of both chemo-sensitive and chemo-resistant ovarian cancer cells. (cancer.news)

Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)
Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
This is because cancer cells maintain high basal level of ROS, thus they are vulnerable to any further increase in ROS (Fig. 1 ). (degruyter.com)
In the study, " Redox-mediated Anticancer Activity of Anti-parasitic Drug Fenbendazole in Triple-negative Breast Cancer Cells," researchers tested fenbendazole on triple negative breast cancer cells, including a highly metastatic type. (cancer.news)
In another 2023 study , the drug was tested on mouse lymphoma and spleen cells to see if there was differentiation between killing cancer cells and preserving healthy spleen cells. (cancer.news)
In a 2022 study, fenbendazole was tested against chemo-resistant colorectal cancer cells . (cancer.news)
In addition, the drug causes autophagy, necroptosis and ferroptosis, killing off even the most resistant cancer cells. (cancer.news)
Statistical Analyses Statistical significance was assessed by using the two-tailed Students in breast cancer cells. (bms-911543.com)
B) Luciferase reporter gene detection in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with expression in ZR75-1 and MDA-MB-231 cells, which were transfected with ZKSCAN5 shRNA, control shRNA, or ZKSCAN5 shRNA plus shRNA-resistant ZKSCAN5 (ZKSCAN5-R). The representative Western blot further showed the expression of ZKSCAN5. (bms-911543.com)
Because ZKSCAN5 improved the secretion of VEGFC by breast cancer cells, the effects of the conditioned medium on HLEC proliferation and migration were investigated in ZKSCAN5 knockdown stable cell lines. (bms-911543.com)
However, cancer cells can become multidrug resistant, a phenomenon due to cells expressing mechanisms that cause simultaneous resistance to many different, structurally and functionally, unrelated drugs [6]. (savedelicious.com)
Increased drug efflux, via these transporters, lowers intracellular drug concentration, allowing cancer cells to escape the toxic effects of the drugs. (savedelicious.com)

Recent studies indicate that nutrient fluctuations and insulin resistance increase proinsulin synthesis in β cells beyond the capacity for folding of nascent polypeptides within the endoplasmic reticulum (ER) lumen, thereby disrupting ER homeostasis and triggering the unfolded protein response (UPR). (jci.org)

An aggressive HeLa, a metastatic ME-180 and a primary SiHa cell lines were purchased from ATCC (USA, MD). Camptothecin was supplied by Calbiochem® and cannabidiol was purchased from Sigma-Aldrich and used as a standard reference. (biomedcentral.com)

A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. (umassmed.edu)
We advance the hypothesis that antigen presentation by beta cells, their stress responses and functional heterogeneity are critical factors that will provide clues towards solving the enigma posed by islet autoimmunity in type 1 diabetes. (springer.com)

Results obtained indicate that both cannabidiol and Cannabis sativa extracts were able to halt cell proliferation in all cell lines at varying concentrations. (biomedcentral.com)

We assessed the transcription ranges of EGFR, HIF-1A, AKT1 and RAF-1 by real-time RT-PCR following A549 or GLC-82 cells were taken care of with 17-AAGorDMSO for 24 h. (hsp90-inhibitors.com)

Those complexes, in turn, activate different downstream targets to promote or prevent cell cycle progression. (wikipedia.org)

Anatomy22

Organisms10

Diseases8

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes82

Disciplines and Occupations1

Information Science3

Health Care1

Apoptosis25

Checkpoints13

Disease progression3

Induces cell cycle arrest1

Regulates3

Proteins13

Tumor cells4

Mitotic2

Mitosis4

Survival10

Metastasis3

Pathways8

Genes11

Replication fork2

Inhibition5

Receptors6

Inhibitors2

Regulate2

Dysregulation1

Apoptotic2

Enzymes2

Oxidative stress3

Embryonic2

Processes4

Therapeutic2

Vivo4

Cyclin depende2

Tumour1

Spindle2

Orderly2

Angiogenesis1

Ovulatory1

Selective1

Chemotherapy4

Regulation4

Prevention2

Regulatory4

Inhibits1

Restriction point3

Proliferative4

Mammalian cell1

Granulosa cells5

Senescent cells5

Endothelial cells2

Glioblastoma cells1

Regulators2

Tumors3

Tightly1

Inflammation3

Stages of the cell cycle2

Microenvironment1

Occurs2

Reactive oxygen2

Transition1

Invasion2

Cellular7

Membranes6

Protein levels1

Ovarian cancer3

Cancer cells14

Synthesis1

Metastatic1

Responses2

Concentrations1

Transcription1

Targets1