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  • adherence
  • Despite increased recognition of the negative impact of arthralgia on function and the poor adherence that results, very few interventions have been developed to target this side effect. (medjournal.com)
  • reactions
  • Significant adverse drug reactions are associated with AIs, the most common being arthralgia. (uwo.ca)
  • Localized in the endoplasmic reticulum of cells, aromatase catalyzes three hydroxylation reactions that convert androstenedione to E1, and testosterone to E2. (pubmedcentralcanada.ca)
  • women
  • OBJECTIVE: This study aimed to determine the feasibility of tai chi to improve well-being for women experiencing AI-associated arthralgias (AIAAs). (medjournal.com)
  • impact
  • Understanding the impact of genes and drug levels on AI-induced arthralgia will help clinicians better manage AI therapy. (uwo.ca)
  • development
  • Further pharmacogenetic investigations revealed that four SNPs within the estrogen synthesis and metabolism pathway, namely, CYP19A1 (rs4775936) and ESR1 (rs9322336, rs2234693, rs930799), were associated with the development of arthralgia. (uwo.ca)