• Alterations in the splice pattern and resulting expression of MAPK kinase are implicated in mediating the antitumoral effects resulting from SRPK1 down-regulation. (aacrjournals.org)
  • The up-regulation of SRPK1 in multiple cancers and its ability to regulate multiple relevant signaling pathways provide support for developing agents to inhibit this kinase for possible broad application to treat epithelial cancers. (aacrjournals.org)
  • Removal of the spacer in SRPK1 has little effect on the kinase activity, but triggers the nuclear translocation of kinases and consequently induces aggregation of splicing factors in the nucleus. (aacrjournals.org)
  • Moreover, cell cycle signal induces nuclear translocation of the kinases at the G 2 -M boundary, indicating that SRPKs play a role in cell cycle progression ( 10 ). (aacrjournals.org)
  • Recent reports have described multifaceted interactions between the mitogen-activated protein kinase (MAPK) and AKT signaling networks and the splice regulatory machinery. (aacrjournals.org)
  • 3. With the lobster enzyme NO3- has no effect on the exchange reaction alone and inhibit only slightly the apparent enhancement of the exchange reaction produced by the addition of arginine. (portlandpress.com)
  • The objective of this trial is to determine the safety and effect on pulmonary function of 14 days of inhaled L-arginine versus placebo administered over a period of 14 days in a cohort of. (bioportfolio.com)
  • The amygdala plays a paramount role in the modulation of anxiety and numerous studies have shown that arginine vasopressin (AVP) elicits anxiogenic effects following either its systemic or septal admi. (bioportfolio.com)
  • We selected two target genes [Vacuolar ATPase-A and Arginine kinase] based on the RNAi response reported for these genes in other pest species. (peerj.com)
  • This is compatible with previous findings for this enzyme that formation of the anion-stabilized dead-end complex, enzyme-arginine-MgADP-NO3-, does not occur to any marked degree. (portlandpress.com)
  • This study evaluates the addition of L-Arginine to the usual regimen in the treatment of schizophrenia in adults. (bioportfolio.com)