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  • Caenorhabditis
  • Andrew Fire and Craig C. Mello shared the 2006 Nobel Prize in Physiology or Medicine for their work on RNA interference in the nematode worm Caenorhabditis elegans, which they published in 1998. (wikipedia.org)
  • elegans
  • C. elegans is small, easily cultured, and can readily be made to accept foreign DNA or RNA. (stanford.edu)
  • In 2000, a second small RNA was characterized: let-7 RNA, which represses lin-41 to promote a later developmental transition in C. elegans. (wikipedia.org)
  • Ago1
  • The mutations also caused a substantial reduction in the level of dimethylation of histone H3 at Lys9 at the pericentromere, where association of the Argonaute protein Ago1 was also abrogated. (biomedcentral.com)
  • In addition, levels of Tas3, which is a protein in the RNA-induced transcriptional silencing complex along with Ago1, were reduced in the absence of Mas5. (biomedcentral.com)
  • AGO2
  • Highlighting its role in antiviral defense, fly Ago2 dissociates so slowly from extensively complementary target RNAs that essentially every fully paired target is cleaved. (bioku.cn)
  • bound
  • We discovered sub-domains within the previously defined functional domains created by Argonaute and its bound DNA or RNA guide. (umassmed.edu)