Arenavirus viral hemorrhagic fever. Medical search. Frequent questions

Some VHF viruses (arenaviruses, CCHF virus, filoviruses) spread from person to person by direct contact with symptomatic patients, body fluids, or cadavers, or through inadequate infection control in a hospital setting. (cdc.gov)
Viral hemorrhagic fevers (filoviruses [e.g. (cdc.gov)
It also includes smallpox virus, viral hemorrhagic fevers (filoviruses e.g. (defenseindustrydaily.com)
Dr. Cross' research is centered on the biology and pathogenesis of high priority viral agents with a particular emphasis on elucidating mechanisms of vascular leak, coagulopathy, and immune derangement in viral hemorrhagic fever infections caused by filoviruses, arenaviruses, and bunyaviruses. (utmb.edu)
Laboratory diagnosis consisted of testing for filoviruses, arenaviruses, and bunyaviruses, as well as for chikungunya and dengue viruses by using reverse transcription PCR. (cdc.gov)
Filoviruses are emerging pathogens and causative agents of viral haemorrhagic fever. (flutrackers.com)

Hepatic involvement varies with the infecting organism and is at times seen with Ebola, Marburg, RVF, Crimean-Congo hemorrhagic fever (CCHF), and yellow fever. (medscape.com)
Bleeding complications are particularly prominent with Ebola, Marburg, CCHF, and the South American arenaviruses. (medscape.com)
Ebola, Marburg] and arenaviruses [e.g. (cdc.gov)
Important agents are Lassa fever virus ( Arenavirus ), Ebola virus, Marburg virus ( Filoviradae ) and Crimean-Congo haemorrhagic fever virus. (nsw.gov.au)
These include the Ebola and Marburg, Lassa fever, and yellow fever viruses. (medlineplus.gov)
This discovery could eventually lead to new antiviral drugs for Ebola and Marburg, among other viral infections. (ghtcoalition.org)

Arenaviruses are divided into two groups - New World and Old World viruses - based on genetic differences as well as where the viruses are geographically distributed. (cdc.gov)
Viral hemorrhagic fever (VHF) diseases are caused by 3 families ( Arenaviridae , Filoviridae , Flaviviridae ) and 1 order ( Bunyavirales ) of enveloped RNA viruses. (cdc.gov)
Viruses in the order Bunyavirales include the Arenaviridae family viruses, Crimean-Congo hemorrhagic fever (CCHF) virus (family Nairoviridae ), hantaviruses (family Hantaviridae ), and Rift Valley fever (RVF) virus (family Phenuiviridae ). (cdc.gov)
Viral hemorrhagic fevers (VHFs) are a group of febrile illnesses caused by RNA viruses from several viral families. (medscape.com)
These highly infectious viruses lead to a potentially lethal disease syndrome characterized by fever, malaise, vomiting, mucosal and gastrointestinal (GI) bleeding, edema, and hypotension. (medscape.com)
Hemorrhagic fever viruses have an affinity for the vascular system, leading initially to signs such as flushing, conjunctival injection, and petechial hemorrhages, usually associated with fever and myalgias. (medscape.com)
Nowadays, in Africa many viruses are known to cause haemorrhagic fevers including Ebola, Magdeburg and yellow fever . (omicsonline.org)
2.2 Transmission of haemorrhagic fever viruses. (who.int)
There are 14 distinct viruses associated with haemorrhagic fever in humans. (who.int)
Arenaviruses are the largest family of haemorrhagic fever causing viruses. (nottingham.ac.uk)
Human transmission of these RNA viruses occurs through direct skin contact with infected rodent faeces or urine, ingestion of contaminated food, or through respiratory exposure to rodent excreta, resulting in illnesses ranging from mild flu-like syndromes to severe and highly fatal haemorrhagic diseases. (nottingham.ac.uk)
Dr. Cross also has a long standing interest in the epidemiology and ecology of these viruses where a particular focus has been centered on mammalian reservoirs of viral infection. (utmb.edu)
Viral hemorrhagic fevers (VHFs) are a group of illnesses caused by four families of viruses. (medlineplus.gov)
Overview of Arbovirus, Arenavirus, and Filovirus Infections Arbovirus, arenavirus, and filovirus are viruses that are spread from animals to people and, with some viruses, from people to people. (merckmanuals.com)
The 12 distinct enveloped RNA viruses that cause most viral hemorrhagic fever (VHF) cases are members of 4 families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. (medscape.com)
Hemorrhagic fever viruses are highly contagious by touching bodily fluids of infected patients and then touching your mouth or eyes. (marshallcountyhealthdepartment.com)
Viral Hemorrhagic Fevers of Animals Caused By DNA Viruses. (booksdo.com)
The Arenavirus family has scores of viruses in it, several of which are known to infect and cause disease in people as well as animals. (gavi.org)
While the family's human pathogenic viruses are fairly closely related, they are divided into two groups-the Old World Arenaviruses and the New World Arenaviruses. (gavi.org)
Rats, mice, hamsters, voles and other rodents are the primary carriers of Arenaviruses and are the main route of transmission of the viruses from animals to people. (gavi.org)
It demonstrates the powerful neutralizing effects of silver nanoparticles against hemorrhagic fever viruses, including Arenavirus and Filovirus (i.e. (thesilveredge.com)
The researchers concluded that in vitro , silver nanoparticles neutralize hemorrhagic fever viruses inside the cells by decreasing S segment gene expression and concomitantly decreasing progeny virus production. (thesilveredge.com)
It is prescribed for severe fever with thrombocytopenia syndrome (SFTS), a viral hemorrhagic fever with high fatality rate and is effective against all strains of influenza viruses," Banerjee told PTI. (11xi.in)
We extended our structural and functional studies into the segmented negative strand RNA viruses that also use a single large protein to catalyze all the steps in viral gene expression. (whelan-lab.org)
We have employed those viruses in genome wide loss of function screens to probe the cellular factors for viral entry. (whelan-lab.org)
This group includes several emerging and highly fatal viruses such as Lassa fever virus , bunyaviruses like La Crosse and Rift Valley fever , as well as the better-known and more common influenza viruses. (harvard.edu)
Previous clues about this mechanism came from research on influenza and La Crosse viruses that showed the viral protein responsible for copying the key segment - RNA-dependent RNA-polymerase (RdRP) - interacted with the 5′ end of the segment, which is the exact opposite end to the location where the protein initiates copying. (harvard.edu)

The prime suspects among the New World Arenaviruses are Junin virus, Machupo virus, Guanarito virus and Sabia virus. (gavi.org)
Junin virus, which takes the name of the city in Argentina where it first emerged in the early 1950s, also goes by the aliases Argentine Haemorrhagic Fever and Argentinian Mammarenavirus, while Machupo Virus is also known as Bolivian Haemorrhagic Fever, Black Typhus or Ordog Fever. (gavi.org)
What is known, however, is that the New World Arenaviruses such as Junin and Machupo virus enter human cells after binding to a particular type of molecule known as transferrin receptor 1, or TfR1, and perhaps other types of cell surface receptors too. (gavi.org)
In the study, Whelan and his co-author Jesse Pyle , a graduate student in his lab, worked with the Machupo virus, an arenavirus that, like Lassa virus, infects rodents, which transmit the virus to humans, in whom it can cause fatal hemorrhagic fevers. (harvard.edu)
The experiments revealed that mixing short 13-nucleotide RNAs from the 5′ end of the Machupo virus segments with the RdRP, the catalyst that initiates RNA replication, stimulated the ability of this enzyme to copy the viral segment. (harvard.edu)

There are some arenaviruses - both New and Old World - that have been identified in host animals, but no human infection has been reported yet. (cdc.gov)
In vitro studies reveal these cytokines lead to shock and increased vascular permeability, the basic pathophysiologic processes most often seen in viral hemorrhagic fever infection. (medscape.com)
Acute kidney injury with oliguria is a prominent feature of hemorrhagic fever with renal syndrome (HFRS) seen in Hantavirus infection and may be seen in other VHFs as intravascular volume depletion becomes more pronounced. (medscape.com)
Viral hemorrhagic fever has been associated with high mortality rate which brought serious concern for public health worldwide and prompted a sense of urgency to halt this infection. (omicsonline.org)
The current lack of understanding of the molecular mechanisms of key host-virus interactions that potentiate disease pathogenesis or impede disease potential through evasion of host cellular immunity, hampers the development of novel therapeutic strategies for arenavirus infection. (nottingham.ac.uk)
Our shared interests focus on identifying and developing novel therapeutic strategies for Lassa fever infection and on improving the engagement and support offered to affected communities in Nigeria. (nottingham.ac.uk)
Imagine taking a single pill that could cure almost any viral infection. (voanews.com)
The Role of Viral Protein Phosphorylation During Filovirus Infection. (booksdo.com)
We show that pegivirus C is a common co-infection in individuals with LF and is associated with lower Lassa viral loads and favorable outcomes. (bvsalud.org)
She had been sick for two weeks with shooting fevers, bad throat and mouth, aching, not responding to antibiotics-a viral infection. (gavi.org)
They note that viral neutralization occurs during the early phases of viral replication, so silver nanoparticle treatment would have to be administered prior to viral infection or within the first two to four hours after initial virus exposure. (thesilveredge.com)
Lassa fever is a severe viral hemorrhagic infection caused by Lassa virus, which is affiliated to arenavidae virus family. (bestnursingpapers.com)
The resultant effect is long chain of the viral infection to host and host to people. (bestnursingpapers.com)
Lassa fever is a potentially severe viral infection caused by Lassa virus (family Arenaviridae , genus Arenavirus ), with an overall case-fatality rate of 1%-2% and a case-fatality rate of 15%-20% for hospitalized patients ( 1 , 2 ). (cdc.gov)

Viral haemorrhagic fevers (VHFs) are severe viral infections capable of causing vital death associated with multi-organ failure resulting in high mortality rates. (omicsonline.org)

Ticks Crimean-Congo hemorrhagic fever, various tick- borne encephalitis's etc. (slideshare.net)

In some areas of the world, arenavirus infections in people are relatively common and can cause severe disease. (cdc.gov)
Most infections spread among adult rodents through scratches and bites, although for certain arenaviruses, the virus passes from mother to offspring during pregnancy. (cdc.gov)
In unstable countries of North Africa with fragile health services complicated with armed conflicts and population displacement, such infections could be easily confused with other local parasitic and viral diseases. (omicsonline.org)
Examples of misuse include when antibiotics are taken by people with viral infections like colds and flu, and when they are given as growth promoters in animals and fish. (who.int)
Because there are no effective treatments for some of these viral infections, there is concern about their use in bioterrorism . (medlineplus.gov)
The last two viral infections can cause inflammation of the brain. (voanews.com)
Fauci says there is a trend in microbial research now to develop catch-all drugs like a universal flu vaccine that would protect against all strains of influenza, and DRACO, with its potential to target and eliminate all types of viral infections. (voanews.com)
Hemorrhagic Fevers Overview Hemorrhagic fevers are serious viral infections characterized by bleeding (hemorrhage). (merckmanuals.com)
are viral infections that cause bleeding (hemorrhage) and organ malfunction. (merckmanuals.com)
Categorizing viral infections by the organ system most commonly affected (eg, lungs, gastrointestinal tract, skin, liver, central nervous system, mucous membranes) can be clinically useful, although certain viral disorders (eg, mumps) are hard to categorize. (msdmanuals.com)
Upper respiratory infections are likely the most common viral infections. (msdmanuals.com)
With the exception of Rift Valley fever and the diseases caused by Flaviviruses (Yellow fever, Omsk HF, and Kyasanur Forest Disease) which are not transmissible person-to-person, infected humans can spread the disease to close contacts by touching bodily fluids, which may result in community outbreaks and nosocomial infections. (marshallcountyhealthdepartment.com)
In this account, the authors provide laboratory confirmation that the first suspected viral hemorrhagic fever cases in Angola were yellow fever virus infections and reported preliminary sequencing data. (cdc.gov)
He noted that Favipiravir is available under the name of Avigan for influenza and is often recommended for viral infections such as bunyavirus, filovirus and arenavirus. (11xi.in)
Mainly used to take care of hepatitis C trojan (HCV) within combination therapy, it has additionally been shown to work against other infections, such as for example measles disease, influenza disease, and arenaviruses, specifically, the virus leading to Lassa hemorrhagic fever (36). (colinsbraincancer.com)

Valley fever, dengue haemorrhagic fever, Crimean-Congo haemorrhagic fever and Ebola haemorrhagic fever. (who.int)

Last week, the Coalition for Epidemic Preparedness Innovations (CEPI) and the University of Oxford announced the launch of a new project to develop prototype vaccines against an arenavirus called Junin virus, which causes Argentine hemorrhagic fever. (ghtcoalition.org)
CEPI will invest $25 million in the development of early prototypes of viral vector and mRNA vaccines against the Junin virus, as well as the improvement of the ChAdOx viral vector technology, part of the broader partnership between CEPI and Oxford to support vaccine development for a variety of viral families with future epidemic or pandemic potential. (ghtcoalition.org)

Lassa fever, which can cause mild to severe disease in people, is found in West Africa. (cdc.gov)
Endemic to West Africa and South America, arenaviral haemorrhagic fevers, such as Lassa fever (LF), are on the priority list of the World Health Organisation (WHO) as diseases requiring urgent research and development measures. (nottingham.ac.uk)
Professor Asogun's efforts pioneered the establishment of the molecular diagnostic laboratory at ISTH in 2008, serving as the first National Reference laboratory for viral haemorrhagic fevers in Nigeria, and he has made significant contributions to Lassa fever case management in Nigeria. (nottingham.ac.uk)
For example, Lassa fever is limited to rural areas of West Africa where rats and mice carry the virus. (medlineplus.gov)
Symptoms of Lassa fever and South American arenavirus hemorrhagic fevers usually start about 5 to 16 days after people are exposed to the virus. (merckmanuals.com)
About 80% of cases of Lassa fever are mild and are often not diagnosed. (merckmanuals.com)
About 20 to 30% of people with Lassa fever lose their hearing. (merckmanuals.com)
Obvious bleeding is less common in Lassa fever. (merckmanuals.com)
The diagnosis of Lassa fever or a South American hemorrhagic fever is confirmed by blood tests to identify the virus or antibodies to the virus. (merckmanuals.com)
The first imported case of Lassa fever in more than 20 years occurred in New Jersey in 2004. (medscape.com)
[ 9 ] Lassa fever imported to the US was again reported in 2010. (medscape.com)
In West Africa, Lassa fever is spread to humans when infected rodents are captured for consumption, as well as by person-to-person exposures. (medscape.com)
LHF-535 is a first-in-class small molecule antiviral in development as a therapeutic to treat Lassa fever and other viral hemorrhagic fevers of arenavirus origin. (pharmaceuticalnewswire.com)
We are encouraged by these positive clinical study results for LHF-535 as there are no therapeutic options for patients infected with Lassa fever. (pharmaceuticalnewswire.com)
The unmet need is tremendous both for patients in West Africa where Lassa fever is endemic as well as potentially throughout the world. (pharmaceuticalnewswire.com)
Kineta is receiving funding from the Wellcome Trust and the National Institutes of Health to advance the clinical development of LHF-535 in patients with Lassa fever and to evaluate its activity against other arenaviruses. (pharmaceuticalnewswire.com)
The febrile illness, which soon inherited the name of the town and became known as Lassa Fever, was later found to be caused by a virus related to another called Lymphocytic Choriomeningitis virus, or LCMV. (gavi.org)
The recent emergence of Zaire ebolavirus in West Africa has come as a surprise in a region more commonly known for its endemic Lassa fever, another viral hemorrhagic fever caused by an Old World arenavirus. (org.in)
The project is aimed at kickstarting the broader development of vaccines for arenaviruses, which include the virus that causes Lassa fever, one of CEPI's priority pathogens. (ghtcoalition.org)
Lassa fever is an acute viral zoonotic illness caused by Lassa virus, an arenavirus known to be responsible for a severe haemorrhagic fever characterised by fever, muscle aches, sore throat, nausea, vomiting and, chest and abdominal pain. (folkhalsomyndigheten.se)
Lassa fever is endemic in West Africa and has been reported from Sierra Leone, Guinea, Liberia, and Nigeria. (folkhalsomyndigheten.se)
Studies reported in English, that investigated Lassa fever with reference to West Africa were identified using the Medline Entrez-PubMed search and were used for this review. (folkhalsomyndigheten.se)
The scarcity of resources available for health care delivery system and the political instability that characterise the West African countries would continue to impede efforts for the control of Lassa fever in the sub-region. (folkhalsomyndigheten.se)
Epidemics of Lassa fever were have comprehensive information about the virus and also documented in other West African countries in- the disease it causes. (folkhalsomyndigheten.se)
Lassa reported in English, that investigated Lassa fever with virus is spherical in shape and measures between 70 reference to West Africa were identified using the and 150 nm in diameter (Fig. 1). (folkhalsomyndigheten.se)
Combinations of face envelope with T-shaped spikes measuring 7-10 key words such as Lassa fever and West Africa were nm and built with glycoprotein. (folkhalsomyndigheten.se)
This paper discusses Lassa fever, an infectious disease with regard to its causality organism, transmission, epidemiology, and factors causing the illness, clinical manifestation and diagnosis and the role of the nurse in controlling the illness. (bestnursingpapers.com)
Lassa virus, the causality of the Lassa fever belongs to genus arenavirus and arenavidae family (Clercq & Kern, 2003). (bestnursingpapers.com)
The multimammate rat scientifically referred to as mastomys natalensis is the natural reservoir of Lassa virus, which causes Lassa fever. (bestnursingpapers.com)
Like Ebola virus, Lassa fever starts with flu-like symptoms and can lead to debilitating vomiting, neurological problems and even hemorrhaging from the eyes, gums and nose. (gvn.org)
We report a case of Lassa fever in a US traveler who visited rural Liberia, became ill while in country, sought medical care upon return to the United States, and subsequently had his illness laboratory confirmed. (cdc.gov)
Being infected with the Lassa fever virus, for example, is rarely fatal, but once the actual disease develops, it can cause hemorrhaging in multiple organs in one out of five people. (harvard.edu)

We have partnered with Lassa virus epidemiologists and virologists, Professor Danny Asogun and Dr Deborah Ehichioya, at the Irrua Specialist Teaching Hospital (ISTH) and Ambrose Alli University (AAU) in Nigeria to link the biomedical investigation with social engagement and communication to tackle the spread of the highly fatal arenavirus, Lassa (LASV), in endemic regions in Nigeria. (nottingham.ac.uk)
Yellow fever virus is endemic in tropical and subtropical Africa and South America, and it's transmitted to humans and nonhuman primates through the bites of infected mosquitoes. (cdc.gov)
A low capacity for yellow fever diagnosis and lack of surveillance in disease-endemic countries likely contribute to case underreporting. (cdc.gov)
Lassa fe- Lassa virus in many more districts and states in en- ver is endemic in West Africa and has been reported demic countries of the West African sub-region and from Sierra Leone, Guinea, Liberia, and Nigeria4-7. (folkhalsomyndigheten.se)
Arenaviruses certainly are a main reason behind hemorrhagic fevers endemic to Sub-Saharan Africa and SOUTH USA and thus a significant public health Hydroxocobalamin (Vitamin B12a) insurance and medical concern. (biospraysehatalami.com)

Viral hemorrhagic fevers are rare diseases in the United States but more prevalent in Africa. (marshallcountyhealthdepartment.com)
Download instantly Global Virology I - Identifying and Investigating Viral Diseases by Paul Shapshak, John T. Sinnott, Charurut Somboonwit, Jens H. Kuhn. (booksdo.com)
We provide additional pharmacological characterizations supporting the potential development of BCX4430 as a countermeasure against human filovirus diseases and other viral diseases representing major public health threats. (flutrackers.com)

They include Chapare virus, a severe or fatal hemorrhagic fever, found in Bolivia, as well as Guanarito virus found in Venezuela. (cdc.gov)
Guanarito virus, named after the municipality in Venezuela where it was first detected and identified in 1989, is also sometimes referred to as Guanarito mammarenavirus or Venezuelan Haemorrhagic Fever. (gavi.org)

Chapare Hemorrhagic Fever and Virus Detection in Rodents in Bolivia in 2019. (cdc.gov)
The etiologic agent was identified as Mammarenavirus Chapare mammarenavirus, or Chapare virus (CHAPV), which causes Chapare hemorrhagic fever (CHHF). (cdc.gov)

We then review the tools used to obtain viral genomic sequences used for phylogeny and molecular diagnostics, before shifting to a population perspective to assess the contributions of phylogenetic analysis in understanding the evolution and ecology of Lassa virus in West Africa. (bvsalud.org)

[4] Brazilian mammarenavirus is one of the arenaviruses from South America to cause hemorrhagic fever . (mdwiki.org)

For details on dengue and yellow fever, see the respective chapters in this section. (cdc.gov)
Yellow fever (the prototype virus of the Flaviviridae family), dengue, Hantavirus pulmonary syndrome (HPS), and hemorrhagic fever with renal failure syndrome (HFRS) are discussed in separate chapters (see Differentials). (medscape.com)
The virus causes yellow fever which, in severe cases, manifests as fulminant hemorrhagic fever. (cdc.gov)
Outbreaks of yellow fever in humans occur mostly in the urban cycle of the virus, which involves its transmission through the bites of the day-feeding infected Aedes aegypti mosquitoes. (cdc.gov)
Yellow fever was first recognized in Angola in the 1930s, but not until 1971 and 1988 were sizeable outbreaks reported. (cdc.gov)
A real time RT-PCR for yellow fever virus produced positive results for samples from all 3 patients. (cdc.gov)
The initially localized outbreak in Angola developed into the biggest and most widespread yellow fever epidemic recorded in Africa for decades. (cdc.gov)
This finding reiterates the endemicity of yellow fever in Angola and emphasizes the need for consistent routine mass vaccination of the at-risk population to prevent future outbreaks. (cdc.gov)
I've been reading an abridged version of the October 2016 article, "Resurgence of Yellow Fever in Angola, 2015-2016. (cdc.gov)
We help uncover the causes of three outbreaks as yellow fever virus, monkeypox virus, and a noninfectious cause, the latter ultimately determined to be pesticide poisoning. (bvsalud.org)

Lujo, a fatal hemorrhagic fever, is found in southern Africa. (cdc.gov)
Among the Old World Arenaviruses, Lassa virus, Lujo virus and Lymphocytic Choriomeningitis virus are considered the most worthy of disease detectives' attention, largely because of their ability to cause severe disease in people. (gavi.org)

The clinical syndrome became known as hemorrhagic fever with renal syndrome (HFRS), formerly Korean hemorrhagic fever, and the virus was named Hanta after the Hantaan River of Korea. (medscape.com)

Filovirus disease - Ebola fever. (medscape.com)

Infectious agents that are arthropod-borne (usually mosquitoes) cause many viral hemorrhagic fevers. (medscape.com)
Brazilian hemorrhagic fever ( BzHF ) is an infectious disease caused by Brazilian mammarenavirus , an arenavirus . (mdwiki.org)

Arenavirus , Filoviridae , Bunyaviridae and Flavivirus . (who.int)

The viral envelope or covering is studded with glycoproteins comprising of tetrameric composites that belong to viral glycoproteins GP1 and GP2. (bestnursingpapers.com)
The GPC is subsequently cleaved to form two viral glycoproteins, GP1 and GP2 which ultimately form the T-shaped glycoprotein spike which extends from the viral envelope. (wikidoc.org)

This transmission electron microscopic (TEM) image depicted eight virions (viral particles) of a newly-discovered virus, which was determined to be a member of the genus, Arenavirus . (cdc.gov)

Flexal mammarenavirus (also known as the Flexal virus or FLEV, and previously known by the laboratory code BeAn 293022) is a mammarenavirus: an arenavirus with a mammalian host. (wikipedia.org)
A number of mammalian arenaviruses cross-infect humans, often causing a life-threatening viral hemorrhagic fever. (bvsalud.org)

For several viral hemorrhagic fevers, person-to-person transmission may occur through direct contact with infected patients, their blood, or their secretions and excretions. (medscape.com)
As many as 130,000 cases with fever and jaundice or hemorrhage may occur annually with a concomitant 78,000 deaths. (cdc.gov)
hemorrhagic signs or deafness may also occur during illness ( 1 , 6 ). (cdc.gov)

Lymphocytic choriomeningitis virus (LCMV) was the first arenavirus identified. (cdc.gov)
In addition, new strains of arenaviruses are being discovered, hence, virus sequence diversity is expanding and the likelihood of new outbreaks is increasing, for which disease severity and treatment options are unknown. (nottingham.ac.uk)
we've cured the polio virus, various DNA adenoviruses, dengue hemorrhagic fever and several examples of arenavirus and bunyavirus. (voanews.com)
Hemorrhagic fevers can be caused by many different types of virus. (merckmanuals.com)
A cause of fatal hemorrhagic fever, it was confirmed that this virus was responsible for causing illness in five South Africans, four of whom died having succumbed to its devastating effects. (cdc.gov)
It inhibits virus entry into target host cells and serves to suppress viral replication. (pharmaceuticalnewswire.com)
Like other arenaviruses, Lassa virus lacks a ogy and clinical presentation, treatment, prevention conventional negative-strand coding arrangement and control as well as the current theories of its patho- and the isolates of the virus differ in their genetic, genesis and efforts in vaccine development. (folkhalsomyndigheten.se)
This process is essential to the virus since it guarantees sufficient provision of viral proteins for the forthcoming replication step, which involves transformation of proteins N and L from the mRNA (Dworkin, 2011). (bestnursingpapers.com)
The flexibility of the receptor is extended to its usage by the prototypic arenavirus lymphocytic choriomeningitis virus. (bestnursingpapers.com)
Now a team led by Staff Scientist Kathryn Hastie and Professor Erica Ollmann Saphire at The Scripps Research Institute (TSRI) has solved the structure of the viral machinery that Lassa virus uses to enter human cells. (gvn.org)
Hundreds of thousands of people are infected with the virus every year, and it is the viral hemorrhagic fever that most frequently comes to the United States and Europe," said Ollmann Saphire, senior author of the new study and co-director of the TSRI Global Virus Network (GVN) Center of Excellence. (gvn.org)

The clinical symptoms are very general and could be easily missed, consisting of onset of fever, myalgia , and general malaise accompanied by chills. (omicsonline.org)

Host restriction factors are components of the intrinsic anti-viral response, that act at crucial steps to potently inhibit viral entry, replication and exit from the host cell. (nottingham.ac.uk)
Despite the high genetic similarity amongst arenavirus strains, disease can vary from asymptomatic to fatal implying that the interplay between the host immune response and viral replication is a major predictive factor for disease outcome. (nottingham.ac.uk)
Harvard Medical School researchers identify new targets to inhibit viral replication and may inform the development of a new class of antiviral drugs. (harvard.edu)
Such exquisite regulation is critical to making the correct levels of the viral proteins necessary for successful replication. (harvard.edu)
For instance, the nucleoside analogue ribavirin goals viral nucleic acidity replication. (colinsbraincancer.com)

Geographic distribution and viral cause of Hantavirus cardiopulmonary syndrome (HCPS). (medscape.com)

Key findings and successes from this work have influenced her current avenue of research that focuses on the molecular and cellular biology of arenaviruses and structural characterisation of host-protein interactions. (wcgvr.org)
Molecular mechanisms of viral gene expression. (whelan-lab.org)

As we have learned from the COVID pandemic, emerging viral outbreaks can have a tremendous impact on individuals, families and communities across the globe" said Eric Tarcha , PhD, EVP Research and Development at Kineta. (pharmaceuticalnewswire.com)

This ongoing work emphasizes the need for subtle differences in viral strains that determine disease outcomes. (biospraysehatalami.com)

Biochemical, reporter-based and primer-extension assays indicate that BCX4430 inhibits viral RNA polymerase function, acting as a non-obligate RNA chain terminator. (flutrackers.com)
A differ from a lysine (K) to a glutamine (Q) at placement 1079 in the L proteins an RNA-dependent RNA polymerase selectively elevated viral titers in macrophages however not in various other cell types examined (14). (biospraysehatalami.com)
The long segment (around 7200 nucleotides in length) encodes the viral [[polymerase]] and a zinc binding protein. (wikidoc.org)

The types of rodents that spread arenaviruses are located across much of the world, including Europe, Asia, Africa, and the Americas. (cdc.gov)
[ 11 ] More recently, a novel arenavirus was identified in 5 patients in southern Africa. (medscape.com)

Inadequate or delayed immune response to these novel viral antigens may lead to rapid development of overwhelming viremia. (medscape.com)
This letter, written from Nigeria in 1969 by an American missionary nurse named Lily Pinneo, tells the story of the emergence of a novel viral haemorrhagic fever in the town of Lassa in northeastern Nigeria, near the border with Cameroon. (gavi.org)

Sandflies Sicilian sandfly fever, Rift valley fever. (slideshare.net)

We are currently investigating the mechanisms of host restriction of arenavirus entry that may inform novel strategies to design therapeutic agents that utilise the host cell antiviral immunity to block emerging arenaviruses. (nottingham.ac.uk)
The more we learn about the fundamental basics of viral biology and bacterial biology and other microbial biologies, the more opportunities we have to develop interventions such as this particular apparently broad-spectrum antiviral,' he said. (voanews.com)
LHF-535 is a first-in-class antiviral treatment with potent activity against Lassa and other arenaviruses. (pharmaceuticalnewswire.com)

The drug - known by the acronym DRACO - works by chemically targeting viral-infected cells and prompting them to self-destruct, eliminating the disease in the process. (voanews.com)
Despite multiple intensive studies by disease investigators, the way in which Arenaviruses enter host cells is still something of a mystery. (gavi.org)
The precise species of the rodent associated with disease has not yet been discovered, but it is largely believed that species natalensis is responsible for fever. (bestnursingpapers.com)

In some instances, arenaviruses can spread to people when consuming infected rodents as a food source. (cdc.gov)

Viral encephalitis (alphaviruses [e.g. (cdc.gov)

The name describes the sandy grain-like appearance of Arenavirus particles, or virions, under a microscope. (gavi.org)
Aerolization of the feces and urine makes the viral tiny particles vulnerable inhalation by human beings. (bestnursingpapers.com)

Anatomy1

Organisms18

Diseases17

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Anthropology, Education, Sociology and Social Phenomena1

Health Care2

Geographicals1

Filoviruses6

Marburg6

Viruses27

Machupo5

Infection14

VHFs1

Crimean-Congo1

Infections15

Dengue haemo1

Junin2

Lassa Fever32

Endemic5

Diseases3

Guanarito2

Chapare2

West Africa1

South America1

Yellow fever10

Lujo2

HFRS1

Filovirus1

Infectious2

Bunyaviridae1

Glycoproteins2

Genus1

Mammalian2

Occur3

Virus11

Myalgia1

Replication5

Hantavirus1

Molecular2

Outbreaks1

Strains1

Polymerase3

Africa2

Novel viral2

Rift1

Antiviral3

Disease3

Rodents1

Encephalitis1

Particles2