• Kim JJ, Flueck C, Franz E, Sanabria-Figueroa E, Thompson E, Lorenz R, Bertinetti D, Baker DA, Herberg FW, Kim C. Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.PLoS Pathog. (uni-kassel.de)
  • Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation. (uni-kassel.de)
  • We are a basic research laboratory that studies the structural and functional basis of protein kinase signaling. (nih.gov)
  • Kinase signaling systems function as multi-domain and multi-component entities to achieve precise regulation of biological processes, and they are frequently deregulated in human diseases. (nih.gov)
  • Oncogenic kinase fusion proteins represent an important class of cancer drivers. (nih.gov)
  • It is driven by J-PKAcα, which is a kinase fusion chimera of the J-domain of heat shock co-chaperone DNAJB1 with PKAcα, the catalytic subunit of PKA, which has been used as a model system for the kinase family for the last 40 years. (nih.gov)
  • They are large multi-domain proteins containing two putative catalytic domains, a GTPase ROCO domain and a kinase domain, in addition to armadillo, ankyrin, leucin rich and WD40 domains. (nih.gov)
  • LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. (biomedcentral.com)
  • Characterization of src mutants with host-dependent and dominant-negative phenotypes that define important functional domains outside the protein-tyrosine kinase domain of sre proteins (15, 16, 17, 18). (nih.gov)
  • Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication]. (cdc.gov)
  • Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study. (cdc.gov)
  • 2. Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1). (nih.gov)
  • Intercellular Signaling Peptides and Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. (childrensmercy.org)
  • This graph shows the total number of publications written about "Intercellular Signaling Peptides and Proteins" by people in this website by year, and whether "Intercellular Signaling Peptides and Proteins" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Intercellular Signaling Peptides and Proteins" by people in Profiles. (childrensmercy.org)
  • Our model predicts that the homology domain PCI is not a true domain in the structural sense but rather consists of two subdomains: a C-terminal 'winged helix' domain with a key role in PCI:PCI interaction, preceded by a helical repeat region. (biomedcentral.com)
  • Here, we report an enzymatic approach using bacterially produced asparagine endopeptidase from Oldenlandia affinis for segmental isotopic labeling of a protein with repetitive sequences, a designed armadillo repeat protein, by overcoming some of the shortcomings of enzymatic ligation for segmental isotopic labeling. (uzh.ch)
  • Unlike most negative regulators of Wnt activity, Pbl/ECT2 functions downstream of Armadillo (Arm)/beta-catenin stabilization. (silverchair.com)
  • The ARM protein interacts with both the N- and C-terminal domains of AtTERT in different cellular compartments. (ista.ac.at)
  • ARM interacts with CHR19 and TRF-like I family proteins that also bind AtTERT directly or through interaction with POT1a. (ista.ac.at)
  • The putative human ARM homolog co-precipitates telomerase activity and interacts with hTRF2 protein in vitro. (ista.ac.at)
  • The ectodomain of TLR4, in conjunction with MD-2, a required coreceptor, interacts with the lipid A moiety of LPS and LPS-binding protein, [ 19 ] and creates a homodimer of two TLR4 proteins. (medscape.com)
  • Our studies have demonstrated that the mitochondrial trafficking protein, armadillo-domain protein (Alex3), directly interacts with Gq and acts as an activator independent of Gbg and GPCRs. (csic.es)
  • The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. (nih.gov)
  • The adhesome contains multi domain proteins with various functions, some of which are specifically enriched in the adhesome compared to the cell proteome. (wikipedia.org)
  • Segmental isotopic labeling can facilitate NMR studies of large proteins, multi-domain proteins, and proteins with repetitive sequences by alleviating NMR signal overlaps. (uzh.ch)
  • It consists of the beta-beta-alpha-beta-alpha-fold typical of U-box and RING domains (see PDB:2QIZ). (embl.de)
  • Os01t0772700-00 Armadillo-type fold domain containing protein. (or.jp)
  • Cloning of the chicken and quail genes encoding the putative receptor for RSV, subgroup A. Although the sequencing of genes encoding this long-sought receptor is not yet complete, it will undoubtedly offer a new perspective on viral-host interactions, the mechanism of early events in the virus life cycle, and the nature of the presumptively polymorphic avian proteins that recognize the several subgroups of RSV. (nih.gov)
  • They bind to other proteins through their armadillo domains and play a variety of roles in the CELL including SIGNAL TRANSDUCTION , regulation of DESMOSOME assembly, and CELL ADHESION . (bvsalud.org)
  • Encodes a basic soluble protein which can independently bind to either PHYA or PHYB, regardless of whether the phytochromes are in the Pr or Pfr state. (or.jp)
  • [ 18 ] The various TLR proteins and the specific ligands they bind are a key mechanism that allow for the differentiation between Gram-negative and -positive bacterial sources and the resulting immune response. (medscape.com)
  • Specialized domains bind cyclic nucleotides such as cAMP or cGMP to transduce signals into physiological responses. (uni-kassel.de)
  • AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
  • Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes. (nih.gov)
  • This includes finding out what other proteins the SUNs bind to and what functions they have during cell division. (brookes.ac.uk)
  • For Schwann cells in particular, the mycobacteria bind to the G domain of the alpha-chain of laminin 2 (found only in peripheral nerves) in the basal lamina, causing demyelination. (medscape.com)
  • Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this site, termed "Site #1", can also bind additional LRRK2 substrates, Rab8A and Rab10. (biorxiv.org)
  • Familia de proteínas que contienen varios dominios de repetición de 42 aminioácidos y son homólogas a la proteína armadillo de Drosophila. (bvsalud.org)
  • A family of proteins that contain several 42-amino acid repeat domains and are homologous to the Drosophila armadillo protein. (bvsalud.org)
  • The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. (nih.gov)
  • Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES . (nih.gov)
  • During an exhaustive bioinformatical analysis of proteasome components, we detected multiple instances of tetratrico-peptide repeats (TPR) in the N-terminal region of most PCI proteins, suggesting that their homology is not restricted to the PCI domain. (biomedcentral.com)
  • The TPR-like repeats detected in the N-terminal region of PCI proteins most likely form an uninterrupted extension of the repeats found within the PCI domain boundaries. (biomedcentral.com)
  • Arabidopsis and human ARM protein interact with telomerase. (ista.ac.at)
  • Deregulated mRNA levels of DNA repair and ribosomal protein genes in an Arabidopsis arm mutant suggest non-telomeric ARM function. (ista.ac.at)
  • We previously identified interaction of the C-terminal domain of Arabidopsis telomerase reverse transcriptase (AtTERT) with an armadillo/β-catenin-like repeat (ARM) containing protein. (ista.ac.at)
  • The demonstration that recombinant Arabidopsis variant P protein has NO-synthesizing activity was a critical piece of evidence leading to the above conclusion. (nih.gov)
  • 13. Targeting intrinsically disordered proteins involved in cancer. (nih.gov)
  • No InterPro domain matches or not analyzed. (cornell.edu)
  • 17. Determinants of the pKa values of ionizable residues in an intrinsically disordered protein. (nih.gov)
  • This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. (nih.gov)
  • Encodes a transducin protein whose gene expression is induced by UV-B. This induction is reduced in hy5 mutant and may be a target of HY5 during UV-B response. (or.jp)
  • [ 11 ] This dimerization initiates a tightly-controlled intracellular signal transmission via a family of at least five intracellular adaptor proteins: myeloid differentiation primary-response gene 88 (MyD88), MyD88-adaptor-like (MAL), TIR-domain-containing adaptor protein inducing IFNβ (TRIF), TRIF-related adaptor molecule (TRAM) and sterile α- and armadillo-motif-containing protein (SARM). (medscape.com)
  • Alex protein is a member of the Eutherian-specific Armcx gene family localized to the mitochondria. (csic.es)
  • These proteins are related to the active E3 Ubiquitin Ligases and can be sorted alphabetically by Gene Symbol or Class by clicking on the respective header. (nih.gov)
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
  • HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
  • HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
  • HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
  • Among proteins unique to the UT-A1 list were those involved in posttranslational modifications: phosphorylation (protein kinases Cdc42bpb, Phkb, Camk2d, and Mtor), ubiquitylation/deubiquitylation (Uba1, Usp9x), and neddylation (Nae1 and Uba3). (nih.gov)
  • Protein kinases regulate almost every aspect of cellular function through phosphorylation of their substrates. (nih.gov)
  • This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. (nih.gov)
  • The literature-based adhesome contains enzymes, such as protein tyrosine and serine/threonine kinases and phosphatases, guanine nucleotide exchange factors and GTPase activating proteins, E3-ligases and proteases, that regulate adhesion through post translational modification of the many structural and scaffolding proteins found in the adhesome. (wikipedia.org)
  • Demonstration that an ectopically expressed transmembrane protein (human CD4) can be efficiently incorporated into RSV envelopes during virus assembly (8). (nih.gov)
  • The term Adhesome was first used by Richard Hynes to describe the complement of cell-cell and cell-matrix adhesion receptors in an organism and later expanded by Benny Geiger and co-workers to include the entire network of structural and signaling proteins involved in regulating cell-matrix adhesion. (wikipedia.org)
  • This analysis identified a group of proteins involved in the process of mitophagy and others in control of the mitochondria motility, among others. (csic.es)
  • A group of proteins that are salt-soluble and form a large fraction of BLOOD PROTEINS . (nih.gov)
  • Tripartite Motif Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Below are the most recent publications written about "Tripartite Motif Proteins" by people in Profiles. (uchicago.edu)
  • NAD(+) hydrolase sterile alpha and TIR motif-containing protein 1 (SARM1), is the fifth member of the Toll/Il-1 Receptor (TIR) domain protein family. (phosphosolutions.com)
  • It was named the WWE domain after its most conservedresidues and is predicted to mediate specific protein-protein interactionsin ubiquitin and ADP-ribose conjugation systems. (embl.de)
  • armadillo (ARM) GUK and LIM domains, which mediate specific protein-protein binding. (wikipedia.org)
  • All these effectors share a highly conserved cyclic nucleotide binding (CNB) domain. (uni-kassel.de)
  • As an ancient and highly conserved protein, APP and its homologs are found across animal species in both vertebrates and invertebrates ( Shariati and De Strooper, 2013 ). (elifesciences.org)
  • The highly conserved 724 amino acid protein is predominantly expressed in the brain, kidney and liver (Mink, M., et al 2001). (phosphosolutions.com)
  • An armadillo-domain protein participates in a telomerase interaction network," Plant Molecular Biology , vol. 97, no. 5. (ista.ac.at)
  • The recruitement of substrate in these proteins involves protein interaction modules such as a WD-40 repeat, TPR, and armadillo repeat domains. (embl.de)
  • The WWE domain: a common interaction module in protein ubiquitination andADP ribosylation. (embl.de)
  • The role of SUN3 in the ER is reinforced by the identification of a protein interaction between SUN3 and the ER membrane-bound transcription factor maMYB. (brookes.ac.uk)
  • The NBS domain functions in signaling, and the LRR domain usually plays an important role in R-AVR protein-protein interaction (Marone et al. (springeropen.com)
  • Biochemical and genetic characterization of Wnt-1 protein as a secretory glycoprotein (11,12) that can function in autocrine or paracrine modes, presumably by interaction with membrane receptor(s). (nih.gov)
  • Here we explore protein-protein interactions of the ARM protein, AtTERT domains, POT1a, TRF-like family and SMH family proteins, and the chromatin remodeling protein CHR19 using bimolecular fluorescence complementation (BiFC), yeast two-hybrid (Y2H) analysis, and co-immunoprecipitation. (ista.ac.at)
  • The observed interactions with telomerase and Myb-like domain proteins (TRF-like family I) may therefore reflect possible non-telomeric functions. (ista.ac.at)
  • Adaptors subsequently activate downstream protein kinases that conclude with the modulation of transcription factors (e.g., nuclear factor [NF]-κB and members of the interferon regulatory factor family), which regulate cytokine expression, conditioning the subsequent adaptive immune response. (medscape.com)
  • A protein family defined by the presence of three ZINC FINGER domains, one of which is a RING FINGER DOMAIN, a coiled-coil region, and a highly variable C-terminal region. (uchicago.edu)
  • Mid-SUN proteins are a neglected family of conserved type III membrane proteins of ancient origin with representatives in plants, animals and fungi. (brookes.ac.uk)
  • [ 14 ] In 1998, it was reported that the mammalian TLR4 protein was responsible for the recognition of microbial lipopolysaccharide (LPS) by immune cells and signal transduction across the plasma membrane. (medscape.com)
  • The major mammalian effector proteins for cNMP signaling encompass PKA, PKG, the exchange protein directly activated by cAMP (EPAC), hyperpolarization-activated cyclic nucleotide-gated cation channels (HCN) as well as cyclic nucleotide-gated ion channels (CNG). (uni-kassel.de)
  • The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. (elifesciences.org)
  • Transcript levels of several DNA repair and ribosomal genes are affected in arm mutants, and ARM, likely in association with other proteins, suppressed expression of XRCC3 and RPSAA promoter constructs in luciferase reporter assays. (ista.ac.at)
  • The U-box is a domain of ~70 amino acids that is present in proteins from yeast to human. (embl.de)
  • These adaptor proteins couple the signal of the activated TLR dimers (heterodimers and homodimers) by interacting with the Toll/IL-1 receptor (TIR) domain on the cytosolic surface of each TLR complex. (medscape.com)
  • 10. The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue. (nih.gov)
  • 11. Intrinsically Disordered Chromatin Protein NUPR1 Binds to the Enzyme PADI4. (nih.gov)
  • 14. Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1. (nih.gov)
  • 16. Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B. (nih.gov)
  • Gram-positive/negative bacteria, fungi and viruses), endogenous danger signals (e.g., heat shock proteins and chromatin-IgG complexes) and products of synthetic origin (e.g., imiquimod and bropirimine). (medscape.com)
  • The specifics of adaptor protein signaling are quite complex and are reviewed elsewhere. (medscape.com)
  • Later, unbiased proteomic approaches utilizing mass spectrometry have detected hundreds more proteins associated with integrin adhesions. (wikipedia.org)
  • Prepared from pooled rabbit serum by affinity purification using a column to which the recombinant protein antigen was coupled. (phosphosolutions.com)
  • In eukaryotic organisms, there exist at least three distinct multi-protein assemblies that are jointly referred to as 'PCI complexes' [ 1 ] and have a similar subunit architecture despite their fundamentally different function: i) the proteasome lid, a subcomplex of the 19S proteasome regulator and the 26S proteasome, ii) the COP9 signalosome or CSN complex, and iii) the eukaryotic translation initiation factor eIF3. (biomedcentral.com)
  • Finally, a ligating enzyme (E3) recruits both the Ub-charged E2 species and the target protein. (embl.de)
  • Proteins obtained from species of fish (FISHES). (ucdenver.edu)
  • The first attempts to establish the set of proteins that participate directly ('bona fide' adhesome components) or affect indirectly ('associated' adhesome components) cell adhesion were based on mining of the primary research literature, and resulted in approximately 200 protein in either integrin or cadherin adhesomes. (wikipedia.org)
  • The proteomic-based studies have identified many proteins from functional groups that haven't previously been associated with cell adhesion sites, such as proteins involved in RNA splicing, translation, trafficking, golgi, endoplasmic reticulum, and metabolic enzymes. (wikipedia.org)
  • The long-term goal of our studies is to gain a better understanding of how these large multi-domain kinases affect human health. (nih.gov)
  • In conjunction with work in several other labs, these mutants brought the Src-homology (SH) domains 2 and 3 to widespread attention, providing new opportunites for identifying the proteins that are crucial modifiers and targets for Sre-like kinases. (nih.gov)
  • Fifty-three proteins that were present in both the UT-A1 and the AQP2 interactomes can be considered as mediators of housekeeping interactions, likely common to all plasma membrane proteins. (nih.gov)
  • We focus our attention on G proteins that are molecular switches that signal through their receptors, GPCRs, at the plasma membrane. (csic.es)
  • GPCRs, G proteins and their signaling pathways are linked to a myriad of physiological processes and to the prognosis of numerous human diseases including cancer and neurodegenerative diseases. (csic.es)
  • Although signaling pathways are important in the control cellular homeostasis, until recently, not much was known about the G protein signaling effects on the mitochondria. (csic.es)
  • Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). (nih.gov)