Arginine deficiency. Medical search. Frequent questions

This enzyme catalyzes the first step in creatine biosynthesis, the combination of arginine and glycine to form guanidinoacetate, which also results in the formation or ornithine as a by product. (wikipedia.org)
The second reason may be attributed to the inducibility of the type II isozyme in peripheral tissues, which can attack the arginine released by the hepatocyte and produce urea and ornithine. (medscape.com)
The products of the reaction are fumarate, which is oxidized in the TCA cycle, and arginine, which is rapidly cleaved to urea and ornithine via hepatic arginase. (nih.gov)
Ornithine transcarbamylase (OTC) deficiency is an X-linked genetic disorder of the urea cycle that leads to elevated levels of ammonia in the blood. (medscape.com)
Ornithine transcarbamylase (OTC) deficiency is the most common urea cycle disorder. (medscape.com)
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. (nih.gov)
6 Schulze A, Ebinger F, Rating D, Mayatepek E. Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation. (thieme-connect.de)
Score and biochemical data were assessed before and during treatment with oral creatine substitution alone or with additional dietary arginine restriction and ornithine supplementation. (neurology.org)
Arginine is one of most versatile functional amino acids because it is a precursor of several molecules, such as creatine, ornithine, nitric oxide, citrulline, proline, and polyamines. (redox.com)
Lysine competes with other dibasic amino acids like arginine and ornithine for transportation not only in intestinal mucosa and renal tubule but also in mitochondria. (empowerpharmacy.com)

Arginine:glycine amidinotransferase deficiency or AGAT deficiency is an autosomal recessive cerebral creatine deficiency caused by a deficiency of the enzyme arginine:glycine amidinotransferase. (wikipedia.org)
AGAT deficiency is inherited in an autosomal recessive manner, which means pathogenic variants must be inherited from each parent. (wikipedia.org)
Pyridoxine-dependent epilepsy (PDE-ALDH7A1) is an autosomal recessive condition due to a deficiency of α-aminoadipic semialdehyde dehydrogenase, which is a key enzyme in lysine oxidation. (nih.gov)
ASA lyase deficiency is an autosomal recessive genetic disorder. (medscape.com)
Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. (nih.gov)
Guanidinoacetate methyltransferase (GAMT) deficiency is an autosomal recessive inborn error of creatine synthesis that results in intellectual disability, epilepsy, expressive language delay, and dystonia. (thieme-connect.de)
Guanidinoactetate methyltransferase (GAMT) deficiency is an autosomal recessive disorder of creatine synthesis. (neurology.org)
Guanidinoacetate methyltransferase (GAMT) deficiency is an autosomal recessive disorder of creatine biosynthesis due to pathogenic variants in the GAMT gene that lead to cerebral creatine deficiency and neurotoxic levels of guanidinoacetate. (cdc.gov)

The multiple primary causes of hyperammonemia, specifically the urea cycle enzyme deficiencies, vary in manifestation, diagnostic features, and management. (medscape.com)
Scaglia F, Brunetti-Pierri N, Kleppe S, Marini J, Carter S, Garlick P, Jahoor F, O'Brien W, Lee B. Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism. (medlineplus.gov)

Oral creatine supplementation can be used to treat AGAT deficiency, with early intervention providing the best results. (wikipedia.org)
The main focus of treatment for AGAT deficiency is supplementation of creatine, with the goal of replenishing cerebral creatine to normal levels. (wikipedia.org)
44 Deficiency of this neurotransmitter has also been suspected to occur in CFS and supplementation with choline ( see below ) can also be helpful. (vitality101.com)
This study examined if leucine, arginine or glycine supplementation in adult obese patients (body mass index of 33 ± 4 kg/m²) consuming a Brazilian low energy and protein diet (4.2 MJ/day and 0.6 g protein/kg) affects protein and amino acid metabolism. (scielo.br)
There was no difference in amino acid profiles due to leucine, arginine or glycine supplementation. (scielo.br)
The present results suggest that 0.6 g/kg of dietary protein is enough to maintain protein turnover in obese women consuming a reduced energy diet and that leucine, arginine or glycine supplementation does not change kinetic balance or protein synthesis. (scielo.br)
This study examined if leucine, arginine or glycine supplementation in adult obese patients (body mass index of 33 ± 4 kg/m 2 ) consuming a Brazilian low energy and protein diet (4.2 MJ/day and 0.6 g protein/kg) affects protein and amino acid metabolism. (scielo.br)
Supplementation of L-Arginine has been approved significantly increase Nitric oxide and reduce ascites related mortality. (redox.com)
Lysine supplementation was also found to not lower arginine levels in several studies. (cats.com)

This enzyme deficiency results in decreased creatine synthesis, and is caused by biallelic pathogenic variants in GATM. (wikipedia.org)
The GATM gene provides instructions for making the enzyme arginine:glycine amidinotransferase. (medlineplus.gov)
GATM gene mutations impair the ability of the arginine:glycine amidinotransferase enzyme to participate in creatine synthesis, resulting in a shortage of creatine. (medlineplus.gov)
These enzyme deficiencies lead to disorders with nearly identical clinical presentations. (medscape.com)
This enzyme controls the final step of the urea cycle, which produces urea by removing nitrogen from arginine. (medlineplus.gov)
PRMT5 is a major enzyme responsible for symmetrical demethylation of arginine on target proteins 12 . (nature.com)
Arginase-1 deficiency (ARG1-D) is a genetic disorder caused by lack of an enzyme called arginase-1, or ARG1. (childneurologyfoundation.org)

Because the production of the two hormones is so close anatomically, disorders that cause vasopressin deficiency could also affect the neurons that produce oxytocin," explains Dr. Cihan Atila, endocrinologist and lead author of a study that has now been published in the journal Lancet Diabetes and Endocrinology . (unibas.ch)
Researchers at the University of Basel and the University Hospital of Basel, led by Professor Mirjam Christ-Crain, have now shown that oxytocin levels are 8.5 times higher in healthy individuals after a single dose of MDMA, while they remain unchanged in those with vasopressin deficiency. (unibas.ch)
The patients with vasopressin deficiency, on the other hand, showed no changes in these areas. (unibas.ch)
Oxytocin deficiency in people with vasopressin deficiency would at least partially explain this finding," says the endocrinologist Atila. (unibas.ch)
The same researchers at the Department of Clinical Research are currently planning a large study to investigate whether treatment with oxytocin can improve the psychological symptoms in patients with vasopressin deficiency. (unibas.ch)
Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial. (unibas.ch)

The symptoms of AGAT deficiency are caused by the lack of creatine in specific tissues, most notably muscle and brain. (wikipedia.org)
citation needed] AGAT deficiency can be suspected from clinical findings, although there is significant phenotypic overlap with the most common presenting symptoms of intellectual disability and muscle weakness. (wikipedia.org)
After that we will provide you with a list of way to assure you are consuming an appropriate amount of essential vitamins and trace minerals to avoid the symptoms of deficiencies. (cclsupplements.com)
arginase deficiency causes a somewhat different set of signs and symptoms (see Arginase Deficiency ). (medscape.com)
In some affected individuals, signs and symptoms of arginase deficiency may be less severe, and may not appear until later in life. (medlineplus.gov)
The accumulation of ammonia and arginine are believed to cause the neurological problems and other signs and symptoms of arginase deficiency. (medlineplus.gov)
Interestingly, symptoms of thiamine deficiency can mimic symptoms often seen in CFS/FMS. (vitality101.com)
Who needs it and what are some symptoms of deficiency? (modelwelt.net)
An ARG1 deficiency primarily causes symptoms in the nervous system, such as seizures, delays in development, and difficulties with walking. (childneurologyfoundation.org)

Arginase deficiency is an inherited disorder that causes the amino acid arginine (a building block of proteins) and ammonia to accumulate gradually in the blood. (medlineplus.gov)
Most "nitric oxide" supplements contain the amino acid Arginine-alpha-keto-glutarate. (modelwelt.net)
ARG1 breaks down the amino acid arginine in the liver. (childneurologyfoundation.org)
Newswise - Philadelphia, March 9, 2018 - Children with mitochondrial disease s who suffered acute metabolic strokes benefited from rapid intravenous treatment with the amino acid arginine, experiencing no side effects from the treatment. (newswise.com)

An amino acid compound called arginine alpha-ketoglutarate (A-AKG) and arginine-ketoisocaproate (A-KIC) can boost short term Nitric Oxide levels. (modelwelt.net)
Arginine boosts nitric oxide, which relaxes blood vessels and thus may help treat angina and other cardiovascular problems. (usda.gov)
Deficiency of tetrahydrobiopterin, an essential cofactor of nitric oxide synthase, causes both impaired nitric oxide activity and increased oxygen radical formation. (jci.org)
In this study we tested whether tetrahydrobiopterin deficiency contributes to the decreased nitric oxide activity observed in hypercholesterolemic patients. (jci.org)
Therefore, L-mono-methyl-arginine to inhibit basal nitric oxide activity, serotonin to stimulate nitric oxide activity, and nitroprusside as endothelium-independent vasodilator were infused in the brachial artery of 13 patients with familial hypercholesterolemia and 13 matched controls. (jci.org)

Introduction: The diagnosis of GH deficiency (GHD) in adults is based on a reduced GH response to provocative tests. (endocrine-abstracts.org)
Patients who have deficiency of 2 or less pituitary hormones or pituitary-hypothalamic disease with low IGF-1 levels require stimulation tests to establish the diagnosis of GH deficiency. (medscape.com)

As with other cerebral creatine deficiency syndromes, individuals affected with AGAT deficiency are intellectually disabled and can have seizures. (wikipedia.org)
Biochemical, molecular, and clinical diagnoses of patients with cerebral creatine deficiency syndromes. (medlineplus.gov)

A variety of influences, including dietary protein, arginine and corticosteroids, augment the concentration of NAG in mitochondria. (nih.gov)
On a cellular level, arginine plays a role in a variety of processes, from nitrogen waste disposal to protein synthesis. (scitechdaily.com)
The good news is that getting arginine from high-protein foods is safe and healthy. (healthline.com)
And since arginine is made from other amino acids, high-protein foods in general help increase arginine levels. (healthline.com)
Pork loin, another high-protein food, comes in a close second with an arginine content of 14 grams per rib. (healthline.com)
One chicken breast has 70 percent of your daily recommended protein and almost 9 grams of arginine. (healthline.com)
Animal sources aren't the only way to get protein and arginine. (healthline.com)
Since they're sources of protein, you can also get arginine from dairy products such as milk, cheese, and yogurt . (healthline.com)
One cup of cooked chickpeas contains 1.3 grams of arginine, 14.5 grams of protein, and 12.5 grams of dietary fiber. (healthline.com)
When exploring the role of protein arginine methyltransferase 5 (PRMT5) in osteoclasts, we serendipitously developed a mouse model in which PSCs are specifically abrogated. (nature.com)
Restricting protein in the diet can help keep arginine levels down. (childneurologyfoundation.org)
Iron and vitamin A deficiencies and protein-energy malnutrition are highly prevalent worldwide and are important to the public health in terms of immunocompetence. (vaclib.org)
Arginine - Cats cannot produce arginine, an amino acid that is an essential building block for protein on their own. (southforkvet.com)
Figure 1 clearly shows that when the reduced protein diet is deficient in Arginine, it will result in increased plasma lysine, methionine plus cysteine, threonine, Valine, and isoleucine concentrations, indicating these surplus essential amino acids could not be degraded for muscle growth. (redox.com)
Arginine also acts as a trigger of target of rapamycin (TOR) signalling system activation for reducing protein degradation. (redox.com)

Arginase deficiency belongs to a class of genetic diseases called urea cycle disorders. (medlineplus.gov)

A 2016 study suggests an adverse effect of arginase-1 deficiency on level 5 cortical motor neurons, as well as diminished synaptic transmission in a neonatal mouse model, recoverable by gene therapy. (medscape.com)

AGAT deficiency is caused by deficient activity of arginine:glycine amidinotransferase, which is coded for by GATM, located on the long arm of chromosome 15. (wikipedia.org)
However, a person during times of stress and rapid growth can become deficient in arginine if the body's production doesn't meet its requirements. (healthline.com)
Mice deficient in PSCs display progressive defects in intramembranous and endochondral bone formation, the latter of which is caused by a deficiency in PSC-derived Indian hedgehog (Ihh). (nature.com)
That's where citrulline helps create arginine, another amino acid--one in which some people are deficient. (usda.gov)
Patients have deficient growth hormone responses to insulin and arginine or levodopa. (lu.se)

To improve outcome, a lysine-restricted diet and competitive inhibition of lysine transport through the use of pharmacologic doses of arginine have been recommended as an adjunct therapy. (nih.gov)
In recent updated amino acids profile recommended by Aviagen breeder company, the SID Arginine to SID Lysine ratio has been increased significantly, up to 110% in the finisher period. (redox.com)
A 42 days broiler chicken trial conducted in the University of Sydney clearly showed that when SID Arginine to Lysine ratio increased from 107% to 113%, plasma Lysine, methionine plus cysteine, and threonine concentrations were significantly reduced (Figure 2). (redox.com)
Increasing SID valine to Lysine ratio from 76% to 81%, SID isoleucine to lysine ratio from 69% to 73%, and SID Arginine to lysine ratio from 107 % to 113%, increased breast meat by 59 grams. (redox.com)
One way that Lysine is proposed to work to help cats is that it competes with arginine in its role with herpes viruses. (cats.com)
When lysine is incorporated into the virus and outcompetes arginine, the virus is then thought to become less infective. (cats.com)
Lysine functions as an antimetabolite of arginine. (empowerpharmacy.com)
Lysine competes with arginine for reabsorption in the renal tubules thereby increasing arginine excretion in urine. (empowerpharmacy.com)
Lysine also competes with arginine for transport into cells and at absorption sites in the intestines. (empowerpharmacy.com)
If there is excess concentration of lysine in the gut, then absorption of arginine is decreased. (empowerpharmacy.com)

One successful method was increasing the amount of amino acid transporter proteins so that the cells could more efficiently take up arginine and other amino acids. (scitechdaily.com)
As L-arginine can generally build proteins in the body, it may also make the muscles strong. (newsbreak.com.ph)

GAMT-associated cerebral creatine deficiency syndrome is a potentially treatable condition and can be identified by elevated levels of guanidinoacetate in plasma or urine or by a significantly decreased creatine peak on magnetic resonance spectroscopy. (thieme-connect.de)
Presymptomatic treatment of neonatal guanidinoacetate methyltransferase deficiency. (thieme-connect.de)
10 O'Rourke DJ, Ryan S, Salomons G, Jakobs C, Monavari A, King MD. Guanidinoacetate methyltransferase (GAMT) deficiency: late onset of movement disorder and preserved expressive language. (thieme-connect.de)
Intellectual disability, epileptic seizures, guanidinoacetate accumulation in body fluids, and deficiency of brain creatine were common in all 27 patients. (neurology.org)
Guanidinoactetate methyltransferase deficiency should be considered in patients with unexplained intellectual disability, and urinary guanidinoacetate should be determined as an initial diagnostic approach. (neurology.org)

The neonatal presentation of argininosuccinate (ASA) lyase deficiency is consistent with the clinical manifestations of hyperammonemia. (medscape.com)
The gene for ASA lyase deficiency is located on chromosome 7 and has been mapped to the locus 7q11.2. (medscape.com)
Nagamani SC, Erez A, Lee B. Argininosuccinate lyase deficiency. (medscape.com)
Long-term outcome of patients with argininosuccinate lyase deficiency diagnosed by newborn screening in Austria. (medscape.com)

Global developmental delay in guanidionacetate methyltransferase deficiency: differences in formal testing and clinical observation. (thieme-connect.de)

In this step, a compound called guanidinoacetic acid is produced by transferring a cluster of nitrogen and hydrogen atoms called a guanidino group from arginine to glycine. (medlineplus.gov)
Consequently, as in argininosuccinic aciduria, both waste nitrogen molecules normally eliminated by the urea cycle are incorporated into the arginine substrate molecule in the reaction. (medscape.com)
The first reason is that formed arginine, which contains 2 waste nitrogen molecules, can be released from the hepatocyte and excreted in urine. (medscape.com)
Urea cycle defects with resulting hyperammonemia are due to deficiencies of the enzymes involved in waste nitrogen metabolism. (medscape.com)
Plasma concentrations of glutamine and alanine, the major nitrogen-carrying amino acids, usually are high and that of arginine is low. (nih.gov)
Arginine contains nitrogen. (childneurologyfoundation.org)

Arginine:glycine amidinotransferase deficiency is an inherited disorder that primarily affects the brain. (medlineplus.gov)
Children with arginine:glycine amidinotransferase deficiency may not gain weight and grow at the expected rate (failure to thrive), and have delayed development of motor skills such as sitting and walking. (medlineplus.gov)
The prevalence of arginine:glycine amidinotransferase deficiency is unknown. (medlineplus.gov)
Mutations in the GATM gene cause arginine:glycine amidinotransferase deficiency. (medlineplus.gov)
glycine, arginine, and methionine. (medlineplus.gov)
Specifically, arginine:glycine amidinotransferase controls the first step of the process. (medlineplus.gov)
The effects of arginine:glycine amidinotransferase deficiency are most severe in organs and tissues that require large amounts of energy, especially the brain. (medlineplus.gov)
Edvardson S, Korman SH, Livne A, Shaag A, Saada A, Nalbandian R, Allouche-Arnon H, Gomori JM, Katz-Brull R. l-arginine:glycine amidinotransferase (AGAT) deficiency: clinical presentation and response to treatment in two patients with a novel mutation. (medlineplus.gov)

Braissant O, Henry H, Beard E, Uldry J. Creatine deficiency syndromes and the importance of creatine synthesis in the brain. (medlineplus.gov)
1 Schulze A. Creatine deficiency syndromes. (thieme-connect.de)

Creatine Deficiency Syndrome. (wikipedia.org)
THURSDAY, Nov. 16, 2023 (HealthDay News) -- Arginine vasopressin (AVP) deficiency is more accurately diagnosed with hypertonic saline-stimulated copeptin than with arginine-stimulated copeptin among adults with polyuria polydipsia syndrome, according to a study published in the Nov. 16 issue of the New England Journal of Medicine . (msdmanuals.com)
5 Schulze A, Mayatepek E, Bachert P, Marescau B, De Deyn PP, Rating D. Therapeutic trial of arginine restriction in creatine deficiency syndrome. (thieme-connect.de)
Arginine is already used to acutely treat these complex strokes in adult patients who have a well-known mitochondrial disease syndrome called MELAS (mitochondrial encephalopathy with lactic acidosis and stroke-like episodes). (newswise.com)
FDA indications in children include GH deficiency (GHD), Turner syndrome, idiopathic short stature, small for gestational age with failure to attain normal growth percentiles, Prader-Willi syndrome (PWS), chronic renal insufficiency, Noonan syndrome, and short stature due to short stature homeobox gene haploinsufficiency. (ajmc.com)
The growth hormone deficiency syndrome in adults. (medscape.com)
1. AIDS: Acquired immune deficiency syndrome Acquired immunodeficiency syndrome 2. (cdc.gov)

Sixteen of these children were subsequently diagnosed as having growth hormone deficiency. (nih.gov)
Some children suffer from growth hormone deficiency which results in growth failure. (myelin.org)
Adults may suffer damage to the pituitary gland from an accident or radiation therapy, resulting in growth hormone deficiency in the blood. (myelin.org)
The treatment of growth hormone deficiency (GHD) in children and adults has been impacted greatly by the availability of recombinant human growth hormone (rhGH). (ajmc.com)
Evaluation for growth hormone (GH) deficiency is recommended in patients with hypothalamic-pituitary disease, surgery or irradiation in these areas, head trauma, or the presence of other pituitary hormone deficiencies. (medscape.com)
Patients with X-linked hypoglammaglobulinemia and isolated growth hormone deficiency have recurrent sinopulmonary infections, short stature and retarded bone age during childhood. (lu.se)

Ganetzky pointed out that intravenous arginine is much more potent than oral arginine, adding "This study was an opportunity to more systematically analyze a therapy that is clinically used on an empiric basis in the course of acute clinical care. (newswise.com)
To assess further the role of insulin in the abnormal alpha-cell dysfunction found in human diabetes mellitus, the effects of acute insulin withdrawal and administration on plasma glucagon responses to intravenous arginine were studied in eight insulin-dependent diabetic subjects. (diabetesjournals.org)

We report data from two siblings with an uncommon GAMT deficiency phenotype and their clinical, biochemical, imaging, and treatment findings. (thieme-connect.de)
This study confirms that in patients with unexplained intellectual disability, epilepsy, and/or movement disorders, GAMT deficiency should be considered. (thieme-connect.de)
Lack of creatine in muscle and brain in an adult with GAMT deficiency. (thieme-connect.de)

A total of 158 patients underwent the two tests: 44 and 56 percent received the diagnosis of AVP deficiency and primary polydipsia, respectively. (msdmanuals.com)
Seventy-two percent of patients preferred testing with arginine versus hypertonic saline. (msdmanuals.com)
For the diagnosis of AVP deficiency, arginine-stimulated copeptin was inferior to hypertonic saline-stimulated copeptin, although arginine-stimulated copeptin was preferred by the trial patients," the authors write. (msdmanuals.com)
The severe hyperammonemia observed in other urea cycle defects is rarely observed in patients with arginase deficiency for at least 2 identifiable reasons. (medscape.com)
The distinct tendency to develop spastic diplegia in patients with arginase deficiency, as compared with patients with other urea cycle disorders, suggests a specific pathogenic mechanism at the CNS level, apart from the generalized toxicity of hyperammonemia. (medscape.com)
To assess the association between vitamin D deficiency and tuberculosis disease progression, we studied vitamin D levels in a cohort of tuberculosis patients and their contacts (N = 129) in Pakistan. (cdc.gov)
Patients with citrullinemia, caused by a deficiency of AS , or argininosuccinic aciduria, caused by a deficiency of AL , will manifest marked increases of blood citrulline and argininosuccinate, respectively. (nih.gov)
Patients with OTC deficiency have increased excretion of orotic acid because carbamyl phosphate spills into the cytoplasm, where it enters the pathway of pyrimidine synthesis. (nih.gov)
There are also nutrients (i.e., glutamine, arginine, fatty acids, vitamin E) that provide additional benefits to immunocompromised persons or patients who suffer from various i nfections. (vaclib.org)
Two mitochondrial medicine experts from Children's Hospital of Philadelphia (CHOP) reported on eight years of clinical experience in providing intravenous (IV) arginine when new-onset neurologic problems concerning for acute stroke-like episode developed in nine pediatric mitochondrial disease patients. (newswise.com)
Recent clinical practice guidelines from the Mitochondrial Medicine Society recommended using IV arginine in patients having stroke-like episodes from MELAS, and considering its use at the time of stroke-like episodes in other mitochondrial diseases. (newswise.com)
Like many patients with mitochondrial disease, nearly all patients in this cohort were already taking oral "mitochondrial cocktails" of vitamins and cofactor supplements, commonly including oral arginine, at the time of their stroke-like episode. (newswise.com)
Magnetic resonance imaging (MRI) performed in some patients showed that brain changes caused by the stroke returned to normal after patients received IV arginine. (newswise.com)
Now, for the first time, researchers from the University of Basel and the University Hospital of Basel have succeeded in demonstrating a deficiency of oxytocin in patients with a deficiency of vasopressin caused by a disease of the pituitary gland. (unibas.ch)
Patients with a rare deficiency of vasopressin cannot concentrate their urine and lose liters of water as a result. (unibas.ch)
Both the attenuated L-mono-methyl-arginine-induced vasoconstriction as well as the impaired serotonin-induced vasodilation were restored in patients during tetrahydrobiopterin infusion. (jci.org)
The proportion of patients with low GH response to provocative tests increases with the number of other pituitary hormone deficiencies and several studies involving panhypopituitary patients have shown that under certain circumstances GH stimulation tests may be unnecessary to diagnose GHD.Objective: Aim of this study was to re-evaluate th. (endocrine-abstracts.org)
[ 15 ] For patients with childhood-onset GH deficiency, retesting for GH deficiency is indicated after achievement of adult height to determine the need to continue therapy. (medscape.com)
Patients with congenital or irreversible hypothalamic-pituitary structural abnormalities do not require retesting for GH deficiency. (medscape.com)
In patients with GH deficiency of hypothalamic origin (eg, irradiation), GHRH can stimulate the pituitary and therefore yields falsely normal results. (medscape.com)

Folate deficiency is one of the most common vitamin deficiencies in the United States…and it is silent. (drjohnlapuma.com)
In a small 2014 study -one of the only real studies linking a vitamin directly to the topic we're discussing-a correlation was found between erectile dysfunction and folate deficiency. (lelo.com)

The stereoisomer (S)-1-pyrroline-5-carboxylate is an intermediate in glutamate metabolism, arginine degradation, and proline biosynthesis and degradation. (hmdb.ca)

Individuals with AGAT deficiency are intellectually disabled and have muscle weakness. (wikipedia.org)
All creatine deficiencies are rare, and there have been fewer than 20 individuals reported in medical literature with AGAT deficiency. (wikipedia.org)
AGAT deficiency was first identified in 2000, in a pair of sisters aged 4 and 6. (wikipedia.org)
The clinical manifestations of AGAT deficiency are caused by the decreased amounts of creatine produced. (wikipedia.org)
This finding is not specific to AGAT deficiency, it can be observed in all three cerebral creatine deficiencies. (wikipedia.org)
The combination of biochemical testing and MRS findings can be strongly suggestive of AGAT deficiency. (wikipedia.org)
Identification of biallelic pathogenic variants in GATM would be confirmation of a diagnosis of AGAT deficiency. (wikipedia.org)
Prenatal testing for AGAT deficiency can be performed on chorionic villi samples if the causative pathogenic variants in the family are known. (wikipedia.org)

The glucagon test can be used if GHRH is not available or the GHRH-arginine test is normal in the context of a high suspicion for GH deficiency and there is a contraindication to using the ITT. (medscape.com)
During the last hour of the 14-hour infusion, glucagon responses to arginine (area under the curve, nanograms per milliliter per minute) were similar to those found in normal subjects (10.3 ± 0.8 vs. 9.0 ± 0.8, respectively). (diabetesjournals.org)
These results demonstrate a rapid effect of insulin on glucagon responses to arginine and suggest that the abnormal responses seen in diabetes mellitus are the immediate result of insulin deficiency. (diabetesjournals.org)

GH deficiency is diagnosed by a low level of serum insulinlike growth factor-1 (IGF-1) in the presence of deficiency of 3 or more pituitary hormones. (medscape.com)

Mutations in the ARG1 gene cause arginase deficiency. (medlineplus.gov)

for moderate to severe infections we propose a tried‑and‑true treatment: the combination of arginine and ascorbate, administered orally or intravenously. (spandidos-publications.com)
iii) The combination of arginine‑ascorbate. (spandidos-publications.com)

Arginase deficiency is thought to be the least common of the urea cycle disorders. (medscape.com)
Cerebral creatine deficiencies: a group of treatable intellectual developmental disorders. (thieme-connect.de)
Arginine or citrulline are often recommended to address these disorders. (usda.gov)

The 2 most common tests are the insulin tolerance test (ITT) and the combination of GH-releasing hormone (GHRH) and arginine (GHRH-arginine test). (medscape.com)

Julie Refardt, M.D., Ph.D., from the University Hospital Basel in Switzerland, and colleagues conducted a noninferiority trial involving adults with polydipsia and hypotonic polyuria or a known diagnosis of AVP deficiency to undergo diagnostic evaluation with hypertonic-saline stimulation and with arginine stimulation on different days. (msdmanuals.com)
Arginine is a semi-essential amino acid because it's typically needed for children's growth, but is nonessential for healthy adults. (healthline.com)

Next to the 8 essential aminos, I will try to discuss a number of them that have made the headlines recently: L-Glutamine, L-Arginine , L-Carnitine, L-Cysteine, and HMB. (bodybuilding.com)
Examples of some non-essential amino acids include alanine, glutamine, and arginine. (cats.com)

Hair loss is scary for both men and women alike and is often associated with old age but deficiencies in iron, zinc, linoleic acid (LA) and alpha-linolenic acid (ALA), niacin (vitamin B3) and biotin can also cause early hair loss . (cclsupplements.com)
As zinc helps the body in producing testosterone, its deficiency may affect sexual health. (newsbreak.com.ph)

Compound 5 is fumaric acid generated in the reaction that converts ASA to arginine (6), which is mediated by ASA lyase. (medscape.com)
Urinary orotic acid generally is very elevated in babies with OTC deficiency and normal or even low in infants with CPS deficiency. (nih.gov)
Arginine is an amino acid naturally produced by our bodies and plentiful in the fish, meat, and nuts that we eat. (scitechdaily.com)
Arginine is a type of amino acid that's important for regulating blood flow. (healthline.com)
It does this by breaking down an amino acid called arginine. (childneurologyfoundation.org)
In the urea cycle, citrulline combines with another acid to create arginine. (usda.gov)

Deficiencies in endogenous NO synthesis are extremely common in people with high CVD risk. (holisticprimarycare.net)

Arginine is a fuel for making NO, but the biochemical "motor" is not working right. (holisticprimarycare.net)

Signs of deficiency include the inability to achieve and sustain erections, physical weakness and extreme fatigue. (modelwelt.net)

Chronically high levels of pyrroline-5-carboxylate are associated with at least five inborn errors of metabolism, including hyperprolinemia type I, hyperprolinemia type II, iminoglycinuria, prolinemia type II, and pyruvate carboxylase deficiency. (hmdb.ca)
Creatine deficiency in the brain: a new, treatable inborn error of metabolism. (thieme-connect.de)

The presence of hyperammonemia, hyperglutaminemia, hyperalaninemia and orotic aciduria in a critically ill infant affords strong presumptive evidence for OTC deficiency. (nih.gov)
Demonstration of hyperammonemia is the sine qua non of diagnosis of OTC deficiency. (medscape.com)

The disease is caused by a deficiency of arginase type I in the liver. (medscape.com)
Hyperargininemia due to liver arginase deficiency. (medlineplus.gov)

There have been no significant new NO-based drugs, and while the market has been flooded with supplements containing arginine-a key precursor for NO-the efficacy of these products is highly variable. (holisticprimarycare.net)

These are three-strand motifs that contain characteristic TRYPTOPHAN, ARGININE, and CYSTEINE residues respectively. (bvsalud.org)

The cut-off limits of GH response to GHRH + arginine test related to body mass index for the diagnosis of adult GH deficiency: do we need to review our diagnostic criteria? (endocrine-abstracts.org)
The GHRH-arginine can be used as an alternative to the ITT. (medscape.com)
[ 22 ] GHRH is administered intravenously at a dose of 1 µg/kg body weight (time 0) followed by an intravenous infusion of 0.5 g/kg body weight (not to exceed 30 g) of arginine over 30 minutes. (medscape.com)

The infusions were repeated during coinfusion of L-arginine (200 microg/kg/min), tetrahydrobiopterin (500 microg/min), or the combination of both compounds. (jci.org)
Arginine infusions (30 gm. (diabetesjournals.org)

Anatomy2

Organisms3

Diseases36

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes13

Information Science3

Ornithine10

Autosomal recessive8

Urea cycle enzyme deficiencies2

Supplementation9

Enzyme7

Vasopressin Deficiency6

Symptoms9

Amino acid arginine4

Nitric5

Diagnosis of GH deficiency2

Cerebral creatine deficiency2

Protein15

Genetic1

Arginase-1 deficiency1

Deficient5

Lysine10

Proteins2

Guanidinoacetate5

Lyase deficiency4

Methyltransferase deficiency1

Nitrogen6

Glycine8

Syndromes2

SYNDROME7

Growth Hormone6

Intravenous arginine2

GAMT3

Patients20

Folate2

Biosynthesis1

AGAT8

Glucagon3

Pituitary1

ARG11

Combination of arginine2

Disorders3

Insulin1

Adults2

Glutamine2

Zinc2

Acid6

Synthesis1

Biochemical1

Signs1

Metabolism2

Hyperammonemia2

Liver2

Supplements1

Cysteine1

GHRH3

Infusions2