Argonaute family protein argonaute proteins. Medical search. Frequent questions

Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). (wikipedia.org)
Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage, translation inhibition, and/or the initiation of mRNA decay. (wikipedia.org)
Non-protein-coding regions of the genome are widely transcribed to produce non-coding RNAs (ncRNAs), which play crucial roles in normal biological processes and disease states (1). (justia.com)
MiRNAs are small noncoding RNAs that are loaded into Argonaute proteins to form the core of the miRNA-Induced Silencing Complex (miRISC). (nih.gov)
Argonaute family proteins use small RNAs (such as siRNAs, miRNAs, and piRNAs) to survey the cellular transcriptome and identify genes to be repressed or silenced. (macraelab.org)
Our lab is studying Argonaute proteins, small RNAs, and the molecular complexes they form from a structural and mechanistic perspective. (macraelab.org)
2020. Loss of function of Oryza sativa Argonaute 18 induces male sterility and reduction in phased small RNAs. . (ncbs.res.in)
2. The Herpesvirus saimiri small nuclear RNAs recruit AU-rich element-binding proteins but do not alter host AU-rich element-containing mRNA levels in virally transformed T cells. (nih.gov)
6. Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function. (nih.gov)
16. High-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) reveals Argonaute-associated microRNAs and targets in Schistosoma japonicum. (nih.gov)
A typical eukaryotic genome encodes several hundred RNA-binding proteins and regulatory RNAs highlighting the wide-spread nature of post-transcriptional control. (utoronto.ca)
In the cytoplasm gene expression is regulated by RNA-binding proteins and regulatory RNAs (represented by the coloured balls) that interact with target transcripts to control mRNA subcellular localization, translational and degradation. (utoronto.ca)
These regulatory mechanisms are controlled by RNA-binding proteins and regulatory RNAs that interact with target mRNAs, thereby controlling their expression. (utoronto.ca)
In my lab we are interested in understanding the molecular mechanisms that underlie the function of RNA-binding proteins and regulatory RNAs and the biologic roles that these regulatory events play. (utoronto.ca)
In this study, we screened all the nonstructural proteins of HCV and found that HCV NS2 could suppress RNAi induced either by small hairpin RNAs (shRNAs) or small interfering RNAs (siRNAs) in mammalian cells. (virosin.org)
MicroRNAs (miRNAs) are members of a vast, evolutionarily ancient, but poorly understood class of regulatory RNA molecules, termed non-protein-coding RNAs (ncRNAs). (nih.gov)

The dsRNA precursors are processed by members of the RNase 3 family of Dicer or Dicer-like enzymes. (medscape.com)
The microRNA (miRNA) biogenesis pathway is regulated by specific proteins and enzymes, including Dicer, Drosha, DGCR8, Exportin 5 and the Argonaute (AGO) family. (nih.gov)
Dicer and Argonaute proteins), the products they produce are not, and hence RNAi might be an example of molecular exaptation [ 19 ]. (biomedcentral.com)
In cells, long dsRNAs, which normally originate from viruses, are degraded by a protein named Dicer, an RNase III ribonuclease family enzyme that is a component of RNA interference pathway. (bitesizebio.com)
These siRNAs are then incorporated into the RISC machinery, which is made up of a number of proteins, including Dicer, TAR RNA-binding protein (TRBP) and Argonaute 2 (AGO2). (bitesizebio.com)
Dicer (Dcr) is the key protein of the RNA interference (RNAi) pathway. (embl-heidelberg.de)

The most well-studied outcome of the RNAi is post-transcriptional gene silencing, which occurs when the guide strand pairs with a complementary sequence in a messenger RNA molecule and induces cleavage by Argonaute, that lies in the core of RNA-induced silencing complex. (wikipedia.org)
Furthermore, we identified the core RNAi protein machinery in Symbiodinium . (biomedcentral.com)
To dissect the biological pathways controlled by these miRNAs, our group will conduct forward (mutagenesis) and reverse (RNAi) screens for suppressors of microRNA family mutant phenotypes. (nih.gov)
The conference's scientific program will focus on Argonaute, the core protein of the RNAi mechanism: and how mutations in the Argonaute gene can lead to rare genetic disorders. (sitoolsbiotech.com)
He will show how large-scale RNAi screening datasets can be used to study the molecular behavior of human Argonaute proteins. (sitoolsbiotech.com)
A Caenorhabditis elegans research discovered an argonaute protein called NRDE-3 (nuclear RNAi defective-3), which imports siRNA to the nucleus. (washingtonindependent.com)

Once the Argonaute is associated with the small RNA, the enzymatic activity conferred by the PIWI domain cleaves only the passenger strand of the small interfering RNA. (wikipedia.org)
In plants, once de novo double-stranded (ds) RNA duplexes are generated with the target mRNA, an unknown RNase-III-like enzyme produces new siRNAs, which are then loaded onto the Argonaute proteins containing PIWI domains, lacking the catalytic amino acid residues, which might induce another level of specific gene silencing. (wikipedia.org)
The Argonaute (AGO) gene family encodes for six characteristic domains: N- terminal (N), Linker-1 (L1), PAZ, Linker-2 (L2), Mid, and a C-terminal PIWI domain. (wikipedia.org)
The name for the PAZ domain is an acronym made from the gene names of Drosophila piwi, Arabidopsis argonaute-1, and Arabidopsis zwille (also known as pinhead, and later renamed argonaute-10), where the domain was first recognized to be conserved. (wikipedia.org)
The Drosophila PIWI protein gave its name to this characteristic motif. (wikipedia.org)
Argonaute proteins are highly basic proteins of about 100 kD that contain 2 common domains, PAZ and Piwi. (medscape.com)
The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. (nih.gov)
The defining features of these RNA classes are the short lengths of 20-31 nucleotides (nt), and interactions with Argonaute family proteins, which can be divided into AGO and PIWI subclasses, to form effector ribonucleoprotein complexes. (justia.com)
Argonaute proteins contain two RNA binding domains: a PAZ domain that interacts with the 3' end of miRNA, and a PIWI domain that resembles ribonuclease-H and is responsible for the endonucleolytic degrading activity. (bitesizebio.com)
A subfamily of argonaute proteins that are related to the Drosophila PIWI protein. (nih.gov)
0.001) for long non-coding transcripts (2.2-fold), known epigenetic regulators (2.3-fold), piwi-interacting RNA clusters (3.6-fold) and curated transcription factors (4.1-fold), including zinc-finger proteins (8.75-fold). (nature.com)

We examined the association of polymorphisms in AGO family genes with AGO expression and with the development and prognosis of autoimmune thyroid diseases. (nih.gov)
The human genome encodes over 2,000 miRNAs (9), which are estimated to regulate the expression of most protein-coding genes (10), thereby exhibiting a tremendous impact on normal developmental and physiological processes and disease states. (justia.com)
Detailed information about target genes, target processes, and open-source software for target prediction (miRanda) is available at http://www.microrna.org Our analysis suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of all human genes. (gene-quantification.org)
MicroRNAs are evolutionarily conserved non-protein-coding regulatory genes that partially complement one or more messenger RNA (mRNA) molecules (target mRNAs). (washingtonindependent.com)

Indeed, owing to the presence of multiple domains TSN protein can interact with nucleic acids, individual proteins and protein complexes in a promiscuous manner. (nature.com)

The Argonaute protein family, first discovered for its evolutionarily conserved stem cell function, plays a central role in RNA silencing processes as essential components of the RNA-induced silencing complex (RISC). (wikipedia.org)
They are part of a larger complex called RNA-induced silencing complex (RISC) that includes several cellular proteins, such as the Argonaute family members whose biological function is still unknown. (medscape.com)
dFMR1, the Drosophila homolog of FMRP -- the protein that is missing or mutated in fragile X syndrome patients -- is a component of the Drosophila RISC/miRNPs. (medscape.com)
Mature miRNAs are integrated into the R NA- i nduced s ilencing c omplex (RISC), whose core component is one of the Argonaute family proteins. (frontiersin.org)
In this study, we investigated the AGO family, which is the primary component of RISC (RNA-induced silencing complex) and directly binds to microRNA. (nih.gov)
Mature miRNA are ~22 nucleotides in length and guide the RNA-induced silencing complex (RISC, the core components of which contain Argonaute proteins) to the target sites, usually located in the 3' untranslated region of gene transcripts[ 4 ]. (biomedcentral.com)
While the guide strands of the miRNA duplexes are incorporated into ARGONAUTE 1(AGO1) of the RNA-induced silencing complex (RISC), the passenger strands called miRNA star (miRNA*) are mostly degraded (Figure 1 ) [ 1 ]. (biomedcentral.com)

A subfamily of argonaute proteins related to the the Arabidopsis AGO1 protein. (nih.gov)

Noncoding RNA (ncRNA) is a class of RNA that normally does not encode a protein, including, for example, microRNA, small interfering RNA (siRNA), long-noncoding RNA, and circle RNA. (jneurosci.org)
Integration of smRNA and mRNA expression profiling identified a variety of processes that could be under microRNA control, e.g. protein modification, signaling, gene expression, and response to DNA damage. (biomedcentral.com)
Understanding the biological networks impacted by the embryonically-expressed microRNA families will yield important insights into how gene expression is controlled to coordinate embryogenesis. (nih.gov)
18. Japanese Macaque Rhadinovirus Encodes a Viral MicroRNA Mimic of the miR-17 Family. (nih.gov)
However, newly identified microRNA and argonaute proteins in human cell nuclei have been demonstrated to suppress nuclear target RNA gene expression. (washingtonindependent.com)
Perhaps nuclear microRNA drives DNA methylation in collaboration with argonaute proteins. (washingtonindependent.com)

In animals, Argonaute associated with miRNA binds to the 3′-untranslated region of mRNA and prevents the production of proteins in various ways. (wikipedia.org)
19. Herpesvirus saimiri open reading frame 14, a protein encoded by T lymphotropic herpesvirus, binds to MHC class II molecules and stimulates T cell proliferation. (nih.gov)
CLEC7A( also elucidated as Dectin-1) binds a degradation domain( PRR) promoted by dominant results( proteins, atrophin-1 classes and receptors) that takes receptors by running to reports in toxic family factors and has large nuclear various spasms to dynamic and microtubule-directed cells. (erik-mill.de)
Aqil M, Naqvi AR, Bano AS, Jameel S (2013) The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference. (virosin.org)

Hopefully the conference can contribute to finding solutions for the life of children and families impacted by AGO2 (Lessel-Kreienkamp/Leskres) syndrome. (sitoolsbiotech.com)

Animals, plants, and other eukaryotes use Argonaute proteins, guided by short RNA sequences, to defend cells against transposons and viruses. (nih.gov)
SVWC is a family of single-domain von Willebrand factor type C proteins from lower eukaryotes. (embl-heidelberg.de)

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. (nih.gov)
Encodes a MADS box protein. (or.jp)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)

The −22-nt mature miRNAs interact with AGO proteins and recognize complementary sequences in the target mRNAs, which are often located in the 3′-UTR. (justia.com)
While at Stanford I discovered the highly conserved Smaug family of RNA-binding proteins that they regulate the translation and stability of target mRNAs. (utoronto.ca)
In the cytoplasm RNA-binding proteins and regulatory mRNAs act to control of mRNA translation, stability and subcellular localization by binding to target mRNAs. (utoronto.ca)
miRNAs with increased abundance in the leaf and root samples of both OE lines (miR158b and miR172a/b) were predicted to target mRNAs coding for Dof zinc finger protein and Apetala 2 (AP2) proteins, respectively. (biomedcentral.com)
miR390 guides cleavage of these transcripts with AGO7 to generate siRNAs which target mRNAs of auxin responsive factors (ARF) family (e.g. (biomedcentral.com)

The name of this protein family is derived from a mutant phenotype resulting from mutation of AGO1 in Arabidopsis thaliana, which was likened by Bohmert et al. (wikipedia.org)

Many bacterial genomes also encode Argonaute proteins, but their functions remain unknown. (nih.gov)
mRNA stabilities can vary from less than a minute to many hours with a long-lived transcript having the potential to encode more protein than does a short-lived one. (utoronto.ca)

The Drosophila Ago-1 and Ago-2 proteins coimmunoprecipitated with miRNAs and siRNAs. (medscape.com)

Tudor staphylococcal nuclease (TSN, also known as Tudor-SN, SND1 or p100) is an evolutionarily conserved protein with invariant domain composition, represented by tandem repeat of staphylococcal nuclease domains and a tudor domain. (nature.com)
TSN is an evolutionarily conserved protein having a pivotal role in the regulation of gene expression. (nature.com)

The recruitment of Argonaute proteins to targeted mRNA can induce mRNA degradation. (wikipedia.org)
A major unanswered question is whether the miRNA and its protein binding partner Argonaute are targeted for degradation together, or can instead be turned over separately. (nih.gov)

Indeed, introduction of sea urchin AGS into the sea star embryo induces asymmetric cell divisions, suggesting that the molecular evolution of AGS protein is key in the transition of echinoderms to micromere formation and the current developmental style of sea urchins not seen in other echinoderms. (echinobase.org)

Furthermore, we found that piR-DQ541777 regulates pain behaviors by targeting CDK5 regulatory subunit-associated protein 1 (Cdk5rap1). (jneurosci.org)
Stability of the regulatory protein complex at the vegetal cortex is sensitive to PLK1 activity. (echinobase.org)
Our goal is to learn to leverage the extraordinary regulatory properties of these molecules towards the further development of Argonaute-based therapeutics, which have tremendous potential for improving human health. (macraelab.org)

Eukaryotic gene expression is a cumulative outcome of a multitude of molecular processes, including transcription, mRNA splicing, stability and translation, chromatin modification, as well as protein stability and modification. (nature.com)

ncRNAs are encoded within the genomes of both eukaryotic and prokaryotic organisms and represent a novel layer of cell regulation and function that rivals the diversity and function of protein-coding mRNAs (for review, see Mattick 2007). (nih.gov)

The method of inhibition is via the destruction of specific mRNA molecules or by simply suppressing the protein translation. (wikipedia.org)
A family of RNA-binding proteins that has specificity for MICRORNAS and SMALL INTERFERING RNA molecules. (nih.gov)
MicroRNAs (miRNAs) are members of a large class of non-protein-coding RNA (ncRNA) molecules that represent a significant, but until recently unappreciated, layer of cellular regulation. (nih.gov)
This means that in contrast to RNA molecules generated during gene expression (i.e., messenger RNA [mRNA] molecules), they are not used as templates for the synthesis of proteins. (nih.gov)

Fabozzi G, Nabel CS, Dolan MA, Sullivan NJ (2011) Ebolavirus proteins suppress the effects of small interfering RNA by direct interaction with the mammalian RNA interference pathway. (virosin.org)
Grapevine fanleaf virus RNA1-encoded proteins 1A and 1BHel suppress RNA silencing. (harvard.edu)

Both Argonaute (Ago) and hiwi are involved in germ cell development and stem cell fate determination. (medscape.com)
2022. Bipartite interaction sites differentially modulate RNA-binding affinity of a protein complex essential for germline stem cell self-renewal. (nih.gov)

The region of chromosome 1p on which 3 members of the Argonaute gene family are located ( EIF2C1, hAGO3 , and hAGO4 ) is, in fact, altered in Wilms' tumors, primitive neuroectodermal tumors, and other types of cancers (1p34-35). (medscape.com)

The multifunctional ~250 kDa L protein of hantaviruses, amongst other functional domains, harbors the RNA-dependent RNA polymerase (RdRp) and an endonuclease and catalyzes transcription as well as replication of the viral RNA genome, making it a promising therapeutic target. (bvsalud.org)
Here, we established expression and purification protocols of the full-length SNV L protein bearing the endonuclease mutation K124A. (bvsalud.org)

Also, the Argonaute-miRNA complex can adjust protein production by recruiting cellular factors such as peptides or post translational modifying enzymes, which degrade the growing of polypeptides. (wikipedia.org)
checkpoint on leaving Additionally human for proteins and enzymes. (erik-mill.de)

These primary transcripts are processed by a nuclease (Drosha) and the double-stranded RNA binding protein, DGCR8, to short 60-70 nucleotide stem-loop structures (pre-miRNA). (biomedcentral.com)

Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. (nih.gov)
Overrepresented groups of targets include mRNAs coding for transcription factors, components of the miRNA machinery, and other proteins involved in translational regulation, as well as components of the ubiquitin machinery, representing novel feedback loops in gene regulation. (gene-quantification.org)
Translational controls can turn on or off the synthesis of the protein encoded by an mRNA. (utoronto.ca)

It is a Direct download teach yourself promoting sulfate( NGF, BDNF) stimulated to its excreted TRK ARNT, here with described downstream consisting disorders, been by nucleus proteins( regulators) from mechanism types to Dolichyl-phosphate-glucose pathway changes, where the Defects include ionizing chips. (erik-mill.de)

We applied different biochemical in vitro assays to provide an extensive characterization of the different enzymatic functions as well as the capacity of the hantavirus L protein to interact with the viral RNA. (bvsalud.org)
14. Viral small nuclear ribonucleoproteins bind a protein implicated in messenger RNA destabilization. (nih.gov)
RVFV's nucleocapsid protein (N) is an RNA-binding protein that is necessary for viral transcription, replication, and the production of nascent viral particles. (mdpi.com)

Being highly basic, Argonaute proteins are thought to be able to bind RNA. (medscape.com)

The full-length cDNA of LvDcr2 was 5513bp long, with an openreading frame encoding a putative protein of 1502 amino acids. (embl-heidelberg.de)
TheseLvSVCs were between 102 and 190 amino acids in length and all contained a motifsimilar to Drosophila melanogaster SVC proteins (DmSVCs). (embl-heidelberg.de)

One of them is spinal muscular atrophy, a pediatric neurodegenerative disorder caused by reduced protein levels or loss-of-function mutations in the SMN (survival of motor neurons) gene. (medscape.com)

Argonaute proteins are the active part of RNA-induced silencing complex, cleaving the target mRNA strand complementary to their bound siRNA. (wikipedia.org)
As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. (nih.gov)

Taken together, this study provides an excellent basis for future structural and functional studies on the hantavirus L protein and for the development of antiviral compounds. (bvsalud.org)

Analysis of DEGs also revealed that minicircle-encoded photosynthesis proteins seem to be common targets of transcriptional regulation. (biomedcentral.com)
Experimental support for the validity of the method comes from known targets and from strong enrichment of predicted targets in mRNAs associated with the fragile X mental retardation protein in mammals. (gene-quantification.org)

Owing to its high protein-protein binding affinity coexistent with enzymatic activity, TSN can exert its biochemical function by acting as both a scaffolding molecule of large multiprotein complexes and/or as a nuclease. (nature.com)
TSN acts both as a scaffolding protein and as a nuclease. (nature.com)
However, one protein, Tudor staphylococcal nuclease (TSN, also known as Tudor-SN, SND1 or p100) appears to act in most of the gene expression pathways. (nature.com)

Also the degree of complementarity between the two strands of the intermediate RNA duplex defines how the miRNA are sorted into different types of Argonaute proteins. (wikipedia.org)

Smaug represses the translation of unlocalized nanos mRNA, while nanos mRNA localized to the posterior of the embryo escapes this repression resulting in Nanos protein specifically accumulating to the posterior. (utoronto.ca)

Circ_0005015, circRNA PWWP domain containing 2A, circRNA zinc finger protein 532, circRNA zinc finger protein 609, circRNA DNA methyltransferase 3β, circRNA collagen type I α2 chain and circHIPK3 widely affect multiple biological processes of diabetic retinopathy. (spandidos-publications.com)

In animal models, FAN1 prevents somatic expansion of CAG triplet repeats, whereas MMR proteins promote this process. (bvsalud.org)
Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA. (nih.gov)

The MLL fusion oncoprotein transcriptionally activates oncogenes to induce hematologic malignancy by interacting with BRD4 [ 23 ], which is a member of the bromodomain and extraterminal motif (BET) protein family and an epigenetic reader. (biomedcentral.com)

SVWC family proteins respond to environmental challenges, such as bacterial infection and nutritional status. (embl-heidelberg.de)

The proteins take part in RNA processing events as core components of RNA-induced silencing complex. (nih.gov)
By using single-particle cryo-EM, we obtained a 3D model including the L protein core region containing the RdRp, in complex with the 5' promoter RNA. (bvsalud.org)

The Argonaute-miRNA complex can also affect the formation of functional ribosomes at the 5′-end of the mRNA. (wikipedia.org)
MUNICH, GERMANY - siTOOLs Biotech GmbH, a young, research-driven biotech company based in Munich/Martinsried and rapidly growing in the field of functional genomics and Next-Generation RNA sequencing, today announced its support for the upcoming Argonautes Conference 2022 at University of Regensburg as lead sponsor. (sitoolsbiotech.com)
Identification and functional characterization of Dicer2 and five single VWCdomain proteins of Litopenaeus vannamei. (embl-heidelberg.de)

PAZ is thought to determine protein-protein interactions, mediating homo- and heterodimerization. (medscape.com)

adenosine regulates obligatory in early acts and protein and during initiation, endothelial fragments from Establishment have produced and role corresponds induced. (erik-mill.de)

Several virus families within this order contain important human pathogens, including Sin Nombre virus (SNV) of the Hantaviridae. (bvsalud.org)
The conference will finally come to the 4 human Argonaute proteins and their role in disease. (sitoolsbiotech.com)
Nearly every cell in the human body contains members of a family of programmable gene-silencing proteins named Argonaute. (macraelab.org)
Previous work has shown that hepatic levels of human glutathione transferase zeta 1 (GSTZ1) protein, involved in tyrosine catabolism and responsible for metabolism of the investigational drug dichloroacetate, increase in cytosol after birth before reaching a plateau around age 7. (aspetjournals.org)

Certain circRNAs, such as circRNA ankyrin repeat domain 36, circRNA homeodomain‑interacting protein kinase 3 (circHIPK3) and circRNA WD repeat domain 77, are associated with inflammation, endothelial cell apoptosis and smooth muscle cell proliferation, leading to vascular endothelial dysfunction and atherosclerosis. (spandidos-publications.com)
In addition, circRNA homeodomain interacting protein kinase 3 (circHIPK3) has been demonstrated to be involved in DR and DCM both in vivo and in vitro ( 13 , 14 ). (spandidos-publications.com)

Drosophila embryos stained to show the distribution of nanos mRNA (in blue) and Nanos protein (in red/brown). (utoronto.ca)

15. Kaposi's sarcoma-associated herpesvirus microRNAs repress breakpoint cluster region protein expression, enhance Rac1 activity, and increase in vitro angiogenesis. (nih.gov)
However, the mechanism regulating this change of expression is still unknown, and previous studies showed that GSTZ1 mRNA levels did not correlate with GSTZ1 protein expression. (aspetjournals.org)
There was an inverse correlation of miR-376c-3p and GSTZ1 protein expression in the liver samples. (aspetjournals.org)
Using cell culture, we confirmed that miR-376c-3p could downregulate GSTZ1 protein expression. (aspetjournals.org)
MLL -rearranged leukemia, caused by Mixed Lineage Leukemia ( MLL ) gene translocation-induced expression of the MLL fusion protein, has the worst prognosis and is the most aggressive among leukemia subtypes [ 22 ]. (biomedcentral.com)
CircRNA LDL receptor related protein 6, circRNA actin related protein 2, circ_0000064, circ‑0101383, circ_0123996, hsa_circ_0003928 and circ_0000285 mediate inflammation, apoptosis and autophagy of podocytes, mesangial cell hypertrophy and proliferation, as well as tubulointerstitial fibrosis, in diabetic nephropathy by regulating the expression of microRNAs and proteins. (spandidos-publications.com)

Evolutionary modifications of AGS protein seem to have provided the cortical recruitment and binding of AGS to the vegetal cortex , contributing to formation of micromeres in the sea urchins. (echinobase.org)

Taxonomic distribution of proteins containing SVWC domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with SVWC domain is also avaliable . (embl-heidelberg.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing SVWC domain in the selected taxonomic class. (embl-heidelberg.de)

Subcellular localization of an mRNA acts as a mechanism to control the localization of encoded protein. (utoronto.ca)

The program starts with sessions dedicated to the diverse roles of prokaryotic Argonaute proteins (pAgo), and the functions of Argonaute in plants. (sitoolsbiotech.com)

Considering ever increasing interest to further understand a multitude of TSN-mediated processes and a mechanistic role of TSN in these processes, here we took an attempt to summarize and update the available information about this intriguing multifunctional protein. (nature.com)

Anatomy2

Organisms2

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes11

Information Science3

RNAs16

Dicer6

RNAi6

PIWI11

Genes4

Nucleic acids1

RISC7

Subfamily1

MicroRNA6

Binds4

AGO21

Eukaryotes2

Encodes2

Structural Classifi1

Target mRNAs5

AGO11

Encode2

SiRNAs1

Evolutionarily conserved2

Degradation2

Induces1

Regulatory3

Molecular1

Genomes1

Molecules4

Suppress2

Stem cell2

Gene family1

Endonuclease2

Enzymes2

DGCR81

Translational3

Pathway1

Viral3

Bind1

Amino2

Mutations1

Complementary2

Compounds1

Targets2

Nuclease3

Strands1

Repression1

Biological1

Repeats2

Epigenetic1

Bacterial1

Core2

Functional3

Interactions1

Regulates1

Human4

Kinase2

Embryos1

Expression6

Recruitment1

Domain3

Mechanism1

Roles1

Multifunctional1