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  • germline
  • In the male germline, these processes are ensured by proteins associated with cytoplasmic nuage, but morphologically similar germ granules or nuage have not been identified in mammalian female germ cells. (pnas.org)
  • Thus, functions that in the male germline require protein interactions and cooperative scaffolding are combined in MARF1, allowing a single molecule to execute crucial activities of meiotic regulation and protection of germline genomic integrity. (pnas.org)
  • homologous
  • However, structure determination proved to be difficult since molecular replacement using available structures of homologous Ago-protein did not work due to their low sequence identity. (nature.com)
  • biochemical
  • 2017) we provide biochemical data and X-ray crystal structures of the Ago protein from M. jannaschii . (nature.com)
  • You can learn a lot from biochemical experiments, but to more fully understand a protein like Argonaute, it's useful to know where all of the atoms are and which amino acids are playing important roles," says Whitehead Institute Member Dr. David Bartel, who is also an MIT professor of biology and a Howard Hughes Medical Institute (HHMI) investigator. (bioquicknews.com)
  • mammalian
  • This finding has implications for the evolutionary conservation of Ago proteins in the mammalian lineage and the biological role that potentially redundant Ago proteins may have. (uni-hd.de)
  • Mechanism
  • Note: a general mechanism of Ago-protein action is that binding of the guide nucleic acid results in solvent-exposure of the Watson-Crick faces of the nucleobases of the so-called seed region. (nature.com)
  • By studying the biological function of bacterial Argonautes, we will gain insight into a novel mechanism of prokaryotic gene regulation that is not yet understood. (grantome.com)
  • expression
  • By exploiting this pathway, scientists are able to knock down the expression of specific proteins and thereby determine their roles within the cell or organism. (bioquicknews.com)
  • regulation
  • Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins. (yale.edu)
  • Up-regulation of protein phosphatase 2 catalytic subunit (PPP2CB) is a key feature of the meiotic arrest phenotype of Marf1 mutant oocytes. (pnas.org)
  • molecular
  • Our model is based on the results of a combination of Markov State Models (MSMs), large-scale protein-RNA docking, and molecular dynamics (MD) simulations. (inria.fr)
  • Identification
  • p>This subsection of the 'Names and Taxonomy' section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein. (uniprot.org)