AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
Myocardial Reperfusion InjuryReperfusion InjuryMyocardial IschemiaMyocardiumIschemiaMyocardial ReperfusionReperfusionMyocytes, CardiacBrain IschemiaIschemic Preconditioning, MyocardialHeartCardiotonic AgentsMyocardial InfarctionRats, Sprague-DawleyRats, WistarDisease Models, AnimalIschemic PreconditioningTime FactorsMitochondria, HeartArrhythmias, CardiacMyocardial ContractionElectrocardiographyElectrocardiography, AmbulatoryPerfusionCoronary CirculationAmobarbitalCreatine KinaseVentricular Function, LeftIschemic PostconditioningHeart Arrest, InducedReceptor, Adenosine A3HemodynamicsMice, Inbred C57BLWarm IschemiaApoptosisCardiovascular AgentsCardiac OutputHeart VentriclesReactive Oxygen SpeciesPeroxidaseCold IschemiaChest PainProtective AgentsRabbitsIschemic Attack, TransientMalondialdehydeOxidative StressCoronary VesselsCoronary DiseaseCells, CulturedInfarction, Middle Cerebral ArteryExercise TestNeuroprotective AgentsNecrosisDogsKidneyOxygenBiological MarkersL-Lactate DehydrogenaseConstrictionCardiac Surgical ProceduresRandom AllocationSpinal Cord IschemiaMice, KnockoutAdenosine TriphosphateHeart FailureDeath, Sudden, CardiacCytoprotectionSuperoxide DismutaseCoronary AngiographyAntioxidantsTreatment OutcomeModels, AnimalNitric OxideLiverNeutrophil InfiltrationMyocardial StunningHeart RateHeart Function TestsTioproninGuinea PigsOrgan PreservationGerbillinaeBlood PressureAcute Kidney InjuryProspective StudiesAspartate AminotransferasesSignal TransductionBlotting, WesternMicrocirculationVentricular PressureDecanoic AcidsHydroxy AcidsIn Situ Nick-End LabelingAlanine TransaminaseFree Radical ScavengersEnzyme InhibitorsCardiomegalyCerebral InfarctionHindlimb
Myocardial injuryHypoxiaCerebral ischemiaIschemicMyocardiumInjury followiDysfunctionOxidativePost cardiac arrestCardiopulmonary bypassResuscitation from cardiac arrestSurvival2021Asphyxial cardiac arrestAttenuateExtracorporeal membrane oxSuddenRenalApoptosisArterialSurgeryMyocytesTherapeutic targetOxygenCoronary heart dCardioplegic arrestTransplantationPathophysiologyPathophysiologicalCritically ill patientsPatients with cardiacReturn of spontaneous circulationAdultsOrganNeurologicComplicationIntravenousSeverityIncidenceSignificantlySurvivorsCirculationAcuteOutcomeElectiveOccurrenceMetabolic demandMortalityInotropicIntralipidInfarctStrokeClinicalHeartMurinePathologicalHypothermia
Myocardial injury3
  • The expression levels of the myocardial injury marker cardiac troponin I (CTNI) in serum were tested at 6 hours after CPR or TMZ + CPR. (dirjournal.org)
  • In contrast, myocardial injury and cardiac function were greatly improved with the increase of ATP in the CPR + TMZ group. (dirjournal.org)
  • Hearts from DCD donors have not been utilized as there is a fear that they will have sustained irreversible myocardial injury post cardiac arrest. (whiterose.ac.uk)
Hypoxia7
  • The pathophysiological nature of MIRI is the short-term disturbance of myocardial energy and metabolism caused by reflow after ischemia and hypoxia in the coronary artery and the dynamic changes in apoptosis and the prosurvival signaling pathways in response to related injury factors. (hindawi.com)
  • The team at Mitovation has identified a non-invasive therapeutic treatment in the prevention of brain injuries caused by hypoxia and ischemia reperfusion injury including cardiac arrest resucitation. (teknateam.com)
  • During resuscitation, the brain is exposed to hypoxia and ischaemia , and when circulation is re-established, reperfusion may cause further injury. (dicardiology.com)
  • Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
  • Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
  • We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
  • Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
Cerebral ischemia5
Ischemic8
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • Cryonics patients frequently experience ischemic & reperfusion injury between the time when the heart stops and cryostorage begins. (benbest.com)
  • In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
  • I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
  • Excessive glutamate release resulting in excessive Ca +2 entry into cells is the excitotoxicity which initiates the brain ischemic damage seen in stroke and cardiac arrest. (benbest.com)
  • When after an ischemic event reperfusion is induced, which happens for instance during organ transplantation or resuscitation after cardiac arrest, this reperfusion can paradoxically cause additional damage to the affected tissue. (tu-dresden.de)
  • To determine the mechanism(s) responsible for decreased coronary flow after global cardiac ischemia and reperfusion, we studied 40 isolated rabbit hearts before and after 30 minutes of normothermic ischemic arrest and reperfusion. (elsevierpure.com)
  • On admission, her EKG did not show ischemic changes and her cardiac enzymes were negative. (ctsnet.org)
Myocardium6
  • 7 The metabolism of fatty acids and glucose undergoes adaptive changes in the myocardium due to ischemia-reperfusion injury after cardiopulmonary resuscitation (CPR). (dirjournal.org)
  • This coupled comorbidity of pathological ischemia and therapeutic reinjury of infarcted myocardium, namely, myocardial ischemia-reperfusion injury (MIRI), is particularly refractory to treatment [ 4 , 5 ]. (hindawi.com)
  • During injury stimulation, the major effects on the cardiac function may be those involving mitochondria-dominated events along with potential nucleus-governed genetic/epigenetic alternations within the cardiomyocytes as well as the macrophage-led inflammation and T-cell-led immune responses underlying the myocardium-vessel interactive cascade. (hindawi.com)
  • The del Nido cardioplegia solution was developed for pediatric cardiac surgery due to the specific needs of an immature and developing myocardium. (ccasociety.org)
  • These solutions induce a hyperpolarizing arrest of the myocardium which decreases energy consumption and intracellular accumulation of Ca 2+ . (ccasociety.org)
  • CABG may be performed as an emergency procedure in the context of an ST-segment elevation MI (STEMI) in cases where it has not been possible to perform percutaneous coronary intervention (PCI) or where PCI has failed and there is persistent pain and ischemia threatening a significant area of myocardium despite medical therapy. (medscape.com)
Injury followi1
  • Elevations in the expression of this enzyme may help to explain the role of the ET system in the pathogenesis of ischaemia/reperfusion injury following cardiac surgery and transplantation. (portlandpress.com)
Dysfunction10
  • To investigate the feasibility and usefulness of 2-deoxy-2-( 18 F)-fluoro-D-glucose positron emission tomography/computed tomography [( 18 F)-FDG PET/CT] as a novel examination in the surveillance of abnormal myocardial energy metabolism and cardiac dysfunction after cardiopulmonary resuscitation (CPR). (dirjournal.org)
  • Myocardial dysfunction remains a leading problem in the early period following the return of spontaneous circulation (ROSC) after cardiac arrest. (dirjournal.org)
  • Some in vitro experiments demonstrated that early intervention in cardiac metabolism disorder attenuated myocardial damage and dysfunction. (dirjournal.org)
  • In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
  • Because the present study identified an association between psychological dysfunction and an increase in long-term mortality, we believe it provides evidence that psychological rehabilitation of patients with out-of-hospital cardiac arrest is crucial," the researchers wrote. (sca-aware.org)
  • Objective: To develop a model of in-vivo cardiac arrest and resuscitation in order to characterize the biology of the associated myocardial dysfunction and test potential therapeutic strategies. (whiterose.ac.uk)
  • There is substantial evidence that endothelial injury during organ procurement and preservation, caused by ischemia and subsequent reperfusion, results in endothelial dysfunction. (frontierspartnerships.org)
  • Cardiac surgery-associated multiorgan dysfunction (CSA-MOD) is well recognized and includes acute kidney injury (AKI), hepatic impairment, myocardial damage, and postoperative neurologic deficit. (silverchair.com)
  • This study aimed to determine whether the avoidance of arterial hyperoxemia decreased oxidative stress and reduced the severity of the multiorgan dysfunction in patients undergoing cardiac surgery utilizing CPB. (silverchair.com)
  • Its unique pharmacological features have created growing interest for adult cardiac surgery, especially for elderly patients or those with ventricular dysfunction who are more prone to ischemia-reperfusion injury. (researchprotocols.org)
Oxidative2
  • 6 Sixty to seventy percent of the energy required for cardiac contraction under normal physiological conditions is mainly furnished by the oxidative metabolism of fatty acids, with the remainder predominantly from glucose. (dirjournal.org)
  • Therefore, early, high-dose i. v. vitamin C is a promising therapeutic intervention after cardiac arrest to diminish the systemic ischemia/reperfusion injury due to overwhelming oxidative stress. (neilriordanivc.com)
Post cardiac arrest3
  • Study author Professor Jacob Moller of Odense University Hospital , Denmark said: "The findings should reassure clinicians that targeting a partial arterial oxygen pressure (PaO2) of 9 to 10 kilopascal (kPa) in post cardiac arrest patients does not cause harm. (dicardiology.com)
  • We have a limited understanding of Post cardiac arrest myocardial depression due to the lack of a good physiological model of the disease. (whiterose.ac.uk)
  • Phase 3: The Metabolic Phase - 10+ minutes post cardiac arrest Around the 10 minute mark, cellular ischemia, or lack of oxygen, begins turning into cellular death. At this point, increasing circulation has little effect, and according to some reports, may have adverse effects. (cprcertificationonlinehq.com)
Cardiopulmonary bypass6
  • Cardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. (neilriordanivc.com)
  • Cardiac surgery utilizing cardiopulmonary bypass (CPB) is one of the most common forms of major surgery. (silverchair.com)
  • The use of cardioplegia solutions as a myocardial protection technique is essential during cardiac surgery with cardiopulmonary bypass. (researchprotocols.org)
  • The del Nido cardioplegia solution (DNS) has been widely used as a myocardial preservation technique for pediatric patients undergoing cardiac surgery with cardiopulmonary bypass. (researchprotocols.org)
  • A total of 474 participants over the age of 18 years undergoing elective cardiac surgery with cardiopulmonary bypass will be assigned to groups by simple randomization to receive either DNS or Cardi-Braun blood cardioplegia solution. (researchprotocols.org)
  • For patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), recent study suggested that severe hyperbilirubinemia (5 times the normal upper limit) instead of mild bilirubin significantly increased patient mortality and a maximum bilirubin of 25.5 mg/dl was associated with 99% mortality [ 14 ]. (biomedcentral.com)
Resuscitation from cardiac arrest2
  • Prognostic determination of patients in coma after resuscitation from cardiac arrest is a common and difficult requirement with significant ethical, social, and legal implications. (medlink.com)
  • Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. (dicardiology.com)
Survival18
  • Because of the common pathophysiological pathway of sepsis and ischemia/reperfusion injury, the potential role of vitamin C for ischemia/reperfusion injury is further supported by the results of preliminary sepsis studies, showing earlier recovery from organ failure and higher survival rates. (neilriordanivc.com)
  • Preceding acute respiratory insufficiency is generally responsible for COVID-19-associated in-hospital cardiac arrest, and patients with COVID-19 who received cardiopulmonary resuscitation after in-hospital cardiac arrest have low survival rates. (medlink.com)
  • however, patients with in-hospital cardiac arrest have a better chance of survival. (medlink.com)
  • Therapeutic hypothermia increases the chances of survival and reduces the risk of neurologic damage following cardiac arrest. (medlink.com)
  • A retrospective study noted that sodium bicarbonate administration was associated with better survival in adult cardiac arrests with nonshockable rhythms and asystole. (medlink.com)
  • However, in pediatric cardiac arrests, sodium bicarbonate administration is associated with lower rates of survival. (medlink.com)
  • Professor Moller said: "BOX shows that targeting restrictive oxygenation in comatose patients resuscitated after out-of-hospital cardiac arrest does not alter survival or neurological outcome compared with targeting liberal oxygenation. (dicardiology.com)
  • Expression of baculovirus p35 can improve survival after cardiac arrest in rats, but the mode and site of action remain to be elucidated. (asahq.org)
  • The next Cardiac Arrest Survival Summit will happen December 7-10, 2021 in San Diego, California. (citizencpr.org)
  • The evolution of ECCU into the Cardiac Arrest Survival Summit continues to provide the quality content and speakers you expect, and now include action-oriented programs and dynamic new content that brings together a broader range of partners working on initiatives to INFORM, MOTIVATE AND ACTIVATE our global community. (citizencpr.org)
  • Network with colleagues, resuscitation leaders and experts, professionals, survivors, community leaders and exhibitors - all working together to improve cardiac arrest survival rates. (citizencpr.org)
  • Come to the Cardiac Arrest Survival Summit and Challenge the Status Quo! (citizencpr.org)
  • The award-winning Town and Country Hotel, located in the heart of San Diego, will again host the Cardiac Arrest Survival Summit, Nov. 29-Dec. 2 . (citizencpr.org)
  • Other general sessions include the American Heart Association ILCOR's 10 Steps to Improve In-Hospital Cardiac Arrest, the American Red Cross's Use of Social Media to Engage and Educate, and how the National Expansion of Cardiac Arrest Registry to Enhance Survival (CARES) Addresses Disparities in Outcomes. (citizencpr.org)
  • In 2002, two randomized clinical trials demonstrated the benefit of therapeutic hypothermia (TH) on neurologically intact survival in patients who were cooled in-hospital for 12 to 24 hours to 32-34°C within few hours from ROSC following an out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF) or ventricular tachycardia (VT) as first rhythm. (medscape.com)
  • [ 18 ] In a retrospective analysis of 542 patients where 208 were treated with intra-arrest cold intravenous fluids, the use of IATH associated with improved ROSC rate but not with increased overall survival to hospital discharge. (medscape.com)
  • The ability to understand these phases and recognize them prior to treatment is important in improving the survival rate for victims of cardiac arrest. (cprcertificationonlinehq.com)
  • To evaluate the number of out-of-hospital cardiac arrest (OHCA) patients eligible for extracorporeal cardiopulmonary resuscitation (ECPR) in Saskatchewan and their clinical outcomes, including survival and neurological outcomes at discharge. (biomedcentral.com)
20213
  • European Resuscitation Council Guidelines 2021: Epidemiology of cardiac arrest in Europe. (dicardiology.com)
  • Kristin received an EMS Cardiac Arrest Save Challenge Coin (2020), the Citizen CPR Foundation's 40 Under 40 award (2021), and the American Heart Association's Resuscitation Champion Award (2022). (citizencpr.org)
  • Our new team IRIS (Ischemia-Reperfusion Injury Syndromes), created by the HCERES in January 2021, gathers a fundamental research group and a clinical research group, which drive together an ambitious translational research program. (univ-lyon1.fr)
Asphyxial cardiac arrest2
  • We used single neuron recordings and controlled whisker deflections to examine responses of thalamocortical neurons to sensory stimulation in rat survivors of 9 min of asphyxial cardiac arrest incurred on post-natal day 17. (cdc.gov)
  • Nine min of asphyxial cardiac arrest was associated with extensive degeneration of neurites in the somatosensory nucleus as well as activation of microglia in the Reticular Nucleus. (cdc.gov)
Attenuate3
  • Midiv-1 has been demonstrated to attenuate the effects of ischemia reperfusion injury after cardiac arrest. (wikipedia.org)
  • To attenuate this, guidelines recommend temperature control with sedation and mechanical ventilation.4 Observational studies have shown that high blood oxygen content is associated with high risk of brain injury and mortality.5 Animal studies have suggested that too much oxygen worsens brain damage after cardiac arrest.6 However, too little oxygen also bears risks. (dicardiology.com)
  • The nitric oxide donor S-nitroso-human-serum-albumin (S-NO-HSA) is known to attenuate myocardial ischemia-reperfusion (I/R)-injury. (frontierspartnerships.org)
Extracorporeal membrane ox1
  • Methods and Results: We developed a rodent model of post arrest myocardial depression (DCD model) using extracorporeal membrane oxygenation for resuscitation, followed by invasive haemodynamic measurements. (whiterose.ac.uk)
Sudden10
  • Sudden cardiac death (SCD) is an unexpected death due to cardiac causes that occurs in a short time period (generally within 1 hour of symptom onset) in a person with known or unknown cardiac disease. (medscape.com)
  • Interplay of various risk factors that can lead to sudden cardiac death. (medscape.com)
  • In general, advanced cardiac life support (ACLS) guidelines should be followed in all cases of sudden cardiac arrest (SCA). (medscape.com)
  • Sudden Cardiac Arrest Foundation's mission is to raise awareness about sudden cardiac arrest and help save lives through education, research, and community. (sca-aware.org)
  • Sudden Cardiac Arrest Foundation is a non-profit organization with a 501(c)(3) tax-exempt status. (sca-aware.org)
  • Sudden cardiac death from cardiac arrest is the most common cause of death. (medlink.com)
  • Together they explore the teachable moment that occurred on January 2, when Buffalo Bills safety Damar Hamlin survived sudden cardiac arrest, caught live on Monday Night Football in front of millions. (citizencpr.org)
  • She called 9-1-1, and the dispatcher recognized that Will was in sudden cardiac arrest. (citizencpr.org)
  • Sudden cardiac death is one of the major health issues of the industrialized world. (medscape.com)
  • Although the cardiac hypertrophy is an adaptive response of the heart that responds to a variety of extrinsic and intrinsic stimuli, prolonged hypertrophy typically culminates in chronic heart failure or sudden cardiac death. (karger.com)
Renal2
  • In the "from bench to bedside" approach, the fundamental research results are obtained from our in vitro and in vivo models, and can lead in fine to clinical trials in humans, as already done for Cyclosporine A in the treatment of myocardial infarct, cardiac arrest, stroke and renal ischemia. (univ-lyon1.fr)
  • Acute renal failure (ARF) commonly occurs after whole body ischemia. (johnshopkins.edu)
Apoptosis3
  • These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)
  • Given the role of caspases in apoptosis, caspase inhibitors may provide neuronal protection after cardiac arrest. (asahq.org)
  • These findings suggest that neuronal apoptosis after cardiac arrest is not primarily initiated by activation of caspases. (asahq.org)
Arterial4
  • Due to the aging of the population and the progression of comorbidity factors like diabetes, obesity and arterial hypertension, the occurrence of ischemia-reperfusion syndromes should continue and even worsen in the next decades. (univ-lyon1.fr)
  • During cardiac surgery with CPB, arterial return blood is oxygenated to supranormal levels. (silverchair.com)
  • The study was a multicenter, open-label, parallel-group, randomized controlled study of the avoidance of arterial hyperoxemia versus usual care in patients undergoing cardiac surgery involving CPB. (silverchair.com)
  • REBOA procedures carrying life-threatening risks such as arterial access complications, organ ischemia, vascular trauma, and time loss ( 2 ) should be critically evaluated in addition to resuscitative laparotomy, thoracotomy with aortic cross-clamping, or manual aortic compression. (frontiersin.org)
Surgery14
  • Adequate planning for specific patient variables and predictable problems often encountered in cardiac surgery, though essential, cannot fully eliminate the necessity of intervening and even urgently returning to CPB. (medscape.com)
  • The more than 6.5 million surgical records in this database have helped create surgical risk calculators and have led to improvements in perioperative care for cardiac surgery patients. (medscape.com)
  • The anesthesiology module now included in the Adult Cardiac Surgery Database (ACSD) component of the STS database, created through a partnership with the Society of Cardiovascular Anesthesiologists (SCA), will only further enhance perioperative care. (medscape.com)
  • Anesthesiologists will continue to play primary roles in optimizing patients' medical condition and safely guiding them through cardiac surgery with CPB. (medscape.com)
  • Cardiac vasoplegia is a common complication after cardiac surgery. (neilriordanivc.com)
  • Atrial fibrillation (AF) is a common complication after cardiac surgery, affecting up to 30% of patients. (neilriordanivc.com)
  • Of those, 14 trials measured the incidence of AF after cardiac surgery in a total of 2006 high-risk patients. (neilriordanivc.com)
  • The ability to induce cardiac arrest and facilitate open-heart surgery by infusing a high potassium-containing solution into the coronaries was first demonstrated by Melrose et al. (ccasociety.org)
  • Furthermore, most of these studies focused on NOMI in the postoperative setting of cardiac surgery, whereas the etiologies of NOMI include all conditions in which a persistent low-flow state may be occurring. (springeropen.com)
  • Journal of Cardiac Surgery. (ctsnet.org)
  • The aim of this randomized clinical trial is to assess the benefits of DNS compared to Cardi-Braun blood cardioplegia solution in clinical and biochemical terms regarding myocardial protection during adult cardiac surgery. (researchprotocols.org)
  • We believe that our study addresses an important gap in the knowledge of del Nido cardioplegia in adult patient cardiac surgery and will be able to clarify the possible benefits of this method in a large population of patients undergoing these procedures. (researchprotocols.org)
  • Hyperbilirubinemia is one of the common complications after cardiac surgery and is associated with increased mortality. (biomedcentral.com)
  • Antifibrinolytic therapy in cardiac surgery. (stanford.edu)
Myocytes2
  • A concern with depolarizing arrest is Ca 2+ accumulation in the myocytes, thereby preventing myocardial relaxation. (ccasociety.org)
  • Protective function of tocilizumab in human cardiac myocytes ischemia reperfusion injury.Asian pacific journal of tropical medicine. (z2hospital.com)
Therapeutic target1
  • Thalamic circuitry and normalization of its function may represent a distinct therapeutic target after cardiac arrest. (cdc.gov)
Oxygen4
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • Thus, clinical equipoise exists with regards to the benefits of different targets for oxygen therapy in patients resuscitated after cardiac arrest. (dicardiology.com)
  • BOX examined the effect of two oxygen targets during mechanical ventilation on the composite endpoint of death from any cause or discharge from hospital in a poor neurological state in comatose patients resuscitated after out-of-hospital cardiac arrest. (dicardiology.com)
  • Animal studies have suggested that too much oxygen worsens brain damage after cardiac arrest. (sepoy.net)
Coronary heart d1
Cardioplegic arrest3
  • Isolated rat hearts perfused with Krebs-Henseleit buffer were subjected to 30min of normothermic perfusion, then 4h of cardioplegic arrest at 4°C with St Thomas' Hospital solution, followed by reperfusion for 2h. (portlandpress.com)
  • Thus we conclude that ECE mRNA expression is increased following prolonged hypothermic cardioplegic arrest. (portlandpress.com)
  • The surgeon plans on using a clear pump prime with a hyperpolarized cardioplegic arrest. (ccasociety.org)
Transplantation6
Pathophysiology1
  • Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. (stanford.edu)
Pathophysiological1
Critically ill patients1
  • Ischemia-reperfusion injury is common in critically ill patients, and directed therapies are lacking. (hydrogenstudies.com)
Patients with cardiac1
  • Patients with cardiac arrest due to traumatic or nonmedical causes were excluded. (sca-aware.org)
Return of spontaneous circulation1
  • [ 1 ] Despite decades of efforts to promote cardiopulmonary resuscitation (CPR) education and the introduction of automated external defibrillators, less than 50% of cardiac arrest (CA) victims achieve a return of spontaneous circulation (ROSC) and this percentage drops to 20% or less for those patients that live in rural areas or do not have an initial rhythm that can be defibrillated (e.g., pulseless electrical activity, PEA, and asystole). (medscape.com)
Adults3
  • Adults who survived an out-of-hospital cardiac arrest and developed depression or anxiety within 1 year were 1.4 times more likely to die during follow-up compared with those without a mental health diagnosis, researchers reported. (sca-aware.org)
  • A total of 789 comatose adults were randomized 1:1 after out-of-hospital cardiac arrest of presumed cardiac cause to either restrictive oxygenation targeting a PaO2 of 9-10 kPa or liberal oxygenation targeting 13-14 kPa. (dicardiology.com)
  • See also the American Heart Association [AHA] 2020 guidelines for CPR and emergency cardiovascular care and 2022 AHA Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19. (msdmanuals.com)
Organ2
  • Research on organ protection after deep hypothermic circulatory arrest. (z2hospital.com)
  • Preventable In-Hospital Cardiac Arrests― Are We Monitoring the Wrong Organ? (scirp.org)
Neurologic3
  • This intervention limits neurologic injury associated with brain ischemia during a cardiac arrest and reperfusion injury associated with resuscitation. (medscape.com)
  • Surviving patients could develop neurologic sequelae caused by both initial anoxia and subsequent ischemia-reperfusion injury, and such sequelae could affect their physical, cognitive and psychosocial characteristics. (sca-aware.org)
  • Diffusion tensor magnetic resonance imaging accurately predicted neurologic outcomes in patients who were unconscious after cardiac arrest. (medlink.com)
Complication1
  • Such ischemia-reperfusion injuries (IRI) are a serious complication, responsible for a variety of clinically important conditions including stroke and acute kidney injury. (tu-dresden.de)
Intravenous2
  • This is a review article from the Annual Update in Intensive Care and Emergency Medicine 2018, where they argue that high-dose intravenous vitamin C is no longer alternative medicine, and they recommend the use of after cardiac arrest to prevent damage by ischemia. (neilriordanivc.com)
  • Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury. (neilriordanivc.com)
Severity1
  • Variations between patients include preexisting medical problems, the underlying cause of the cardiac arrest, presence or absence of hemodynamic and circulatory instability, severity of the ischemia-reperfusion injury, and resuscitation-related injuries such as pulmonary aspiration and rib or sternal fractures. (aacnjournals.org)
Incidence2
  • Out-of-hospital cardiac arrest incidence and outcomes vary greatly around the globe. (medlink.com)
  • Reports have indicated that the incidence of out-of-hospital cardiac arrest and in-hospital cardiac arrest have significantly increased. (medlink.com)
Significantly1
  • We found that 48-72 hours after cardiac arrest, thalamocortical neurons demonstrate significantly elevated firing rates both during spontaneous activity and in response to whisker deflections. (cdc.gov)
Survivors4
  • Survivors of out-of-hospital cardiac arrest with anxiety or depression were more likely to die during 14 years of follow-up. (sca-aware.org)
  • A systematic review and meta-analysis recently reported that the prevalence of psychiatric disorders in survivors of out-of-hospital cardiac arrest was higher than that in the general population, stressing the importance of improving physical and mental outcomes in individuals who experience out-of-hospital cardiac arrest," the researchers wrote. (sca-aware.org)
  • Although protocols can be applied to many elements of postresuscitation care, the widely disparate clinical condition of cardiac arrest survivors requires an individualized approach that stratifies patients according to their clinical profile and targets specific treatments to patients most likely to benefit. (aacnjournals.org)
  • If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)
Circulation2
  • Global subendocardial infarcts occur when there is lack of oxygenation despite circulation-for example, when there is a respiratory arrest followed by prolonged hypoxemia. (medscape.com)
  • Cardiac arrest is defined as the cessation of cardiac activity as confirmed by the absence of signs of circulation. (medlink.com)
Acute3
  • Acute MI may be either of the nonreperfusion type, in which case the obstruction to blood flow is permanent, or of the reperfusion type, in which the obstruction or lack of blood flow is long enough in duration (generally hours) but is reversed or restored after myocardial cell death occurs. (medscape.com)
  • Although risk factors of occlusive acute mesenteric ischemia are well known, triggering factors of nonocclusive mesenteric ischemia (NOMI) remain unclear. (springeropen.com)
  • Mesenteric vessel occlusion has long been the sole cause of acute mesenteric ischemia. (springeropen.com)
Outcome2
  • The COVID-19 epidemic has adversely impacted the epidemiology, diagnosis, management, and outcome of cardiac arrest. (medlink.com)
  • Animal studies have shown that cooling induced during CPR and prior to ROSC, the so-called "intra-arrest hypothermia" (IATH), improved neurological outcome when compared to animals that are cooled post-ROSC. (medscape.com)
Elective1
Occurrence1
  • Besides, results showed cardiac arrest (uncontrolled vs. controlled, HR 2.49, P = 0.049), HLA mismatch (4-6 loci vs. 0-3 loci, HR 3.61, P = 0.039), and AR occurrence (HR 2.91, P = 0.006) were demonstrated to be independent risk factors for graft loss. (biomedcentral.com)
Metabolic demand1
  • Cardioplegic solutions cause diastolic arrest, decrease cardiac metabolic demand, and improve myocardial tolerance to ischemia. (ccasociety.org)
Mortality3
  • Cardiopulmonary Resuscitation (CPR) in Infants and Children Despite the use of cardiopulmonary resuscitation (CPR), mortality rates for out-of-hospital cardiac arrest are about 90% for infants and children. (msdmanuals.com)
  • Mortality rates for in-hospital cardiac arrest. (msdmanuals.com)
  • Coronary artery bypass grafting (CABG) is performed for patients with coronary artery disease (CAD) to improve quality of life and reduce cardiac-related mortality. (medscape.com)
Inotropic1
  • However, a recent 2018 study by Panigrahi et al suggests that the del Nido solution may offer some additional benefits including quicker resumption of normal cardiac rhythm and decreased inotropic support compared to conventional blood cardioplegia. (ccasociety.org)
Intralipid1
  • We have previously shown that intralipid (lipid emulsion) protects the heart against ischemia/reperfusion injury and bupivacaine-induced cardiotoxicity. (asahq.org)
Infarct1
Stroke2
Clinical6
  • Therefore, it is crucial in the clinical setting to detect myocardial metabolism conditions in real-time to evaluate the latent cardiac injury and make optimum treatment plans during the ROSC. (dirjournal.org)
  • Previous studies have shown that ischemia/reperfusion (I/R) injury acts as a significant role in PGD(4), contributing to adverse short- and long-term clinical outcomes in the recipients. (researchsquare.com)
  • An increasing number of preclinical and clinical studies show that high-dose i. v. vitamin C can mitigate systemic, cerebral and myocardial ischemia/reperfusion injury. (neilriordanivc.com)
  • In a pre-clinical small animal model of cardiac arrest and resuscitation, the non-invasive treatment resulted in an 83% reduction in brain injury. (teknateam.com)
  • The IRIS team focuses on the physiopathology of the ischemia-reperfusion syndromes in the heart, kidney and brain, by combining fundamental, translational and clinical approaches. (univ-lyon1.fr)
  • Its main objective is to conduct clinical trials aiming to test the effect of therapeutic molecules on ischemia-reperfusion syndromes in collaboration with the Clinical Center of Investigation of Lyon. (univ-lyon1.fr)
Heart6
  • The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
  • With the heart arrested, an anterior ventriculotomy was performed. (ctsnet.org)
  • A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. (curehunter.com)
  • Cardiac-resynchronization therapy for heart failure. (stanford.edu)
  • Cardiac resynchronization in chronic heart failure. (stanford.edu)
  • Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)
Murine1
Pathological1
  • During the pathological development of cardiovascular diseases, cardiac hypertrophy plays a critical role. (karger.com)
Hypothermia1
  • the rare exception is profound hypothermia caused by cold water immersion, when successful resuscitation may be accomplished even after prolonged arrest (up to 60 minutes). (msdmanuals.com)