• Fifteen micromoles of purvalanol induced a reduction in cell viability by 20 and 35% within 24 and 48 h, respectively. (spandidos-publications.com)
  • In this study, we examined the effects of quercetin on cell cycle, viability, and proliferation of cancer cells, either singly or in combination with the microtubule-targeting drugs taxol and nocodazole. (vdocuments.net)
  • Quercetin also partially restored drug-induced loss in viability of treated cells for up to 72 h. (vdocuments.net)
  • Ca9-22 and YD-10B human OSCC cells were treated with 0.25% or 0.5% Sangju honey, and the cell viability was examined using the Cell Counting Kit-8 assay. (jcpjournal.org)
  • Sangju honey reduced cell viability, induced morphological changes, and significantly suppressed the proliferation and migration of Ca9-22 and YD-10B cells. (jcpjournal.org)
  • Knockdown of PERK or IRE1α significantly decreased DEH-induced autophagy and retrieved cell viability in cells treated with DEH. (biomedcentral.com)
  • To investigate P. paniceum 's anticancer ability, HCT116 and HT29 cell lines were treated with a water extract containing P. paniceum , and then the cell viability was examined using the trypan blue exclusion method which were compared to HEK293 (non-cancerous cells). (wjon.org)
  • Treatment with P. paniceum caused a loss of cell viability in HCT116 and HT29 cells (not found in HEK293), which had an IC 50 (half-maximal inhibitory concentration) of 1,156.2 and 1,207.0 µg/mL, respectively. (wjon.org)
  • Under this problem, p53-positive cells exhibited arrest in the G1 stage, whereas p53-null cells inserted the S stage and dropped their viability due to the deposition of DNA harm, recommending that MCMBP is certainly a potential focus on for eliminating p53-deficient malignancies. (treatmentforprostatecancer.info)
  • We have shown that colorectal cancer cell lines defective in DNA MMR exhibit an increased sensitivity to both camptothecin, a topoisomerase I inhibitor, and etoposide, a topoisomerase II inhibitor. (aacrjournals.org)
  • Normal human colon epithelial cell NCM460, human colorectal cancer cell lines (HCT 116 and SW620) and human embryonic renal cell lines (293 FT) were purchased from the American Type Culture Collection (ATCC, USA) and stored in our laboratory. (biomedcentral.com)
  • In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. (frontiersin.org)
  • Our findings revealed that different genetic backgrounds of HCT116 and HT29 cell lines resulted in divergent responses to the combination treatments. (frontiersin.org)
  • We found that P. paniceum significantly inhibited the proliferative function of HCT116 and HT29 cells. (wjon.org)
  • Moreover, P. paniceum could decrease the migration of HCT116 and HT29 cancer cells. (wjon.org)
  • We found that 125 I seeds radiation activated PI3K/AKT signaling pathway and could trigger paraptosis-like cell death. (hindawi.com)
  • Moreover, inhibitor of PI3K/AKT signaling pathway could inhibit paraptosis-like cell death induced by 125 I seeds radiation. (hindawi.com)
  • Our data suggest that 125 I seeds radiation can induce paraptosis-like cell death via PI3K/AKT signaling pathway. (hindawi.com)
  • IRE1α-XBP1 were essential for expansion of activated mouse and human NK cells and are situated downstream of the mammalian target of rapamycin signaling pathway. (cancerindex.org)
  • Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)
  • VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)
  • Sangju honey inhibits Ca9-22 and YD-10B cell proliferation by regulating EMT, inducing apoptosis, and suppressing the MAPK signaling pathway. (jcpjournal.org)
  • Collectively, RPL5 promoted colon cell proliferation and migration, at least in part, by activating the MAPK/ERK signaling pathway. (biomedcentral.com)
  • RPL5 promoted colon cell proliferation and migration, at least in part, by activating the MAPK/ERK signaling pathway, which may serve as a novel therapeutic target for cancers in which MAPK/ERK signaling is a dominant feature. (biomedcentral.com)
  • Here, we demonstrate that RPL5 promotes COAD cell proliferation and migration via the MAPK/ERK signaling pathway. (biomedcentral.com)
  • In the present study, our aim was to determine the time-dependent, ER-mediated apoptotic and autophagy induction of purvalanol in HCT 116 colon cancer cells. (spandidos-publications.com)
  • however, purvalanol triggered autophagy, which functions as a cell survival mechanism at early time-points. (spandidos-publications.com)
  • Autophagy is a major catabolic process that maintains cell metabolism by degrading damaged organelles and other dysfunctional proteins via the lysosome. (koreascience.kr)
  • Moreover, DEH induced strong cellular autophagy, which could be inhibited through autophagic inhibitors, with a rction in the DEH-induced inhibition of cell growth in colorectal cancer cells. (biomedcentral.com)
  • Methods and Materials Cell culture ARN8 cells,40 MCF7 cells (ATCC, Teddington, UK) and HNDFs (no. we discuss the implications of our findings in cancers cell and therapy reprogramming. (cyberdakwah.net)
  • As recommended above, TSA triggered a small decrease in HDM2 mRNA amounts in MCF7 and HCT116 cells cotreated with Nutlin-3 that might be explained by a little decrease in synthesis of p53. (cyberdakwah.net)
  • Results The cytotoxic activity was performed against Huh7, MCF7 and HCT116 cancer cell lines using sulforhodamine B assay. (dntb.gov.ua)
  • Some of the synthesized Schiff bases show significant to moderate antiproliferative properties against MCF7 (breast), HCT116 (colon), and PaCa2 (pancreatic) cancer cell lines with potency compared to reference drugs 5-fluorouracil (5-FU) and Sunitinib. (aucegypt.edu)
  • Among all, compound 17 f (3-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)-1-((1-(2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methyl)-5-methylindolin-2-one) exhibits promising antiproliferative properties against the MCF7 cancer cell line with 2.1-fold more potency than Sunitinib. (aucegypt.edu)
  • The highly tumorigenic cell line HCT116 up-regulates TGFα mRNA expression during growth arrest, whereas the poorly tumorigenic growth factor-dependent FET cell line down- regulates TGFα mRNA expression as it becomes quiescent. (elsevierpure.com)
  • The abberant upregulation of TGFα mRNA in quiescent HCT116 cells may allow them to return to the dividing state under more stringent conditions (nutrient replenishment alone) then quiescent FET cells (requires nutrients and growth factors). (elsevierpure.com)
  • Panobinostat therapy significantly repressed mRNA for DNMT1 and DNMT3a in the two cell lines while no modifications had been observed in DNMT3b levels. (thrombininhibitors.com)
  • Nevertheless, although this little reduction in p53 synthesis by TSA may be the root trigger, it isn't enough to comprehend our observations on PIG3 and P21 mRNA amounts, that the unwanted effects of TSA in Nutlin-3 cotreated cells had been a lot more pronounced. (cyberdakwah.net)
  • New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
  • However, in recent years, there has been increasing evidence that metformin exerts its anticancer effects through the inhibition of oxidative phosphorylation (OXPHOS) of tumor cell mitochondria, and metabolic pathways based on metformin targeting have only recently become the focus of intensive research. (spandidos-publications.com)
  • The dichloromethane extract from the bark of Aglaia lanuginose showed cytotoxicity against HL-60 leukaemia cell line (45% inhibition) at 20 µg/ml and was prioritised for further investigation. (afpm.org.my)
  • Our findings indicated that treatment with DEH arrested the cell cycle of colorectal cancer cells at the G1/S phase, leading to significant inhibition in cell growth. (biomedcentral.com)
  • Targeting of receptor tyrosine kinase pathways results in the inhibition of angiogenesis and cell proliferation that validates kinases as a key target in the management of aggressive cancers. (dntb.gov.ua)
  • In addition, compound 17 f also showed high VEGFR-2 inhibition properties against breast cancer cell lines. (aucegypt.edu)
  • The cells have an epithelial morphology and can metastasize in xenograft models. (wikipedia.org)
  • In this study, the anti-tumor activity of DEH on colorectal cancer was investigated through both the cell-derived xenograft (CDX) and patient-derived tumor xenograft (PDX) model. (biomedcentral.com)
  • To assess the effects of EOPK on cell migration, we performed a wound-healing assay. (biomedcentral.com)
  • Cell morphology studies were conducted to observe morphological changes, and the wound-healing assay was performed to evaluate the proliferation of honey-treated OSCC cells. (jcpjournal.org)
  • Apoptosis induction, cell cycle distribution, and migration abilities were assessed by cell death detection enzyme-linked immunoassay (ELISA), flow cytometry, and wound healing assay. (wjon.org)
  • Some compounds showed potent anticancer activities and three of them were chosen for further evaluation on liver cancer cell lines based on SRB assay and real-time cell growth tracking analysis. (dntb.gov.ua)
  • Open up in another window Amount 8 Nutlin-3 decreases TSA's capability to trigger G2/M arrest and endoreduplication in tumor cells but will not defend tumor cells from TSA-mediated cytotoxicity. (cyberdakwah.net)
  • However, today, it is well known that paclitaxel can induce multiple kinds of cell death in cancers. (biomed.news)
  • Senescence is a stress-response cellular state characterised by proliferative arrest but active metabolism ( 7 ). (frontiersin.org)
  • The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc. (cancerindex.org)
  • Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
  • HCT116 cells can also function in xenografts, with docetaxel, 5-FU, and flavopiridol limiting tumor growth in vitro. (wikipedia.org)
  • Further, a recent report on the effects of EOPK indicated that the oil has anti-obesity and hypolipidemic activity in vitro and in vivo , using 3 T3-L1 cells and high fat diet-fed rats [ 16 ]. (biomedcentral.com)
  • This study examines the effect of RPL5 on the progression of colon adenocarcinoma (COAD), including cell proliferation, migration and determines its underlying molecular mechanism using CRC cell lines in vitro. (biomedcentral.com)
  • Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
  • Moreover, we determined that during purvalanol-mediated ER stress, autophagic machinery was also activated prior to apoptotic cell death finalization. (spandidos-publications.com)
  • Olomoucine, roscovitine and purvalanol are examples of CDK inhibitors (CDKIs) designed and investigated for their apoptotic potential on cancer cells ( 3 ). (spandidos-publications.com)
  • Τheir impact on the apoptotic cell death mechanism requires further elucidation. (spandidos-publications.com)
  • Although purvalanol-induced cell cycle arrest and apoptotic cell death were demonstrated in prostate ( 5 ), breast ( 6 ) and colon cancer cells ( 7 ), the exact molecular mechanism of purvanol-induced apoptosis has not been elucidated yet. (spandidos-publications.com)
  • Moreover, the expression of AIP1 is specifically inhibited in paraptosis cells, while it is not affected in apoptotic cells [ 15 ]. (hindawi.com)
  • Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great interest. (nature.com)
  • In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. (researchsquare.com)
  • The expression of pro-apoptotic proteins and anti-apoptotic proteins in MCF-7 and MDA-MB-231 cells was investigated by Western blotting. (researchsquare.com)
  • Therefore, we aimed to demonstrate the potential anticancer effects of Sangju honey on human oral squamous cell carcinoma (OSCC), particularly focusing on epithelial-mesenchymal transition (EMT) and apoptotic and mitogen-activated protein kinase (MAPK) signaling pathways. (jcpjournal.org)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
  • CDKs show their action by interacting with cyclins and different CDK-cyclin complexes regulate the cell cycle in the G1, S and G2/M phases ( 1 ). (spandidos-publications.com)
  • Purvalanol is a purine-derived CDKI that binds with a high selectivity and competitively to the ATP binding side of CDK1/2 and leads to G2/M cell cycle arrest ( 4 ). (spandidos-publications.com)
  • Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
  • Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
  • To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
  • In addition, some of the MMR components participate in recombination and double-strand break repair as well as cell cycle regulation and apoptosis. (aacrjournals.org)
  • Our results also indicate that neither p53 status, nor cell cycle alterations correlate with the sensitivity of colorectal cancer cells to topoisomerase inhibitors. (aacrjournals.org)
  • The effects of VALD-3 on the cell cycle were analyzed in MCF-7 and MDA-MB-231 cells by PI single staining. (researchsquare.com)
  • Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
  • This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
  • This antagonism of microtubule-targeting drugs was accompanied by a delay in cell cycle progression and inhi- bition of the buildup of cyclin-B1 at the microtubule organizing center of treated cells. (vdocuments.net)
  • Cell cycle analysis was performed by using Muse cell analyzer. (esmo.org)
  • Cell cycle analysis showed that silencing LION causes G2/M phase arrest in cell cycle, suggesting that LION functions to promote G2/M transition. (esmo.org)
  • Mechanistic studies revealed this molecule results in cell cycle arrest, and FACS analysis demonstrated the induction of apoptosis. (dalriadatx.com)
  • Knockdown of RPL5 significantly inhibited the proliferation and migration of HCT16 and RKO cells, and arrested the cell cycle in G0/G1 phase. (biomedcentral.com)
  • Paclitaxel is known as a chemotherapy drug that can suppress the proliferation of cancer cells by inducing cell cycle arrest and induction of mitotic catastrophe. (biomed.news)
  • To find the mechanism that exerts a suppressive proliferation effect on P. paniceum , we determined the DNA fragmentation and cell cycle distribution. (wjon.org)
  • We also found that P. paniceum treatment increased apoptosis and arrested of the cell cycle at G0/G1 remarkably when compared with the control group. (wjon.org)
  • The cell cycle perturbation analysis demonstrated severe DNA damage (G2/M arrest) pointing to a potential DNA alkylating ability of 3. (irb.hr)
  • Compound 17 f exhibited the highest anti-angiogenic effect on the vasculature as it significantly reduced BV from 43 mm to 2 mm in comparison to 5.7 mm for Sunitinib and flow cytometry supports the arrest of the cell cycle at G1/S phases. (aucegypt.edu)
  • Also, a lot of studies has been conducted to investigate the effectiveness of Ginger in preventing cancer or suppressing the growth of the tumour in different cancer types like lymphoma, colorectal cancer, breast cancer, skin cancer, liver cancer, bladder cancer by mechanisms like apoptosis, reducing cell proliferation, cell-cycle arrest, and suppressing activator protein (AP-1) & NF-κB/COX-2 signaling pathways. (zenonco.io)
  • We have identified a 25-bp sequence at -201 to -225 within the TGFα promoter which mediates the differential regulation of TGFα expression during quiescence establishment in these two cell lines. (elsevierpure.com)
  • Al- though quercetin induced cell death in a dose-dependent manner, 12.5-50 µ M quercetin inhibited the activity of both taxol and noco- dazole to induce G2/M arrest in various cell lines. (vdocuments.net)
  • The expression of E-cadherin and N-cadherin was increased and decreased, respectively, in both OSCC cell lines. (jcpjournal.org)
  • The expression level of RPL5 in colon cancer tissues and cell lines was significantly higher than that in adjacent tissues and NCM460 cells, respectively, and its expression level was higher in HCT116 cells and RKO cells. (biomedcentral.com)
  • In this scholarly study, we present proof that MAGI proteins, structural the different parts of AJC whose function continued to be unclear, regulate apical constriction of epithelial cells through the Par polarity proteins. (aboutsciencenow.info)
  • By coupling the adhesion equipment towards the polarity proteins to modify mobile contractility, we suggest that MAGIs play important and central tasks in maintaining stable state intercellular pressure through the entire epithelial cell sheet. (aboutsciencenow.info)
  • Right here, we propose a molecular system where AJC scaffolding proteins control apical cell contractility by differentially recruiting MAGI-1 and MAGI-3 to apical AZD-3965 junctions. (aboutsciencenow.info)
  • Therefore, we exposed the MAGIs are crucial regulators of Par polarity proteins that are central towards the rules of pressure distribution in epithelial cells homeostasis. (aboutsciencenow.info)
  • Results Lack of ZO proteins highly perturbs Par-3 localization and alters apical morphology We previously demonstrated that depletion of ZO proteins in the mouse mammary epithelial cell range, EpH4, delays the forming of the contractile belt-like AJ18, recommending that ZO proteins are necessary for epithelial polarization. (aboutsciencenow.info)
  • Open up in another windowpane Fig. 1 Lack of ZO proteins dysregulates ROCK-dependent contractility to improve apical morphology.a Consultant immunofluorescence pictures of ZO-1 and WT, dKO cells stained for activated -catenin -2. (aboutsciencenow.info)
  • Cellular therapy of liver pathologies is a complex multistage process requiring a thorough understanding of the molecular mechanisms occurring in liver cells during differentiation and regeneration. (actanaturae.ru)
  • An analysis of the current cellular therapy for liver pathologies is presented, the use of various cell types is described, the main molecular mechanisms of hepatocyte differentiation are analyzed, and the challenges and prospects of cell therapy for liver disorders are discussed in this review. (actanaturae.ru)
  • The status of cell adherence to growth ma- trix was critical in determining the sensitivity of HCT116 cells to quercetin. (vdocuments.net)
  • Bile acid treatment also increased the expression of KLF5, CDX2, MUC2 and villin in esophageal epithelial cells in a time-dependent manner. (jcancer.org)
  • We noticed elevated immunofluorescence strength from the 18 antibody staining, which can be specific to triggered -catenin conformation under tensile stress, in ZO-1,-2 DKO cells (Supplementary Fig.?S1a, b). (aboutsciencenow.info)
  • Scale pub, 20?m. b Representative immunofluorescence pictures of the co-culture of ZO-1 and WT,-2 Cldn5 DKO cells stained for phosphorylated MLC (pMLC, magenta) and ZO-1 (green). (aboutsciencenow.info)
  • Size pub, 10?m. c Cross-junctional range scans (pMLC) from immunofluorescence pictures of WT and ZO-1,-2 DKO cells stained for pMLC and triggered -catenin. (aboutsciencenow.info)
  • Natural polyamines, putrescine, spermidine and spermine, play essential roles in the regulation of cell growth and proliferation. (spandidos-publications.com)
  • Thus, our results identify an unexpected function of SGO2 in mitotically dividing cells and a mechanism of separase regulation that is independent of securin but still supervised by the SAC. (nature.com)
  • Transcriptome and chromatin immunoprecipitation analysis revealed c-Myc as a new and direct downstream target of XBP1 for regulation of NK cell proliferation. (cancerindex.org)
  • In this study, we showed that LION is involved in the transcriptional regulation of INK4 locus and cell proliferation. (esmo.org)
  • Despite the short-term protection of cells by quercetin, colony formation and clonogenicity of HCT116 cells were still suppressed by quercetin or quercetin- taxol combination. (vdocuments.net)
  • Sirtuins are NAD + -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. (biomedcentral.com)
  • Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
  • In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
  • The goal of this study was to investigate the anti-cancer mechanism of EOPK in HCT116 colorectal cancer cells. (biomedcentral.com)
  • The latter mechanism facilitates a considerable degree of sister chromatid separation in securin-knockout cells that lack APC/C activity. (nature.com)
  • The mechanism of antiproliferative effect of 5-(2-chloroethyl)-substituted pyrimidine 3 that exerted the pronounced cytostatic activity was studied in further details on colon carcinoma (HCT116) cells. (irb.hr)
  • These observations recommended to us that apical cell junctions of cells in the ZO-1,-2 DKO cell sheet had been AZD-3965 put through unbalanced tensile stress from encircling cells. (aboutsciencenow.info)
  • SPIN1 ablation activates p53, suppresses cell growth, reduces clonogenic ability, and induces apoptosis of human cancer cells. (elifesciences.org)
  • HCT116 cells have a mutation in codon 13 of the KRAS proto-oncogene, and are suitable transfection targets for gene therapy research. (wikipedia.org)
  • When transducted with viral vectors carrying the p53 gene, HCT116 cells remain arrested in the G1 phase. (wikipedia.org)
  • HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1α gene expression, eIF-2α phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. (spandidos-publications.com)
  • This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
  • PAKs are downstream effectors of the Rho family GTPases, which regulate cell motility and survival. (biomedcentral.com)
  • Activated PAK1 enhances cell survival and migration via the AKT pathway, and stimulates transformation through the Ras/Raf/ERK/MAPK pathway. (biomedcentral.com)
  • It is shown that overexpression of the RAD51 protein is correlated with increased survival of cancer cells to cancer treatments. (univ-nantes.fr)
  • EOPK significantly decreased HCT116 cell proliferation and migration, and induced G1 arrest without affecting normal cells. (biomedcentral.com)
  • Our studies indicate that EOPK significantly reduced proliferation and migration of colorectal cancer cells. (biomedcentral.com)
  • By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
  • P. paniceum did not possess any toxicity (cytotoxic and mutagenic) but has the potential for anticancer activity against human colorectal cells by increasing apoptosis, which leads to the suppression of cell proliferation. (wjon.org)
  • It has been observed that ginger extract and, in particular [6]-gingerol effectively reduced the proliferation of YYT colon cancer cells (a cell line) and the angiogenic activity in immortalized MS1 endothelial cells [14]. (zenonco.io)
  • It has been observed that [6]-gingerol suppresses the Reactive oxygen species (ROS) that invades the AH109A cells (ascites hepatoma) by subduing the peroxide levels [ 12 ]. (zenonco.io)
  • Furthermore, it was found that the knockout of MARCH2 limited growth of HCT116 cells via stress on the endoplasmic reticulum. (wikipedia.org)
  • In the 1920s, Otto Heinrich Warburg discovered that cancer cells, unlike normal cells, use the glycolytic pathway to obtain energy for growth even in the presence of oxygen, which is a phenomenon known as 'aerobic glycolysis' or the Warburg effect ( 9 ), and aerobic glycolysis is a common metabolic phenotype in NSCLC ( 11 ). (spandidos-publications.com)
  • Autocrine transforming growth factor α (TGFα) is an important positive growth effector in maligant cells and plays a significant role in generating the growth factor-independent phenotype associated with malignant progression. (elsevierpure.com)
  • Thus, we identify bimodal activity of the flavonoid quercetin, a short-term activity that is cytoprotective against chemotherapeutic drugs and a long-term activity that is inhibitory to cancer cell growth. (vdocuments.net)
  • In summary, the present study demonstrated that PT and ATST produce a powerful synergistic interaction in suppressing colon cancer cell growth. (epiphanyasd.com)
  • HCT116 is a human colon cancer cell line used in therapeutic research and drug screenings. (wikipedia.org)
  • 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced on VALD-3. (researchsquare.com)
  • Human esophageal squamous epithelial (HET-1A) cells were treated with bile acid and used in transfection experiments. (jcancer.org)
  • Human non-small cell lung cancer cell H1299 and colorectal cancer cell HCT116 were transfected with siRNA oligonucleotides against LION. (esmo.org)
  • The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)
  • Therapeutic approaches that target the metabolism of tumor cells have been a popular research topic in recent years. (spandidos-publications.com)
  • However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. (spandidos-publications.com)
  • Given the vast differences in metabolism between healthy and tumor cells, there is hope that selective targeting of tumor metabolism may be achieved while limiting toxicity to healthy tissue. (spandidos-publications.com)
  • The most striking and characteristic metabolic alteration in cancer cells is anomalous glucose metabolism and cancer cells tend to utilize glycolysis to obtain energy even under aerobic conditions via a process called 'aerobic glycolysis' ( 9 ). (spandidos-publications.com)
  • We further focused our interest on the molecular mechanisms that underlie 125 I seeds radiation-induced paraptosis on colorectal cancer cells. (hindawi.com)
  • It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] ( 13 ), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma. (spandidos-publications.com)
  • We examined the effect of the cotreatment of cancer cells with the flavonoid quercetin and 2 antimicrotubule drugs, namely, taxol and nocodazole. (vdocuments.net)
  • The depletion of ANRIL inhibits the proliferation of cancer cells such as non-small cell lung cancer and colorectal cancer, indicating that ANRIL functions to promote cancer cells proliferation. (esmo.org)
  • RT-PCR analysis showed that LION is highly expressed in several cancer cells such as non-small cell lung cancer, cervical cancer and colorectal cancer compared with normal lung fibroblasts. (esmo.org)
  • LION is involved in the promotion of cancer cells proliferation such as H1299 and HCT116 cells via regulating p15, p16 and other genes related to G2/M phase control. (esmo.org)
  • 4156 - Triple blockade of EGFR, MEK and PD-L1 as effective antitumor treatment in PD-L1 overexpressing, MEK inhibitor resistant colon cancer cells. (esmo.org)
  • Chemoresistance of cancer cells is a major problem in treating cancer. (biomed.news)
  • Knowledge of how cancer cells may die or resist cancer drugs is critical to providing certain strategies to overcome tumour resistance to treatment. (biomed.news)
  • However, among all the synthesized compounds, three (5-methylisatin derivatives) were the most effective against HCT116 in comparison to 5-FU. (aucegypt.edu)
  • MAGI ortholog localizes apically to cadherin-based adhesions and its own loss qualified prospects to actin disorganization and decreases the entire robustness of cell adhesions in the embryonic epidermis14,15. (aboutsciencenow.info)
  • Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
  • Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
  • We hypothesized an additive or a synergistic effect with this drug-flavonoid com- bination, but unexpectedly, quercetin protected cells from the activity of these antimicrotubule drugs and sustained the via- bility of the cells. (vdocuments.net)
  • P. paniceum also inhibits cell migration and exerts antimutagenicity, thereby suggesting that P. paniceum might be useful for colorectal cancer treatment. (wjon.org)