Aristolochic acids (English: /əˌrɪstəˈloʊkɪk/) are a family of carcinogenic, mutagenic, and nephrotoxic phytochemicals commonly found in the flowering plant family Aristolochiaceae (birthworts). (wikipedia.org)
Birthwort plants, and the aristolochic acids they contain, were quite common in ancient Greek and Roman medical texts, well-established as an herb there by the fifth century BC. (wikipedia.org)
In the early first century, in Roman texts, aristolochic acids are first mentioned as a component of frequently ingested medicines to treat things such as asthma, hiccups, spasms, pains, and expulsion of afterbirth. (wikipedia.org)
A study reported in the Science Translational Medicine journal in October 2017 reported high incidents of liver cancer in Asia, particularly Taiwan, which bore the "well-defined mutational signature" of aristolochic acids. (wikipedia.org)
The herbal drug known as aristolochic acid contains a mixture of numerous structurally related nitrophenanthrene carboxylic acids generally consisting of two major compounds: aristolochic acid I (AA-I) and aristolochic acid II (AA-II). (wikipedia.org)
Plant-derived aristolochic acids are among the most potent nephrotoxins and carcinogens discovered to date, yet the mechanism of bioactivation in humans remains poorly understood. (jci.org)
Aristolochic acids are various derivatives of aristolochic acid (molecular formula C17H11NO7). (altmeyers.org)
Aristolochic acids are secondary plant compounds, toxic aromatic nitro compounds found in species of the genera Aristolochia (pipe flowers ), Asarum (hazel root), Saruma and Thottea, from the family Aristolochiaceae (Easter lily family). (altmeyers.org)
The occurrence of aristolochic acids outside the family Aristolochiaceae is not documented in plants. (altmeyers.org)
Various aristolochic acids were formerly contained in some common slimming preparations, mainly from Chinese medicine, as well as in tonics (e.g., women's gold). (altmeyers.org)
Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia. (activeherb.com)
Aristolochic acids (AAs) which exist in plants of the genus Aristolochia are the toxins responsible for aristolochic acid nephropathy (AAN). (tmu.edu.tw)
Aristolochic acids (AAs) are a family of natural compounds with AA I and AA II being known carcinogens , whose bioactivation causes DNA adducts formation. (bvsalud.org)
Aristolochic acids (AAs), derived from aristolochia plant species, are a mixture of structural-related compounds. (edu.hk)
Since the toxicity mechanism of action of Aristolochic acids are still unclear, it is necessary to develop a sensitive analytical method to facilitate these studies. (edu.hk)
The industrial chemical formaldehyde and a botanical known as aristolochic acids are listed as known human carcinogens. (sciencedaily.com)
Aristolochic acids have been shown to cause high rates of bladder or upper urinary tract cancer among individuals with kidney or renal disease who consumed botanical products containing aristolochic acids. (sciencedaily.com)
Aristolochic acids are a family of acids that occur naturally in some plant species. (sciencedaily.com)
Despite a warning issued in 2001 by the U.S. Food and Drug Administration that advised consumers to discontinue use of any botanical products containing aristolochic acids, they can still be purchased on the Internet and abroad, and may be found as a contaminant in herbal products used to treat a variety of symptoms and diseases, such as arthritis, gout, and inflammation. (sciencedaily.com)
Contained aristolochic acid1
Aristolochic acid poisoning was first diagnosed at a clinic in Brussels, Belgium, when cases of nephritis leading to rapid kidney failure were seen in a group of women who had all taken the same weight-loss supplement, Aristolochia fangchi, which contained aristolochic acid. (wikipedia.org)
Nephropathy13
A similar condition previously known as Balkan endemic nephropathy (BEN), first characterized in the 1950s in southeastern Europe, was later discovered to be also the result of aristolochic acid (AA) consumption. (wikipedia.org)
CHN and BEN fall under the umbrella of what is now known as aristolochic acid nephropathy, the prevalent symptom of AA poisoning. (wikipedia.org)
Ingestion of aristolochic acid (AA) is associated with development of urothelial tumors linked with aristolochic acid nephropathy, and is implicated in the development of Balkan endemic nephropathy-associated urothelial tumors. (nel.edu)
Thus, the so-called "Balkan nephropathy" (see acute tubulointerstitial nephritis ), a chronic toxic interstitial kidney disease endemic in some regions of Romania, Bulgaria and Serbia, is caused by aristolochic acid (Turesky RJ et al. (altmeyers.org)
Aristolochic acid is found in contaminated alternative Chinese remedies and was the trigger of the so-called "Chinese herb nephropathy" that occurred in Belgium and Japan, a chronic interstitial nephritis that led to a slowly progressive renal insufficiency (Luciano RL et al. (altmeyers.org)
Debelle FD et al (2008) Aristolochic acid nephropathy: a worldwide problem. (altmeyers.org)
Luciano RL et al (2015) Aristolochic acid nephropathy: epidemiology, clinical presentation, and treatment. (altmeyers.org)
2018) Effects of aristolochic acid I and/or hypokalemia on tubular damage in C57BL/6 rat with aristolochic acid nephropathy. (altmeyers.org)
Recurrent upper tract urothelial carcinomas (UTUCs) arise in the context of nephropathy linked to exposure to the herbal carcinogen aristolochic acid (AA). (irb.hr)
Here we delineated the molecular programs underlying UTUC tumorigenesis in patients from endemic aristolochic acid nephropathy (AAN) regions in Southern Europe. (irb.hr)
The effects of heavy metal ions, phthalates and ochratoxin A on oxidation of carcinogenic aristolochic acid I causing Balkan endemic nephropathy. (nel.edu)
Barta F, Levova K, Hodek P, Schmeiser H, Arlt V, Stiborova M. The effects of heavy metal ions, phthalates and ochratoxin A on oxidation of carcinogenic aristolochic acid I causing Balkan endemic nephropathy. (nel.edu)
Using this mouse line, we analyzed cell cycle of proximal tubular cells after DNA damage caused by aristolochic acid and cisplatin nephropathy models. (asn-online.org)
Aristolochia3
This study have a certain significance for better understanding of the toxicity mechanism of action of aristolochic acid Ⅰ and aristolochic acid Ⅱ, as well as for toxicity monitoring of aristolochia plants. (edu.hk)
Over 100 years ago, toxicologists discovered the dangerous properties of aristolochic acid, found in the Aristolochia plant family, which includes hundreds of species of birthworts, also known as "Dutchman's pipes," explained USA Today. (yourlawyer.com)
5. Heinrich M, Chan J, Wanke S, Neinhuis C, Simmonds MS. Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2 - a global assessment based on bibliographic sources. (degruyter.com)
Carcinogen2
We microfluidically linked a kidney-on-a-chip with a liver-on-a-chip to determine the mechanisms of bioactivation and transport of aristolochic acid I (AA-I), an established nephrotoxin and human carcinogen. (jci.org)
The product contains aristolochic acid, a potent carcinogen and nephrotoxin. (recalls.org)
Products containing a1
In Germany, all "human and veterinary medicinal products containing aristolochic acid, including phytotherapeutic and homeopathic medicinal products produced using plants containing aristolochic acid" are considered to be of concern. (altmeyers.org)
Acid exposure1
2015) Aristolochic acid exposure in Romania and implications for renal cell carcinoma. (altmeyers.org)
Carcinogens1
In 2009, the U.S. Public Health Service added aristolochic acid to its list of human carcinogens. (yourlawyer.com)
Toxicity3
Aristolochic acid Ⅰ and aristolochic acid Ⅱ are reported to be the major components that are associated with kidney damage toxicity and carcinogenic mutagenicity toxicity. (edu.hk)
The results indicated that the production of aristololactams is the main cause of the toxicity of aristolochic acid Ⅰ and aristolochic acid Ⅱ in the metabolism of rat liver microsome S9. (edu.hk)
The plant contains aristolochic acid, this has received rather mixed reports on its toxicity. (pfaf.org)
Exposure1
It corresponds to a maximum daily exposure of 3.6 pg Aristolochic acid. (altmeyers.org)
Carcinogenic3
Aristolochic acid has been shown to be nephrotoxic and carcinogenic. (altmeyers.org)
According to one report aristolochic acid stimulates white blood cell activity and speeds the healing of wounds, but is also carcinogenic and damaging to the kidneys[254]. (pfaf.org)
The plant contains aristolochic acid which, whilst stimulating white blood cell activity and speeding the healing of wounds, is also carcinogenic and damaging to the kidneys[254]. (pfaf.org)
Mutagenic1
Furthermore Aristolochic acid is mutagenic. (altmeyers.org)
Sodium1
Various preparations contained the sodium salt of aristolochic acid and were used as immunostimulants in infections. (altmeyers.org)
Mutations3
Moreover, such changes displayed the typical trait of mutations caused by a chemical named aristolochic acid (AA). (activeherb.com)
For example, they found specific cancerous mutations in a gene called p53 known to arise from the aristolochic acid, a chemical found in birthwort. (newscientist.com)
In a 2007 Proceedings of the National Academy of Sciences paper, Grollman and his team revealed that the same toxin caused the Balkan and Belgian cases, said USA Today, finding that mutations in certain people matched those of mice poisoned with aristolochic acid. (yourlawyer.com)
Toxic2
Aristolochic acid I (AAI), the major toxic component of AA, is more toxic than its demethoxylated derivate AAII. (nel.edu)
Aristolochic acid is a toxic compound found in some Chinese herbs and may cause kidney failure and cancer. (activeherb.com)
Herbal1
The Department of Health today (September 8) called on members of the public not to buy or use a proprietary Chinese medicine called "Jie Jie Pills" ( ѵ Y), which contains Aristolochic Acid (AA), a harmful herbal ingredient prohibited in Hong Kong. (gov.hk)
Increases2
Another report says that aristolochic acid has anti-cancer properties and can be used in conjunction with chemotherapy and radiotherapy and that it also increases the cellular immunity and phagocytosis function of the phagocytic cells[176]. (pfaf.org)
Conversely, aristolochic acid inhibited [Ca2+]i increases from endothelin-1 but not histamine. (jefferson.edu)
Determination1
In this work, a rapid and sensitive method based on high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was applied for the determination of aristolochic acid Ⅰ, aristolochic acid Ⅱ and their major metabolites in samples from in vitro metabolism studies. (edu.hk)
Molecular1
For more information on SMILES, see https://en.wikipedia.org/wiki/Simplified_molecular-input_line-entry_system . (pharosproject.net)
Herbs1
It claimed that we push herbs that contain aristolochic acid (AA). (fundamentalmed.com)
Liver3
Aristolochic acid Ⅰ and aristolochic acid Ⅱ were incubated with rat liver microsome S9 fractions under aerobic and anaerobic conditions. (edu.hk)
Besides, the fragmentation behaviors of aristolochic acid Ⅰ, aristolochic acid Ⅱ and their metabolites in rat liver microsomes S9 fractions were characterized and summarized. (edu.hk)
Dive into the research topics of 'Research of aristolochic acid I, aristolochic Acid II and their metabolites in rat liver microsomes using HPLC-MS/MS'. Together they form a unique fingerprint. (edu.hk)
Natural1
This document specifies a method for using high-performance liquid chromatography (HPLC) to determine the presence of aristolochic acid I in natural products. (iso.org)
Medicine2
Aristolochic Acid: Is Your Chinese Medicine Safe? (activeherb.com)
Naturopaths know about aristolochic acid because it is part of our training in botanical medicine. (fundamentalmed.com)
High1
The plasma concentrations of the main components of AAs, aristolochic acid I (AA I) and aristolochic acid II (AA II), were determined by a validated high-performance liquid chromatographic method. (tmu.edu.tw)
Activity1
Preliminary evidence suggests that the aristolochic acid isolated from oregano leaves have anti-thrombin activity in vitro experiments. (selfgrowth.com)