Arginine metabolism in mammalian cells. Medical search. Frequent questions

Arginine is catabolized via multiple pathways mediated by nitric oxide synthase, arginase, arginine:glycine aminotransferase (AGAT), and arginine decarboxylase (ADC) [ 9 ]. (biomedcentral.com)
Metabolic creatine synthesis occurs via two enzymatic reactions: L-arginine, glycine amidinotransferase (AGAT) transfers an amidino group from arginine to glycine to produce guanidinoacetate (GAA) and ornithine and second, guanidinoacetate methyltransferase (GAMT) transfers a methyl group from S-adenosylmethionine to GAA to form creatine and S-adenosyl homocysteine [ 3 ]. (oatext.com)
Amino acid metabolism has extremely extensive effects in cancer cells, including, but not limited to, (1) establishing amino acid pools as building blocks, especially the production of non-essential amino acids … An overview of the metabolism of the sulfur amino acids is depicted in Fig. The outline of glycine metabolism is depicted in Fig. Oxidation via TCA cycle to produce energy (about 10-15% of body needs). (slimwithlynne.com)
This study examined if leucine, arginine or glycine supplementation in adult obese patients (body mass index of 33 ± 4 kg/m²) consuming a Brazilian low energy and protein diet (4.2 MJ/day and 0.6 g protein/kg) affects protein and amino acid metabolism. (scielo.br)
There was no difference in amino acid profiles due to leucine, arginine or glycine supplementation. (scielo.br)
The present results suggest that 0.6 g/kg of dietary protein is enough to maintain protein turnover in obese women consuming a reduced energy diet and that leucine, arginine or glycine supplementation does not change kinetic balance or protein synthesis. (scielo.br)
This study examined if leucine, arginine or glycine supplementation in adult obese patients (body mass index of 33 ± 4 kg/m 2 ) consuming a Brazilian low energy and protein diet (4.2 MJ/day and 0.6 g protein/kg) affects protein and amino acid metabolism. (scielo.br)

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. (wikipedia.org)
Krebs-Henseleit cycle Ornithine citrulline arginine urea cycle. (inje.ac.kr)
This cytosolic arginine is then translocated into the mitochondria where it is split by arginase 2 to urea and ornithine. (biomed.news)

The in vivo trial was designed as a 2 × 2 factorial arrangement to evaluated the effects of arginine supplementation on inflammatory responses, arginine transporters, arginine catabolism and JAK-STAT signalling pathway in broiler chickens challenged with C. perfringens or without C. perfringens . (biomedcentral.com)
Furthermore, we validated the in vivo results using intestinal epithelial cells of chicken embryos. (biomedcentral.com)
However, few studies have investigated nutrient acquisition and metabolism of S. aureus in vivo during infection, which is an important aspect of S. aureus pathophysiology. (biomedcentral.com)
ASS1 overexpression effectively inhibited tumor growth and enhanced the efficacy of in vitro and in vivo anti-HCC combination chemotherapy via activation of the PERK/eIF2α/ATF4/CHOP axis, but was not dependent on the status of p53 and arginine metabolism. (biomedcentral.com)
Presently, two-dimensional (2D) cell-based models fail to predict in vivo efficacy, contributing to limited success in translating new drugs for clinical use. (biomedcentral.com)
Competitive antagonism of TLR8 with non-targeting locked nucleic acids was found to prevent native LDL-induced macrophage polarization in vitro, and re-organize lesion macrophage phenotypes in vivo, as determined by single-cell RNA sequencing. (biomed.news)

Here, two ß-gal probes (TNap-ßGal and TBNap-ßGal) were synthesized, which can not only image the increase of ß-gal during both fruits softening and cellular senescence, but also prove that bananas are not suitable for storage in refrigerator and the subsequent accumulation of ß-gal still in lysosome of mammalian cells. (bvsalud.org)
HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. (ucsf.edu)
Her contributions place as a key molecular hub, that regulates key signaling pathways to coordinate cell metabolism and cellular function and overall promote anabolism in the context of cycling cells and in differentiated tissues (6-8) . (unil.ch)
Cellular arginine uptake is mainly mediated by the cationic amino acid transporter (CAT) family, also known as y + transporters, which is involved in active transport [ 8 ]. (biomedcentral.com)
An N-terminal arginine-rich cluster and a proline-alanine-threonine repeat region determine the cellular localization of the herpes simplex virus type 1 ICP34.5 protein and its ligand, protein phosphatase 1. (omeka.net)
Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. (life-science-alliance.org)
Among the transporters identified, we characterized the cationic amino acid transporter SLC7A3 as a gene that, when up-regulated, overcame low availability of arginine and lysine by increasing their uptake, whereas SLC7A5 was able to sustain cellular fitness upon deprivation of several neutral amino acids. (life-science-alliance.org)
Amino acid metabolism is essential for cell survival, while the byproduct ammonia is toxic and can injure cellular longevity. (biomed.news)
Maintenance of amino acid homeostasis is important for healthy cellular function, metabolism and growth. (birmingham.ac.uk)

At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. (wikipedia.org)
Title: Arginase and the arginine metabolome in pulmonary hypertension. (clss.org.uk)
Title: Construction of the recombinant producers of bacterial arginine deiminase and human arginase and their use for arginine deprivation. (clss.org.uk)

The obtained results provide compelling evidence that higher level of hisADC transgene expression completely triggered the endogenous agmatine synthesis during H 2 O 2 injury thus protecting NIH3T3 cells against cytotoxicity. (elsevierpure.com)
Synthesis of NO can be pharmacologically abolished by the action of the N-omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of both nNOS and eNOS. (frontiersin.org)
It has been proven that L-arginine: increases the synthesis of growth factors (poliamines) participating in the growth of tissue, and, as proven by clinical research, promotes protein synthesis in the body. (mrsupps.com)
Among the subjects he has studied are the synthesis of urea in the mammalian liver, the synthesis of uric acid and purine bases in birds, the intermediary stages of the oxidation of foodstuffs, the mechanism of the active transport of electrolytes and the relations between cell respiration and the generation of adenosine polyphosphates. (inje.ac.kr)
By focusing on the critical roles of different metabolic programs, such as glycolysis, oxidative phosphorylation, fatty acid oxidation, fatty acid synthesis, and amino acid metabolism, as well as their essential regulators in modulating Treg proliferation, migration, and function, we hope to provide new insights into Treg cell-targeted antitumor immunotherapies. (biomedcentral.com)
The liver is the major site of amino acid metabolism in the body and the major site of urea synthesis. (slimwithlynne.com)
cells and tissues have continuous access to individual amino acids for the synthesis of proteins and essential amino acid derivatives. (slimwithlynne.com)

indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)
showed that adipose tissue from obese mice induced proliferation of splenic CD8+ T cells, indicating a CD8+ T cell-activating environment in obese adipose tissue (31). (exposed-skin-care.net)
BAG-1 (Bcl-2 associated athanogene-1) is a multifunctional protein, linking cell proliferation, cell death, protein folding, and cell stress. (omeka.net)
In this review, we elaborate on the characteristics of Treg metabolism and metabolic determinants involved in regulating Treg proliferation, migration, and suppressive capacity. (biomedcentral.com)
G-MDSC are also referred to as polymorphonuclear (PMN)-MDSC, which differ from conventional neutrophils via expression of lectin-type oxidized LDL receptor 1 (LOX-1), which inhibits T cell proliferation [ 7, 8 ]. (iospress.com)
Metabolic alterations in cancer cells are numerous and include aerobic glycolysis, reduced oxidative phosphorylation, and increased generation of biosynthetic intermediates needed for cell growth and proliferation. (biomedcentral.com)
To infer functional relationships between SLCs and metabolites, we developed a strategy to identify SLCs able to sustain cell viability and proliferation under growth-limiting concentrations of essential nutrients. (life-science-alliance.org)
One-by-one depletion of 13 amino acids required for cell proliferation enabled gain-of-function genetic screens using a SLC-focused CRISPR/Cas9-based transcriptional activation approach to uncover transporters relieving cells from growth-limiting metabolic bottlenecks. (life-science-alliance.org)
Importantly, at late stages of tumorigenesis cancer cells employ autophagy to sustain proliferation in unfavorable conditions, including anti-cancer drug therapy. (biomed.news)

Importantly, the alternative splicing of the LMNA gene was highly sensitive to the levels of specific Serine-Arginine rich (SR) proteins (5) , and produced several splicing isoforms that affect adipose tissue metabolism and aging in opposite manners, with Lamin A and Progerin promoting energy expenditure and aging, while Lamin C favors slower metabolism and moderately slows the aging process in mice (4) . (unil.ch)
From September 2017 develops her independent research program as SNSF Prima fellow at the CIG on the role of SR proteins in metabolism. (unil.ch)
Our research focuses on the roles of two particular RNA binding proteins of the SR protein family, SRSF1 and SRSF2, in metabolism and adipose tissue biology. (unil.ch)
Arginylation is the addition of one extra arginine to proteins catalyzed by an enzymatic reaction. (51fangxue.com)
An arsenal of virulence factors has been identified including toxins, cell surfaces proteins that facilitate attachment and colonization, and factors that contribute to immune evasion and tissue damage [ 2 ]. (biomedcentral.com)
Share Your Word File Amino acids are produced by digestion of dietary proteins in the intestines, absorbed through the intestinal epithelial cells, and enter the blood. (slimwithlynne.com)

Cytosolic arginine is also converted to nitric oxide and citrulline by nitric oxide synthases. (biomed.news)
Thus, both the urea and citrulline cycles are employed by CD8+ T cells to clear ammonia and enable memory development. (biomed.news)

We find a circadian rhythm in antigen processing that correlates with rhythms in both mitochondrial morphology and metabolism, dependent on the molecular clock gene, Bmal1. (biomed.news)

To test our hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, H4R3 and H3R17 protein arginine (R) methyltransferases 1 and 4 (PRMT1 and PRMT4) were investigated. (embl.de)
Macroautophagy/autophagy is emerging as a major pathway that regulates both aging and stem cell function. (biomed.news)

The hepatic urea cycle (see the image below) is the major route for disposal of waste nitrogen chiefly generated from protein and amino acid metabolism. (medscape.com)

We revealed that WDR45 and WDR45B are critical for autophagosome-lysosome fusion in neural cells. (biomed.news)

L -arginine is an essential amino acid for chickens and turns out to be a conditionally essential amino acid for mammals under many stressful conditions [ 4 , 5 , 6 ]. (biomedcentral.com)
3. Gold Salmon Pro has a unique amino acid profile, with a particularly high content of L-arginine (Arg) and L-proline (Pro), respectively 3 and 6 times higher compared to whey protein hydrolysate (WPH). (mrsupps.com)
Although L-arginine is a relatively exogenous amino acid, its internal biosynthesis is not able to compensate for its insufficient supply from food in states of increased demand (i,ii), such as increased physical activity or damage of the body caused by disease or injury. (mrsupps.com)
Urea is the end product of protein metabolism (amino acid metabolism). (slimwithlynne.com)
The vitamin that is a coenzyme in amino acid and nucleic acid metabolism is. (slimwithlynne.com)
Start studying BIOCHEMISTRY: Amino Acid Metabolism. (slimwithlynne.com)
Furthermore, autophagy is specifically activated in response to amino acid starvation via two key signaling cascades: the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) and the general control nonderepressible 2 (GCN2) pathways. (birmingham.ac.uk)
We further explore how sophisticated methods are employed by cells to sense intracellular amino acid concentrations, how amino acids can act as a switch to dictate the temporal and spatial activation of anabolic and catabolic processes and how autophagy contributes to the replenishment of free amino acids, all to ensure cell survival. (birmingham.ac.uk)

Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. (embl.de)
PRMT6 is a protein arginine methyltransferase that has been implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis. (embl.de)
During her PhD, Isabel studied the regulation of the alternative splicing of the Fibronectin (FN1) and Lamin A/C ( LMNA ) genes, and their role in host cell invasion (1) , aging (2) and metabolism (3,4) . (unil.ch)
Furthermore, it mediates the formation of macromolecules in cells which are used in cell structure, energy stores, and regulation of many cell functions. (weeksmd.com)
A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes. (omeka.net)
Title: Coordinated regulation of pyrimidine and arginine biosynthesis in plants. (clss.org.uk)
Saltiel, A.R. & Kahn, C.R. Insulin signalling and the regulation of glucose and lipid metabolism. (nature.com)
Overall, this gain-of-function approach using human cells uncovered functional transporter-nutrient relationships and revealed that transport activity up-regulation may be sufficient to overcome environmental metabolic restrictions. (life-science-alliance.org)

The arginine decarboxylase (ADC) is a significant functional enzyme, synthesizes agmatine through arginine metabolism, and agmatine was reported to posses protective properties in various tissues. (elsevierpure.com)

Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. (embl.de)
We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the marks to different functional consequences of E2F-1 activity. (embl.de)
The ability of E2F-1 to prompt apoptosis in DNA damaged cells coincides with enhanced PRMT1 methylation. (embl.de)
In contrast, cyclin A binding to E2F-1 impedes PRMT1 methylation and augments PRMT5 methylation, thus ensuring that E2F-1 is locked into its cell-cycle progression mode. (embl.de)
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. (embl.de)

To achieve accurate 13C-MFA of central carbon and energy metabolism, we proposed a dual strategy for the detection of 101 metabolites in glucose metabolism pathways. (bvsalud.org)
Lamin C Counteracts Glucose Intolerance in Aging, Obesity and Diabetes Through beta-Cell Adaptation. (unil.ch)
The hormone insulin is recognized as having actions that affect the trans-membrane transport of different substances, particularly glucose, into numerous different kinds of cells. (weeksmd.com)
The hormone is made in the beta cells of the pancreas, and the stimulus for its secretion into the blood stream is a rise in the blood glucose concentration. (weeksmd.com)

An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)

This local metabolism within the brain is important for the full expression of male sexual behavior in many species, including green anole lizards. (karger.com)
stream (and ultimate removal from airway tissue), local metabolism, and/or direct reaction with tissue substrates. (cdc.gov)

Central carbon and energy metabolism are the most concerned metabolic pathways in 13C-Metabolic flux analysis (13C-MFA). (bvsalud.org)
However, some α-keto acids, ribonucleoside triphosphate (NTPs) and deoxyribonucleoside triphosphate (dNTPs) involved in central carbon and energy metabolism pathways were unstable or reactive, leading to inaccurate metabolic flux analysis. (bvsalud.org)
In the phosphorylated form, it is used in energy metabolism to transfer phosphate from ADP to ATP [ 3 ]. (oatext.com)

Diagram showing the synthetic pathway responsible for nitric oxide (NO) production from arginine and O 2 and catalyzed by the enzyme nitric oxide synthase (NOS). (frontiersin.org)
Arginine prevented C. perfringens challenge-induced circulated arginine deficiency, normalized intestinal arginine transport and catabolism, down-regulated JAK-STAT signalling pathway and attenuated the inflammatory response, which exerted protective effects on the intestine of broiler chickens. (biomedcentral.com)
The evolutionarily conserved Arginyltransferase1 mediates a pVHL-independent oxygen sensing pathway in mammalian cells. (51fangxue.com)
For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)
Here we show that CD8+ memory T (TM) cells mobilize the carbamoyl phosphate (CP) metabolic pathway to clear ammonia, thus promoting memory development. (biomed.news)

However, its role in aging-related adipose tissue CD4+ T cell activation remains to be investigated. (exposed-skin-care.net)
CD8+ T Cell Activation Compared to CD4+ T cells, CD8+ T cells show a greater increase in adipose tissue in obesity and in aging (31, 43, 106). (exposed-skin-care.net)
Similar to CD4+ T cells, CD8+ T cells exhibit effector memory or effector phenotypes expressing elevated levels of IFN- in obese adipose tissue (31, 44). (exposed-skin-care.net)
The mechanism for CD8+ T cell activation in adipose tissue is not fully understood. (exposed-skin-care.net)
Indeed, CD8+ T cells from mouse adipose tissue respond to cytokines and become activated and proliferate under stimulation of IL-12 and IL-18, which are mainly produced by APCs and are elevated in obese adipose tissue (44). (exposed-skin-care.net)

Our comparative proteomic analysis of HCC cells grown in culture as monolayers (2D) and spheroids (3D) revealed that argininosuccinate synthase 1 (ASS1) expression was higher in 3D cells than in 2D cells due to upregulated endoplasmic reticulum (ER) stress responses. (biomedcentral.com)

67.20, an outline of glutamate and glutamine metabolism is given. (slimwithlynne.com)

This ammonia clearance machinery might be targeted to improve T cell-based cancer immunotherapies. (biomed.news)

Associated eponyms: Krebs' cycle A complicated series of reactions in the body involving the oxidative metabolism of pyruvic acid and liberation of energy. (inje.ac.kr)

The macroautophagy/autophagy deficiency in wdr45 wdr45b DKO cells is ameliorated by suppression of O-GlcNAcylation, which promotes autophagosome maturation. (biomed.news)
however, these studies did not directly address the consequence of altered autophagy in stem cells during aging. (biomed.news)
In this study, we used Becn1F121A/F121A knockin mice (designated as Becn1 KI mice) with the F121A allele in the autophagy gene Becn1 to investigate the consequences of enhanced autophagy in postnatal neural stem cells (NSCs) during aging. (biomed.news)

CD8+ TM cells use β-hydroxybutyrylation to upregulate CP synthetase 1 and trigger the CP metabolic cascade to form arginine in the cytosol. (biomed.news)

Title: Targeting arginine in human cancers: from the lab to the clinic. (clss.org.uk)
Many tumors, including HCC, malignant melanoma, malignant pleural mesothelioma, and prostate and renal cancers, are arginine auxotrophic due to their variable loss of argininosuccinate synthase 1 (ASS1), which is severely reduced or absent in numerous types of aggressive and chemoresistant cancers. (biomedcentral.com)
As we learn more and more about cancer metabolism, we understand that individual cancers are addicted to particular things. (kreftfri.no)

Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. (bvsalud.org)

Title: Purine metabolism, cell cycle and circadian clock. (clss.org.uk)

Interestingly, small dogs have a longer lifespan than larger dogs [ 4 ], which differs from what is observed in other mammalian species. (hindawi.com)
Our objective was to determine whether this would be the case in another mammalian species, the bovine. (bioone.org)
In mice, MDSC can be identified by species-specific cell surface markers (CD11b + Gr-1 + ) and may be further classified as monocytic (M-MDSC, Ly-6C hi ) or granulocytic (G-MDSC, Ly-6G + ) based on additional cell surface markers [ 6 ]. (iospress.com)

His laboratory investigates the molecular mechanisms that cause cancer and those that determine the response of malignant tumour cells to diverse anti-cancer agents. (unibas.ch)
As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
Unfortunately, patients are already in the terminal stage at this time, and the cancer cells have already invaded the surrounding organs or metastasized far away, which leads to the loss of the curative chance for most patients ( 1 ). (frontiersin.org)
Characterized by the expression of the critical transcription factor forkhead box protein P3, regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the pathogenesis of autoimmune diseases and cancer. (biomedcentral.com)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Cancer Cell Metabolism: Unique Features Inform New Therapeutic Opportunities. (nyas.org)

Nearly all multi-exon mammalian genes undergo alternative splicing in a tissue specific or signal-induced manner, however the regulatory mechanisms and functional consequences of such splicing changes have been well characterized only for a small fraction of genes. (unil.ch)
Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion. (unil.ch)
Newer approaches are looking instead for ways of altering the pharmacokinetics of established drugs, particularly with respect to improving the ability of these to penetrate cell membranes at the end-organ/tissue level. (weeksmd.com)
A wide range of test models including yeast, mammalian cell lines, and live animals (mouse and rat), a well as human tissue samples are currently being used in our investigations. (51fangxue.com)
Roughly 95% of creatine is released in close proximity to the muscle tissue and transported into the cell via a limited capacity creatine-transporter system. (oatext.com)
A substantial portion of free or bound creatine and creatine phosphate are found in mammalian skeletal muscle tissue. (oatext.com)
and/or metabolism being allowed in each tissue compartment. (cdc.gov)

Developmental Cell 2022 Mar 14;57(5):654-669.e9. (51fangxue.com)

With HypoPP hyperpolarization-activated cation leak counteracting K + -rectifying current, mutations cause outermost arginine or lysine substitution. (medscape.com)

Det anbefales derfor å holde et jevnt lavt blodsukker for å hemme energiforsyningen til kreftcellene (spesielt hypoksiske kreftceller med dårlig blodforsyning), men mer viktig er nok effekten en lavkalori-/lav-blodsukker-diett har på vekstfaktorer som insulin, IGF og signalveien PI3K−Akt−mTOR . (kreftfri.no)

RNA splicing is a key phase in gene expression in eukaryotic cells. (unil.ch)
for example, they provide structural stability to cells and tissues, give motility to individual cells, carry messages within and between cells, and regulate gene expression and metabolism. (biologists.com)

These results demonstrate the critical functional roles for the arginine metabolism-independent tumor suppressor activity of ASS1 in HCC and suggest that upregulating ASS1 in these tumors is a potential strategy in HCC cells with low ASS1 expression. (biomedcentral.com)

The alpha unit is predominantly located on the outer surface of the cell membrane, and the insulin binding domain is located here. (weeksmd.com)
Recent reports have shown that an artificially created alkaline environment can influence cell membrane permeability and cell behavior. (oatext.com)
The ability of alkaline buffered creatine to produce micro-environmental remodeling, influence cell membrane behavior and impact cisplatin-mediated toxicity, are also examined in this paper. (oatext.com)
Carnosine is widely believed to he an antioxidant which stabilizes and protects the cell membrane. (natmedtalk.com)
Specifically, as a water-soluble free radical scavenger it prevents lipid peroxidation within the cell membrane (3). (natmedtalk.com)
Each of those cells is surrounded by a membrane that is bean shaped. (vitanetonline.com)

In vitro endothelial cell adhesion experiments demonstrate that, as creatine concentrations increase, endothelial cell surface adhesion and permeability were both modified. (oatext.com)
To achieve this, cells of in vitro produced bovine embryos were traced from the 2-cell stage to the blastocyst stage. (bioone.org)

We previously reported that dietary arginine supplementation protected the intestinal mucosa of broiler chickens with necrotic enteritis, but the related protective mechanisms remain unclear. (biomedcentral.com)
Creatine supplementation, in and of itself, has been shown to influence endothelial permeability and cell surface reactivity to a modest degree, potentially interfering/blocking an inflammatory stimulus. (oatext.com)
Its concentration in mammalian muscles possibly decreases with age, a fact which strengthens the case for supplementation. (natmedtalk.com)
Moreover, some amino acids have known pharmacological properties which could be of potential benefit for protein metabolism (4), and the effect of supplementation with these amino acids during low energy diets on obese persons has not been reported. (scielo.br)

RT-PCR and western blot results showed the specific and strong detection of hisADC genes in hisADC PT67 transfected cells compared with normal control and pLXSN transfected PT67 cells. (elsevierpure.com)
Blencowe's research team studies the mechanisms by which genes are regulated and coordinated to provide critical functions in mammalian cells. (unibas.ch)

Identification and characterization of new molecular partners for the protein arginine methyltransferase 6 (PRMT6). (embl.de)

During the war he worked in the field of nutritional requirements, with particular attention to the dietary roles of vitamins A and C. In 1954 he was appointed Whitley Professor of Biochemistry in the University of Oxford and the Medical Research Council's Unit for Research in Cell Metabolism was transferred to Oxford. (inje.ac.kr)

From a physiological standpoint, MDSC can be thought of as effectors of a homeostatic mechanism that regulate T cell-mediated inflammatory responses to pathogens [ 5 ]. (iospress.com)

however, the role of circadian rhythms in dendritic cell function is still unclear. (biomed.news)

Lluis Fajas at UNIL and investigated the role of the cell cycle regulator CDK4 in metabolism. (unil.ch)
Title: ArgR, a versatil regulator affecting primary and secondary metabolism on Streptomyces coelicolor. (clss.org.uk)

Myeloid derived suppressor cells (MDSC) are immune cells that dampen immune responses. (iospress.com)
Here, we show greater T cell responses when mice are immunised in the middle of their rest versus their active phase. (biomed.news)

When confronted with bacterial pathogens, macrophages, frontline defenders in the immune system, switch to a glycolysis-driven metabolism to carry out their antibacterial functions. (biomed.news)

There are insulin receptors on the capillary endothelial cells making up the blood-brain barrier (BBB) and it is proposed that these may play a role, along with exogenously administered insulin, in enhancing the transport of drug molecules across the BBB. (weeksmd.com)

The reason for such a substantial change was the increased retention of nitrogen in the cells caused by Pro - from 1.27 to 1.53 g/kg of body weight. (mrsupps.com)

Anatomy29

Organisms19

Diseases2

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes79

Information Science4

Health Care2

Glycine7

Ornithine3

Vivo6

Cellular9

Arginase3

Synthesis7

Proliferation9

Proteins6

Citrulline2

Mitochondrial1

Regulates2

Urea cycle1

Lysosome1

Amino acid8

Regulation8

Decarboxylase1

Methylation5

Glucose4

Tumor microenvironment1

Local metabolism2

Energy metabolism3

Pathway5

Adipose tissue5

Endoplasmic reticulum1

Glutamate1

Ammonia1

Oxidative1

Autophagy3

Cytosol1

Cancers3

Epithelial cells1

Nitric oxide1

Purine1

Species3

Cancer6

Tissue7

20221

Lysine1

MTOR1

Gene expression2

Functional1

Membrane6

Vitro2

Supplementation4

Genes2

Molecular1

Roles1

Inflammatory1

Circadian1

Regulator2

Responses2

Bacterial1

Endothelial cells1

Nitrogen1